Protein: CAN1
Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP)

Gene: CAN1, CAPN1
Organism: Homo sapiens
Interactions: 138
UniProt ID: P07384

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0004198 - calcium-dependent cysteine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

427843

ICAL
Calpastatin

5

5

Small-scale

0.925

High

427918

CPNS2
Calpain small subunit 2

3

15

High-throughput

0.861

High

62711

CAN8
Calpain-8

2

13

High-throughput

0.811

High

427838

CAN2
Calpain-2 catalytic subunit

2

15

High-throughput

0.811

High

385827

CPNS1
Calpain small subunit 1

5

15

Small-scale

0.724

High

427919

KCTD7
BTB/POZ domain-containing protein KCTD7

1

10

Small-scale

0.724

High

427841

PTN1
Tyrosine-protein phosphatase non-receptor type 1

3

1

Small-scale

0.670

High

345170

KNG1
Kininogen-1

3

2

High-throughput

0.667

High

427840

LEG3
Galectin-3

3

1

High-throughput

0.667

High

427862

FNTB
Protein farnesyltransferase subunit beta

3

3

High-throughput

0.667

High

427830

CAN1
Calpain-1 catalytic subunit

1

14

Small-scale

0.647

High

427885

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

7

Small-scale

0.647

High

422324

NFM
Neurofilament medium polypeptide

2

7

High-throughput

0.628

High

427861

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

2

1

High-throughput

0.628

High

427891

TRIPC
E3 ubiquitin-protein ligase TRIP12

2

11

High-throughput

0.628

High

427896

AINX
Alpha-internexin

2

6

High-throughput

0.628

High

427902

CD109
CD109 antigen

2

1

High-throughput

0.628

High

427904

KTN1
Kinectin

2

2

High-throughput

0.628

High

427847

MAP4
Microtubule-associated protein 4

2

9

High-throughput

0.621

High

427855

ACTN2
Alpha-actinin-2

1

2

Small-scale

0.621

High

427874

ACTC
Actin, alpha cardiac muscle 1

1

1

Small-scale

0.621

High

427865

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.618

High

427879

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

3

High-throughput

0.618

High

427831

VIME
Vimentin

2

6

Small-scale

0.614

High

427909

C99L2
CD99 antigen-like protein 2

2

0

High-throughput

0.602

High

427852

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.586

High

427832

TAU
Microtubule-associated protein tau

2

7

Small-scale

0.585

High

226283

PRKN
E3 ubiquitin-protein ligase parkin

2

11

High-throughput

0.584

High

427899

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.575

High

427930

TB22B
TBC1 domain family member 22B

2

7

High-throughput

0.574

High

427856

STAT3
Signal transducer and activator of transcription 3

1

3

High-throughput

0.573

High

427842

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.571

High

427880

CAV1
Caveolin-1

2

2

High-throughput

0.571

High

224272

RAD21
Double-strand-break repair protein rad21 homolog

2

0

Small-scale

0.569

High

427923

ATG5
Autophagy protein 5

1

1

Small-scale

0.569

High

427833

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.554

High

427864

PSN2
Presenilin-2

1

2

Small-scale

0.552

High

257548

ANR17
Ankyrin repeat domain-containing protein 17

1

3

High-throughput

0.536

High

265386

KTNA1
Katanin p60 ATPase-containing subunit A1

1

2

High-throughput

0.536

High

427853

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.536

High

427860

NEST
Nestin

1

8

High-throughput

0.536

High

427876

HTRA4
Serine protease HTRA4

1

2

High-throughput

0.536

High

427877

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

3

High-throughput

0.536

High

427895

ZIC1
Zinc finger protein ZIC 1

1

3

High-throughput

0.536

High

427901

MPRIP
Myosin phosphatase Rho-interacting protein

1

5

High-throughput

0.536

High

427915

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

1

High-throughput

0.536

High

427928

BIRC6
Baculoviral IAP repeat-containing protein 6

1

1

High-throughput

0.536

High

427935

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

2

High-throughput

0.536

High

427938

PRC2C
Protein PRRC2C

1

5

High-throughput

0.536

High

174342

FANCG
Fanconi anemia group G protein

1

0

Small-scale

0.529

High

176534

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.529

High

427850

PDIA3
Protein disulfide-isomerase A3

1

1

High-throughput

0.515

High

393939

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

427916

OPTN
Optineurin

1

3

High-throughput

0.515

High

427871

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

427888

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.513

High

427907

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.513

High

427925

SYCM
Probable cysteine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

427835

EZRI
Ezrin

1

2

Small-scale

0.501

High

427845

IKBA
NF-kappa-B inhibitor alpha

1

5

Small-scale

0.501

High

427867

RCAN1
Calcipressin-1

1

2

Small-scale

0.501

High

427868

ATX3
Ataxin-3

1

3

Small-scale

0.501

High

427849

KCY
UMP-CMP kinase

1

0

High-throughput

0.493

High

427914

BAD
Bcl2-associated agonist of cell death

1

0

High-throughput

0.493

High

303631

OR2A4
Olfactory receptor 2A4

1

1

High-throughput

0.489

High

427893

SAFB1
Scaffold attachment factor B1

1

5

High-throughput

0.489

High

427920

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

2

High-throughput

0.489

High

427921

WDR33
pre-mRNA 3' end processing protein WDR33

1

3

High-throughput

0.489

High

427900

CLC4G
C-type lectin domain family 4 member G

1

0

High-throughput

0.486

High

427839

DESM
Desmin

1

6

Small-scale

0.481

High

427844

ALAT1
Alanine aminotransferase 1

1

1

Small-scale

0.481

High

427848

ECHM
Enoyl-CoA hydratase, mitochondrial

1

1

Small-scale

0.481

High

427866

CATC
Dipeptidyl peptidase 1

1

1

Small-scale

0.481

High

427886

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

1

High-throughput

0.481

High

427889

FHL2
Four and a half LIM domains protein 2

1

2

Small-scale

0.481

High

427890

NF2L1
Endoplasmic reticulum membrane sensor NFE2L1

1

1

Small-scale

0.481

High

427892

MYPC3
Myosin-binding protein C, cardiac-type

1

5

Small-scale

0.481

High

427922

TINAL
Tubulointerstitial nephritis antigen-like

1

1

Small-scale

0.481

High

427872

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

0

Small-scale

0.480

High

329250

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.479

High

345710

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

362696

FINC
Fibronectin

1

4

High-throughput

0.479

High

384106

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

385931

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

427834

ITA4
Integrin alpha-4

1

2

High-throughput

0.479

High

427851

NMT1
Glycylpeptide N-tetradecanoyltransferase 1

1

1

Small-scale

0.479

High

427858

YAP1
Transcriptional coactivator YAP1

1

4

High-throughput

0.479

High

427859

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

427863

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

427873

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

427875

H31
Histone H3.1

1

1

High-throughput

0.479

High

427878

FANCC
Fanconi anemia group C protein

1

1

Small-scale

0.479

High

427882

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

427884

CUL3
Cullin-3

1

7

Small-scale

0.479

High

427887

TRI14
Tripartite motif-containing protein 14

1

2

High-throughput

0.479

High

427897

RBBP7
Histone-binding protein RBBP7

1

1

High-throughput

0.479

High

427898

HIF1A
Hypoxia-inducible factor 1-alpha

1

1

Small-scale

0.479

High

427903

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

427906

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

427912

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

427913

REQU
Zinc finger protein ubi-d4

1

3

High-throughput

0.479

High

427924

ECT2
Protein ECT2

1

5

High-throughput

0.479

High

427926

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

High-throughput

0.479

High

427927

ANLN
Anillin

1

2

High-throughput

0.479

High

427932

FXL12
F-box/LRR-repeat protein 12

1

1

Small-scale

0.479

High

427934

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

427936

CE164
Centrosomal protein of 164 kDa

1

6

High-throughput

0.479

High

427937

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

153539

ANM5
Protein arginine N-methyltransferase 5

1

0

Small-scale

0.460

High

173334

S22A1
Solute carrier family 22 member 1

1

0

Small-scale

0.460

High

254225

SLIT3
Slit homolog 3 protein

1

0

Small-scale

0.460

High

271824

CREG1
Protein CREG1

1

0

Small-scale

0.460

High

358449

CO1A1
Collagen alpha-1(I) chain

1

0

Small-scale

0.460

High

427837

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

1

0

Small-scale

0.460

High

427857

PTGDS
Prostaglandin-H2 D-isomerase

1

0

Small-scale

0.460

High

427869

SH3BG
SH3 domain-binding glutamic acid-rich protein

1

0

Small-scale

0.460

High

217072

GAS2
Growth arrest-specific protein 2

1

0

Small-scale

0.458

High

322084

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

324173

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

351218

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.458

High

427894

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

427911

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.458

High

427929

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

427931

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.458

High

427933

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

427870

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

2

High-throughput

0.445

High

243810

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.437

High

427836

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

427846

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

427854

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

427883

TIF1B
Transcription intermediary factor 1-beta

1

8

High-throughput

0.437

High

120803

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.426

High

427917

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.426

High

427908

RP9
Retinitis pigmentosa 9 protein

2

0

High-throughput

0.328

High

427910

COG1
Conserved oligomeric Golgi complex subunit 1

1

0

High-throughput

0.279

Low

427881

TLE5
TLE family member 5

1

0

Small-scale

0.251

Low

427905

PALB2
Partner and localizer of BRCA2

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024