HitPredict

Interactor 1: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Interactor 2: SRSF5 (Q13243)
Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)
Gene: SRSF5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0006397 - mRNA processing GO:0016607 - nuclear speck
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 494 Hs			1 272
+	Hs
		992736 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		992751 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		SRSF5_HUMAN (1-240): 2.63e-54: 178: 100.00
+	Hs
		992737 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64
+	Hs
		992750 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		SRSF9_HUMAN (2-211): 1.47e-52: 172: 33.02
+	Hs
		1028637 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		SRSF5_HUMAN (1-240): 2.63e-54: 178: 100.00
+	Hs
		992752 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96
+	Hs
		993701 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64
+	At
		955329 SR30_ARATH (4-253): 1.45e-54: 185: 36.33		SRS31_ARATH (6-267): 2.4e-48: 162: 27.24
+	Hs
		516478 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56
+	Sc
		376750 NOP4_YEAST (1-492): 1.19e-52: 190: 11.82		PABP_YEAST (86-192): 7.08e-15: 75.9: 19.64
+	Mm
		857340 SRSF1_MOUSE (3-166): 2.36e-57: 192: 41.42		TIA1_MOUSE (2-101): 7.98e-13: 69.3: 15.69
+	Mm
		857324 Q542V3_MOUSE (1-468): 2.02e-54: 191: 80.38		TIA1_MOUSE (2-101): 7.98e-13: 69.3: 15.69
+	Mm
		1208011 SRSF9_MOUSE (3-216): 4.58e-52: 177: 36.53		RBM4_MOUSE (2-122): 2.58e-17: 82.4: 21.49
+	Hs
		516493 SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53		PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56
+	Mm
		936481 SRSF1_MOUSE (3-166): 2.36e-57: 192: 41.42		TIAR_MOUSE (100-193): 5.2e-11: 64.3: 16.67
+	Hs
		951932 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		SRSF3_HUMAN (4-78): 1.85e-11: 62.8: 47.56
+	Hs
		474020 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		PAB4L_HUMAN (5-75): 5.48e-14: 72.8: 24.68
+	Hs
		951942 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		SRSF3_HUMAN (4-78): 1.85e-11: 62.8: 47.56