Protein: GDIR1
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha)

Gene: GDIR1, ARHGDIA
Organism: Homo sapiens
Interactions: 159
UniProt ID: P52565

Gene Ontology (top 5):
GO:0001772 - immunological synapse
GO:0005094 - Rho GDP-dissociation inhibitor activity
GO:0005096 - GTPase activator activity
GO:0005634 - nucleus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

854769

RAC1
Ras-related C3 botulinum toxin substrate 1

16

20

Small-scale

0.985

High

854763

RHOA
Transforming protein RhoA

14

20

Small-scale

0.983

High

854760

CDC42
Cell division control protein 42 homolog

8

20

Small-scale

0.966

High

436218

RHOC
Rho-related GTP-binding protein RhoC

3

20

Small-scale

0.855

High

854771

RHOG
Rho-related GTP-binding protein RhoG

3

20

Small-scale

0.854

High

854759

RAC3
Ras-related C3 botulinum toxin substrate 3

2

20

High-throughput

0.806

High

854792

RHOH
Rho-related GTP-binding protein RhoH

2

20

Small-scale

0.775

High

545278

RAC2
Ras-related C3 botulinum toxin substrate 2

2

20

Small-scale

0.767

High

854767

RHOB
Rho-related GTP-binding protein RhoB

2

20

Small-scale

0.743

High

854750

GDIR1
Rho GDP-dissociation inhibitor 1

2

0

Small-scale

0.728

High

719684

RADI
Radixin

2

3

Small-scale

0.629

High

349995

RASK
GTPase KRas

1

2

High-throughput

0.618

High

591782

RAB4A
Ras-related protein Rab-4A

1

2

High-throughput

0.618

High

854757

RAB25
Ras-related protein Rab-25

1

3

High-throughput

0.618

High

854766

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.618

High

788165

CASP3
Caspase-3

2

8

Small-scale

0.602

High

854754

CASP7
Caspase-7

2

8

Small-scale

0.602

High

854776

EWS
RNA-binding protein EWS

2

1

High-throughput

0.601

High

854784

CUL3
Cullin-3

2

0

Small-scale

0.585

High

226930

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

854772

XIAP
E3 ubiquitin-protein ligase XIAP

2

1

Small-scale

0.584

High

584349

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

3

Small-scale

0.575

High

632223

TNR6
Tumor necrosis factor receptor superfamily member 6

1

3

Small-scale

0.575

High

854782

FADD
FAS-associated death domain protein

1

2

Small-scale

0.575

High

546984

EZRI
Ezrin

2

3

Small-scale

0.571

High

854808

SH2D3
SH2 domain-containing protein 3C

2

1

High-throughput

0.571

High

201275

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

High-throughput

0.536

High

734896

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

1

High-throughput

0.536

High

854793

MYLK
Myosin light chain kinase, smooth muscle

1

1

High-throughput

0.536

High

854820

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.536

High

428981

ADRB2
Beta-2 adrenergic receptor

1

0

Small-scale

0.529

High

542241

PLAK
Junction plakoglobin

1

0

High-throughput

0.518

High

764347

FEN1
Flap endonuclease 1

1

0

High-throughput

0.518

High

804087

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

0

High-throughput

0.518

High

854752

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.518

High

854817

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

0

High-throughput

0.518

High

852000

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

1

High-throughput

0.515

High

854785

EI2BA
Translation initiation factor eIF2B subunit alpha

1

1

High-throughput

0.515

High

854821

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

1

High-throughput

0.515

High

154329

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

2

Small-scale

0.514

High

170307

TIF1A
Transcription intermediary factor 1-alpha

1

0

High-throughput

0.513

High

359787

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.513

High

854777

KPCZ
Protein kinase C zeta type

1

0

High-throughput

0.513

High

854826

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.513

High

854764

UFM1
Ubiquitin-fold modifier 1

1

1

High-throughput

0.508

High

854796

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.508

High

667442

CASP1
Caspase-1

1

8

Small-scale

0.501

High

854806

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

1

Small-scale

0.501

High

854813

KAT2B
Histone acetyltransferase KAT2B

1

2

Small-scale

0.501

High

854843

NEMO
NF-kappa-B essential modulator

1

1

Small-scale

0.501

High

854823

SH3G3
Endophilin-A3

1

1

High-throughput

0.494

High

854778

DHX9
ATP-dependent RNA helicase A

1

0

High-throughput

0.493

High

854836

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

0

High-throughput

0.493

High

854805

MYLK4
Myosin light chain kinase family member 4

1

1

High-throughput

0.489

High

159039

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

0

High-throughput

0.486

High

800323

CBX5
Chromobox protein homolog 5

1

0

High-throughput

0.486

High

809646

3HAO
3-hydroxyanthranilate 3,4-dioxygenase

1

0

High-throughput

0.486

High

854790

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.486

High

854795

BAK
Bcl-2 homologous antagonist/killer

1

0

High-throughput

0.486

High

854801

TWF2
Twinfilin-2

1

0

High-throughput

0.486

High

854803

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

0

High-throughput

0.486

High

854819

C560
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

1

0

High-throughput

0.486

High

331477

ACL6A
Actin-like protein 6A

1

1

High-throughput

0.481

High

486156

GRAB
Granzyme B

1

0

Small-scale

0.480

High

854770

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.480

High

854779

EP300
Histone acetyltransferase p300

1

0

Small-scale

0.480

High

854838

HDAC6
Histone deacetylase 6

1

0

Small-scale

0.480

High

244153

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

276157

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

2

Small-scale

0.479

High

369228

ESR1
Estrogen receptor

1

1

Small-scale

0.479

High

373918

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

447666

ENOG
Gamma-enolase

1

1

High-throughput

0.479

High

569435

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

641678

U2AF2
Splicing factor U2AF 65 kDa subunit

1

2

High-throughput

0.479

High

726677

FUS
RNA-binding protein FUS

1

1

High-throughput

0.479

High

777430

MDHC
Malate dehydrogenase, cytoplasmic

1

1

High-throughput

0.479

High

792945

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

1

Small-scale

0.479

High

854758

MTPN
Myotrophin

1

1

High-throughput

0.479

High

854774

VIGLN
Vigilin

1

1

High-throughput

0.479

High

854783

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

854798

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.479

High

854810

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

854811

HS105
Heat shock protein 105 kDa

1

1

High-throughput

0.479

High

854812

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

854815

FBXW7
F-box/WD repeat-containing protein 7

1

1

Small-scale

0.479

High

854825

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

854830

WDR26
WD repeat-containing protein 26

1

2

Small-scale

0.479

High

854832

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

854841

EI2BD
Translation initiation factor eIF2B subunit delta

1

1

High-throughput

0.479

High

854751

ATX3
Ataxin-3

1

0

Small-scale

0.460

High

62722

DDTL
D-dopachrome decarboxylase-like protein

1

0

High-throughput

0.458

High

121132

LEG8
Galectin-8

1

0

Small-scale

0.458

High

129721

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.458

High

260014

TBCA
Tubulin-specific chaperone A

1

0

High-throughput

0.458

High

294563

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

346291

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

376076

CYTB
Cystatin-B

1

0

High-throughput

0.458

High

384533

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

552292

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

562537

IL7RA
Interleukin-7 receptor subunit alpha

1

0

High-throughput

0.458

High

625258

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

646147

STOM
Stomatin

1

0

High-throughput

0.458

High

650734

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

669941

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

Small-scale

0.458

High

724188

MSX2
Homeobox protein MSX-2

1

0

High-throughput

0.458

High

779067

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

796710

RANG
Ran-specific GTPase-activating protein

1

0

High-throughput

0.458

High

817820

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

854753

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

854761

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

854762

RL26
Large ribosomal subunit protein uL24

1

0

High-throughput

0.458

High

854765

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.458

High

854768

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.458

High

854773

CYC
Cytochrome c

1

0

High-throughput

0.458

High

854775

SET
Protein SET

1

0

Small-scale

0.458

High

854781

PAK1
Serine/threonine-protein kinase PAK 1

1

0

Small-scale

0.458

High

854787

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

854789

CUL7
Cullin-7

1

0

High-throughput

0.458

High

854791

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

854794

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

854802

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

854804

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

854822

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

854827

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

854831

MYO10
Unconventional myosin-X

1

0

Small-scale

0.458

High

854833

TNR19
Tumor necrosis factor receptor superfamily member 19

1

0

Small-scale

0.458

High

854835

KCTD5
BTB/POZ domain-containing protein KCTD5

1

0

Small-scale

0.458

High

854837

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

854839

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

854842

SGT1
Protein SGT1 homolog

1

0

High-throughput

0.458

High

854818

LMTK3
Serine/threonine-protein kinase LMTK3

1

1

High-throughput

0.457

High

401678

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

640073

MOES
Moesin

1

3

Small-scale

0.445

High

800731

MK08
Mitogen-activated protein kinase 8

1

1

Small-scale

0.445

High

854756

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

854788

CASP8
Caspase-8

1

8

Small-scale

0.445

High

854814

CASPA
Caspase-10

1

8

Small-scale

0.445

High

416385

S10A9
Protein S100-A9

1

0

Small-scale

0.438

High

854800

Q6IBE6
SIAT4C protein

1

0

High-throughput

0.438

High

854807

AN13A
Ankyrin repeat domain-containing protein 13A

1

3

High-throughput

0.437

High

854828

Q9H4D1
Protein kinase

1

1

High-throughput

0.437

High

854840

SUN2
SUN domain-containing protein 2

1

1

High-throughput

0.437

High

496613

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

815665

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

0

Small-scale

0.426

High

854755

BID
BH3-interacting domain death agonist

1

0

Small-scale

0.426

High

854780

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.426

High

854816

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

854799

Q6FI97
BAF53A protein

1

1

High-throughput

0.417

High

854809

KCNRG
Potassium channel regulatory protein

1

1

High-throughput

0.417

High

831125

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

854824

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.296

High

854834

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.282

High

242829

TRI13
E3 ubiquitin-protein ligase TRIM13

1

0

High-throughput

0.251

Low

329520

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

720029

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

854786

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

854797

PRC2B
Protein PRRC2B

1

0

High-throughput

0.249

Low

854829

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024