Protein: P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1)

Gene: P4R3A, PPP4R3A
Organism: Homo sapiens
Interactions: 114
UniProt ID: Q6IN85

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0006974 - DNA damage response
GO:0016607 - nuclear speck

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

890978

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

11

5

Small-scale

0.761

High

1153060

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

6

2

Small-scale

0.743

High

1081071

CCDC6
Coiled-coil domain-containing protein 6

3

2

High-throughput

0.667

High

246579

MCE1
mRNA-capping enzyme

3

1

High-throughput

0.656

High

1129234

P4R3B
Serine/threonine-protein phosphatase 4 regulatory subunit 3B

3

0

High-throughput

0.638

High

1153048

ALKB3
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

3

0

High-throughput

0.638

High

1069890

PTPA
Serine/threonine-protein phosphatase 2A activator

2

1

High-throughput

0.628

High

1153040

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

2

1

High-throughput

0.628

High

264935

MPPB
Mitochondrial-processing peptidase subunit beta

3

1

High-throughput

0.609

High

1058226

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

2

0

High-throughput

0.602

High

1153037

RHPN1
Rhophilin-1

2

0

High-throughput

0.602

High

1153039

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.602

High

1153070

PPME1
Protein phosphatase methylesterase 1

2

0

High-throughput

0.602

High

66670

ZN785
Zinc finger protein 785

2

1

High-throughput

0.574

High

1153030

TAFA3
Chemokine-like protein TAFA-3

2

1

High-throughput

0.574

High

1153049

CRML
Protein cramped-like

2

1

High-throughput

0.574

High

182796

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.561

High

123980

SPT5H
Transcription elongation factor SPT5

1

2

High-throughput

0.536

High

796593

KSYK
Tyrosine-protein kinase SYK

1

1

High-throughput

0.536

High

1073586

SF3B4
Splicing factor 3B subunit 4

1

1

High-throughput

0.536

High

1153042

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

2

High-throughput

0.536

High

1153064

EHD2
EH domain-containing protein 2

1

1

High-throughput

0.536

High

1153067

SF3B6
Splicing factor 3B subunit 6

1

1

High-throughput

0.536

High

831418

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.527

High

159226

CSKP
Peripheral plasma membrane protein CASK

1

0

High-throughput

0.518

High

1082573

MK14
Mitogen-activated protein kinase 14

1

0

High-throughput

0.518

High

559138

H15
Histone H1.5

1

2

High-throughput

0.515

High

971217

H11
Histone H1.1

1

2

High-throughput

0.515

High

196116

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.513

High

236943

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

0

High-throughput

0.513

High

268758

SF3B1
Splicing factor 3B subunit 1

1

0

High-throughput

0.513

High

278825

DNJC8
DnaJ homolog subfamily C member 8

1

0

High-throughput

0.513

High

304629

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.513

High

441313

RU2B
U2 small nuclear ribonucleoprotein B''

1

0

High-throughput

0.513

High

453844

RU2A
U2 small nuclear ribonucleoprotein A'

1

0

High-throughput

0.513

High

539010

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

603061

OSBP1
Oxysterol-binding protein 1

1

0

High-throughput

0.513

High

911870

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.513

High

912486

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.513

High

971478

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.513

High

1034311

SF3B2
Splicing factor 3B subunit 2

1

0

High-throughput

0.513

High

1073021

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.513

High

1076164

MED1
Mediator of RNA polymerase II transcription subunit 1

1

0

High-throughput

0.513

High

1153038

CATIN
Splicing factor Cactin

1

0

High-throughput

0.513

High

1153044

LRCH3
DISP complex protein LRCH3

1

0

High-throughput

0.513

High

1153051

SF3B5
Splicing factor 3B subunit 5

1

0

High-throughput

0.513

High

1153052

NADAP
Kanadaptin

1

0

High-throughput

0.513

High

1153054

DOCK5
Dedicator of cytokinesis protein 5

1

0

High-throughput

0.513

High

1153056

SYF1
Pre-mRNA-splicing factor SYF1

1

0

High-throughput

0.513

High

1153063

ITSN2
Intersectin-2

1

0

High-throughput

0.513

High

1153065

NSF1C
NSFL1 cofactor p47

1

0

High-throughput

0.513

High

1153066

GUAD
Guanine deaminase

1

0

High-throughput

0.513

High

414961

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.501

High

1086183

H31T
Histone H3.1t

1

0

High-throughput

0.493

High

833752

CLK1
Dual specificity protein kinase CLK1

1

1

High-throughput

0.489

High

1132351

F120S
Uncharacterized protein FAM120AOS

1

1

High-throughput

0.489

High

1153034

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

1

High-throughput

0.489

High

1153062

PA2GE
Group IIE secretory phospholipase A2

1

1

High-throughput

0.489

High

1130198

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.480

High

244569

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

552955

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

708465

MCM4
DNA replication licensing factor MCM4

1

1

High-throughput

0.479

High

826293

CDK8
Cyclin-dependent kinase 8

1

2

High-throughput

0.479

High

832524

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

1026443

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

1153035

SIR6
NAD-dependent protein deacylase sirtuin-6

1

2

High-throughput

0.479

High

1153055

COG4
Conserved oligomeric Golgi complex subunit 4

1

1

High-throughput

0.479

High

559765

H12
Histone H1.2

1

2

High-throughput

0.470

High

1068210

PEA15
Astrocytic phosphoprotein PEA-15

1

0

Small-scale

0.460

High

229687

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

0

High-throughput

0.458

High

255863

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

523818

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

651457

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

673413

MPIP1
M-phase inducer phosphatase 1

1

0

High-throughput

0.458

High

684818

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

720701

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

742352

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

896126

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

1038466

HDAC1
Histone deacetylase 1

1

0

Small-scale

0.458

High

1041804

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1153031

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

1153032

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1153045

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

1153050

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1153061

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1153069

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

High-throughput

0.458

High

517309

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.438

High

385005

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

1153028

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1153046

UBX10
UBX domain-containing protein 10

1

1

High-throughput

0.437

High

1153053

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

374394

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.426

High

111276

J3KNI1
Conserved oligomeric Golgi complex subunit 4

1

1

High-throughput

0.407

High

483696

CT456
Cancer/testis antigen family 45 member A6

1

1

High-throughput

0.407

High

577463

PACA
Pituitary adenylate cyclase-activating polypeptide

2

0

High-throughput

0.328

High

823262

MRP
MARCKS-related protein

2

0

High-throughput

0.328

High

1153043

CC120
Coiled-coil domain-containing protein 120

2

0

High-throughput

0.328

High

1153071

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

2

0

High-throughput

0.318

High

577030

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

0

High-throughput

0.279

Low

794397

GRK6
G protein-coupled receptor kinase 6

1

0

High-throughput

0.279

Low

1121918

COBL1
Cordon-bleu protein-like 1

1

0

High-throughput

0.279

Low

1131700

DACT2
Dapper homolog 2

1

0

High-throughput

0.279

Low

1131948

TMM69
Transmembrane protein 69

1

0

High-throughput

0.279

Low

1153027

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.279

Low

1153033

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

1

0

High-throughput

0.279

Low

1153036

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

1153047

SIG12
Sialic acid-binding Ig-like lectin 12

1

0

High-throughput

0.279

Low

1153057

NECT3
Nectin-3

1

0

High-throughput

0.279

Low

1153058

FBX28
F-box only protein 28

1

0

High-throughput

0.279

Low

1153059

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.279

Low

1153068

SKAP
Small kinetochore-associated protein

1

0

High-throughput

0.279

Low

1153072

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.279

Low

1153029

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1153041

NELL1
Protein kinase C-binding protein NELL1

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024