Protein: KLK6
Kallikrein-6 (EC 3.4.21.-) (Neurosin) (Protease M) (SP59) (Serine protease 18) (Serine protease 9) (Zyme)

Gene: KLK6
Organism: Homo sapiens
Interactions: 187
UniProt ID: Q92876

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

395374

A4
Amyloid-beta precursor protein

2

13

Small-scale

0.789

High

225972

KLK8
Kallikrein-8

1

12

High-throughput

0.665

High

1215896

TMPS6
Transmembrane protease serine 6

1

17

High-throughput

0.665

High

361773

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

5

Small-scale

0.647

High

361895

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

5

Small-scale

0.647

High

1271929

KLK6
Kallikrein-6

1

11

Small-scale

0.647

High

1271979

CDYL
Chromodomain Y-like protein

2

8

High-throughput

0.621

High

742447

SYUA
Alpha-synuclein

2

2

Small-scale

0.611

High

1271942

STAC
SH3 and cysteine-rich domain-containing protein

1

3

High-throughput

0.594

High

1159406

FBX42
F-box only protein 42

2

2

High-throughput

0.574

High

788971

MATK
Megakaryocyte-associated tyrosine-protein kinase

1

0

High-throughput

0.556

High

973871

PAX2
Paired box protein Pax-2

1

1

High-throughput

0.541

High

1271945

TS101
Tumor susceptibility gene 101 protein

1

1

High-throughput

0.541

High

518440

ADT3
ADP/ATP translocase 3

1

15

High-throughput

0.536

High

686717

CCR1
C-C chemokine receptor type 1

1

6

High-throughput

0.536

High

933554

TBA4A
Tubulin alpha-4A chain

1

20

High-throughput

0.536

High

987793

GABPA
GA-binding protein alpha chain

1

3

High-throughput

0.536

High

1037334

TBB3
Tubulin beta-3 chain

1

20

High-throughput

0.536

High

1215935

CERS3
Ceramide synthase 3

1

4

High-throughput

0.536

High

1271935

SARAF
Store-operated calcium entry-associated regulatory factor

1

2

High-throughput

0.536

High

1271941

STRBP
Spermatid perinuclear RNA-binding protein

1

1

High-throughput

0.536

High

1271946

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

7

High-throughput

0.536

High

1271953

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

5

High-throughput

0.536

High

1271976

PHF11
PHD finger protein 11

1

3

High-throughput

0.536

High

1271983

SSUH2
Protein SSUH2 homolog

1

4

High-throughput

0.536

High

1271985

RN115
E3 ubiquitin-protein ligase RNF115

1

2

High-throughput

0.536

High

1205477

PALB2
Partner and localizer of BRCA2

1

0

High-throughput

0.518

High

2021

A0A0A0MR05
Target of rapamycin complex subunit LST8

1

1

High-throughput

0.515

High

125618

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.515

High

155616

TNPO2
Transportin-2

1

4

High-throughput

0.515

High

235986

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

2

High-throughput

0.515

High

237749

TSN2
Tetraspanin-2

1

2

High-throughput

0.515

High

324543

BAG3
BAG family molecular chaperone regulator 3

1

3

High-throughput

0.515

High

418515

NPM
Nucleophosmin

1

1

High-throughput

0.515

High

448134

DOPO
Dopamine beta-hydroxylase

1

2

High-throughput

0.515

High

453981

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

3

High-throughput

0.515

High

554493

GATA1
Erythroid transcription factor

1

1

High-throughput

0.515

High

596125

CO9A1

1

3

High-throughput

0.515

High

826326

CDK8
Cyclin-dependent kinase 8

1

1

High-throughput

0.515

High

847586

BAP31
B-cell receptor-associated protein 31

1

3

High-throughput

0.515

High

856104

RBM5
RNA-binding protein 5

1

1

High-throughput

0.515

High

856280

HXK3
Hexokinase-3

1

2

High-throughput

0.515

High

884216

KLF3
Krueppel-like factor 3

1

3

High-throughput

0.515

High

902984

DCAF7
DDB1- and CUL4-associated factor 7

1

3

High-throughput

0.515

High

920886

RS30
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

1

4

High-throughput

0.515

High

1016644

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

1

High-throughput

0.515

High

1025664

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

1

High-throughput

0.515

High

1033129

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

1

High-throughput

0.515

High

1047692

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

1

3

High-throughput

0.515

High

1055217

KRT81
Keratin, type II cuticular Hb1

1

2

High-throughput

0.515

High

1060026

LASP1
LIM and SH3 domain protein 1

1

4

High-throughput

0.515

High

1078197

MK11
Mitogen-activated protein kinase 11

1

1

High-throughput

0.515

High

1083086

PCSK7
Proprotein convertase subtilisin/kexin type 7

1

7

High-throughput

0.515

High

1120749

ACSM3
Acyl-coenzyme A synthetase ACSM3, mitochondrial

1

1

High-throughput

0.515

High

1139509

TUT7
Terminal uridylyltransferase 7

1

1

High-throughput

0.515

High

1157134

ESRP1
Epithelial splicing regulatory protein 1

1

5

High-throughput

0.515

High

1183803

5MP2
eIF5-mimic protein 2

1

1

High-throughput

0.515

High

1184811

FA2H
Fatty acid 2-hydroxylase

1

5

High-throughput

0.515

High

1185174

G2E3
G2/M phase-specific E3 ubiquitin-protein ligase

1

3

High-throughput

0.515

High

1216678

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

1

High-throughput

0.515

High

1216777

TMTC1
Protein O-mannosyl-transferase TMTC1

1

9

High-throughput

0.515

High

1236280

EFNMT
eEF1A lysine and N-terminal methyltransferase

1

1

High-throughput

0.515

High

1268131

LAR4B
La-related protein 4B

1

2

High-throughput

0.515

High

1271931

RNF34
E3 ubiquitin-protein ligase RNF34

1

1

High-throughput

0.515

High

1271938

LOXL4
Lysyl oxidase homolog 4

1

10

High-throughput

0.515

High

1271943

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

4

High-throughput

0.515

High

1271944

SMAD5
Mothers against decapentaplegic homolog 5

1

1

High-throughput

0.515

High

1271947

LSMD1
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

1

High-throughput

0.515

High

1271952

RBM4
RNA-binding protein 4

1

2

High-throughput

0.515

High

1271955

SCAPE
S phase cyclin A-associated protein in the endoplasmic reticulum

1

5

High-throughput

0.515

High

1271956

SPY4
Protein sprouty homolog 4

1

1

High-throughput

0.515

High

1271961

CARD9
Caspase recruitment domain-containing protein 9

1

1

High-throughput

0.515

High

1271963

TLE6
Transducin-like enhancer protein 6

1

3

High-throughput

0.515

High

1271965

XPO5
Exportin-5

1

4

High-throughput

0.515

High

1271970

RFOX1
RNA binding protein fox-1 homolog 1

1

2

High-throughput

0.515

High

1271971

TSAP1
tRNA selenocysteine 1-associated protein 1

1

1

High-throughput

0.515

High

1271972

GFOD1
Glucose-fructose oxidoreductase domain-containing protein 1

1

1

High-throughput

0.515

High

1271974

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.515

High

1271975

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

4

High-throughput

0.515

High

1271978

BAIP2
BAR/IMD domain-containing adapter protein 2

1

2

High-throughput

0.515

High

1271981

COF2
Cofilin-2

1

2

High-throughput

0.515

High

317849

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

1

0

High-throughput

0.513

High

358666

CO4A1

1

5

Small-scale

0.501

High

441075

CO4A2

1

5

Small-scale

0.501

High

666823

CO4A5

1

5

Small-scale

0.501

High

812797

CASA1
Alpha-S1-casein [Cleaved into: Casoxin-D]

1

1

Small-scale

0.501

High

862506

CO4A4

1

5

Small-scale

0.501

High

968109

CO4A3
Collagen alpha-3(IV) chain

1

5

Small-scale

0.501

High

1047981

CO4A6

1

5

Small-scale

0.501

High

703473

LSP1
Lymphocyte-specific protein 1

1

1

High-throughput

0.494

High

203751

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

0

High-throughput

0.493

High

583760

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.493

High

597404

PTN
Pleiotrophin

1

0

High-throughput

0.493

High

622968

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

0

High-throughput

0.493

High

821506

NMU
Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36

1

0

High-throughput

0.493

High

864924

PTTG
Pituitary tumor-transforming gene 1 protein-interacting protein

1

0

High-throughput

0.493

High

898987

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.493

High

903411

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.493

High

928416

DYL1
Dynein light chain 1, cytoplasmic

1

0

High-throughput

0.493

High

934365

CSK21
Casein kinase II subunit alpha

1

0

High-throughput

0.493

High

966271

TFAP4
Transcription factor AP-4

1

0

High-throughput

0.493

High

1012295

INCA1
Protein INCA1

1

0

High-throughput

0.493

High

1032857

PHLP
Phosducin-like protein

1

0

High-throughput

0.493

High

1129968

ERIC3
Glutamate-rich protein 3

1

0

High-throughput

0.493

High

1132418

SPT46
Spermatogenesis-associated protein 46

1

0

High-throughput

0.493

High

1157484

FAP20
Fanconi anemia core complex-associated protein 20

1

0

High-throughput

0.493

High

1240654

ACBD4
Acyl-CoA-binding domain-containing protein 4

1

0

High-throughput

0.493

High

1252682

BAHD1
Bromo adjacent homology domain-containing 1 protein

1

0

High-throughput

0.493

High

1261689

TP8L1
Tumor necrosis factor alpha-induced protein 8-like protein 1

1

0

High-throughput

0.493

High

1262129

PCNP
PEST proteolytic signal-containing nuclear protein

1

0

High-throughput

0.493

High

1271933

TET5B
Terminal nucleotidyltransferase 5B

1

0

High-throughput

0.493

High

1271934

ALKB8
Alkylated DNA repair protein alkB homolog 8

1

0

High-throughput

0.493

High

1271949

INP5K
Inositol polyphosphate 5-phosphatase K

1

0

High-throughput

0.493

High

1271950

DCNL5
DCN1-like protein 5

1

0

High-throughput

0.493

High

1271954

BEX2
Protein BEX2

1

0

High-throughput

0.493

High

1271957

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.493

High

1271958

TWSG1
Twisted gastrulation protein homolog 1

1

0

High-throughput

0.493

High

1271959

CK054
Ester hydrolase C11orf54

1

0

High-throughput

0.493

High

1271960

RN208
RING finger protein 208

1

0

High-throughput

0.493

High

1271969

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

High-throughput

0.493

High

1271977

SUFU
Suppressor of fused homolog

1

0

High-throughput

0.493

High

1271980

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

0

High-throughput

0.493

High

1271982

INVS
Inversin

1

0

High-throughput

0.493

High

1271984

KLH20
Kelch-like protein 20

1

0

High-throughput

0.493

High

1271986

ATP23
Mitochondrial inner membrane protease ATP23 homolog

1

0

High-throughput

0.493

High

303709

OR2A4
Olfactory receptor 2A4

1

5

High-throughput

0.489

High

1104012

CR021
UPF0711 protein C18orf21

1

2

High-throughput

0.489

High

1138896

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

1

High-throughput

0.489

High

1223983

NRSN1
Neurensin-1

1

1

High-throughput

0.489

High

1240091

TM87A
Transmembrane protein 87A

1

1

High-throughput

0.489

High

1271932

PIGT
GPI transamidase component PIG-T

1

4

High-throughput

0.489

High

1271967

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

1

High-throughput

0.489

High

1261385

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

169565

BET1
BET1 homolog

1

1

High-throughput

0.470

High

259213

CAD16
Cadherin-16

1

12

High-throughput

0.470

High

269460

STX11
Syntaxin-11

1

1

High-throughput

0.470

High

299607

TOX
Thymocyte selection-associated high mobility group box protein TOX

1

3

High-throughput

0.470

High

419013

TPM3
Tropomyosin alpha-3 chain

1

1

High-throughput

0.470

High

444442

K1C19
Keratin, type I cytoskeletal 19

1

4

High-throughput

0.470

High

503236

PPAL
Lysosomal acid phosphatase

1

3

High-throughput

0.470

High

560365

EPB42
Protein 4.2

1

3

High-throughput

0.470

High

618686

IF4B
Eukaryotic translation initiation factor 4B

1

1

High-throughput

0.470

High

685210

FCG2B
Low affinity immunoglobulin gamma Fc region receptor II-b

1

3

High-throughput

0.470

High

814011

RGR
RPE-retinal G protein-coupled receptor

1

6

High-throughput

0.470

High

1052858

FASTK
Fas-activated serine/threonine kinase

1

4

High-throughput

0.470

High

1058661

MFS10
Major facilitator superfamily domain-containing protein 10

1

1

High-throughput

0.470

High

1125988

ARMX4
Armadillo repeat-containing X-linked protein 4

1

6

High-throughput

0.470

High

1150398

LEG9C
Galectin-9C

1

1

High-throughput

0.470

High

1169584

D19L3
Protein C-mannosyl-transferase DPY19L3

1

1

High-throughput

0.470

High

1192445

Q7Z783
Protein sprouty homolog 2

1

1

High-throughput

0.470

High

1197873

SDCG8
Serologically defined colon cancer antigen 8

1

4

High-throughput

0.470

High

1199237

PRP39
Pre-mRNA-processing factor 39

1

3

High-throughput

0.470

High

1199564

TSN33
Tetraspanin-33

1

2

High-throughput

0.470

High

1203532

Q86WV2
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

1

High-throughput

0.470

High

1229744

ZN444
Zinc finger protein 444

1

1

High-throughput

0.470

High

1264014

ASB13
Ankyrin repeat and SOCS box protein 13

1

2

High-throughput

0.470

High

1271939

TNIP3
TNFAIP3-interacting protein 3

1

1

High-throughput

0.470

High

1271940

PRAM
PML-RARA-regulated adapter molecule 1

1

1

High-throughput

0.470

High

1271948

CNPY3
Protein canopy homolog 3

1

1

High-throughput

0.470

High

1271951

SPON2
Spondin-2

1

5

High-throughput

0.470

High

1271964

UNKL
Putative E3 ubiquitin-protein ligase UNKL

1

3

High-throughput

0.470

High

1271968

SEM4G
Semaphorin-4G

1

12

High-throughput

0.470

High

1271973

PDXL2
Podocalyxin-like protein 2

1

1

High-throughput

0.470

High

70427

B2RAF7
HCG1818547

1

0

High-throughput

0.268

Low

267329

CLD11
Claudin-11

1

0

High-throughput

0.268

Low

311361

O95332
LOC57228 protein

1

0

High-throughput

0.268

Low

648058

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

0

High-throughput

0.268

Low

1109454

KR195
Keratin-associated protein 19-5

1

0

High-throughput

0.268

Low

1110415

KR197
Keratin-associated protein 19-7

1

0

High-throughput

0.268

Low

1115449

SPAS1
Spermatogenesis-associated serine-rich protein 1

1

0

High-throughput

0.268

Low

1118838

Q4VB01
HOXB1 protein

1

0

High-throughput

0.268

Low

1159714

PBIR3
PABIR family member 1

1

0

High-throughput

0.268

Low

1168074

THADA
tRNA

1

0

High-throughput

0.268

Low

1168317

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.268

Low

1185614

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.268

Low

1204625

CTSRD
Cation channel sperm-associated auxiliary subunit delta

1

0

High-throughput

0.268

Low

1216039

KRA81
Keratin-associated protein 8-1

1

0

High-throughput

0.268

Low

1222744

IHO1
Interactor of HORMAD1 protein 1

1

0

High-throughput

0.268

Low

1242884

CHDH
Choline dehydrogenase, mitochondrial

1

0

High-throughput

0.268

Low

1255356

TCP1L
T-complex protein 10A homolog 1

1

0

High-throughput

0.268

Low

1255790

LMX1A
LIM homeobox transcription factor 1-alpha

1

0

High-throughput

0.268

Low

1271930

NGN1
Neurogenin-1

1

0

High-throughput

0.268

Low

1271936

HVCN1
Voltage-gated hydrogen channel 1

1

0

High-throughput

0.268

Low

1271937

Q96EJ4
PLAC8 protein

1

0

High-throughput

0.268

Low

1271962

S26A1
Sulfate anion transporter 1

1

0

High-throughput

0.268

Low

1271966

ARFG3
ADP-ribosylation factor GTPase-activating protein 3

1

0

High-throughput

0.268

Low


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Last updated: 15 Jul 2024