Protein: RPGF4
Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII)

Gene: RPGF4, Rapgef4
Organism: Mus musculus
Interactions: 12
UniProt ID: Q9EQZ6

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0007188 - adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007264 - small GTPase-mediated signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1193954

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

2

9

High-throughput

0.705

High

60123

KALRN
Kalirin

1

6

High-throughput

0.691

High

1190205

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

12

High-throughput

0.691

High

1013707

TNIK
Traf2 and NCK-interacting protein kinase

1

3

High-throughput

0.618

High

1296368

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

6

High-throughput

0.479

High

1408935

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

7

Small-scale

0.479

High

1424394

RIMS2
Regulating synaptic membrane exocytosis protein 2

1

6

Small-scale

0.479

High

1424396

PCLO
Protein piccolo

1

6

Small-scale

0.479

High

1247213

NEB2
Neurabin-2

1

12

High-throughput

0.437

High

1424395

SRCN1
SRC kinase signaling inhibitor 1

1

3

High-throughput

0.407

High

1424054

DLGP1
Disks large-associated protein 1

2

0

High-throughput

0.318

High

205136

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025