Protein: SIR2
NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (NAD-dependent protein defatty-acylase sirtuin-2) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2)

Gene: SIR2, SIRT2
Organism: Homo sapiens
Interactions: 155
UniProt ID: Q8IXJ6

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000183 - rDNA heterochromatin formation
GO:0000781 - chromosome, telomeric region
GO:0000792 - heterochromatin
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

829394

SYSC
Serine--tRNA ligase, cytoplasmic

4

3

High-throughput

0.697

High

1016210

FOXO1
Forkhead box protein O1

3

13

Small-scale

0.670

High

998872

EP300
Histone acetyltransferase p300

3

13

Small-scale

0.670

High

326707

SNAI1
Zinc finger protein SNAI1

3

4

High-throughput

0.667

High

1220765

NUD12
NAD-capped RNA hydrolase NUDT12

3

7

High-throughput

0.667

High

168270

DEGS1
Sphingolipid delta(4)-desaturase DES1

3

0

High-throughput

0.638

High

234127

FADS1
Acyl-CoA

3

0

High-throughput

0.638

High

850581

VAMP7
Vesicle-associated membrane protein 7

3

0

High-throughput

0.638

High

1033428

ORC2
Origin recognition complex subunit 2

3

0

High-throughput

0.638

High

1065381

RB3GP
Rab3 GTPase-activating protein catalytic subunit

3

0

High-throughput

0.638

High

1199356

LYRIC
Protein LYRIC

3

0

High-throughput

0.638

High

1220771

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

3

0

High-throughput

0.638

High

1220773

GPAT1
Glycerol-3-phosphate acyltransferase 1, mitochondrial

3

0

High-throughput

0.638

High

474680

GSTT2
Glutathione S-transferase theta-2B

2

1

High-throughput

0.628

High

513878

DMD
Dystrophin

2

9

High-throughput

0.628

High

675613

GSTT1
Glutathione S-transferase theta-1

2

1

High-throughput

0.628

High

1220755

MOAP1
Modulator of apoptosis 1

2

1

High-throughput

0.628

High

1220740

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

11

Small-scale

0.618

High

1220757

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

11

Small-scale

0.618

High

1220752

KAT2B
Histone acetyltransferase KAT2B

2

15

Small-scale

0.611

High

934960

H31
Histone H3.1

2

10

Small-scale

0.602

High

49747

S22AN
Solute carrier family 22 member 23

2

0

High-throughput

0.602

High

1220785

FZR1
Fizzy-related protein homolog

1

7

Small-scale

0.586

High

1198619

SYVN1
E3 ubiquitin-protein ligase synoviolin

2

3

Small-scale

0.584

High

1220779

HDAC6
Histone deacetylase 6

2

9

Small-scale

0.584

High

1220769

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

4

High-throughput

0.582

High

214315

SPOP
Speckle-type POZ protein

2

0

Small-scale

0.576

High

812824

PA24A
Cytosolic phospholipase A2

1

2

Small-scale

0.573

High

162963

XPO1
Exportin-1

2

9

Small-scale

0.563

High

978800

TF65
Transcription factor p65

1

7

Small-scale

0.561

High

1017405

CDC20
Cell division cycle protein 20 homolog

1

7

Small-scale

0.561

High

1085601

HIF1A
Hypoxia-inducible factor 1-alpha

1

10

Small-scale

0.561

High

988102

RAD51
DNA repair protein RAD51 homolog 1

1

1

High-throughput

0.541

High

1220750

ATRIP
ATR-interacting protein

1

0

Small-scale

0.537

High

1220788

MORC2
ATPase MORC2

1

0

Small-scale

0.537

High

236953

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

6

Small-scale

0.536

High

906525

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

5

High-throughput

0.536

High

674903

OXYR
Oxytocin receptor

1

0

High-throughput

0.518

High

239358

CC14B
Dual specificity protein phosphatase CDC14B

1

7

Small-scale

0.515

High

604173

PUR2
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase

1

3

High-throughput

0.515

High

1220742

K2C78
Keratin, type II cytoskeletal 78

1

4

High-throughput

0.515

High

657887

CYTD
Cystatin-D

1

0

High-throughput

0.513

High

858150

NAR1
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1

1

0

High-throughput

0.513

High

1220743

HORM2
HORMA domain-containing protein 2

1

0

High-throughput

0.513

High

1220746

RP9
Retinitis pigmentosa 9 protein

1

0

High-throughput

0.513

High

625510

CDK2
Cyclin-dependent kinase 2

1

6

Small-scale

0.501

High

854806

GDIR1
Rho GDP-dissociation inhibitor 1

1

1

Small-scale

0.501

High

933513

TBA4A
Tubulin alpha-4A chain

1

3

Small-scale

0.501

High

962854

MDM2
E3 ubiquitin-protein ligase Mdm2

1

4

Small-scale

0.501

High

992178

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

2

Small-scale

0.501

High

509254

G6PD
Glucose-6-phosphate 1-dehydrogenase

1

0

Small-scale

0.493

High

533702

GYS1
Glycogen [starch] synthase, muscle

1

0

High-throughput

0.493

High

1220764

PHB2
Prohibitin-2

1

0

High-throughput

0.493

High

1220774

RTN4
Reticulon-4

1

0

High-throughput

0.493

High

546004

MYOD1
Myoblast determination protein 1

1

4

Small-scale

0.484

High

197343

SERA
D-3-phosphoglycerate dehydrogenase

1

0

Small-scale

0.480

High

116598

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

3

High-throughput

0.479

High

214985

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

1

Small-scale

0.479

High

227996

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

258093

DNJB6
DnaJ homolog subfamily B member 6

1

4

Small-scale

0.479

High

347271

MYC
Myc proto-oncogene protein

1

7

Small-scale

0.479

High

387065

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

391782

H2A1B
Histone H2A type 1-B/E

1

10

Small-scale

0.479

High

397438

ADT2
ADP/ATP translocase 2

1

6

Small-scale

0.479

High

409154

K2C8
Keratin, type II cytoskeletal 8

1

2

High-throughput

0.479

High

444417

K1C19
Keratin, type I cytoskeletal 19

1

1

High-throughput

0.479

High

450569

RET1
Retinol-binding protein 1

1

1

Small-scale

0.479

High

455633

PARP1
Poly [ADP-ribose] polymerase 1

1

6

Small-scale

0.479

High

499902

CH60
60 kDa heat shock protein, mitochondrial

1

5

Small-scale

0.479

High

504364

HSP7C
Heat shock cognate 71 kDa protein

1

6

Small-scale

0.479

High

535462

GFAP
Glial fibrillary acidic protein

1

7

High-throughput

0.479

High

547128

EZRI
Ezrin

1

4

High-throughput

0.479

High

553138

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

569864

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

575100

RL7
Large ribosomal subunit protein uL30

1

1

Small-scale

0.479

High

610450

CBL
E3 ubiquitin-protein ligase CBL

1

6

Small-scale

0.479

High

651638

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

670105

MARCS
Myristoylated alanine-rich C-kinase substrate

1

2

High-throughput

0.479

High

675197

CLIP1
CAP-Gly domain-containing linker protein 1

1

7

High-throughput

0.479

High

681927

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

Small-scale

0.479

High

716728

CTNA1
Catenin alpha-1

1

2

High-throughput

0.479

High

724446

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

1

Small-scale

0.479

High

729137

K22E
Keratin, type II cytoskeletal 2 epidermal

1

3

Small-scale

0.479

High

781933

PERI
Peripherin

1

7

High-throughput

0.479

High

800032

VDAC2
Voltage-dependent anion-selective channel protein 2

1

2

Small-scale

0.479

High

808759

YAP1
Transcriptional coactivator YAP1

1

6

Small-scale

0.479

High

827472

EFTU
Elongation factor Tu, mitochondrial

1

6

Small-scale

0.479

High

843549

PAPOA
Poly(A) polymerase alpha

1

1

Small-scale

0.479

High

862432

ACLY
ATP-citrate synthase

1

4

Small-scale

0.479

High

876649

ELL
RNA polymerase II elongation factor ELL

1

2

High-throughput

0.479

High

896930

ARP2
Actin-related protein 2

1

2

High-throughput

0.479

High

919154

RAN
GTP-binding nuclear protein Ran

1

1

Small-scale

0.479

High

972224

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

12

Small-scale

0.479

High

1021429

ANK3
Ankyrin-3

1

4

High-throughput

0.479

High

1027615

CBLB
E3 ubiquitin-protein ligase CBL-B

1

5

Small-scale

0.479

High

1031229

SKP2
S-phase kinase-associated protein 2

1

4

Small-scale

0.479

High

1033292

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

6

High-throughput

0.479

High

1036716

SQSTM
Sequestosome-1

1

4

High-throughput

0.479

High

1038136

ATR
Serine/threonine-protein kinase ATR

1

9

Small-scale

0.479

High

1043093

CUL4A
Cullin-4A

1

5

High-throughput

0.479

High

1081092

CCDC6
Coiled-coil domain-containing protein 6

1

7

High-throughput

0.479

High

1084328

SRSF7
Serine/arginine-rich splicing factor 7

1

3

Small-scale

0.479

High

1124554

ODFP2
Outer dense fiber protein 2

1

8

High-throughput

0.479

High

1147617

FTM
Protein fantom

1

7

High-throughput

0.479

High

1163744

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.479

High

1220741

AHI1
Jouberin

1

5

High-throughput

0.479

High

1220745

DNJB8
DnaJ homolog subfamily B member 8

1

5

Small-scale

0.479

High

1220747

FBF1
Fas-binding factor 1

1

7

High-throughput

0.479

High

1220751

KAT2A
Histone acetyltransferase KAT2A

1

15

Small-scale

0.479

High

1220753

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

9

High-throughput

0.479

High

1220759

SCLT1
Sodium channel and clathrin linker 1

1

9

High-throughput

0.479

High

1220761

CEP89
Centrosomal protein of 89 kDa

1

7

High-throughput

0.479

High

1220766

RIOK1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

1220767

TINF2
TERF1-interacting nuclear factor 2

1

1

High-throughput

0.479

High

1220770

UNK
RING finger protein unkempt homolog

1

1

High-throughput

0.479

High

1220780

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1220781

TBK1
Serine/threonine-protein kinase TBK1

1

4

High-throughput

0.479

High

1220782

ANC2
Anaphase-promoting complex subunit 2

1

6

High-throughput

0.479

High

1220783

ING1
Inhibitor of growth protein 1

1

8

Small-scale

0.479

High

1220784

FBXL4
F-box/LRR-repeat protein 4

1

4

High-throughput

0.479

High

1220786

FBW1A
F-box/WD repeat-containing protein 1A

1

5

High-throughput

0.479

High

1220787

MTCH2
Mitochondrial carrier homolog 2

1

4

High-throughput

0.479

High

314353

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

Small-scale

0.458

High

324489

BAG3
BAG family molecular chaperone regulator 3

1

0

Small-scale

0.458

High

434404

TPM2
Tropomyosin beta chain

1

0

Small-scale

0.458

High

912330

SMD1
Small nuclear ribonucleoprotein Sm D1

1

0

Small-scale

0.458

High

915431

ACTA
Actin, aortic smooth muscle

1

0

Small-scale

0.458

High

1039252

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.458

High

1040161

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

1045131

RUNX3
Runt-related transcription factor 3

1

0

Small-scale

0.458

High

1053545

GCKR
Glucokinase regulatory protein

1

0

Small-scale

0.458

High

1151955

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1200483

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1220744

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.458

High

1220749

TPC12
Trafficking protein particle complex subunit 12

1

0

High-throughput

0.458

High

1220756

ENTR1
Endosome-associated-trafficking regulator 1

1

0

High-throughput

0.458

High

1220760

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

1220763

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

1220768

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1220776

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

1220775

BMP2K
BMP-2-inducible protein kinase

1

2

Small-scale

0.457

High

497275

TAU
Microtubule-associated protein tau

1

5

Small-scale

0.445

High

1220762

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.437

High

1220778

SEP10
Septin-10

1

1

High-throughput

0.437

High

1220748

SCFD2
Sec1 family domain-containing protein 2

3

0

High-throughput

0.347

High

1152476

K0930
Uncharacterized protein KIAA0930

2

0

High-throughput

0.328

High

1220772

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.328

High

132527

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

720873

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

961719

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.249

Low

1220754

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

1220758

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.249

Low

1220777

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.249

Low

1001527

ZNFS1
Putative uncharacterized protein ZNF252P-AS1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024