HitPredict

Interactor 1: PP2AA (P67775)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)
Gene: PPP2CA

Interactor 2: INT6 (Q9UL03)
Integrator complex subunit 6 (Int6) (DBI-1) (Protein deleted in cancer 1) (DICE1)
Gene: INTS6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.927

Property	Details
Experiments	26496610, 28330616, 35271311, 34004147, 20133760
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Metallophos~VWA_2
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0160232 - INTAC complex GO:0160240 - RNA polymerase II transcription initiation surveillance
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 309 Hs			1 887
+	Hs
		977608 PP2AB_HUMAN (1-309): 0: 528: 97.41		INT6_HUMAN (1-887): 0: 1561: 100.00
+	Hs
		786923 PP1G_HUMAN (7-306): 0: 505: 45.96		INT6_HUMAN (1-887): 0: 1561: 100.00
+	Mm
		994009 PP2AA_MOUSE (1-309): 0: 528: 99.68		INT6_MOUSE (1-887): 0: 1525: 95.94
+	Hs
		516086 PP4C_HUMAN (4-309): 0: 508: 64.82		CT456_HUMAN (627-874): 2.61e-34: 131: 23.79
+	Hs
		952004 PP4C_HUMAN (4-309): 0: 508: 64.82		CT453_HUMAN (627-874): 3.7e-34: 131: 23.79