Protein: PTC
Protein patched (Hedgehog receptor)

Gene: PTC
Organism: Drosophila melanogaster
Interactions: 122
UniProt ID: P18502

Gene Ontology (top 5):
GO:0001746 - Bolwig's organ morphogenesis
GO:0005119 - smoothened binding
GO:0005886 - plasma membrane
GO:0005929 - cilium
GO:0007346 - regulation of mitotic cell cycle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

577329

PTC
Protein patched

4

11

Small-scale

0.898

High

577340

HH
Protein hedgehog

4

3

Small-scale

0.861

High

577405

NEDD4
E3 ubiquitin-protein ligase Nedd-4

4

13

Small-scale

0.677

High

577378

SMUF1
E3 ubiquitin-protein ligase Smurf1

2

13

Small-scale

0.620

High

577424

SUDX
E3 ubiquitin-protein ligase Su(dx)

2

13

Small-scale

0.586

High

577338

SMO
Protein smoothened

2

5

Small-scale

0.584

High

577394

IHOG
Interference hedgehog

2

4

Small-scale

0.584

High

577348

TID
Protein tumorous imaginal discs, mitochondrial

1

0

Small-scale

0.549

High

577377

APLP
Apolipophorins

1

0

Small-scale

0.513

High

442750

BTKL
Tyrosine-protein kinase Btk

1

1

High-throughput

0.508

High

577406

FRIZ2
Frizzled-2

1

5

High-throughput

0.508

High

577409

Q9VX41
LD29081p

1

6

High-throughput

0.508

High

577341

SAS
Putative epidermal cell surface receptor

1

0

High-throughput

0.486

High

577347

NETB
Netrin-B

1

3

High-throughput

0.484

High

52254

A1Z7C4
LDL receptor protein 1, isoform G

1

2

High-throughput

0.481

High

55132

A1ZAF5
FI18622p1

1

7

High-throughput

0.481

High

66034

A8JTM7
Megalin, isoform A

1

2

High-throughput

0.481

High

112249

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

5

High-throughput

0.481

High

218252

ITA3
Integrin alpha-PS3

1

5

High-throughput

0.481

High

513935

ITBX
Integrin beta-PS

1

1

High-throughput

0.481

High

572844

KCNAB
Potassium voltage-gated channel protein Shab

1

1

High-throughput

0.481

High

577335

ECR
Ecdysone receptor

1

1

High-throughput

0.481

High

577339

LAMA
Laminin subunit alpha

1

6

High-throughput

0.481

High

577361

Q7YU60
receptor protein serine/threonine kinase

1

2

High-throughput

0.481

High

577380

NPL4
Nuclear protein localization protein 4 homolog

1

1

High-throughput

0.481

High

577383

FLNA
Filamin-A

1

2

High-throughput

0.481

High

577387

Q9VJ37
Tailup, isoform A

1

2

High-throughput

0.481

High

577388

Q9VJJ9
FI20237p1

1

3

High-throughput

0.481

High

577425

X2JE09
Terribly reduced optic lobes, isoform AV

1

6

High-throughput

0.481

High

577331

CI
Transcriptional activator cubitus interruptus

1

1

Small-scale

0.479

High

577359

Q7KUL1
Dally-like, isoform C

1

1

Small-scale

0.479

High

577376

Q9V3X2
Tetraspanin

1

2

Small-scale

0.479

High

577422

Q9W4Y6
Interference hedgehog

1

4

Small-scale

0.479

High

577333

SINA
E3 ubiquitin-protein ligase sina

1

2

High-throughput

0.464

High

577334

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.464

High

577337

RL22
Large ribosomal subunit protein eL22

1

1

High-throughput

0.464

High

577344

ABRU
Protein abrupt

1

1

High-throughput

0.464

High

577346

MLP2
Muscle LIM protein Mlp84B

1

5

High-throughput

0.464

High

577412

CYHR1
Zinc finger TRAF-type-containing protein 1 homolog

1

2

High-throughput

0.464

High

52373

A1Z7J1
Sticks and stones, isoform A

1

0

High-throughput

0.460

High

112305

M9MRS9
Formin homology 2 domain containing, isoform E

1

0

High-throughput

0.460

High

114832

M9PD94
Crooked legs, isoform F

1

0

High-throughput

0.460

High

116151

M9PHS8
Uncharacterized protein, isoform C

1

0

High-throughput

0.460

High

577336

MOEH
Moesin/ezrin/radixin homolog 1

1

0

High-throughput

0.460

High

577345

LACH
Lachesin

1

0

High-throughput

0.460

High

577352

Q7K4M9
LD31969p

1

0

High-throughput

0.460

High

577357

CHD1
Chromodomain-helicase-DNA-binding protein 1

1

0

High-throughput

0.460

High

577373

HIW
E3 ubiquitin-protein ligase highwire

1

0

High-throughput

0.460

High

577375

Q9TVI0
FI23915p1

1

0

High-throughput

0.460

High

577420

Q9W3R6
Downstream of kinase

1

0

High-throughput

0.460

High

184185

COS
Kinesin-like protein costa

1

0

Small-scale

0.458

High

519453

KAPC1
cAMP-dependent protein kinase catalytic subunit 1

1

0

Small-scale

0.458

High

577342

DGK2
Eye-specific diacylglycerol kinase

1

1

High-throughput

0.439

High

577350

Q3YMU0
Protein disulfide-isomerase

1

1

High-throughput

0.439

High

577351

GALT6
N-acetylgalactosaminyltransferase 6

1

7

High-throughput

0.439

High

577358

Q7KUB3
Ecdysone-inducible gene E1, isoform A

1

3

High-throughput

0.439

High

577363

PPN
Papilin

1

1

High-throughput

0.439

High

577364

Q8IMK1
WD repeat-containing protein 44

1

3

High-throughput

0.439

High

577365

Q8INQ9
LIM domain-containing protein

1

2

High-throughput

0.439

High

577367

Q8SXN9
polynucleotide adenylyltransferase

1

1

High-throughput

0.439

High

577370

HRD1
E3 ubiquitin-protein ligase HRD1

1

10

High-throughput

0.439

High

577372

Q961D1
Cyclin K, isoform A

1

1

High-throughput

0.439

High

577374

CEG1A
Centaurin-gamma-1A

1

1

High-throughput

0.439

High

577382

Q9VEH3
Uncharacterized protein, isoform A

1

1

High-throughput

0.439

High

577384

Q9VGK8
Tyrosine-protein kinase

1

1

High-throughput

0.439

High

577385

Q9VHJ3
Enhancer of variegation 3-9

1

3

High-throughput

0.439

High

577386

GZL
E3 ubiquitin-protein ligase Godzilla

1

13

High-throughput

0.439

High

577391

Q9VL21
LD11652p

1

1

High-throughput

0.439

High

577400

Q9VQ95
Testis EndoG-Like 3

1

1

High-throughput

0.439

High

577402

Q9VRV4
D19B

1

1

High-throughput

0.439

High

577408

RG190
Rho GTPase-activating protein 190

1

1

High-throughput

0.439

High

577410

Q9VXR3
HECT-type E3 ubiquitin transferase

1

13

High-throughput

0.439

High

577415

Q9W0Y0
RE57840p

1

2

High-throughput

0.439

High

577418

Q9W3F1
RE21057p

1

3

High-throughput

0.439

High

577330

SXL
Protein sex-lethal

1

1

Small-scale

0.437

High

52133

A1Z743
polynucleotide adenylyltransferase

1

1

High-throughput

0.417

High

434868

SNAI
Protein snail

1

0

High-throughput

0.265

Low

577332

NCD
Protein claret segregational

1

0

High-throughput

0.265

Low

577379

ZN330
Zinc finger protein 330 homolog

1

0

High-throughput

0.265

Low

577416

POF
Protein painting of fourth

1

0

High-throughput

0.265

Low

52131

A1Z739
Acyltransferase

1

0

High-throughput

0.251

Low

81466

B7Z143
Protein interacting with Ttk69 and Sin3A, isoform D

1

0

High-throughput

0.251

Low

112859

M9NES5
Histone gene-specific epigenetic repressor in late S phase, isoform H

1

0

High-throughput

0.251

Low

114770

M9PD73
Thioester-containing protein 4, isoform B

1

0

High-throughput

0.251

Low

115389

M9PF26
Zizimin, isoform B

1

0

High-throughput

0.251

Low

220798

O46070
EG:25E8.4 protein

1

0

High-throughput

0.251

Low

221034

LIP3
Lipase 3

1

0

High-throughput

0.251

Low

577343

Q0E8J0
MEP-1, isoform A

1

0

High-throughput

0.251

Low

577349

RAD51
DNA repair protein Rad51 homolog

1

0

High-throughput

0.251

Low

577353

Q7KLX3
Translocon-associated protein subunit delta

1

0

High-throughput

0.251

Low

577354

Q7KMH9
BcDNA.LD26050

1

0

High-throughput

0.251

Low

577355

Q7KN75
Dodeca-satellite-binding protein 1, isoform A

1

0

High-throughput

0.251

Low

577356

Q7KNM2
Dorsal interacting protein 4

1

0

High-throughput

0.251

Low

577360

DCLK
Serine/threonine-protein kinase CG17528

1

0

High-throughput

0.251

Low

577362

Q7Z2C5
Uncharacterized protein

1

0

High-throughput

0.251

Low

577366

Q8SXL5
RE09177p

1

0

High-throughput

0.251

Low

577368

Q8SXV4
RH68528p

1

0

High-throughput

0.251

Low

577369

Q8T092
LD21421p

1

0

High-throughput

0.251

Low

577371

Q95U38
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.251

Low

577381

Q9VED4
MIP30824p1

1

0

High-throughput

0.251

Low

577389

NU160
Nuclear pore complex protein Nup160 homolog

1

0

High-throughput

0.251

Low

577390

Q9VKQ7
LD46233p

1

0

High-throughput

0.251

Low

577392

Q9VL77
Cysteine-rich PDZ-binding protein

1

0

High-throughput

0.251

Low

577393

Q9VL91
LD23102p

1

0

High-throughput

0.251

Low

577395

Q9VMP7
Uncharacterized protein

1

0

High-throughput

0.251

Low

577396

Q9VNE0
Uncharacterized protein, isoform A

1

0

High-throughput

0.251

Low

577397

Q9VP16
Kazal-like domain-containing protein

1

0

High-throughput

0.251

Low

577398

Q9VPX3
LD40271p

1

0

High-throughput

0.251

Low

577399

Q9VPX6
Adenylyl cyclase-associated protein

1

0

High-throughput

0.251

Low

577401

Q9VRQ4
LD47944p

1

0

High-throughput

0.251

Low

577403

TONSL
Tonsoku-like protein

1

0

High-throughput

0.251

Low

577404

Q9VUD3
GH07353p

1

0

High-throughput

0.251

Low

577407

Q9VW34
FI03450p

1

0

High-throughput

0.251

Low

577411

Q9VZJ4
Uncharacterized protein, isoform B

1

0

High-throughput

0.251

Low

577413

Q9W0C4
Gamma-glutamyl carboxylase, isoform A

1

0

High-throughput

0.251

Low

577414

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.251

Low

577417

Q9W219
GEO12575p1

1

0

High-throughput

0.251

Low

577419

Q9W3J0
FI23536p1

1

0

High-throughput

0.251

Low

577421

Q9W3V3
RING-type E3 ubiquitin transferase

1

0

High-throughput

0.251

Low

577423

Q9XZ29
EG:BACR25B3.9 protein

1

0

High-throughput

0.251

Low

577426

X2JG79
Supervillin, isoform W

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024