Protein: CFAH
Complement factor H (H factor 1)

Gene: CFAH, CFH
Organism: Homo sapiens
Interactions: 139
UniProt ID: P08603

Gene Ontology (top 5):
GO:0001851 - complement component C3b binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006508 - proteolysis
GO:0006956 - complement activation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

344624

CO3
Complement C3

8

16

Small-scale

0.971

High

441723

FHR3
Complement factor H-related protein 3

2

15

High-throughput

0.802

High

441690

CFAH
Complement factor H

2

13

Small-scale

0.768

High

362354

CRP

9

5

Small-scale

0.760

High

126346

MATN2
Matrilin-2

1

9

High-throughput

0.691

High

198381

KLK10
Kallikrein-10

1

9

High-throughput

0.691

High

420733

KLK1
Kallikrein-1

1

11

Small-scale

0.647

High

441694

LYAM1
L-selectin

1

11

Small-scale

0.647

High

441693

BMP1
Bone morphogenetic protein 1

1

9

Small-scale

0.618

High

441734

LRP8
Low-density lipoprotein receptor-related protein 8

1

9

Small-scale

0.618

High

441703

PTX3
Pentraxin-related protein PTX3

2

5

Small-scale

0.611

High

361429

APOE
Apolipoprotein E

1

0

Small-scale

0.564

High

363694

ALBU
Albumin

1

2

High-throughput

0.536

High

441696

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

441718

GRB2
Growth factor receptor-bound protein 2

1

6

High-throughput

0.508

High

441692

VDR
Vitamin D3 receptor

1

2

High-throughput

0.494

High

441733

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

4

High-throughput

0.494

High

441760

RSPH1
Radial spoke head 1 homolog

1

1

High-throughput

0.494

High

441707

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.489

High

441743

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

2

High-throughput

0.489

High

441765

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

2

High-throughput

0.489

High

441766

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

441774

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

4

High-throughput

0.489

High

441789

PHF11
PHD finger protein 11

1

2

High-throughput

0.489

High

441790

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

3

High-throughput

0.489

High

441796

SSUH2
Protein SSUH2 homolog

1

1

High-throughput

0.489

High

129881

PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

1

1

Small-scale

0.479

High

254034

WDR1
WD repeat-containing protein 1

1

1

Small-scale

0.479

High

441699

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

5

Small-scale

0.479

High

441705

LCN1
Lipocalin-1

1

1

Small-scale

0.479

High

441706

PRDX2
Peroxiredoxin-2

1

2

Small-scale

0.479

High

441712

PSB3
Proteasome subunit beta type-3

1

1

Small-scale

0.479

High

441737

PDIA6
Protein disulfide-isomerase A6

1

1

Small-scale

0.479

High

441740

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

1

Small-scale

0.479

High

441759

SYNE2
Nesprin-2

1

4

Small-scale

0.479

High

441768

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

4

Small-scale

0.479

High

441775

GTPB2
GTP-binding protein 2

1

1

Small-scale

0.479

High

441793

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

1

Small-scale

0.479

High

441798

MTCL1
Microtubule cross-linking factor 1

1

2

Small-scale

0.479

High

117562

MYO1C
Unconventional myosin-Ic

1

0

Small-scale

0.458

High

441702

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

441704

PSB6
Proteasome subunit beta type-6

1

0

Small-scale

0.458

High

441722

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

0

Small-scale

0.458

High

441726

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

Small-scale

0.458

High

441739

P3H1
Prolyl 3-hydroxylase 1

1

0

Small-scale

0.458

High

441763

UCN3
Urocortin-3

1

0

Small-scale

0.458

High

441778

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

0

Small-scale

0.458

High

441720

SMAD3
Mothers against decapentaplegic homolog 3

1

10

High-throughput

0.439

High

441728

EP300
Histone acetyltransferase p300

1

4

High-throughput

0.439

High

59090

VWA8
von Willebrand factor A domain-containing protein 8

1

2

Small-scale

0.437

High

70643

MYO9A
Unconventional myosin-IXa

1

1

Small-scale

0.437

High

135200

E2F3
Transcription factor E2F3

1

1

Small-scale

0.437

High

204952

TGON2
Trans-Golgi network integral membrane protein 2

1

7

High-throughput

0.437

High

206790

FOXO3
Forkhead box protein O3

1

4

Small-scale

0.437

High

260459

PITX3
Pituitary homeobox 3

1

2

Small-scale

0.437

High

297713

MICA2
[F-actin]-monooxygenase MICAL2

1

4

Small-scale

0.437

High

302337

CMTA2
Calmodulin-binding transcription activator 2

1

1

Small-scale

0.437

High

308157

LC7L3
Luc7-like protein 3

1

1

Small-scale

0.437

High

441691

SPTB1
Spectrin beta chain, erythrocytic

1

2

Small-scale

0.437

High

441695

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

Small-scale

0.437

High

441697

EPHA1
Ephrin type-A receptor 1

1

5

High-throughput

0.437

High

441701

MCM3
DNA replication licensing factor MCM3

1

1

Small-scale

0.437

High

441710

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

2

Small-scale

0.437

High

441721

VIGLN
Vigilin

1

1

Small-scale

0.437

High

441724

DYST
Dystonin

1

4

Small-scale

0.437

High

441727

ZO1
Tight junction protein ZO-1

1

3

Small-scale

0.437

High

441729

FOXO1
Forkhead box protein O1

1

3

High-throughput

0.437

High

441731

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

2

Small-scale

0.437

High

441732

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

5

Small-scale

0.437

High

441735

TFDP1
Transcription factor Dp-1

1

1

Small-scale

0.437

High

441736

TFDP2
Transcription factor Dp-2

1

1

Small-scale

0.437

High

441738

E2F4
Transcription factor E2F4

1

1

Small-scale

0.437

High

441741

SH319
SH3 domain-containing protein 19

1

3

Small-scale

0.437

High

441742

ATD3B
ATPase family AAA domain-containing protein 3B

1

1

Small-scale

0.437

High

441745

ANR12
Ankyrin repeat domain-containing protein 12

1

3

Small-scale

0.437

High

441746

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

2

Small-scale

0.437

High

441748

BRAP
BRCA1-associated protein

1

2

Small-scale

0.437

High

441749

MGAP
MAX gene-associated protein

1

1

Small-scale

0.437

High

441750

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

1

Small-scale

0.437

High

441751

NALCN
Sodium leak channel NALCN

1

2

Small-scale

0.437

High

441756

ARH40
Rho guanine nucleotide exchange factor 40

1

1

Small-scale

0.437

High

441770

CC136
Coiled-coil domain-containing protein 136

1

2

Small-scale

0.437

High

441783

ATD3A
ATPase family AAA domain-containing protein 3A

1

1

Small-scale

0.437

High

441784

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

1

1

Small-scale

0.437

High

441785

RAI14
Ankycorbin

1

7

Small-scale

0.437

High

441787

SEPT9
Septin-9

1

1

Small-scale

0.437

High

441788

PUF60
Poly(U)-binding-splicing factor PUF60

1

3

Small-scale

0.437

High

441791

F184B
Protein FAM184B

1

3

Small-scale

0.437

High

441792

G3BP2
Ras GTPase-activating protein-binding protein 2

1

1

Small-scale

0.437

High

441795

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

1

Small-scale

0.437

High

441797

LC7L2
Putative RNA-binding protein Luc7-like 2

1

1

Small-scale

0.437

High

441799

ASB1
Ankyrin repeat and SOCS box protein 1

1

2

Small-scale

0.437

High

403575

AP2A
Transcription factor AP-2-alpha

1

3

High-throughput

0.417

High

441762

AP2C
Transcription factor AP-2 gamma

1

3

High-throughput

0.417

High

299505

KLH18
Kelch-like protein 18

2

0

High-throughput

0.324

High

441769

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

441698

MUTA
Methylmalonyl-CoA mutase, mitochondrial

1

0

High-throughput

0.279

Low

441715

STX17
Syntaxin-17

1

0

High-throughput

0.279

Low

441755

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.279

Low

441776

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.279

Low

441780

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.279

Low

441725

ZBT16
Zinc finger and BTB domain-containing protein 16

1

0

High-throughput

0.251

Low

441772

YTDC1
YTH domain-containing protein 1

1

0

High-throughput

0.251

Low

63272

MET15
12S rRNA N4-methylcytidine

1

0

Small-scale

0.249

Low

129457

MANBA
Beta-mannosidase

1

0

Small-scale

0.249

Low

259821

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

0

Small-scale

0.249

Low

278990

RAD17
Cell cycle checkpoint protein RAD17

1

0

Small-scale

0.249

Low

414131

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.249

Low

441700

LORI
Loricrin

1

0

Small-scale

0.249

Low

441708

MCM5
DNA replication licensing factor MCM5

1

0

Small-scale

0.249

Low

441709

T2FA
General transcription factor IIF subunit 1

1

0

Small-scale

0.249

Low

441711

SRP09
Signal recognition particle 9 kDa protein

1

0

Small-scale

0.249

Low

441713

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.249

Low

441714

PGTB2
Geranylgeranyl transferase type-2 subunit beta

1

0

Small-scale

0.249

Low

441716

TMM33
Transmembrane protein 33

1

0

Small-scale

0.249

Low

441717

PSME3
Proteasome activator complex subunit 3

1

0

Small-scale

0.249

Low

441719

MAP1A
Microtubule-associated protein 1A

1

0

Small-scale

0.249

Low

441730

TF3C1
General transcription factor 3C polypeptide 1

1

0

Small-scale

0.249

Low

441744

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

1

0

Small-scale

0.249

Low

441747

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

Small-scale

0.249

Low

441752

INT1
Integrator complex subunit 1

1

0

Small-scale

0.249

Low

441753

SEN2
tRNA-splicing endonuclease subunit Sen2

1

0

Small-scale

0.249

Low

441754

CI043
Uncharacterized protein C9orf43

1

0

Small-scale

0.249

Low

441757

CATIN
Splicing factor Cactin

1

0

Small-scale

0.249

Low

441758

SEN15
tRNA-splicing endonuclease subunit Sen15

1

0

Small-scale

0.249

Low

441761

S39A7
Zinc transporter SLC39A7

1

0

Small-scale

0.249

Low

441764

TF3C6
General transcription factor 3C polypeptide 6

1

0

Small-scale

0.249

Low

441767

SYNM
Asparaginyl-tRNA synthetase

1

0

Small-scale

0.249

Low

441771

TEAN2
Transcription elongation factor A N-terminal and central domain-containing protein 2

1

0

Small-scale

0.249

Low

441773

WRIP1
ATPase WRNIP1

1

0

Small-scale

0.249

Low

441777

STEEP
STING ER exit protein

1

0

Small-scale

0.249

Low

441779

NCK5L
Nck-associated protein 5-like

1

0

Small-scale

0.249

Low

441781

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

Small-scale

0.249

Low

441782

SPS2L
SPATS2-like protein

1

0

Small-scale

0.249

Low

441786

SLAI2
SLAIN motif-containing protein 2

1

0

Small-scale

0.249

Low

441794

SMC3
Structural maintenance of chromosomes protein 3

1

0

Small-scale

0.249

Low

441800

TF3C5
General transcription factor 3C polypeptide 5

1

0

Small-scale

0.249

Low

441801

FHOD1
FH1/FH2 domain-containing protein 1

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024