Interactor 1: ITK (Q08881)
Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk)
Gene: ITK
Interactor 2: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.87 | 1.00 | 0.938 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 15388330, 10636929, 12190313, 17420479, 21725281, 10556826 |
| Identification Methods | affinity chromatography technology, pull down, enzymatic study, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1 |
| Common GO terms | GO:0005829 - cytosol GO:0005911 - cell-cell junction GO:0035556 - intracellular signal transduction GO:0050852 - T cell receptor signaling pathway |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
