Protein: SLX1
Structure-specific endonuclease subunit SLX1 (EC 3.1.-.-) (GIY-YIG domain-containing protein 1)

Gene: SLX1, SLX1A
Organism: Homo sapiens
Interactions: 71
UniProt ID: Q9BQ83

Gene Ontology (top 5):
GO:0000724 - double-strand break repair via homologous recombination
GO:0005654 - nucleoplasm
GO:0006281 - DNA repair
GO:0008821 - crossover junction DNA endonuclease activity
GO:0010792 - DNA double-strand break processing involved in repair via single-strand annealing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1222541

SLX4
Structure-specific endonuclease subunit SLX4

9

1

Small-scale

0.976

High

1272213

XPF
DNA repair endonuclease XPF

3

0

Small-scale

0.647

High

1298949

MUS81
Crossover junction endonuclease MUS81

3

0

Small-scale

0.645

High

434596

ERCC1
DNA excision repair protein ERCC-1

3

0

Small-scale

0.642

High

1078539

NCOA1
Nuclear receptor coactivator 1

2

1

High-throughput

0.628

High

157233

BACH1
Transcription regulator protein BACH1

2

0

High-throughput

0.602

High

649151

ARNT
Aryl hydrocarbon receptor nuclear translocator

2

0

High-throughput

0.602

High

1024406

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

2

0

High-throughput

0.602

High

1035346

TOP3A
DNA topoisomerase 3-alpha

2

0

High-throughput

0.602

High

1061394

PSME4
Proteasome activator complex subunit 4

2

0

High-throughput

0.602

High

861913

PLK1
Serine/threonine-protein kinase PLK1

2

1

High-throughput

0.601

High

1284707

EME1
Crossover junction endonuclease EME1

2

0

Small-scale

0.592

High

1309149

SLX1
Structure-specific endonuclease subunit SLX1

1

0

High-throughput

0.586

High

259617

HMMR
Hyaluronan mediated motility receptor

2

1

High-throughput

0.574

High

1136477

M3K21
Mitogen-activated protein kinase kinase kinase 21

2

1

High-throughput

0.574

High

121847

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

1

High-throughput

0.536

High

156346

PSA7
Proteasome subunit alpha type-7

1

4

High-throughput

0.536

High

594620

PSB1
Proteasome subunit beta type-1

1

7

High-throughput

0.536

High

610906

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

1

High-throughput

0.536

High

637531

PSA1
Proteasome subunit alpha type-1

1

4

High-throughput

0.536

High

637737

PSA2
Proteasome subunit alpha type-2

1

5

High-throughput

0.536

High

637993

PSA3
Proteasome subunit alpha type-3

1

4

High-throughput

0.536

High

638184

PSA4
Proteasome subunit alpha type-4

1

4

High-throughput

0.536

High

656300

PSA5
Proteasome subunit alpha type-5

1

4

High-throughput

0.536

High

656765

PSB5
Proteasome subunit beta type-5

1

3

High-throughput

0.536

High

832034

PSB3
Proteasome subunit beta type-3

1

4

High-throughput

0.536

High

832154

PSB2
Proteasome subunit beta type-2

1

4

High-throughput

0.536

High

893737

PSA6
Proteasome subunit alpha type-6

1

5

High-throughput

0.536

High

1062866

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

1

High-throughput

0.536

High

1289756

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.518

High

376302

ANXA1
Annexin A1

1

0

High-throughput

0.513

High

884065

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.513

High

899013

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.513

High

919242

RAN
GTP-binding nuclear protein Ran

1

0

High-throughput

0.513

High

1041173

CUL1
Cullin-1

1

0

High-throughput

0.513

High

1084880

SMN
Survival motor neuron protein

1

0

High-throughput

0.513

High

1122721

EAPP
E2F-associated phosphoprotein

1

0

High-throughput

0.513

High

1133475

UBR4
E3 ubiquitin-protein ligase UBR4

1

0

High-throughput

0.513

High

1192191

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.513

High

1263362

GEMI6
Gem-associated protein 6

1

0

High-throughput

0.513

High

1302589

INT14
Integrator complex subunit 14

1

0

High-throughput

0.513

High

1309151

PAGR1
PAXIP1-associated glutamate-rich protein 1

1

0

High-throughput

0.513

High

1309157

HDAC6
Histone deacetylase 6

1

0

High-throughput

0.513

High

1309158

DDX20
Probable ATP-dependent RNA helicase DDX20

1

0

High-throughput

0.513

High

924824

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.460

High

1309162

DUS10
Dual specificity protein phosphatase 10

1

0

High-throughput

0.460

High

517781

K2C3
Keratin, type II cytoskeletal 3

1

2

High-throughput

0.407

High

580150

K2C4
Keratin, type II cytoskeletal 4

1

2

High-throughput

0.407

High

1309154

KRT84
Keratin, type II cuticular Hb4

1

2

High-throughput

0.407

High

791000

CDN2C
Cyclin-dependent kinase 4 inhibitor C

2

0

High-throughput

0.328

High

1203334

GPBP1
Vasculin

2

0

High-throughput

0.328

High

1286991

FWCH2
FLYWCH family member 2

2

0

High-throughput

0.328

High

242188

TI17B
Mitochondrial import inner membrane translocase subunit Tim17-B

1

0

High-throughput

0.279

Low

365038

FRIL
Ferritin light chain

1

0

High-throughput

0.279

Low

396794

S10A8
Protein S100-A8

1

0

High-throughput

0.279

Low

728511

MYH11
Myosin-11

1

0

High-throughput

0.279

Low

1139553

SLX4I
Protein SLX4IP

1

0

High-throughput

0.279

Low

1237352

UBR7
Putative E3 ubiquitin-protein ligase UBR7

1

0

High-throughput

0.279

Low

1284717

FKB10
Peptidyl-prolyl cis-trans isomerase FKBP10

1

0

High-throughput

0.279

Low

1309150

UQCC2
Ubiquinol-cytochrome c reductase complex assembly factor 2

1

0

High-throughput

0.279

Low

1309152

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

0

High-throughput

0.279

Low

1309153

FA83D
Protein FAM83D

1

0

High-throughput

0.279

Low

1309156

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

High-throughput

0.279

Low

1309159

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

0

High-throughput

0.279

Low

933331

TBA1B
Tubulin alpha-1B chain

1

0

High-throughput

0.251

Low

56720

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.232

Low

306293

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

0

High-throughput

0.232

Low

1309155

ATG3
Ubiquitin-like-conjugating enzyme ATG3

1

0

High-throughput

0.232

Low

1309160

STRAP
Serine-threonine kinase receptor-associated protein

1

0

High-throughput

0.232

Low

1309161

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024