Protein: AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (Phosphatidylinositol 3-kinase enhancer) (PIKE)

Gene: AGAP2
Organism: Mus musculus
Interactions: 232
UniProt ID: Q3UHD9

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005096 - GTPase activator activity
GO:0005524 - ATP binding
GO:0005525 - GTP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

104519

SYGP1
Ras/Rap GTPase-activating protein SynGAP

3

19

High-throughput

0.861

High

1190125

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

3

8

High-throughput

0.861

High

1190138

DLG4
Disks large homolog 4

3

10

High-throughput

0.861

High

1190151

NEB2
Neurabin-2

3

16

High-throughput

0.847

High

1013569

TNIK
Traf2 and NCK-interacting protein kinase

2

5

High-throughput

0.811

High

1190156

CYFP1
Cytoplasmic FMR1-interacting protein 1

2

1

High-throughput

0.811

High

1190163

CNKR2
Connector enhancer of kinase suppressor of ras 2

2

12

High-throughput

0.811

High

60087

KALRN
Kalirin

1

9

High-throughput

0.691

High

73887

B2RQ57
Tyrosine-protein kinase

1

16

High-throughput

0.691

High

73961

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

6

High-throughput

0.691

High

92676

SHAN1
SH3 and multiple ankyrin repeat domains protein 1

1

8

High-throughput

0.691

High

109261

ANK3
Ankyrin-3

1

2

High-throughput

0.691

High

236471

CSK22
Casein kinase II subunit alpha'

1

2

High-throughput

0.691

High

266873

E41L2
Band 4.1-like protein 2

1

9

High-throughput

0.691

High

267015

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

1

6

High-throughput

0.691

High

424711

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

5

High-throughput

0.691

High

431343

SRC
Proto-oncogene tyrosine-protein kinase Src

1

16

High-throughput

0.691

High

548946

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

8

High-throughput

0.691

High

591043

KPCE
Protein kinase C epsilon type

1

7

High-throughput

0.691

High

617639

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

5

High-throughput

0.691

High

636980

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

6

High-throughput

0.691

High

636984

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

6

High-throughput

0.691

High

693464

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

5

High-throughput

0.691

High

704212

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

8

High-throughput

0.691

High

728908

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

4

High-throughput

0.691

High

757454

FAK1
Focal adhesion kinase 1

1

20

High-throughput

0.691

High

810517

DYN1
Dynamin-1

1

1

High-throughput

0.691

High

861870

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

3

High-throughput

0.691

High

873441

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

4

High-throughput

0.691

High

884988

CDK5
Cyclin-dependent kinase 5

1

1

High-throughput

0.691

High

947831

RHG39
Rho GTPase-activating protein 39

1

9

High-throughput

0.691

High

953800

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.691

High

968088

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

2

High-throughput

0.691

High

968500

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

2

High-throughput

0.691

High

989553

MK01
Mitogen-activated protein kinase 1

1

5

High-throughput

0.691

High

993934

KPCG
Protein kinase C gamma type

1

15

High-throughput

0.691

High

993976

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

5

High-throughput

0.691

High

996596

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

5

High-throughput

0.691

High

998175

KPCB
Protein kinase C beta type

1

9

High-throughput

0.691

High

1021091

NPTN
Neuroplastin

1

3

High-throughput

0.691

High

1021194

PKP1
Plakophilin-1

1

2

High-throughput

0.691

High

1047363

NF1
Neurofibromin

1

18

High-throughput

0.691

High

1071135

TRIO
Triple functional domain protein

1

12

High-throughput

0.691

High

1190096

DAB2P
Disabled homolog 2-interacting protein

1

19

High-throughput

0.691

High

1190122

IQGA2
Ras GTPase-activating-like protein IQGAP2

1

19

High-throughput

0.691

High

1190128

PRAG1
Inactive tyrosine-protein kinase PRAG1

1

6

High-throughput

0.691

High

1190132

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

1

High-throughput

0.691

High

1190136

GDIB
Rab GDP dissociation inhibitor beta

1

2

High-throughput

0.691

High

1190140

SRBS1
Sorbin and SH3 domain-containing protein 1

1

20

High-throughput

0.691

High

1190141

MK03
Mitogen-activated protein kinase 3

1

5

High-throughput

0.691

High

1190145

RGPA1
Ral GTPase-activating protein subunit alpha-1

1

4

High-throughput

0.691

High

1190146

SIK3
Serine/threonine-protein kinase SIK3

1

1

High-throughput

0.691

High

1190147

ARHGI
Rho guanine nucleotide exchange factor 18

1

9

High-throughput

0.691

High

1190150

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

8

High-throughput

0.691

High

1190154

TLN2
Talin-2

1

7

High-throughput

0.691

High

1190160

LRRC7
Leucine-rich repeat-containing protein 7

1

2

High-throughput

0.691

High

1190162

C170B
Centrosomal protein of 170 kDa protein B

1

4

High-throughput

0.691

High

1190166

NRCAM
Neuronal cell adhesion molecule

1

2

High-throughput

0.691

High

1190168

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

1

8

High-throughput

0.691

High

1190171

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

1

8

High-throughput

0.691

High

1190174

LIPA2
Liprin-alpha-2

1

6

High-throughput

0.691

High

1190176

PKN2
Serine/threonine-protein kinase N2

1

11

High-throughput

0.691

High

1190177

TENR
Tenascin-R

1

4

High-throughput

0.691

High

1190179

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

1

5

High-throughput

0.691

High

1190180

ANK2
Ankyrin-2

1

2

High-throughput

0.691

High

1190182

ASPP2
Apoptosis-stimulating of p53 protein 2

1

6

High-throughput

0.691

High

1190183

RPGF2
Rap guanine nucleotide exchange factor 2

1

13

High-throughput

0.691

High

1190186

DP13A
DCC-interacting protein 13-alpha

1

15

High-throughput

0.691

High

1190195

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

9

High-throughput

0.691

High

1190198

MYO5A
Unconventional myosin-Va

1

2

High-throughput

0.691

High

1190200

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

12

High-throughput

0.691

High

1190205

RPGF4
Rap guanine nucleotide exchange factor 4

1

12

High-throughput

0.691

High

1190206

RIMS2
Regulating synaptic membrane exocytosis protein 2

1

13

High-throughput

0.691

High

1190209

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

19

High-throughput

0.691

High

1190211

DCLK1
Serine/threonine-protein kinase DCLK1

1

20

High-throughput

0.691

High

1190216

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

16

High-throughput

0.691

High

1190222

PCLO
Protein piccolo

1

12

High-throughput

0.691

High

1190224

GSK3B
Glycogen synthase kinase-3 beta

1

5

High-throughput

0.691

High

1190225

E41L3
Band 4.1-like protein 3

1

9

High-throughput

0.691

High

1190228

RASL1
RasGAP-activating-like protein 1

1

18

High-throughput

0.691

High

1190229

E41L1
Band 4.1-like protein 1

1

9

High-throughput

0.691

High

1190202

DLGP1
Disks large-associated protein 1

3

7

High-throughput

0.667

High

1190231

HOME1
Homer protein homolog 1

2

7

High-throughput

0.628

High

204320

NCAM2
Neural cell adhesion molecule 2

1

5

High-throughput

0.618

High

1190123

SRBS2
Sorbin and SH3 domain-containing protein 2

1

20

High-throughput

0.618

High

74694

B2RXW8
Ppfia1 protein

1

6

High-throughput

0.618

High

109284

G5E8K8
AHNAK nucleoprotein

1

1

High-throughput

0.618

High

116260

H3BJX1
Ecotropic viral integration site 5 like

1

2

High-throughput

0.618

High

581962

INSR
Insulin receptor

1

14

Small-scale

0.618

High

632511

KPCA
Protein kinase C alpha type

1

9

High-throughput

0.618

High

725578

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

5

High-throughput

0.618

High

999784

DLG3
Disks large homolog 3

1

8

High-throughput

0.618

High

999928

DCC
Netrin receptor DCC

1

3

Small-scale

0.618

High

1021559

RGS14
Regulator of G-protein signaling 14

1

3

High-throughput

0.618

High

1064400

PRLR
Prolactin receptor

1

5

Small-scale

0.618

High

1081338

Q0VAV5
RAS protein activator like 2

1

19

High-throughput

0.618

High

1190137

MK10
Mitogen-activated protein kinase 10

1

7

High-throughput

0.618

High

1190143

GIT1
ARF GTPase-activating protein GIT1

1

15

High-throughput

0.618

High

1190167

DLG1
Disks large homolog 1

1

8

High-throughput

0.618

High

1190184

UNC5B
Netrin receptor UNC5B

1

1

Small-scale

0.618

High

1190192

LNX2
Ligand of Numb protein X 2

1

12

High-throughput

0.618

High

1190193

DLG2
Disks large homolog 2

1

8

High-throughput

0.618

High

1190197

GRIP1
Glutamate receptor-interacting protein 1

1

18

Small-scale

0.618

High

1190212

MINK1
Misshapen-like kinase 1

1

6

High-throughput

0.618

High

1190213

FAK2
Protein-tyrosine kinase 2-beta

1

20

High-throughput

0.618

High

663090

GRIA2
Glutamate receptor 2

2

7

Small-scale

0.611

High

85883

B8QI33
Liprin-alpha 1

1

6

High-throughput

0.575

High

92615

D3YUZ8
Discs large MAGUK scaffold protein 2

1

8

High-throughput

0.575

High

94735

E0CZD7
non-specific serine/threonine protein kinase

1

5

High-throughput

0.575

High

97698

E9PW37
RAS protein activator like 2

1

19

High-throughput

0.575

High

97867

E9Q2A6
Protein-tyrosine kinase 2-beta

1

20

High-throughput

0.575

High

98156

E9Q616
AHNAK nucleoprotein

1

7

High-throughput

0.575

High

104422

F6QQP6
Disabled 2 interacting protein

1

19

High-throughput

0.575

High

104771

F7AMS7
non-specific serine/threonine protein kinase

1

8

High-throughput

0.575

High

116262

H3BKQ3
Ecotropic viral integration site 5 like

1

2

High-throughput

0.575

High

597650

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

8

High-throughput

0.575

High

989824

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

5

High-throughput

0.575

High

1189543

Q3TQZ7
Stress-activated protein kinase JNK

1

7

High-throughput

0.575

High

1190126

Q4VA93
Protein kinase C

1

9

High-throughput

0.575

High

1190127

Q52KF7
Discs large MAGUK scaffold protein 3

1

8

High-throughput

0.575

High

1190131

Q5F258
GIT ArfGAP 1

1

15

High-throughput

0.575

High

1190218

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4

1

7

High-throughput

0.575

High

86344

B9EKJ1
Spectrin alpha chain, non-erythrocytic 1

1

7

High-throughput

0.553

High

1190157

Q7TN74
Neurabin-1

1

18

High-throughput

0.553

High

147503

DPYL2
Dihydropyrimidinase-related protein 2

1

1

High-throughput

0.536

High

147947

STXB1
Syntaxin-binding protein 1

1

3

High-throughput

0.536

High

148514

NUMBL
Numb-like protein

1

9

High-throughput

0.536

High

205696

PITM1
Membrane-associated phosphatidylinositol transfer protein 1

1

1

High-throughput

0.536

High

237141

STRN
Striatin

1

2

High-throughput

0.536

High

237183

SEPT7
Septin-7

1

10

High-throughput

0.536

High

470771

NFL
Neurofilament light polypeptide

1

2

High-throughput

0.536

High

559570

GELS
Gelsolin

1

1

High-throughput

0.536

High

604456

AP2A1
AP-2 complex subunit alpha-1

1

6

High-throughput

0.536

High

604481

AP2A2
AP-2 complex subunit alpha-2

1

6

High-throughput

0.536

High

771417

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

10

High-throughput

0.536

High

771468

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

10

High-throughput

0.536

High

858166

AINX
Alpha-internexin

1

4

High-throughput

0.536

High

945617

ACTN4
Alpha-actinin-4

1

4

High-throughput

0.536

High

983626

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

4

High-throughput

0.536

High

984354

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

4

High-throughput

0.536

High

1021374

DPYL1
Dihydropyrimidinase-related protein 1

1

1

High-throughput

0.536

High

1021858

GRM1
Metabotropic glutamate receptor 1

1

5

High-throughput

0.536

High

1029191

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

10

High-throughput

0.536

High

1041720

ENAH
Protein enabled homolog

1

13

High-throughput

0.536

High

1135324

GRM2
Metabotropic glutamate receptor 2

1

5

High-throughput

0.536

High

1189349

IQEC3
IQ motif and SEC7 domain-containing protein 3

1

2

High-throughput

0.536

High

1190124

GRM5
Metabotropic glutamate receptor 5

1

5

High-throughput

0.536

High

1190130

IQEC2
IQ motif and SEC7 domain-containing protein 2

1

3

High-throughput

0.536

High

1190139

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

7

High-throughput

0.536

High

1190142

CLH1
Clathrin heavy chain 1

1

1

High-throughput

0.536

High

1190144

Q68FG2
Spectrin beta chain

1

6

High-throughput

0.536

High

1190152

PI5L1
Phosphatidylinositol 4-phosphate 5-kinase-like protein 1

1

2

High-throughput

0.536

High

1190155

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

1

High-throughput

0.536

High

1190158

ACTN1
Alpha-actinin-1

1

4

High-throughput

0.536

High

1190159

MAP6
Microtubule-associated protein 6

1

7

High-throughput

0.536

High

1190164

MYOME
Myomegalin

1

5

High-throughput

0.536

High

1190165

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

1

20

High-throughput

0.536

High

1190172

DLGP2
Disks large-associated protein 2

1

7

High-throughput

0.536

High

1190187

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

3

High-throughput

0.536

High

1190189

LUZP1
Leucine zipper protein 1

1

3

High-throughput

0.536

High

1190190

WASF1
Actin-binding protein WASF1

1

5

High-throughput

0.536

High

1190196

ATD3A
ATPase family AAA domain-containing protein 3A

1

4

High-throughput

0.536

High

1190203

AP2B1
AP-2 complex subunit beta

1

6

High-throughput

0.536

High

1190204

NBEA
Neurobeachin

1

3

High-throughput

0.536

High

1190214

SRCN1
SRC kinase signaling inhibitor 1

1

3

High-throughput

0.536

High

1190217

DREB
Drebrin

1

7

High-throughput

0.536

High

1190220

MAP1A
Microtubule-associated protein 1A

1

5

High-throughput

0.536

High

1190221

GRM3
Metabotropic glutamate receptor 3

1

5

High-throughput

0.536

High

1190223

ARC1A
Actin-related protein 2/3 complex subunit 1A

1

1

High-throughput

0.536

High

1190230

SEPT5
Septin-5

1

10

High-throughput

0.536

High

838406

STA5A
Signal transducer and activator of transcription 5A

1

3

Small-scale

0.515

High

94734

E0CZ78
Serine/threonine-protein phosphatase

1

4

High-throughput

0.514

High

104678

F6UDT8
Discs large MAGUK scaffold protein 1

1

15

High-throughput

0.514

High

116261

H3BK84
Protein kinase, cAMP dependent regulatory, type II beta

1

3

High-throughput

0.514

High

116263

H3BL28
Neurabin-1

1

19

High-throughput

0.514

High

73915

B2RQG2
PHD finger protein 3

1

0

High-throughput

0.513

High

456913

ANXA2
Annexin A2

1

0

High-throughput

0.513

High

569629

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

0

High-throughput

0.513

High

578745

GLNA
Glutamine synthetase

1

0

High-throughput

0.513

High

609538

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.513

High

704276

NCKP1
Nck-associated protein 1

1

0

High-throughput

0.513

High

928754

CACB3
Voltage-dependent L-type calcium channel subunit beta-3

1

0

High-throughput

0.513

High

1000339

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

0

High-throughput

0.513

High

1179050

PHAR1
Phosphatase and actin regulator 1

1

0

High-throughput

0.513

High

1190161

PPM1E
Protein phosphatase 1E

1

0

High-throughput

0.513

High

1190175

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

1

0

High-throughput

0.513

High

1190185

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.513

High

1190188

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

0

High-throughput

0.513

High

1190191

PQBP1
Polyglutamine-binding protein 1

1

0

High-throughput

0.513

High

1190194

KAD5
Adenylate kinase isoenzyme 5

1

0

High-throughput

0.513

High

1190207

UBE4B
Ubiquitin conjugation factor E4 B

1

0

High-throughput

0.513

High

1190208

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.513

High

1190210

SACS
Sacsin

1

0

High-throughput

0.513

High

1190226

NCDN
Neurochondrin

1

0

High-throughput

0.513

High

312375

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

2

High-throughput

0.489

High

470797

NFM
Neurofilament medium polypeptide

1

2

High-throughput

0.489

High

1190129

KCD16
BTB/POZ domain-containing protein KCTD16

1

6

High-throughput

0.489

High

1190148

ANM8
Protein arginine N-methyltransferase 8

1

1

High-throughput

0.489

High

1190153

SYNE1
Nesprin-1

1

6

High-throughput

0.489

High

73161

DLGP4
Disks large-associated protein 4

1

7

High-throughput

0.479

High

205315

AP1B1
AP-1 complex subunit beta-1

1

6

High-throughput

0.479

High

663026

GRIA1
Glutamate receptor 1

1

7

High-throughput

0.479

High

1190149

DLGP3
Disks large-associated protein 3

1

7

High-throughput

0.479

High

1190170

Q8BH80
Vesicle-associated membrane protein, associated protein B and C

1

1

High-throughput

0.479

High

1190173

Q8BPK8
Fragile X messenger ribonucleoprotein 1

1

7

High-throughput

0.479

High

1190181

Q8CFX3
Protocadherin 1

1

7

High-throughput

0.479

High

1190199

NLGN1
Neuroligin-1

1

4

High-throughput

0.479

High

1190201

CNTP2
Contactin-associated protein-like 2

1

3

High-throughput

0.479

High

1190215

HOME2
Homer protein homolog 2

1

7

High-throughput

0.479

High

1190227

GNAS3
Neuroendocrine secretory protein 55

1

0

High-throughput

0.458

High

2043

A0A0A6YY83
Protocadherin 7

1

11

High-throughput

0.445

High

72644

NLGN4
Neuroligin 4-like

1

4

High-throughput

0.445

High

98311

E9QK34
Neuroligin 1

1

4

High-throughput

0.445

High

777875

FMR1
Fragile X messenger ribonucleoprotein 1

1

7

High-throughput

0.445

High

414

A0A087WS83
Voltage-dependent R-type calcium channel subunit alpha

1

2

High-throughput

0.437

High

92767

D3Z656
Synaptojanin-1

1

2

High-throughput

0.437

High

97873

E9Q2S0
Protocadherin 7

1

10

High-throughput

0.437

High

1190134

SC6A4
Sodium-dependent serotonin transporter

1

4

High-throughput

0.437

High

1190169

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

6

High-throughput

0.437

High

1190178

NLGN3
Neuroligin-3

1

4

High-throughput

0.437

High

59319

A2AGI3
Neuroligin 3

1

4

High-throughput

0.407

High

73011

B1AS06
DLG associated protein 3

1

7

High-throughput

0.407

High

85511

B7ZNS2
DLG associated protein 4

1

7

High-throughput

0.407

High

94715

E0CXD4
Protocadherin 1

1

7

High-throughput

0.407

High

98000

E9Q4F9
Homer scaffolding protein 2

1

5

High-throughput

0.407

High

98222

E9Q7S0
Synaptojanin-1

1

3

High-throughput

0.407

High

98353

E9QMC2
Metabotropic glutamate receptor 5

1

6

High-throughput

0.407

High

104740

F6YNQ1
Glutamate receptor

1

7

High-throughput

0.407

High

1190133

Q5SVG5
AP complex subunit beta

1

6

High-throughput

0.407

High

1190135

CAC1E
Voltage-dependent R-type calcium channel subunit alpha-1E

1

2

High-throughput

0.407

High

1190219

VAPB
Vesicle-associated membrane protein-associated protein B

1

1

High-throughput

0.407

High

95464

MTCL2
Microtubule cross-linking factor 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025