Protein: PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) (Protein phosphatase X) (PP-X)

Gene: PP4C, PPP4C
Organism: Homo sapiens
Interactions: 140
UniProt ID: P60510

Gene Ontology (top 5):
GO:0000724 - double-strand break repair via homologous recombination
GO:0000785 - chromatin
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

951961

IGBP1
Immunoglobulin-binding protein 1

12

19

Small-scale

0.982

High

952005

PP4R1
Serine/threonine-protein phosphatase 4 regulatory subunit 1

9

19

Small-scale

0.975

High

717747

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

6

20

Small-scale

0.956

High

951976

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

5

20

Small-scale

0.930

High

289854

TIPRL
TIP41-like protein

5

6

Small-scale

0.927

High

951955

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

4

13

High-throughput

0.906

High

951979

PTPA
Serine/threonine-protein phosphatase 2A activator

3

10

High-throughput

0.839

High

952038

PPME1
Protein phosphatase methylesterase 1

3

3

High-throughput

0.839

High

952030

LCMT1
Leucine carboxyl methyltransferase 1

2

1

High-throughput

0.789

High

952027

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

14

1

Small-scale

0.765

High

951993

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

12

5

Small-scale

0.761

High

951987

P4R3B
Serine/threonine-protein phosphatase 4 regulatory subunit 3B

9

5

Small-scale

0.754

High

951984

CCDC6
Coiled-coil domain-containing protein 6

7

18

Small-scale

0.750

High

951994

PP4R4
Serine/threonine-protein phosphatase 4 regulatory subunit 4

6

20

Small-scale

0.741

High

951991

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

4

19

High-throughput

0.706

High

610592

TCPA
T-complex protein 1 subunit alpha

4

20

Small-scale

0.704

High

821279

TCPZ
T-complex protein 1 subunit zeta

4

20

Small-scale

0.704

High

875889

TCPE
T-complex protein 1 subunit epsilon

4

20

Small-scale

0.704

High

881851

TCPG
T-complex protein 1 subunit gamma

4

20

Small-scale

0.704

High

899317

TCPD
T-complex protein 1 subunit delta

4

20

Small-scale

0.704

High

951962

TCPB
T-complex protein 1 subunit beta

4

20

Small-scale

0.704

High

952016

TCPH
T-complex protein 1 subunit eta

4

20

Small-scale

0.704

High

130418

SPT5H
Transcription elongation factor SPT5

4

13

High-throughput

0.699

High

952007

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

4

3

Small-scale

0.697

High

718094

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

20

High-throughput

0.691

High

951959

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

13

High-throughput

0.691

High

951970

2A5G
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

1

20

High-throughput

0.691

High

898972

TCPQ
T-complex protein 1 subunit theta

3

20

Small-scale

0.662

High

262503

MCE1
mRNA-capping enzyme

3

4

High-throughput

0.656

High

951963

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

2

19

High-throughput

0.640

High

588345

RFA2
Replication protein A 32 kDa subunit

2

5

Small-scale

0.624

High

951969

TIF1B
Transcription intermediary factor 1-beta

2

10

Small-scale

0.624

High

952009

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

2

20

Small-scale

0.624

High

143605

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

13

High-throughput

0.618

High

952010

SNX27
Sorting nexin-27

1

17

High-throughput

0.618

High

952028

CALL5
Calmodulin-like protein 5

1

2

High-throughput

0.618

High

952032

PRP19
Pre-mRNA-processing factor 19

2

4

High-throughput

0.611

High

951973

TRI14
Tripartite motif-containing protein 14

2

6

High-throughput

0.601

High

952022

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

2

6

High-throughput

0.601

High

126302

TLR4
Toll-like receptor 4

1

0

Small-scale

0.586

High

188228

HDAC3
Histone deacetylase 3

1

10

Small-scale

0.578

High

952018

DDA1
DET1- and DDB1-associated protein 1

2

0

High-throughput

0.576

High

485596

RU2A
U2 small nuclear ribonucleoprotein A'

1

7

High-throughput

0.575

High

951965

REL
Proto-oncogene c-Rel

1

8

Small-scale

0.573

High

951980

RBP1
RalA-binding protein 1

2

5

High-throughput

0.571

High

951995

FBX42
F-box only protein 42

2

1

High-throughput

0.558

High

350443

GPAN1
G patch domain and ankyrin repeat-containing protein 1

2

9

High-throughput

0.553

High

952036

TRAF6
TNF receptor-associated factor 6

1

11

Small-scale

0.552

High

138819

STK25
Serine/threonine-protein kinase 25

1

20

High-throughput

0.536

High

186522

TRI18
E3 ubiquitin-protein ligase Midline-1

1

14

High-throughput

0.536

High

216656

HTRA2
Serine protease HTRA2, mitochondrial

1

4

High-throughput

0.536

High

285841

SF3B1
Splicing factor 3B subunit 1

1

16

High-throughput

0.536

High

951956

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

19

High-throughput

0.536

High

951967

FOXD4
Forkhead box protein D4

1

6

High-throughput

0.536

High

951968

LIPA1
Liprin-alpha-1

1

14

High-throughput

0.536

High

951972

CUL3
Cullin-3

1

11

High-throughput

0.536

High

951978

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.536

High

951981

SF3B3
Splicing factor 3B subunit 3

1

1

High-throughput

0.536

High

951982

SF3B4
Splicing factor 3B subunit 4

1

7

High-throughput

0.536

High

952000

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

3

High-throughput

0.536

High

952006

TCPW
T-complex protein 1 subunit zeta-2

1

20

High-throughput

0.536

High

952015

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

952020

SF3B5
Splicing factor 3B subunit 5

1

1

High-throughput

0.536

High

952021

CDCA4
Cell division cycle-associated protein 4

1

5

High-throughput

0.536

High

952031

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

12

High-throughput

0.536

High

952034

2ABG
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

1

19

High-throughput

0.536

High

952035

SF3B6
Splicing factor 3B subunit 6

1

7

High-throughput

0.536

High

856618

BAG6
Large proline-rich protein BAG6

1

4

High-throughput

0.515

High

270909

CLAP2
CLIP-associating protein 2

1

0

High-throughput

0.513

High

297947

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.513

High

482680

SPRC
SPARC

1

0

High-throughput

0.513

High

570867

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.513

High

951971

SF3B2
Splicing factor 3B subunit 2

1

0

High-throughput

0.513

High

413506

P53
Cellular tumor antigen p53

1

4

Small-scale

0.501

High

429612

JUN
Transcription factor Jun

1

7

Small-scale

0.501

High

951953

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

2

High-throughput

0.501

High

951964

TF65
Transcription factor p65

1

5

Small-scale

0.501

High

951988

TCHL1
Trichohyalin-like protein 1

1

3

High-throughput

0.489

High

952013

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.489

High

952014

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

405429

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

167859

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

20

Small-scale

0.479

High

172635

XPO1
Exportin-1

1

7

High-throughput

0.479

High

177830

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

Small-scale

0.479

High

186196

PPM1D
Protein phosphatase 1D

1

1

Small-scale

0.479

High

194078

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

241244

PRKN
E3 ubiquitin-protein ligase parkin

1

13

High-throughput

0.479

High

259699

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

318298

MYO1D
Unconventional myosin-Id

1

11

High-throughput

0.479

High

587604

DESP
Desmoplakin

1

7

High-throughput

0.479

High

626139

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

10

Small-scale

0.479

High

655757

TBG1
Tubulin gamma-1 chain

1

7

Small-scale

0.479

High

695076

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

767834

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

919849

PLK1
Serine/threonine-protein kinase PLK1

1

14

High-throughput

0.479

High

951957

DYLT1
Dynein light chain Tctex-type 1

1

3

High-throughput

0.479

High

951958

SPT4H
Transcription elongation factor SPT4

1

1

High-throughput

0.479

High

951960

EF1A1
Elongation factor 1-alpha 1

1

2

High-throughput

0.479

High

951974

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

18

High-throughput

0.479

High

951975

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

High-throughput

0.479

High

951977

HAPR1
HUWE1-associated protein modifying stress responses 1

1

2

High-throughput

0.479

High

951986

WDR81
WD repeat-containing protein 81

1

5

High-throughput

0.479

High

951990

ATD3B
ATPase family AAA domain-containing protein 3B

1

13

High-throughput

0.479

High

951996

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.479

High

951997

TRM1L
tRNA

1

1

High-throughput

0.479

High

951999

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

4

High-throughput

0.479

High

952002

SIR6
NAD-dependent protein deacylase sirtuin-6

1

2

High-throughput

0.479

High

952003

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

952008

CSN5
COP9 signalosome complex subunit 5

1

2

High-throughput

0.479

High

952012

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

952023

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.479

High

952024

ADT4
ADP/ATP translocase 4

1

2

High-throughput

0.479

High

952025

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.479

High

952029

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

952033

SRRM2
Serine/arginine repetitive matrix protein 2

1

10

High-throughput

0.479

High

952039

NEMO
NF-kappa-B essential modulator

1

12

Small-scale

0.479

High

251877

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

0

High-throughput

0.458

High

281198

CDC45
Cell division control protein 45 homolog

1

0

High-throughput

0.458

High

567326

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

944440

GEMI4
Gem-associated protein 4

1

0

Small-scale

0.458

High

951985

SMN
Survival motor neuron protein

1

0

Small-scale

0.458

High

952017

GCP2
Gamma-tubulin complex component 2

1

0

Small-scale

0.458

High

952019

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.458

High

425409

ISG15
Ubiquitin-like protein ISG15

1

12

High-throughput

0.445

High

488161

IFIT1
Antiviral innate immune response effector IFIT1

1

4

High-throughput

0.445

High

936900

CASP7
Caspase-7

1

3

High-throughput

0.445

High

951966

SLFN5
Schlafen family member 5

1

1

High-throughput

0.445

High

951983

OASL
2'-5'-oligoadenylate synthase-like protein

1

11

High-throughput

0.445

High

951992

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.445

High

952001

ZN695
Zinc finger protein 695

1

5

High-throughput

0.445

High

952004

CT453
Cancer/testis antigen family 45 member A3

1

5

High-throughput

0.445

High

952026

ATD3A
ATPase family AAA domain-containing protein 3A

1

13

High-throughput

0.437

High

952037

CSDC2
Cold shock domain-containing protein C2

1

0

High-throughput

0.426

High

516086

CT456
Cancer/testis antigen family 45 member A6

1

5

High-throughput

0.407

High

952040

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

4

High-throughput

0.407

High

951954

SELT
Thioredoxin reductase-like selenoprotein T

1

0

High-throughput

0.279

Low

951989

GLYL3
Glycine N-acyltransferase-like protein 3

1

0

High-throughput

0.279

Low

71791

TTC34
Tetratricopeptide repeat protein 34

1

0

High-throughput

0.249

Low

952011

UBX10
UBX domain-containing protein 10

1

0

High-throughput

0.249

Low

951998

RIC3
Protein RIC-3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025