Protein: HEM1
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS-H) (EC 2.3.1.37) (5-aminolevulinic acid synthase 1) (Delta-ALA synthase 1) (Delta-aminolevulinate synthase 1)

Gene: HEM1, ALAS1
Organism: Homo sapiens
Interactions: 136
UniProt ID: P13196

Gene Ontology (top 5):
GO:0003870 - 5-aminolevulinate synthase activity
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

526362

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

3

14

High-throughput

0.861

High

526427

DUS19
Dual specificity protein phosphatase 19

7

3

High-throughput

0.686

High

526400

LONF1
LON peptidase N-terminal domain and RING finger protein 1

3

4

High-throughput

0.675

High

526438

EP400
E1A-binding protein p400

3

2

High-throughput

0.674

High

526443

TR61B
tRNA

3

1

High-throughput

0.667

High

526365

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

3

1

High-throughput

0.656

High

526413

CDC73
Parafibromin

3

0

High-throughput

0.654

High

234181

PEPL
Periplakin

3

0

High-throughput

0.646

High

526469

ZN175
Zinc finger protein 175

3

0

High-throughput

0.646

High

526467

PDIP2
Polymerase delta-interacting protein 2

2

1

High-throughput

0.640

High

526382

TYB10
Thymosin beta-10

4

2

High-throughput

0.639

High

526404

OXLD1
Oxidoreductase-like domain-containing protein 1

3

0

High-throughput

0.638

High

261778

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

2

1

High-throughput

0.628

High

526459

TMOD3
Tropomodulin-3

2

2

High-throughput

0.628

High

526444

HINT2
Adenosine 5'-monophosphoramidase HINT2

2

2

High-throughput

0.611

High

526435

LRC45
Leucine-rich repeat-containing protein 45

2

2

High-throughput

0.606

High

526363

FPPS
Farnesyl pyrophosphate synthase

2

0

High-throughput

0.602

High

526398

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

2

0

High-throughput

0.602

High

526408

THEM4
Acyl-coenzyme A thioesterase THEM4

2

0

High-throughput

0.602

High

526421

FABD
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

2

0

High-throughput

0.602

High

526439

ZN363
RING finger and CHY zinc finger domain-containing protein 1

2

0

High-throughput

0.602

High

262694

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

526397

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

2

Small-scale

0.584

High

87359

HSBPL
Heat shock factor-binding protein 1-like protein 1

2

0

High-throughput

0.580

High

441222

RU2B
U2 small nuclear ribonucleoprotein B''

2

0

High-throughput

0.580

High

526409

UT14C
U3 small nucleolar RNA-associated protein 14 homolog C

2

0

High-throughput

0.580

High

526423

RN168
E3 ubiquitin-protein ligase RNF168

2

0

High-throughput

0.580

High

526433

FBXL8
F-box/LRR-repeat protein 8

2

0

High-throughput

0.580

High

526461

TMOD4
Tropomodulin-4

2

3

High-throughput

0.574

High

206678

WIPF1
WAS/WASL-interacting protein family member 1

1

1

High-throughput

0.573

High

526451

SH24A
SH2 domain-containing protein 4A

1

2

High-throughput

0.573

High

526466

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

1

High-throughput

0.573

High

526422

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

3

High-throughput

0.571

High

526417

MTSS2
Protein MTSS 2

2

1

High-throughput

0.553

High

526455

KIF9
Kinesin-like protein KIF9

2

2

High-throughput

0.553

High

526396

TCEA2
Transcription elongation factor A protein 2

1

0

High-throughput

0.549

High

526414

MTFR2
Mitochondrial fission regulator 2

1

0

High-throughput

0.549

High

526419

SNX20
Sorting nexin-20

1

0

High-throughput

0.549

High

526426

CCHCR
Coiled-coil alpha-helical rod protein 1

1

0

High-throughput

0.549

High

526457

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

1

0

High-throughput

0.549

High

526458

CB042
Uncharacterized protein C2orf42

1

0

High-throughput

0.549

High

526377

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.541

High

380727

S100B
Protein S100-B

1

1

High-throughput

0.536

High

526420

ECHD2
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial

1

2

High-throughput

0.536

High

526462

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

1

High-throughput

0.536

High

526425

CERK1
Ceramide kinase

1

1

High-throughput

0.523

High

495675

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.513

High

526381

ACTG
Actin, cytoplasmic 2

1

0

High-throughput

0.513

High

526391

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

0

High-throughput

0.513

High

526415

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

0

High-throughput

0.513

High

526442

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.513

High

526378

RAP1B
Ras-related protein Rap-1b

1

1

High-throughput

0.508

High

526379

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.508

High

526384

CDK5
Cyclin-dependent kinase 5

1

1

High-throughput

0.508

High

341485

UROK
Urokinase-type plasminogen activator

1

2

High-throughput

0.494

High

526364

OXYR
Oxytocin receptor

1

2

High-throughput

0.494

High

526373

MAGA9
Melanoma-associated antigen 9

1

2

High-throughput

0.489

High

317707

STABP
STAM-binding protein

1

0

High-throughput

0.486

High

329076

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.486

High

378622

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

526367

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.486

High

526371

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

0

High-throughput

0.486

High

526380

TYB4
Thymosin beta-4

1

1

High-throughput

0.481

High

59098

VWA8
von Willebrand factor A domain-containing protein 8

1

2

High-throughput

0.479

High

226391

PRKN
E3 ubiquitin-protein ligase parkin

1

9

High-throughput

0.479

High

264826

MPPB
Mitochondrial-processing peptidase subunit beta

1

4

High-throughput

0.479

High

269974

RF1M
Peptide chain release factor 1, mitochondrial

1

5

High-throughput

0.479

High

327346

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

2

High-throughput

0.479

High

440323

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

2

High-throughput

0.479

High

486453

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

499498

CH60
60 kDa heat shock protein, mitochondrial

1

6

High-throughput

0.479

High

526366

LONM
Lon protease homolog, mitochondrial

1

3

High-throughput

0.479

High

526370

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

526372

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

526374

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

526375

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.479

High

526376

EFTU
Elongation factor Tu, mitochondrial

1

3

High-throughput

0.479

High

526383

TFAM
Transcription factor A, mitochondrial

1

2

High-throughput

0.479

High

526385

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

526386

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

526388

MPPA
Mitochondrial-processing peptidase subunit alpha

1

4

High-throughput

0.479

High

526389

GRSF1
G-rich sequence factor 1

1

2

High-throughput

0.479

High

526390

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

5

High-throughput

0.479

High

526392

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

2

High-throughput

0.479

High

526393

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.479

High

526394

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

526395

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.479

High

526403

AGK
Acylglycerol kinase, mitochondrial

1

1

Small-scale

0.479

High

526407

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

526412

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

526418

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

6

High-throughput

0.479

High

526430

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

6

High-throughput

0.479

High

526431

FAKD4
FAST kinase domain-containing protein 4

1

6

High-throughput

0.479

High

526432

CHCH1
Small ribosomal subunit protein mS37

1

1

High-throughput

0.479

High

526434

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

2

High-throughput

0.479

High

526436

MTEF3
Transcription termination factor 3, mitochondrial

1

1

High-throughput

0.479

High

526437

RCC1L
RCC1-like G exchanging factor-like protein

1

1

High-throughput

0.479

High

526440

EFGM
Elongation factor G, mitochondrial

1

6

High-throughput

0.479

High

526441

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.479

High

526445

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.479

High

526446

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

526447

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

2

High-throughput

0.479

High

526448

IF3M
Translation initiation factor IF-3, mitochondrial

1

1

High-throughput

0.479

High

526449

MTRFR
Mitochondrial translation release factor in rescue

1

5

High-throughput

0.479

High

526450

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.479

High

526453

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

526454

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

526456

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

526460

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

6

High-throughput

0.479

High

526463

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

526464

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

5

High-throughput

0.479

High

526468

RM11
Large ribosomal subunit protein uL11m

1

1

High-throughput

0.479

High

2025

A0A0A0MR80
E1A binding protein p400

1

1

High-throughput

0.470

High

526387

Q0P5Q0
Thymosin beta-4

1

2

High-throughput

0.470

High

526401

Q4G0R1
PIBF1 protein

1

1

High-throughput

0.470

High

526465

ICAM5
Intercellular adhesion molecule 5

1

1

High-throughput

0.470

High

526369

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

69725

B1AK13
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

1

High-throughput

0.445

High

526470

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

4

High-throughput

0.445

High

526429

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.439

High

526399

RTL8B
Retrotransposon Gag-like protein 8B

3

0

High-throughput

0.352

High

526424

ZN564
Zinc finger protein 564

3

0

High-throughput

0.352

High

526428

TEKT4
Tektin-4

3

0

High-throughput

0.352

High

526416

KLH35
Kelch-like protein 35

2

0

High-throughput

0.329

High

68488

GRCR1
Glutaredoxin domain-containing cysteine-rich protein 1

2

0

High-throughput

0.316

High

254777

COBL
Protein cordon-bleu

2

0

High-throughput

0.316

High

526368

CAP2
Adenylyl cyclase-associated protein 2

2

0

High-throughput

0.316

High

526405

ZMAT1
Zinc finger matrin-type protein 1

2

0

High-throughput

0.304

High

526402

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

0

High-throughput

0.299

High

526410

TTC23
Tetratricopeptide repeat protein 23

1

0

High-throughput

0.299

High

526411

ZFY26
Zinc finger FYVE domain-containing protein 26

1

0

High-throughput

0.299

High

526406

CC038
Uncharacterized protein C3orf38

1

0

High-throughput

0.279

Low

151284

IDLC
Axonemal dynein light intermediate polypeptide 1

1

0

High-throughput

0.268

Low

269548

JERKY
Jerky protein homolog

1

0

High-throughput

0.268

Low

526452

CH033
UPF0488 protein C8orf33

1

0

High-throughput

0.265

Low


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Last updated: 15 Jul 2024