Protein: VKOR1
Vitamin K epoxide reductase complex subunit 1 (EC 1.17.4.4) (Vitamin K1 2,3-epoxide reductase subunit 1)

Gene: VKOR1, VKORC1
Organism: Homo sapiens
Interactions: 136
UniProt ID: Q9BQB6

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen
GO:0005789 - endoplasmic reticulum membrane
GO:0006805 - xenobiotic metabolic process
GO:0007596 - blood coagulation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1384341

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

1

High-throughput

0.606

High

230411

CREB3
Cyclic AMP-responsive element-binding protein 3

2

1

High-throughput

0.590

High

1286885

TM11B
Transmembrane protease serine 11B

2

2

High-throughput

0.558

High

1214421

GORAB
RAB6-interacting golgin

2

1

High-throughput

0.553

High

1348627

S7A14
Solute carrier family 7 member 14

2

2

High-throughput

0.553

High

1351692

GP152
Probable G-protein coupled receptor 152

2

7

High-throughput

0.553

High

1403765

RMD3
Regulator of microtubule dynamics protein 3

2

1

High-throughput

0.553

High

1410454

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

1

Small-scale

0.552

High

762157

CNR2
Cannabinoid receptor 2

1

3

Small-scale

0.536

High

1410470

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.536

High

1142927

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

0

Small-scale

0.529

High

1410479

SERP1
Stress-associated endoplasmic reticulum protein 1

1

0

Small-scale

0.529

High

396820

ESR1
Estrogen receptor

2

3

High-throughput

0.521

High

1410476

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

2

High-throughput

0.515

High

1105549

OS9
Protein OS-9

1

0

High-throughput

0.513

High

1410458

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

1410478

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.513

High

1410463

SAR1A
Small COPII coat GTPase SAR1A

1

0

High-throughput

0.493

High

1212292

TM63B
Mechanosensitive cation channel TMEM63B

1

1

High-throughput

0.489

High

1310348

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.489

High

333159

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

Small-scale

0.481

High

388007

FIBG
Fibrinogen gamma chain

1

1

Small-scale

0.481

High

464714

CXB1
Gap junction beta-1 protein

1

1

Small-scale

0.481

High

904092

BAP31
B-cell receptor-associated protein 31

1

1

Small-scale

0.481

High

1065021

FGL1
Fibrinogen-like protein 1

1

1

Small-scale

0.481

High

1249159

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1322210

VKORL
Vitamin K epoxide reductase complex subunit 1-like protein 1

1

1

Small-scale

0.479

High

188978

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.470

High

184500

SURF4
Surfeit locus protein 4

1

0

Small-scale

0.460

High

292729

RENR
Renin receptor

1

0

Small-scale

0.460

High

297257

PRAF3
PRA1 family protein 3

1

0

Small-scale

0.460

High

317083

DPM2
Dolichol phosphate-mannose biosynthesis regulatory protein

1

0

Small-scale

0.460

High

325590

YIF1A
Protein YIF1A

1

0

Small-scale

0.460

High

369390

A1AT
Alpha-1-antitrypsin

1

0

Small-scale

0.460

High

387317

APOA1
Apolipoprotein A-I

1

0

Small-scale

0.460

High

387555

APOA2
Apolipoprotein A-II

1

0

Small-scale

0.460

High

387601

APOC1
Apolipoprotein C-I

1

0

Small-scale

0.460

High

389760

FETUA
Alpha-2-HS-glycoprotein

1

0

Small-scale

0.460

High

390945

TRFE
Serotransferrin

1

0

Small-scale

0.460

High

656226

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

0

Small-scale

0.460

High

942509

DHB7
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

1

0

Small-scale

0.460

High

1027154

REEP5
Receptor expression-enhancing protein 5

1

0

Small-scale

0.460

High

1050056

PLP2
Proteolipid protein 2

1

0

Small-scale

0.460

High

1055350

APLP2
Amyloid beta precursor like protein 2

1

0

Small-scale

0.460

High

1126351

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

Small-scale

0.460

High

1142378

PDIA6
Protein disulfide-isomerase A6

1

0

Small-scale

0.460

High

1150606

TRAM1
Translocating chain-associated membrane protein 1

1

0

Small-scale

0.460

High

1154071

MSMO1
Methylsterol monooxygenase 1

1

0

Small-scale

0.460

High

1249608

TMT1B
Thiol S-methyltransferase TMT1B

1

0

Small-scale

0.460

High

1328189

JAGN1
Protein jagunal homolog 1

1

0

Small-scale

0.460

High

1381434

SPTSA
Serine palmitoyltransferase small subunit A

1

0

Small-scale

0.460

High

1382496

TM230
Transmembrane protein 230

1

0

Small-scale

0.460

High

1410455

TACAN
Transmembrane protein 120A

1

0

Small-scale

0.460

High

1410461

LFG4
Protein lifeguard 4

1

0

Small-scale

0.460

High

1410465

TREX1
Three-prime repair exonuclease 1

1

0

Small-scale

0.460

High

1410475

EPCR
Endothelial protein C receptor

1

0

Small-scale

0.460

High

1179024

S35G1
Solute carrier family 35 member G1

1

1

High-throughput

0.445

High

366205

HPT
Haptoglobin

1

4

Small-scale

0.439

High

366235

HPTR
Haptoglobin-related protein

1

2

Small-scale

0.439

High

455933

ASGR1
Asialoglycoprotein receptor 1

1

1

Small-scale

0.439

High

456004

ASGR2
Asialoglycoprotein receptor 2

1

1

Small-scale

0.439

High

477460

CD63
CD63 antigen

1

5

Small-scale

0.439

High

486873

C1S
Complement C1s subcomponent

1

4

Small-scale

0.439

High

641974

CD9
CD9 antigen

1

6

Small-scale

0.439

High

948921

CD81
CD81 antigen

1

6

Small-scale

0.439

High

1387307

RMD1
Regulator of microtubule dynamics protein 1

1

1

Small-scale

0.439

High

1403493

KCNKH
Potassium channel subfamily K member 17

1

1

Small-scale

0.439

High

217328

PROM1
Prominin-1

1

0

Small-scale

0.438

High

404379

GCR
Glucocorticoid receptor

1

3

High-throughput

0.437

High

1367128

ESR2
Estrogen receptor beta

1

3

High-throughput

0.437

High

1047331

P
P protein

1

0

High-throughput

0.426

High

1410456

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

3

High-throughput

0.407

High

1410471

HDAC6
Protein deacetylase HDAC6

2

0

Small-scale

0.320

High

590336

MUC1
Mucin-1

2

0

High-throughput

0.316

High

1207593

F209A
Protein FAM209A

2

0

High-throughput

0.316

High

1281188

CPLX4
Complexin-4

2

0

High-throughput

0.316

High

1396394

F210B
Protein FAM210B, mitochondrial

2

0

High-throughput

0.316

High

1410462

MANBL
Protein MANBAL

2

0

High-throughput

0.316

High

167173

T4S5
Transmembrane 4 L6 family member 5

1

0

High-throughput

0.279

Low

1101408

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

1104473

ILK
Scaffold protein ILK

1

0

High-throughput

0.279

Low

1142641

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.279

Low

1410474

CDC23
Cell division cycle protein 23 homolog

1

0

High-throughput

0.279

Low

905767

CAV2
Caveolin-2

1

0

High-throughput

0.269

Low

3414

A0A0S2Z4U3
Syndecan

1

0

High-throughput

0.268

Low

1102445

BIK
Bcl-2-interacting killer

1

0

High-throughput

0.268

Low

183960

S22A2
Solute carrier family 22 member 2

1

0

Small-scale

0.251

Low

190564

COPT2
Protein SLC31A2

1

0

Small-scale

0.251

Low

386155

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.251

Low

387666

APOC3
Apolipoprotein C-III

1

0

Small-scale

0.251

Low

391432

FRIL
Ferritin light chain

1

0

Small-scale

0.251

Low

515899

SAA1
Serum amyloid A-1 protein

1

0

Small-scale

0.251

Low

639638

SAT1
Diamine acetyltransferase 1

1

0

Small-scale

0.251

Low

642281

COMT
Catechol O-methyltransferase

1

0

Small-scale

0.251

Low

643552

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

Small-scale

0.251

Low

838250

STAT6
Signal transducer and activator of transcription 6

1

0

Small-scale

0.251

Low

870991

AT5G3
ATP synthase F(0) complex subunit C3, mitochondrial

1

0

Small-scale

0.251

Low

892722

DNLI4
DNA ligase 4

1

0

High-throughput

0.251

Low

916334

TXTP
Tricarboxylate transport protein, mitochondrial

1

0

Small-scale

0.251

Low

933984

APOC4
Apolipoprotein C-IV

1

0

Small-scale

0.251

Low

1004180

CXAR
Coxsackievirus and adenovirus receptor

1

0

Small-scale

0.251

Low

1006971

CLD10
Claudin-10

1

0

Small-scale

0.251

Low

1009819

MT1X
Metallothionein-1X

1

0

Small-scale

0.251

Low

1010438

HEPC
Hepcidin

1

0

Small-scale

0.251

Low

1031518

IFM3
Interferon-induced transmembrane protein 3

1

0

Small-scale

0.251

Low

1062187

PCDH1
Protocadherin-1

1

0

Small-scale

0.251

Low

1148316

CNN3
Calponin-3

1

0

Small-scale

0.251

Low

1313815

S15A3
Solute carrier family 15 member 3

1

0

Small-scale

0.251

Low

1324295

ZCH24
Zinc finger CCHC domain-containing protein 24

1

0

Small-scale

0.251

Low

1324551

TM256
Transmembrane protein 256

1

0

Small-scale

0.251

Low

1336015

TM35B
Transmembrane protein 35B

1

0

Small-scale

0.251

Low

1356563

CCD12
Coiled-coil domain-containing protein 12

1

0

Small-scale

0.251

Low

1383961

TM45B
Transmembrane protein 45B

1

0

Small-scale

0.251

Low

1393357

T176A
Transmembrane protein 176A

1

0

Small-scale

0.251

Low

1410457

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

0

Small-scale

0.251

Low

1410459

TM134
Transmembrane protein 134

1

0

Small-scale

0.251

Low

1410460

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

0

Small-scale

0.251

Low

1410464

HOME2
Homer protein homolog 2

1

0

Small-scale

0.251

Low

1410466

ECHD1
Ethylmalonyl-CoA decarboxylase

1

0

Small-scale

0.251

Low

1410467

TM242
Transmembrane protein 242

1

0

Small-scale

0.251

Low

1410468

MSRB1
Methionine-R-sulfoxide reductase B1

1

0

Small-scale

0.251

Low

1410469

CC167
Coiled-coil domain-containing protein 167

1

0

Small-scale

0.251

Low

1410477

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.251

Low

227653

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

294244

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

879400

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

980221

H4
Histone H4

1

0

High-throughput

0.249

Low

1115388

CUL4B
Cullin-4B

1

0

High-throughput

0.249

Low

1314537

TM192
Transmembrane protein 192

1

0

High-throughput

0.249

Low

1334839

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.249

Low

1410472

UBQL2
Ubiquilin-2

1

0

High-throughput

0.249

Low

1163637

MEP1B
Meprin A subunit beta

1

0

Small-scale

0.238

Low

222321

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.232

Low

1178992

SC5A9
Sodium/glucose cotransporter 4

1

0

High-throughput

0.232

Low

1410473

S23A1
Solute carrier family 23 member 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025