Protein: IQGA3
Ras GTPase-activating-like protein IQGAP3

Gene: IQGA3, IQGAP3
Organism: Homo sapiens
Interactions: 141
UniProt ID: Q86VI3

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0001934 - positive regulation of protein phosphorylation
GO:0005096 - GTPase activator activity
GO:0005516 - calmodulin binding
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

894176

CDC42
Cell division control protein 42 homolog

4

20

High-throughput

0.903

High

925404

RAC1
Ras-related C3 botulinum toxin substrate 1

3

20

Small-scale

0.847

High

892462

RAC3
Ras-related C3 botulinum toxin substrate 3

2

20

High-throughput

0.789

High

1201460

ANLN
Anillin

4

7

High-throughput

0.694

High

428282

TBB5
Tubulin beta chain

1

5

High-throughput

0.691

High

777209

PEX19
Peroxisomal biogenesis factor 19

3

3

High-throughput

0.667

High

609394

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.665

High

1065953

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.656

High

891555

MYL6
Myosin light polypeptide 6

2

20

High-throughput

0.628

High

1022929

CDC16
Cell division cycle protein 16 homolog

2

2

High-throughput

0.628

High

296460

ACL6B
Actin-like protein 6B

1

19

High-throughput

0.618

High

120515

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

338644

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

385102

NTRK1
High affinity nerve growth factor receptor

1

19

High-throughput

0.618

High

436384

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

900647

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

915797

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1201457

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1201473

NINL
Ninein-like protein

1

14

High-throughput

0.618

High

483946

CALM1
Calmodulin-1

1

13

High-throughput

0.575

High

369929

ESR1
Estrogen receptor

2

16

High-throughput

0.571

High

823433

PAXI
Paxillin

2

9

High-throughput

0.571

High

564593

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.553

High

1170639

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

1201440

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.553

High

1201453

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.553

High

149882

RFXK
DNA-binding protein RFXANK

1

12

High-throughput

0.536

High

281010

KRT38
Keratin, type I cuticular Ha8

1

3

High-throughput

0.536

High

347213

MYC
Myc proto-oncogene protein

1

9

High-throughput

0.536

High

358815

CRYAA
Alpha-crystallin A chain

1

6

High-throughput

0.536

High

364950

FRIL
Ferritin light chain

1

1

High-throughput

0.536

High

521684

MYL4
Myosin light chain 4

1

20

High-throughput

0.536

High

529357

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.536

High

729133

K22E
Keratin, type II cytoskeletal 2 epidermal

1

1

High-throughput

0.536

High

818210

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.536

High

848412

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

High-throughput

0.536

High

975448

PPARD
Peroxisome proliferator-activated receptor delta

1

3

High-throughput

0.536

High

1078022

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

4

High-throughput

0.536

High

1160247

PKN3
Serine/threonine-protein kinase N3

1

7

High-throughput

0.536

High

1201433

KIFA3
Kinesin-associated protein 3

1

8

High-throughput

0.536

High

1201434

TRI52
E3 ubiquitin-protein ligase TRIM52

1

7

High-throughput

0.536

High

1201436

ARMC5
Armadillo repeat-containing protein 5

1

7

High-throughput

0.536

High

1201463

GPC5B
G-protein coupled receptor family C group 5 member B

1

2

High-throughput

0.536

High

1201466

KLH14
Kelch-like protein 14

1

1

High-throughput

0.536

High

1201470

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

1

2

High-throughput

0.536

High

1201471

HECD1
E3 ubiquitin-protein ligase HECTD1

2

10

Small-scale

0.533

High

1201467

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

2

High-throughput

0.515

High

413977

GELS
Gelsolin

1

7

High-throughput

0.515

High

1191428

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

11

High-throughput

0.515

High

484020

CALM2
Calmodulin-2

1

13

High-throughput

0.514

High

484161

CALM3
Calmodulin-3

1

13

High-throughput

0.514

High

277327

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.513

High

311721

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.513

High

1108759

INAVA
Innate immunity activator protein

1

0

High-throughput

0.513

High

1201432

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

1201449

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1201454

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

1201464

FLRT1
Leucine-rich repeat transmembrane protein FLRT1

1

0

High-throughput

0.513

High

475999

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

7

High-throughput

0.501

High

157945

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.493

High

124516

TULP2
Tubby-related protein 2

1

1

High-throughput

0.489

High

316080

CBX6
Chromobox protein homolog 6

1

1

High-throughput

0.489

High

331390

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

1

19

High-throughput

0.489

High

471619

TFPT
TCF3 fusion partner

1

1

High-throughput

0.489

High

794400

GRK6
G protein-coupled receptor kinase 6

1

10

High-throughput

0.489

High

1021198

FOXD4
Forkhead box protein D4

1

4

High-throughput

0.489

High

1200389

ST32C
Serine/threonine-protein kinase 32C

1

11

High-throughput

0.489

High

1201425

SIR6
NAD-dependent protein deacylase sirtuin-6

1

6

High-throughput

0.489

High

1201427

ACRBP
Acrosin-binding protein

1

1

High-throughput

0.489

High

1201441

DMRTB
Doublesex- and mab-3-related transcription factor B1

1

1

High-throughput

0.489

High

1201444

PSKH2
Serine/threonine-protein kinase H2

1

17

High-throughput

0.489

High

1201446

NPAS1
Neuronal PAS domain-containing protein 1

1

3

High-throughput

0.489

High

1201468

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

1

High-throughput

0.489

High

1201475

RPKL1
Ribosomal protein S6 kinase-like 1

1

15

High-throughput

0.489

High

151067

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

15

High-throughput

0.479

High

210109

PRC1
Protein regulator of cytokinesis 1

1

11

High-throughput

0.479

High

322833

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.479

High

329819

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.479

High

359038

CRYAB
Alpha-crystallin B chain

1

6

High-throughput

0.479

High

455611

PARP1
Poly [ADP-ribose] polymerase 1

1

12

High-throughput

0.479

High

538684

MYL6B
Myosin light chain 6B

1

20

High-throughput

0.479

High

587619

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

13

High-throughput

0.479

High

875081

TERA
Transitional endoplasmic reticulum ATPase

1

4

Small-scale

0.479

High

969823

KIF23
Kinesin-like protein KIF23

1

6

High-throughput

0.479

High

974600

MECOM
Histone-lysine N-methyltransferase MECOM

1

3

High-throughput

0.479

High

1041944

CUL3
Cullin-3

1

6

High-throughput

0.479

High

1085598

HIF1A
Hypoxia-inducible factor 1-alpha

1

3

High-throughput

0.479

High

1101142

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1188506

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

1201423

SLX4
Structure-specific endonuclease subunit SLX4

1

7

High-throughput

0.479

High

1201430

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

1201445

PASK
PAS domain-containing serine/threonine-protein kinase

1

6

High-throughput

0.479

High

1201455

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1201456

PRD16
Histone-lysine N-methyltransferase PRDM16

1

3

High-throughput

0.479

High

1201459

BRD7
Bromodomain-containing protein 7

1

5

High-throughput

0.479

High

1201469

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1201472

FZR1
Fizzy-related protein homolog

1

7

High-throughput

0.479

High

1150984

CARL2
Capping protein, Arp2/3 and myosin-I linker protein 2

1

2

High-throughput

0.470

High

103782

G5E9A7
DM1 locus, WD repeat containing

1

7

High-throughput

0.470

High

1201461

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.458

High

92828

E9PSE9
Coiled-coil domain containing 198

1

1

High-throughput

0.451

High

1130274

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.445

High

1201462

FAME
Factor associated with metabolism and energy

1

1

High-throughput

0.439

High

720835

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

1029591

TIF1B
Transcription intermediary factor 1-beta

1

8

High-throughput

0.437

High

1165721

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

1166836

LRC31
Leucine-rich repeat-containing protein 31

1

4

High-throughput

0.437

High

1201431

ESR2
Estrogen receptor beta

1

16

High-throughput

0.437

High

1201435

CLUA1
Clusterin-associated protein 1

1

2

High-throughput

0.437

High

1201447

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

2

High-throughput

0.437

High

1201448

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

3

High-throughput

0.437

High

1201452

Q9H4D1
Protein kinase

1

9

High-throughput

0.437

High

56656

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

4

High-throughput

0.407

High

321117

PTBP3
Polypyrimidine tract-binding protein 3

1

3

High-throughput

0.407

High

883552

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

10

High-throughput

0.407

High

1169866

PKHG7
Pleckstrin homology domain-containing family G member 7

1

12

High-throughput

0.407

High

1201465

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

4

High-throughput

0.407

High

1152343

CNDH2
Condensin-2 complex subunit H2

2

0

High-throughput

0.328

High

208049

HAIR
Lysine-specific demethylase hairless

1

0

High-throughput

0.279

Low

224977

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.279

Low

245710

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.279

Low

272366

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.279

Low

645986

CRBB3
Beta-crystallin B3

1

0

High-throughput

0.279

Low

1073043

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.279

Low

1114439

AMZ1
Archaemetzincin-1

1

0

High-throughput

0.279

Low

1128334

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.279

Low

1156810

SWAP1
ATPase SWSAP1

1

0

High-throughput

0.279

Low

1201424

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1201428

MYBPP
MYCBP-associated protein

1

0

High-throughput

0.279

Low

1201429

BSND
Barttin

1

0

High-throughput

0.279

Low

1201437

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

1201438

HES6
Transcription cofactor HES-6

1

0

High-throughput

0.279

Low

1201439

F167A
Protein FAM167A

1

0

High-throughput

0.279

Low

1201443

PUS7
Pseudouridylate synthase 7 homolog

1

0

High-throughput

0.279

Low

1201450

BC11B
B-cell lymphoma/leukemia 11B

1

0

High-throughput

0.279

Low

1201451

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.279

Low

1201458

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

0

High-throughput

0.279

Low

1201474

Q9Y649
GW128

1

0

High-throughput

0.268

Low

1201442

YI001
Uncharacterized protein FLJ30774

1

0

High-throughput

0.249

Low

1108472

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

0

High-throughput

0.232

Low

1201426

CI163
Uncharacterized protein C9orf163

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024