Protein: AP2A
Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2)

Gene: AP2A, TFAP2A
Organism: Homo sapiens
Interactions: 162
UniProt ID: P05549

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

403573

SP1
Transcription factor Sp1

3

1

Small-scale

0.665

High

385919

P53
Cellular tumor antigen p53

2

2

Small-scale

0.651

High

403638

EP300
Histone acetyltransferase p300

2

2

Small-scale

0.631

High

403660

KCTD1
BTB/POZ domain-containing protein KCTD1

2

5

Small-scale

0.631

High

403621

UBC9
SUMO-conjugating enzyme UBC9

2

2

Small-scale

0.628

High

403571

NPM
Nucleophosmin

2

0

Small-scale

0.628

High

403685

CITE2
Cbp/p300-interacting transactivator 2

2

4

Small-scale

0.625

High

403631

EWS
RNA-binding protein EWS

2

7

High-throughput

0.611

High

403662

AP2D
Transcription factor AP-2-delta

2

9

High-throughput

0.611

High

403670

AP2B
Transcription factor AP-2-beta

2

9

Small-scale

0.611

High

403639

INCA1
Protein INCA1

2

1

High-throughput

0.606

High

403682

KCD15
BTB/POZ domain-containing protein KCTD15

2

5

Small-scale

0.595

High

403623

CSK2B
Casein kinase II subunit beta

1

1

Small-scale

0.586

High

377005

GCR
Glucocorticoid receptor

2

5

Small-scale

0.584

High

403628

H33
Histone H3.3

2

1

Small-scale

0.584

High

403607

EPS15
Epidermal growth factor receptor substrate 15

2

0

Small-scale

0.577

High

118527

EYA2
Eyes absent homolog 2

2

2

High-throughput

0.576

High

403701

EPN1
Epsin-1

2

0

Small-scale

0.569

High

345688

MYC
Myc proto-oncogene protein

1

4

Small-scale

0.561

High

403583

XRCC6
X-ray repair cross-complementing protein 6

1

4

Small-scale

0.561

High

403584

XRCC5
X-ray repair cross-complementing protein 5

1

4

Small-scale

0.561

High

403620

AP2B1
AP-2 complex subunit beta

2

0

Small-scale

0.559

High

403612

MAX
Protein max

1

4

High-throughput

0.554

High

403611

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

0

Small-scale

0.554

High

403634

TF65
Transcription factor p65

1

4

Small-scale

0.552

High

403570

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.537

High

403594

APC
Adenomatous polyposis coli protein

1

0

Small-scale

0.537

High

126420

FOXE1
Forkhead box protein E1

1

2

High-throughput

0.536

High

156995

AIM2
Interferon-inducible protein AIM2

1

2

High-throughput

0.536

High

403637

SSRP1
FACT complex subunit SSRP1

1

2

High-throughput

0.536

High

403656

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.536

High

403684

FOXB1
Forkhead box protein B1

1

2

High-throughput

0.536

High

267845

EED
Polycomb protein EED

1

0

High-throughput

0.513

High

401259

JUN
Transcription factor Jun

1

0

High-throughput

0.513

High

403578

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.513

High

403650

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.513

High

403671

MY18A
Unconventional myosin-XVIIIa

1

0

High-throughput

0.513

High

403679

RBM14
RNA-binding protein 14

1

0

High-throughput

0.513

High

403602

PPARG
Peroxisome proliferator-activated receptor gamma

1

7

Small-scale

0.501

High

403647

KPCD1
Serine/threonine-protein kinase D1

1

1

Small-scale

0.501

High

403680

CITE4
Cbp/p300-interacting transactivator 4

1

7

Small-scale

0.501

High

403581

BCL2
Apoptosis regulator Bcl-2

1

0

Small-scale

0.493

High

403694

SH3B4
SH3 domain-binding protein 4

1

0

Small-scale

0.493

High

403699

AP4E1
AP-4 complex subunit epsilon-1

1

1

High-throughput

0.489

High

403591

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

4

Small-scale

0.481

High

403589

VEGFA
Vascular endothelial growth factor A, long form

1

0

Small-scale

0.480

High

403622

YBOX1
Y-box-binding protein 1

1

0

Small-scale

0.480

High

403624

CSK21
Casein kinase II subunit alpha

1

0

Small-scale

0.480

High

403632

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

Small-scale

0.480

High

403691

SRA1
Steroid receptor RNA activator 1

1

0

Small-scale

0.480

High

160328

AURKA
Aurora kinase A

1

2

Small-scale

0.479

High

243793

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

324164

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

337762

EGFR
Epidermal growth factor receptor

1

2

Small-scale

0.479

High

403580

ANDR
Androgen receptor

1

5

Small-scale

0.479

High

403585

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

Small-scale

0.479

High

403603

BRCA1
Breast cancer type 1 susceptibility protein

1

1

Small-scale

0.479

High

403608

ATRX
Transcriptional regulator ATRX

1

1

Small-scale

0.479

High

403609

SOX2
Transcription factor SOX-2

1

1

Small-scale

0.479

High

403617

H4
Histone H4

1

2

High-throughput

0.479

High

403625

H31
Histone H3.1

1

1

High-throughput

0.479

High

403648

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

2

Small-scale

0.479

High

403664

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

1

High-throughput

0.479

High

403665

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

403672

AP2C
Transcription factor AP-2 gamma

1

9

Small-scale

0.479

High

403683

EPAS1
Endothelial PAS domain-containing protein 1

1

1

Small-scale

0.479

High

403686

WWTR1
WW domain-containing transcription regulator protein 1

1

2

High-throughput

0.479

High

157823

IRF6
Interferon regulatory factor 6

1

0

Small-scale

0.458

High

403572

ADRB2
Beta-2 adrenergic receptor

1

0

Small-scale

0.458

High

403582

CADH1
Cadherin-1

1

0

Small-scale

0.458

High

403596

TYY1
Transcriptional repressor protein YY1

1

0

Small-scale

0.458

High

403599

CTNB1
Catenin beta-1

1

0

Small-scale

0.458

High

403601

DEK
Protein DEK

1

0

Small-scale

0.458

High

403604

COIL
Coilin

1

0

High-throughput

0.458

High

403610

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.458

High

403629

DAB2
Disabled homolog 2

1

0

Small-scale

0.458

High

403635

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.458

High

403646

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

403651

ZN750
Zinc finger protein 750

1

0

Small-scale

0.458

High

403667

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

403669

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

403702

DNM3A
DNA

1

0

Small-scale

0.458

High

172632

LAMA5
Laminin subunit alpha-5

1

1

High-throughput

0.457

High

178910

TOX3
TOX high mobility group box family member 3

1

2

High-throughput

0.457

High

211463

ACTN4
Alpha-actinin-4

1

1

High-throughput

0.457

High

283118

CCN5
CCN family member 5

1

1

High-throughput

0.457

High

358445

CO1A1
Collagen alpha-1(I) chain

1

4

High-throughput

0.457

High

365258

MT2
Metallothionein-2

1

1

High-throughput

0.457

High

403592

TENX
Tenascin-X

1

6

High-throughput

0.457

High

403593

FBLN1
Fibulin-1

1

10

High-throughput

0.457

High

403606

IFI27
Interferon alpha-inducible protein 27, mitochondrial

1

3

High-throughput

0.457

High

403641

KLF10
Krueppel-like factor 10

1

2

High-throughput

0.457

High

403645

FHL2
Four and a half LIM domains protein 2

1

3

High-throughput

0.457

High

403653

ZN326
DBIRD complex subunit ZNF326

1

1

High-throughput

0.457

High

403657

MCAF1
Activating transcription factor 7-interacting protein 1

1

1

High-throughput

0.457

High

403658

MOB2
MOB kinase activator 2

1

1

High-throughput

0.457

High

403659

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.457

High

403681

RANB9
Ran-binding protein 9

1

1

High-throughput

0.457

High

403690

UNKL
Putative E3 ubiquitin-protein ligase UNKL

1

1

High-throughput

0.457

High

403693

DMRT3
Doublesex- and mab-3-related transcription factor 3

1

1

High-throughput

0.457

High

277884

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.438

High

334104

LDHA
L-lactate dehydrogenase A chain

1

0

High-throughput

0.438

High

375847

ALDOA
Fructose-bisphosphate aldolase A

1

0

High-throughput

0.438

High

403576

RSSA
Small ribosomal subunit protein uS2

1

0

High-throughput

0.438

High

403586

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.438

High

403587

GLNA
Glutamine synthetase

1

0

High-throughput

0.438

High

403595

THTM
3-mercaptopyruvate sulfurtransferase

1

0

High-throughput

0.438

High

403613

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.438

High

403614

RHOA
Transforming protein RhoA

1

0

High-throughput

0.438

High

403615

DCAF7
DDB1- and CUL4-associated factor 7

1

0

High-throughput

0.438

High

403616

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.438

High

403627

IN35
Interferon-induced 35 kDa protein

1

0

High-throughput

0.438

High

403630

CDK5
Cyclin-dependent kinase 5

1

0

High-throughput

0.438

High

403642

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.438

High

403644

TBB2A
Tubulin beta-2A chain

1

0

High-throughput

0.438

High

403652

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

High-throughput

0.438

High

403668

DBF4B
Protein DBF4 homolog B

1

0

High-throughput

0.438

High

403675

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

0

High-throughput

0.438

High

403678

ZN641
Zinc finger protein 641

1

0

High-throughput

0.438

High

403696

RERE
Arginine-glutamic acid dipeptide repeats protein

1

0

High-throughput

0.438

High

403697

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.438

High

403700

PPME1
Protein phosphatase methylesterase 1

1

0

High-throughput

0.438

High

403673

AP2M1
AP-2 complex subunit mu

1

1

Small-scale

0.437

High

403677

MEG10
Multiple epidermal growth factor-like domains protein 10

1

5

Small-scale

0.437

High

403695

HECW2
E3 ubiquitin-protein ligase HECW2

1

1

High-throughput

0.437

High

403703

AP1M2
AP-1 complex subunit mu-2

1

1

Small-scale

0.437

High

403600

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

403619

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.426

High

60274

POTEF
POTE ankyrin domain family member F

1

1

High-throughput

0.417

High

362574

C1QC
Complement C1q subcomponent subunit C

1

1

High-throughput

0.417

High

403574

CO1A2
Collagen alpha-2(I) chain

1

4

High-throughput

0.417

High

403575

CFAH
Complement factor H

1

3

High-throughput

0.417

High

403605

COFA1
Collagen alpha-1(XV) chain [Cleaved into: Restin

1

6

High-throughput

0.417

High

403636

LOXL1
Lysyl oxidase homolog 1

1

2

High-throughput

0.417

High

403649

TENXA
Putative tenascin-XA

1

4

High-throughput

0.417

High

403661

CCD80
Coiled-coil domain-containing protein 80

1

1

High-throughput

0.417

High

403687

I27L2
Interferon alpha-inducible protein 27-like protein 2

1

3

High-throughput

0.417

High

403698

DPP2
Dipeptidyl peptidase 2

1

1

High-throughput

0.417

High

403704

FCGBP
IgGFc-binding protein

1

3

High-throughput

0.417

High

403689

GSTO2
Glutathione S-transferase omega-2

5

0

High-throughput

0.378

High

403663

ACOT1
Acyl-coenzyme A thioesterase 1

3

0

High-throughput

0.345

High

403640

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

1

0

High-throughput

0.299

High

403598

TMOD1
Tropomodulin-1

1

0

High-throughput

0.279

Low

322073

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

203056

ERI3
ERI1 exoribonuclease 3

1

0

High-throughput

0.238

Low

380171

THY1
Thy-1 membrane glycoprotein

1

0

High-throughput

0.238

Low

403577

LEG1
Galectin-1

1

0

High-throughput

0.238

Low

403579

PA24B
Cytosolic phospholipase A2 beta

1

0

High-throughput

0.238

Low

403588

ARSA
Arylsulfatase A

1

0

High-throughput

0.238

Low

403590

CBPE
Carboxypeptidase E

1

0

High-throughput

0.238

Low

403597

ATPA
ATP synthase subunit alpha, mitochondrial

1

0

High-throughput

0.238

Low

403618

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.238

Low

403626

NOMO3
BOS complex subunit NOMO3

1

0

High-throughput

0.238

Low

403633

ACY1
Aminoacylase-1

1

0

High-throughput

0.238

Low

403643

SNTA1
Alpha-1-syntrophin

1

0

High-throughput

0.238

Low

403654

HYI
Putative hydroxypyruvate isomerase

1

0

High-throughput

0.238

Low

403655

MORN1
MORN repeat-containing protein 1

1

0

High-throughput

0.238

Low

403666

A16A1
Aldehyde dehydrogenase family 16 member A1

1

0

High-throughput

0.238

Low

403674

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

High-throughput

0.238

Low

403676

RCC1L
RCC1-like G exchanging factor-like protein

1

0

High-throughput

0.238

Low

403688

TMPS5
Transmembrane protease serine 5

1

0

High-throughput

0.238

Low

403692

SERHL
Serine hydrolase-like protein

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024