Protein: UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)

Gene: UB2L6, UBE2L6
Organism: Homo sapiens
Interactions: 118
UniProt ID: O14933

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

159008

ARI2
E3 ubiquitin-protein ligase ARIH2

7

20

Small-scale

0.969

High

159065

LONF1
LON peptidase N-terminal domain and RING finger protein 1

4

20

High-throughput

0.911

High

159089

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

4

20

High-throughput

0.911

High

159069

R144B
E3 ubiquitin-protein ligase RNF144B

3

20

Small-scale

0.873

High

159075

DTX3
Probable E3 ubiquitin-protein ligase DTX3

3

20

High-throughput

0.861

High

159090

TRIM8
E3 ubiquitin-protein ligase TRIM8

3

20

High-throughput

0.861

High

159082

RN125
E3 ubiquitin-protein ligase RNF125

3

20

Small-scale

0.858

High

159002

PRKN
E3 ubiquitin-protein ligase parkin

3

20

Small-scale

0.847

High

48080

UBA6
Ubiquitin-like modifier-activating enzyme 6

2

20

Small-scale

0.799

High

159038

R144A
E3 ubiquitin-protein ligase RNF144A

2

20

Small-scale

0.791

High

159074

HERC6
Probable E3 ubiquitin-protein ligase HERC6

2

20

High-throughput

0.789

High

158996

TRI18
E3 ubiquitin-protein ligase Midline-1

2

20

High-throughput

0.783

High

159017

UBA1
Ubiquitin-like modifier-activating enzyme 1

2

20

Small-scale

0.778

High

159028

UBA7
Ubiquitin-like modifier-activating enzyme 7

2

20

Small-scale

0.778

High

159052

UBE3A
Ubiquitin-protein ligase E3A

2

20

Small-scale

0.778

High

159084

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

20

High-throughput

0.768

High

158997

PJA2
E3 ubiquitin-protein ligase Praja-2

1

20

High-throughput

0.698

High

159067

TRAF7
E3 ubiquitin-protein ligase TRAF7

1

11

High-throughput

0.698

High

159080

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

20

High-throughput

0.698

High

159081

RNF25
E3 ubiquitin-protein ligase RNF25

1

16

High-throughput

0.698

High

159092

RN122
RING finger protein 122

1

20

High-throughput

0.698

High

159095

TOPRS
E3 ubiquitin-protein ligase Topors

1

7

High-throughput

0.698

High

159102

RN150
RING finger protein 150

1

20

High-throughput

0.698

High

159103

CBLC
E3 ubiquitin-protein ligase CBL-C

1

20

High-throughput

0.698

High

158995

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

16

Small-scale

0.692

High

159068

RN19B
E3 ubiquitin-protein ligase RNF19B

1

20

Small-scale

0.690

High

159046

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

5

High-throughput

0.665

High

159097

RN216
E3 ubiquitin-protein ligase RNF216

3

20

Small-scale

0.653

High

159045

RBX1
E3 ubiquitin-protein ligase RBX1

1

20

Small-scale

0.647

High

159055

TIF1B
Transcription intermediary factor 1-beta

1

20

Small-scale

0.647

High

159085

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

20

Small-scale

0.647

High

159100

HERC5
E3 ISG15--protein ligase HERC5

1

20

Small-scale

0.647

High

159049

RNF4
E3 ubiquitin-protein ligase RNF4

1

20

High-throughput

0.621

High

125000

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

20

High-throughput

0.618

High

159005

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

14

Small-scale

0.618

High

159012

ISG15
Ubiquitin-like protein ISG15

1

20

High-throughput

0.618

High

159035

RBP2
E3 SUMO-protein ligase RanBP2

1

1

High-throughput

0.618

High

159048

RACK1
Small ribosomal subunit protein RACK1

1

9

High-throughput

0.618

High

159050

XIAP
E3 ubiquitin-protein ligase XIAP

1

20

Small-scale

0.618

High

159056

BIRC2
Baculoviral IAP repeat-containing protein 2

1

20

Small-scale

0.618

High

159058

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

20

Small-scale

0.618

High

159059

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

20

High-throughput

0.618

High

159060

IMB1
Importin subunit beta-1

1

1

High-throughput

0.618

High

159066

SMU1
WD40 repeat-containing protein SMU1

1

12

High-throughput

0.618

High

159070

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

20

High-throughput

0.618

High

159077

COP1
E3 ubiquitin-protein ligase COP1

1

12

High-throughput

0.618

High

159083

OTUB1
Ubiquitin thioesterase OTUB1

1

13

Small-scale

0.618

High

159096

RN19A
E3 ubiquitin-protein ligase RNF19A

1

20

Small-scale

0.618

High

159107

FBW1A
F-box/WD repeat-containing protein 1A

1

19

High-throughput

0.618

High

159108

ARI1
E3 ubiquitin-protein ligase ARIH1

1

20

Small-scale

0.618

High

159088

TRI62
E3 ubiquitin-protein ligase TRIM62

2

20

High-throughput

0.606

High

159086

MINT
Msx2-interacting protein

1

2

Small-scale

0.573

High

159076

UBAC2
Ubiquitin-associated domain-containing protein 2

1

1

High-throughput

0.553

High

159016

TRI27
Zinc finger protein RFP

1

20

High-throughput

0.541

High

159054

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

15

High-throughput

0.541

High

159031

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

20

High-throughput

0.527

High

159087

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

1

1

High-throughput

0.515

High

159078

GNPI2
Glucosamine-6-phosphate isomerase 2

1

0

High-throughput

0.513

High

159025

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

7

Small-scale

0.512

High

159072

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

20

Small-scale

0.501

High

159039

GDIR1
Rho GDP-dissociation inhibitor 1

1

0

High-throughput

0.486

High

159051

RUNX1
Runt-related transcription factor 1

1

0

Small-scale

0.480

High

158999

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

20

Small-scale

0.479

High

159003

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

3

High-throughput

0.479

High

159004

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.479

High

159007

WFS1
Wolframin

1

1

High-throughput

0.479

High

159010

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

3

High-throughput

0.479

High

159013

HS90B
Heat shock protein HSP 90-beta

1

4

High-throughput

0.479

High

159014

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

159015

PABP1
Polyadenylate-binding protein 1

1

2

High-throughput

0.479

High

159019

PTBP1
Polypyrimidine tract-binding protein 1

1

1

High-throughput

0.479

High

159020

EF1G
Elongation factor 1-gamma

1

2

High-throughput

0.479

High

159021

1433T
14-3-3 protein theta

1

4

High-throughput

0.479

High

159022

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

4

Small-scale

0.479

High

159023

RL12
Large ribosomal subunit protein uL11

1

1

High-throughput

0.479

High

159024

CTNB1
Catenin beta-1

1

2

High-throughput

0.479

High

159027

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

159030

RS9
Small ribosomal subunit protein uS4

1

1

High-throughput

0.479

High

159034

MCM2
DNA replication licensing factor MCM2

1

5

High-throughput

0.479

High

159036

DYN2
Dynamin-2

1

1

High-throughput

0.479

High

159037

CDK9
Cyclin-dependent kinase 9

1

5

High-throughput

0.479

High

159040

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

1

High-throughput

0.479

High

159043

1433G
14-3-3 protein gamma

1

4

High-throughput

0.479

High

159044

RS15A
Small ribosomal subunit protein uS8

1

2

High-throughput

0.479

High

159047

1433Z
14-3-3 protein zeta/delta

1

4

High-throughput

0.479

High

159053

TADBP
TAR DNA-binding protein 43

1

4

High-throughput

0.479

High

159062

IPYR
Inorganic pyrophosphatase

1

1

High-throughput

0.479

High

159071

TAXB1
Tax1-binding protein 1

1

6

High-throughput

0.479

High

159079

HDAC2
Histone deacetylase 2

1

4

High-throughput

0.479

High

159091

PKHA4
Pleckstrin homology domain-containing family A member 4

1

10

High-throughput

0.479

High

159093

DCP1A
mRNA-decapping enzyme 1A

1

1

High-throughput

0.479

High

159101

BAG5
BAG family molecular chaperone regulator 5

1

2

High-throughput

0.479

High

159105

RUVB2
RuvB-like 2

1

1

High-throughput

0.479

High

159106

RUVB1
RuvB-like 1

1

1

High-throughput

0.479

High

158998

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.458

High

159000

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

159006

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.458

High

159009

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.458

High

159018

COF1
Cofilin-1

1

0

High-throughput

0.458

High

159026

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

159033

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

High-throughput

0.458

High

159041

ACTZ
Alpha-centractin

1

0

High-throughput

0.458

High

159042

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.458

High

159057

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.458

High

159063

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

159094

TF7L2
Transcription factor 7-like 2

1

0

High-throughput

0.458

High

159099

SEPT9
Septin-9

1

0

High-throughput

0.458

High

159104

SMC3
Structural maintenance of chromosomes protein 3

1

0

High-throughput

0.458

High

159029

NAMPT
Nicotinamide phosphoribosyltransferase

1

1

Small-scale

0.457

High

159109

SNURF
SNRPN upstream reading frame protein

1

5

High-throughput

0.457

High

159011

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.437

High

159032

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.408

High

159073

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

0

High-throughput

0.279

Low

159001

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

0

Small-scale

0.249

Low

159061

OXA1L
Mitochondrial inner membrane protein OXA1L

1

0

High-throughput

0.249

Low

159064

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.249

Low

159098

ABCF2
ATP-binding cassette sub-family F member 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024