Protein: FRDA
Frataxin, mitochondrial (EC 1.16.3.1) (Friedreich ataxia protein) (Fxn) [Cleaved into: Frataxin intermediate form (i-FXN); Frataxin(56-210) (m56-FXN); Frataxin(78-210) (d-FXN) (m78-FXN); Frataxin mature form (Frataxin(81-210)) (m81-FXN); Extramitochondrial frataxin]

Gene: FRDA, FXN
Organism: Homo sapiens
Interactions: 26
UniProt ID: Q16595

Gene Ontology (top 5):
GO:0004322 - ferroxidase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005829 - cytosol
GO:0006119 - oxidative phosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1083732

NFS1
Cysteine desulfurase

1

4

Small-scale

0.647

High

1083731

DAPP1
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

3

0

High-throughput

0.632

High

1083725

ISCU
Iron-sulfur cluster assembly enzyme ISCU

1

2

Small-scale

0.618

High

1083722

RN126
E3 ubiquitin-protein ligase RNF126

1

0

Small-scale

0.537

High

264912

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

Small-scale

0.527

High

1083721

PASK
PAS domain-containing serine/threonine-protein kinase

1

1

Small-scale

0.501

High

278102

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.493

High

1083724

SKI8
Superkiller complex protein 8

1

0

High-throughput

0.493

High

1083726

CAN10
Calpain-10

1

0

High-throughput

0.493

High

521555

ACTN1
Alpha-actinin-1

1

0

High-throughput

0.486

High

1083728

PICK1
PRKCA-binding protein

1

0

High-throughput

0.486

High

681875

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.480

High

602106

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

1

Small-scale

0.479

High

677982

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

1

Small-scale

0.479

High

1083727

LYRM4
LYR motif-containing protein 4

1

1

High-throughput

0.479

High

882329

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

1083730

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

378069

PRIO
Major prion protein

1

0

High-throughput

0.426

High

62313

GG6L9
Golgin subfamily A member 6-like protein 9

2

0

High-throughput

0.316

High

1083717

SAMD3
Sterile alpha motif domain-containing protein 3

1

0

High-throughput

0.268

Low

1083718

RN138
E3 ubiquitin-protein ligase RNF138

1

0

High-throughput

0.268

Low

1083719

COR2A
Coronin-2A

1

0

High-throughput

0.268

Low

1083720

RN183
E3 ubiquitin-protein ligase RNF183

1

0

High-throughput

0.268

Low

1083723

Q9BVU5
ARL17 protein

1

0

High-throughput

0.268

Low

1083729

RASF1
Ras association domain-containing protein 1

1

0

High-throughput

0.268

Low

100801

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024