Protein: CD4
T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)

Gene: CD4
Organism: Homo sapiens
Interactions: 97
UniProt ID: P01730

Gene Ontology (top 5):
GO:0001618 - virus receptor activity
GO:0001934 - positive regulation of protein phosphorylation
GO:0002250 - adaptive immune response
GO:0004888 - transmembrane signaling receptor activity
GO:0005201 - extracellular matrix structural constituent

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

353225

CD4
T-cell surface glycoprotein CD4

2

0

Small-scale

0.749

High

353234

LCK
Tyrosine-protein kinase Lck

8

1

Small-scale

0.744

High

353283

CXCR4
C-X-C chemokine receptor type 4

3

3

Small-scale

0.656

High

353300

VPP1
V-type proton ATPase 116 kDa subunit a 1

2

1

High-throughput

0.628

High

353314

VPP2
V-type proton ATPase 116 kDa subunit a 2

2

1

High-throughput

0.628

High

353245

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

0

Small-scale

0.614

High

353295

VAMP3
Vesicle-associated membrane protein 3

2

0

High-throughput

0.602

High

353298

K319L
Dyslexia-associated protein KIAA0319-like protein

2

0

High-throughput

0.602

High

353305

ARV1
Protein ARV1

2

0

High-throughput

0.602

High

353306

CD320
CD320 antigen

2

0

High-throughput

0.602

High

353278

CCR5
C-C chemokine receptor type 5

2

3

Small-scale

0.588

High

353291

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

1

1

Small-scale

0.561

High

353290

U119A
Protein unc-119 homolog A

1

0

Small-scale

0.537

High

353239

ADRB2
Beta-2 adrenergic receptor

1

0

Small-scale

0.529

High

176335

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

0

High-throughput

0.518

High

353242

MDR1
ATP-dependent translocase ABCB1

1

0

High-throughput

0.518

High

353254

TMM11
Transmembrane protein 11, mitochondrial

1

0

High-throughput

0.513

High

353266

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.513

High

175413

SIVA
Apoptosis regulatory protein Siva

1

0

Small-scale

0.504

High

353265

AA2AR
Adenosine receptor A2a

1

1

Small-scale

0.501

High

353227

GCR
Glucocorticoid receptor

1

0

Small-scale

0.493

High

353248

LEG1
Galectin-1

1

0

Small-scale

0.493

High

353284

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

High-throughput

0.493

High

353286

PCDH1
Protocadherin-1

1

0

High-throughput

0.493

High

353253

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.493

High

353313

SHLB1
Endophilin-B1

1

0

High-throughput

0.493

High

353296

MK14
Mitogen-activated protein kinase 14

1

0

Small-scale

0.480

High

133818

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

Small-scale

0.479

High

353226

ANXA1
Annexin A1

1

2

Small-scale

0.479

High

353237

ANXA2
Annexin A2

1

2

Small-scale

0.479

High

353240

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.479

High

353241

ANXA6
Annexin A6

1

2

Small-scale

0.479

High

353243

HS90B
Heat shock protein HSP 90-beta

1

1

Small-scale

0.479

High

353246

VIME
Vimentin

1

1

Small-scale

0.479

High

353255

DDX5
Probable ATP-dependent RNA helicase DDX5

1

1

Small-scale

0.479

High

353259

VDAC1
Voltage-dependent anion-selective channel protein 1

1

2

Small-scale

0.479

High

353264

CD82
CD82 antigen

1

1

Small-scale

0.479

High

353273

ZAP70
Tyrosine-protein kinase ZAP-70

1

3

Small-scale

0.479

High

353274

KSYK
Tyrosine-protein kinase SYK

1

3

Small-scale

0.479

High

353275

VDAC2
Voltage-dependent anion-selective channel protein 2

1

2

Small-scale

0.479

High

353282

CD81
CD81 antigen

1

1

Small-scale

0.479

High

353292

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

2

Small-scale

0.479

High

353294

IMB1
Importin subunit beta-1

1

1

Small-scale

0.479

High

159832

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

0

Small-scale

0.458

High

353228

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

Small-scale

0.458

High

353229

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

0

Small-scale

0.458

High

353235

ENOA
Alpha-enolase

1

0

Small-scale

0.458

High

353236

NPM
Nucleophosmin

1

0

Small-scale

0.458

High

353238

TBB5
Tubulin beta chain

1

0

Small-scale

0.458

High

353244

NEP
Neprilysin

1

0

Small-scale

0.458

High

353247

RSSA
Small ribosomal subunit protein uS2

1

0

Small-scale

0.458

High

353250

CH60
60 kDa heat shock protein, mitochondrial

1

0

Small-scale

0.458

High

353251

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.458

High

353258

NUCL
Nucleolin

1

0

Small-scale

0.458

High

353263

ATPA
ATP synthase subunit alpha, mitochondrial

1

0

Small-scale

0.458

High

353268

PHB1
Prohibitin 1

1

0

Small-scale

0.458

High

353270

RS19
Small ribosomal subunit protein eS19

1

0

Small-scale

0.458

High

353271

EPS15
Epidermal growth factor receptor substrate 15

1

0

Small-scale

0.458

High

353280

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

353302

RANB9
Ran-binding protein 9

1

0

Small-scale

0.458

High

353311

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

Small-scale

0.458

High

353249

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

2

Small-scale

0.437

High

353260

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

2

Small-scale

0.437

High

353267

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

1

Small-scale

0.437

High

353293

IF4A2
Eukaryotic initiation factor 4A-II

1

2

Small-scale

0.437

High

353299

TNPO1
Transportin-1

1

1

Small-scale

0.437

High

353312

VDAC3
Voltage-dependent anion-selective channel protein 3

1

2

Small-scale

0.437

High

63719

CC85C
Coiled-coil domain-containing protein 85C

2

0

High-throughput

0.328

High

353297

POGZ
Pogo transposable element with ZNF domain

2

0

High-throughput

0.328

High

353301

SAAL1
Protein SAAL1

2

0

High-throughput

0.328

High

353310

EI2BD
Translation initiation factor eIF2B subunit delta

2

0

High-throughput

0.328

High

353309

SPG21
Maspardin

1

0

Small-scale

0.288

High

353303

UBL7
Ubiquitin-like protein 7

1

0

High-throughput

0.282

High

353307

EI2BG
Translation initiation factor eIF2B subunit gamma

1

0

High-throughput

0.279

Low

353232

K1C18
Keratin, type I cytoskeletal 18

1

0

High-throughput

0.269

Low

353233

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.269

Low

353252

PIP
Prolactin-inducible protein

1

0

Small-scale

0.261

Low

176695

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

Small-scale

0.249

Low

353230

RLA1
Large ribosomal subunit protein P1

1

0

Small-scale

0.249

Low

353231

RLA0
Large ribosomal subunit protein uL10

1

0

Small-scale

0.249

Low

353256

RL7
Large ribosomal subunit protein uL30

1

0

Small-scale

0.249

Low

353257

ML12A
Myosin regulatory light chain 12A

1

0

Small-scale

0.249

Low

353261

EF1B
Elongation factor 1-beta

1

0

Small-scale

0.249

Low

353262

RS12
Small ribosomal subunit protein eS12

1

0

Small-scale

0.249

Low

353269

RL22
Large ribosomal subunit protein eL22

1

0

Small-scale

0.249

Low

353272

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

Small-scale

0.249

Low

353276

RS9
Small ribosomal subunit protein uS4

1

0

Small-scale

0.249

Low

353277

RS10
Small ribosomal subunit protein eS10

1

0

Small-scale

0.249

Low

353279

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.249

Low

353281

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

Small-scale

0.249

Low

353285

RL18
Large ribosomal subunit protein eL18

1

0

Small-scale

0.249

Low

353287

SSRP1
FACT complex subunit SSRP1

1

0

Small-scale

0.249

Low

353288

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

0

Small-scale

0.249

Low

353289

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

0

Small-scale

0.249

Low

353304

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

Small-scale

0.249

Low

353308

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024