Protein: SF3A3
Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61)

Gene: SF3A3
Organism: Homo sapiens
Interactions: 207
UniProt ID: Q12874

Gene Ontology (top 5):
GO:0000375 - RNA splicing, via transesterification reactions
GO:0000389 - mRNA 3'-splice site recognition
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1018804

SF3A1
Splicing factor 3A subunit 1

12

4

Small-scale

0.984

High

1018852

SPF45
Splicing factor 45

4

2

High-throughput

0.903

High

1018801

SF3B3
Splicing factor 3B subunit 3

4

1

High-throughput

0.892

High

911815

RUXF
Small nuclear ribonucleoprotein F

3

5

High-throughput

0.871

High

441271

RU2B
U2 small nuclear ribonucleoprotein B''

3

4

High-throughput

0.861

High

726780

FUS
RNA-binding protein FUS

3

2

High-throughput

0.847

High

1018784

SF3B2
Splicing factor 3B subunit 2

3

1

High-throughput

0.847

High

1018806

U2AFM
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

3

0

High-throughput

0.816

High

538927

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

2

High-throughput

0.811

High

911623

RUXE
Small nuclear ribonucleoprotein E

2

1

High-throughput

0.811

High

927944

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

2

High-throughput

0.811

High

912034

RUXG
Small nuclear ribonucleoprotein G

2

7

High-throughput

0.789

High

1018791

RBM39
RNA-binding protein 39

2

2

High-throughput

0.789

High

1018884

SF3B6
Splicing factor 3B subunit 6

2

3

High-throughput

0.789

High

1018885

RBM7
RNA-binding protein 7

2

2

High-throughput

0.789

High

453805

RU2A
U2 small nuclear ribonucleoprotein A'

7

1

Small-scale

0.746

High

446606

SNRPA
U1 small nuclear ribonucleoprotein A

1

4

High-throughput

0.691

High

912281

SMD1
Small nuclear ribonucleoprotein Sm D1

1

5

High-throughput

0.691

High

912439

SMD2
Small nuclear ribonucleoprotein Sm D2

1

2

High-throughput

0.691

High

951936

SRSF3
Serine/arginine-rich splicing factor 3

1

1

High-throughput

0.691

High

1018800

RNPS1
RNA-binding protein with serine-rich domain 1

1

3

High-throughput

0.691

High

1018803

SF3A2
Splicing factor 3A subunit 2

4

2

Small-scale

0.686

High

503985

HSP7C
Heat shock cognate 71 kDa protein

3

1

High-throughput

0.667

High

1018881

PUF60
Poly(U)-binding-splicing factor PUF60

1

1

High-throughput

0.665

High

856059

RBM5
RNA-binding protein 5

1

0

High-throughput

0.656

High

346649

MYC
Myc proto-oncogene protein

3

3

High-throughput

0.640

High

266344

TAD2A
Transcriptional adapter 2-alpha

2

1

High-throughput

0.633

High

1018826

TRI69
E3 ubiquitin-protein ligase TRIM69

2

1

High-throughput

0.633

High

1018821

PHF5A
PHD finger-like domain-containing protein 5A

2

1

High-throughput

0.628

High

165458

SR140
U2 snRNP-associated SURP motif-containing protein

1

1

High-throughput

0.618

High

1018802

SF3B4
Splicing factor 3B subunit 4

1

1

High-throughput

0.618

High

1018829

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

5

High-throughput

0.618

High

1018844

RBP56
TATA-binding protein-associated factor 2N

1

1

High-throughput

0.618

High

268693

SF3B1
Splicing factor 3B subunit 1

2

1

High-throughput

0.611

High

1018866

SF3B5
Splicing factor 3B subunit 5

2

1

High-throughput

0.611

High

1018851

CCD97
Coiled-coil domain-containing protein 97

2

0

High-throughput

0.602

High

1018877

ZN212
Zinc finger protein 212

2

0

High-throughput

0.601

High

153655

ANM5
Protein arginine N-methyltransferase 5

2

1

Small-scale

0.600

High

278931

SPF30
Survival of motor neuron-related-splicing factor 30

2

0

High-throughput

0.595

High

154791

TCRG1
Transcription elongation regulator 1

2

2

Small-scale

0.595

High

1018839

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

1

0

Small-scale

0.586

High

1018886

SPIN1
Spindlin-1

2

0

High-throughput

0.585

High

1018843

KAT6A
Histone acetyltransferase KAT6A

2

1

Small-scale

0.584

High

68416

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

7

High-throughput

0.575

High

853873

NCBP2
Nuclear cap-binding protein subunit 2

1

4

High-throughput

0.575

High

227300

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

998620

EP300
Histone acetyltransferase p300

2

0

High-throughput

0.559

High

1018795

EMC2
ER membrane protein complex subunit 2

2

3

High-throughput

0.558

High

388404

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.558

High

433728

LYN
Tyrosine-protein kinase Lyn

2

0

High-throughput

0.547

High

1018807

CC85B
Coiled-coil domain-containing protein 85B

1

1

High-throughput

0.541

High

574312

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.536

High

871545

HSP72
Heat shock-related 70 kDa protein 2

1

1

High-throughput

0.536

High

1018786

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.536

High

1018812

KDM4D
Lysine-specific demethylase 4D

1

1

High-throughput

0.536

High

1018825

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

1018845

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.536

High

1018859

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.536

High

1018862

FOXB1
Forkhead box protein B1

1

2

High-throughput

0.536

High

1018869

FOXQ1
Forkhead box protein Q1

1

2

High-throughput

0.536

High

1018870

KDM4C
Lysine-specific demethylase 4C

1

1

High-throughput

0.536

High

269226

WBP4
WW domain-binding protein 4

1

2

High-throughput

0.527

High

451784

ANXA4
Annexin A4

1

1

High-throughput

0.515

High

791519

HD
Huntingtin

1

1

High-throughput

0.515

High

278800

DNJC8
DnaJ homolog subfamily C member 8

1

0

High-throughput

0.513

High

314035

BAG4
BAG family molecular chaperone regulator 4

1

0

High-throughput

0.513

High

448630

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

496933

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

801109

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

1018783

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1018827

DDX42
ATP-dependent RNA helicase DDX42

1

0

High-throughput

0.513

High

1018833

TRM2A
tRNA

1

0

High-throughput

0.513

High

1018853

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

0

High-throughput

0.513

High

1018872

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

0

High-throughput

0.513

High

174835

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

263609

PR40A
Pre-mRNA-processing factor 40 homolog A

1

4

High-throughput

0.501

High

1018828

ZDH17
Palmitoyltransferase ZDHHC17

1

1

High-throughput

0.494

High

868458

ATX1
Ataxin-1

1

0

High-throughput

0.493

High

1018815

TTC33
Tetratricopeptide repeat protein 33

1

3

High-throughput

0.489

High

1018848

ARRD3
Arrestin domain-containing protein 3

1

2

High-throughput

0.489

High

120907

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.480

High

130867

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.479

High

244357

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

268054

EED
Polycomb protein EED

1

2

High-throughput

0.479

High

308660

KI20A
Kinesin-like protein KIF20A

1

1

High-throughput

0.479

High

322539

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

345415

FOS
Protein c-Fos

1

1

High-throughput

0.479

High

379341

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.479

High

552594

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

584939

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

651066

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

720334

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

749431

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

841687

CDK9
Cyclin-dependent kinase 9

1

1

High-throughput

0.479

High

908453

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

934706

H31
Histone H3.1

1

2

High-throughput

0.479

High

943821

RAE1L
mRNA export factor RAE1

1

1

High-throughput

0.479

High

944760

RED1
Double-stranded RNA-specific editase 1

1

1

High-throughput

0.479

High

961078

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

1018779

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.479

High

1018780

FOXC1
Forkhead box protein C1

1

1

High-throughput

0.479

High

1018782

RFA4
Replication protein A 30 kDa subunit

1

3

High-throughput

0.479

High

1018787

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1018797

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1018808

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

1018813

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.479

High

1018814

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

1018817

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1018820

MEPCE
7SK snRNA methylphosphate capping enzyme

1

1

High-throughput

0.479

High

1018850

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

1

High-throughput

0.479

High

1018860

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

1018863

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

1018867

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

1018874

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1018879

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

665227

EPHA2
Ephrin type-A receptor 2

1

1

High-throughput

0.470

High

122711

MEN1
Menin

1

0

High-throughput

0.458

High

124202

TAF4
Transcription initiation factor TFIID subunit 4

1

0

High-throughput

0.458

High

209935

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

294768

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

298472

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

303199

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

313265

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.458

High

551516

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.458

High

569658

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

617839

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.458

High

622580

RAE1
Rab proteins geranylgeranyltransferase component A 1

1

0

High-throughput

0.458

High

637866

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

708619

MCM5
DNA replication licensing factor MCM5

1

0

High-throughput

0.458

High

713503

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

798877

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.458

High

823939

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

868160

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

873405

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.458

High

896424

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

917183

H4
Histone H4

1

0

High-throughput

0.458

High

1018781

TP4A2
Protein tyrosine phosphatase type IVA 2

1

0

High-throughput

0.458

High

1018785

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1018788

FHL1
Four and a half LIM domains protein 1

1

0

High-throughput

0.458

High

1018792

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.458

High

1018794

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1018796

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

1018798

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1018811

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1018819

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.458

High

1018822

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

1018823

SLN11
Schlafen family member 11

1

0

Small-scale

0.458

High

1018824

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1018831

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.458

High

1018832

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1018837

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.458

High

1018838

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1018841

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1018842

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1018846

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.458

High

1018847

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

1018849

KCD12
BTB/POZ domain-containing protein KCTD12

1

0

Small-scale

0.458

High

1018855

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1018856

CIC
Protein capicua homolog

1

0

High-throughput

0.458

High

1018858

CRBN
Protein cereblon

1

0

Small-scale

0.458

High

1018861

MYD88
Myeloid differentiation primary response protein MyD88

1

0

Small-scale

0.458

High

1018865

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1018868

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1018873

ANLN
Anillin

1

0

High-throughput

0.458

High

1018875

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1018878

TRM7
tRNA

1

0

High-throughput

0.458

High

1018880

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.458

High

1018883

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.458

High

195412

DHX15
ATP-dependent RNA helicase DHX15

1

1

High-throughput

0.445

High

401914

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

1018805

SF01
Splicing factor 1

1

1

High-throughput

0.445

High

1018882

DDX41
Probable ATP-dependent RNA helicase DDX41

1

1

High-throughput

0.445

High

148741

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.437

High

444883

ANXA5
Annexin A5

1

1

High-throughput

0.437

High

1018871

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1018809

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

1018810

ODFP2
Outer dense fiber protein 2

1

0

High-throughput

0.426

High

1018816

ZN793
Zinc finger protein 793

1

0

High-throughput

0.426

High

1018836

POC5
Centrosomal protein POC5

1

0

High-throughput

0.426

High

968570

TAGL
Transgelin

1

1

High-throughput

0.407

High

1018854

CEP63
Centrosomal protein of 63 kDa

1

1

High-throughput

0.407

High

1018857

CK5P2
CDK5 regulatory subunit-associated protein 2

1

1

High-throughput

0.407

High

1018799

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

3

0

High-throughput

0.347

High

323718

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

363112

FINC
Fibronectin

1

0

High-throughput

0.279

Low

515848

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.279

Low

537637

NCF1
Neutrophil cytosol factor 1

1

0

High-throughput

0.279

Low

1018790

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.279

Low

1018818

NKAP1
Uncharacterized protein NKAPD1

1

0

High-throughput

0.279

Low

1018835

GPT11
G patch domain-containing protein 11

1

0

High-throughput

0.279

Low

1018876

HPBP1
Hsp70-binding protein 1

1

0

High-throughput

0.279

Low

277788

RGS9
Regulator of G-protein signaling 9

1

0

High-throughput

0.269

Low

1018840

JPH3
Junctophilin-3

1

0

High-throughput

0.268

Low

825689

MTR1B
Melatonin receptor type 1B

1

0

High-throughput

0.265

Low

855790

VAV2
Guanine nucleotide exchange factor VAV2

1

0

High-throughput

0.265

Low

394622

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

62923

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.249

Low

255730

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

384738

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

822461

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.249

Low

870781

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.249

Low

932126

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.249

Low

1018793

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

1018830

SKA3
Spindle and kinetochore-associated protein 3

1

0

Small-scale

0.249

Low

1018834

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1018864

ERP44
Endoplasmic reticulum resident protein 44

1

0

High-throughput

0.249

Low

1018789

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024