Protein: SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)

Gene: SHIP2, INPPL1
Organism: Homo sapiens
Interactions: 195
UniProt ID: O15357

Gene Ontology (top 5):
GO:0000132 - establishment of mitotic spindle orientation
GO:0000922 - spindle pole
GO:0001958 - endochondral ossification
GO:0002376 - immune system process
GO:0003779 - actin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

176390

SHC1
SHC-transforming protein 1

4

20

Small-scale

0.886

High

176333

EGFR
Epidermal growth factor receptor

4

10

Small-scale

0.873

High

176424

GRB2
Growth factor receptor-bound protein 2

2

20

High-throughput

0.820

High

176413

STAT2
Signal transducer and activator of transcription 2

2

1

High-throughput

0.811

High

176504

SMAG1
Protein Smaug homolog 1

2

1

High-throughput

0.811

High

176353

MET
Hepatocyte growth factor receptor

2

9

Small-scale

0.789

High

176453

SMAG2
Protein Smaug homolog 2

2

1

High-throughput

0.789

High

176419

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

12

Small-scale

0.761

High

176494

SRBS1
Sorbin and SH3 domain-containing protein 1

1

20

Small-scale

0.756

High

176332

ABL1
Tyrosine-protein kinase ABL1

2

17

Small-scale

0.754

High

176477

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

8

Small-scale

0.740

High

176322

M3K13
Mitogen-activated protein kinase kinase kinase 13

2

9

High-throughput

0.726

High

176389

EPHA2
Ephrin type-A receptor 2

1

8

Small-scale

0.692

High

129144

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.691

High

176388

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

8

High-throughput

0.691

High

176391

MK04
Mitogen-activated protein kinase 4

1

4

High-throughput

0.691

High

176402

STAT6
Signal transducer and activator of transcription 6

1

1

High-throughput

0.691

High

176404

CRK
Adapter molecule crk

1

20

High-throughput

0.691

High

176432

CDK16
Cyclin-dependent kinase 16

1

1

High-throughput

0.691

High

176472

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

2

High-throughput

0.691

High

176383

CBL
E3 ubiquitin-protein ligase CBL

4

3

Small-scale

0.686

High

176448

ITSN1
Intersectin-1

1

15

Small-scale

0.683

High

176345

INSR
Insulin receptor

2

10

Small-scale

0.675

High

176386

EF1G
Elongation factor 1-gamma

3

2

High-throughput

0.667

High

176392

RIR2
Ribonucleoside-diphosphate reductase subunit M2

3

1

High-throughput

0.667

High

176434

PLIN5
Perilipin-5

3

1

High-throughput

0.667

High

176462

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

3

1

High-throughput

0.667

High

176488

ALKB3
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

3

1

High-throughput

0.667

High

176480

ARAP2
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

2

5

High-throughput

0.659

High

176455

KAZRN
Kazrin

1

0

High-throughput

0.656

High

176326

VINEX
Vinexin

1

20

Small-scale

0.653

High

176340

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

10

High-throughput

0.647

High

176382

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

12

High-throughput

0.647

High

176447

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

11

High-throughput

0.647

High

176473

ABI1
Abl interactor 1

1

17

Small-scale

0.647

High

176450

DDR2
Discoidin domain-containing receptor 2

1

20

High-throughput

0.646

High

176395

PPM1A
Protein phosphatase 1A

3

0

High-throughput

0.638

High

176414

TF2AA
Transcription initiation factor IIA subunit 1

3

0

High-throughput

0.638

High

176496

BHMT2
S-methylmethionine--homocysteine S-methyltransferase BHMT2

3

0

High-throughput

0.638

High

176403

EAA3
Excitatory amino acid transporter 3

2

1

High-throughput

0.628

High

176475

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

2

2

High-throughput

0.628

High

69199

A9UF07
non-specific protein-tyrosine kinase

1

19

High-throughput

0.625

High

145960

SH2B2
SH2B adapter protein 2

1

20

Small-scale

0.618

High

176341

NTRK1
High affinity nerve growth factor receptor

1

14

High-throughput

0.618

High

176351

LYN
Tyrosine-protein kinase Lyn

1

17

High-throughput

0.618

High

176363

BCR
Breakpoint cluster region protein

1

6

High-throughput

0.618

High

176409

GSK3A
Glycogen synthase kinase-3 alpha

1

2

High-throughput

0.618

High

176410

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.618

High

176452

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

3

High-throughput

0.618

High

176460

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.618

High

176483

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

2

High-throughput

0.618

High

176497

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

2

Small-scale

0.618

High

176509

CD2AP
CD2-associated protein

1

20

Small-scale

0.618

High

176349

PROF1
Profilin-1

2

3

High-throughput

0.611

High

176479

ACO12
Acetyl-coenzyme A thioesterase

2

0

High-throughput

0.602

High

176490

DPYL5
Dihydropyrimidinase-related protein 5

2

0

High-throughput

0.602

High

176422

RHOB
Rho-related GTP-binding protein RhoB

2

7

High-throughput

0.584

High

176485

SH3K1
SH3 domain-containing kinase-binding protein 1

2

20

Small-scale

0.584

High

176381

EPHA1
Ephrin type-A receptor 1

1

3

Small-scale

0.579

High

176492

LRC61
Leucine-rich repeat-containing protein 61

1

0

High-throughput

0.578

High

176438

DDR1
Epithelial discoidin domain-containing receptor 1

1

19

Small-scale

0.575

High

176464

MILR1
Allergin-1

2

6

High-throughput

0.574

High

176379

VCAM1
Vascular cell adhesion protein 1

2

2

High-throughput

0.571

High

176468

HID1
Protein HID1

1

0

Small-scale

0.558

High

176469

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

1

1

High-throughput

0.553

High

176446

FLNC
Filamin-C

1

5

Small-scale

0.552

High

176444

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

0

High-throughput

0.546

High

176360

ANDR
Androgen receptor

1

2

High-throughput

0.536

High

176441

GAB1
GRB2-associated-binding protein 1

1

4

High-throughput

0.536

High

176324

ACTN4
Alpha-actinin-4

1

2

High-throughput

0.536

High

176325

AK1BA
Aldo-keto reductase family 1 member B10

1

3

High-throughput

0.536

High

176337

ANXA1
Annexin A1

1

2

High-throughput

0.536

High

176343

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.536

High

176347

ENOA
Alpha-enolase

1

1

High-throughput

0.536

High

176367

ACTN1
Alpha-actinin-1

1

2

High-throughput

0.536

High

176372

ALDR
Aldo-keto reductase family 1 member B1

1

3

High-throughput

0.536

High

176377

ARF4
ADP-ribosylation factor 4

1

5

High-throughput

0.536

High

176378

VINC
Vinculin

1

1

High-throughput

0.536

High

176415

AK1C2
Aldo-keto reductase family 1 member C2

1

3

High-throughput

0.536

High

176423

RAN
GTP-binding nuclear protein Ran

1

13

High-throughput

0.536

High

176426

TYB10
Thymosin beta-10

1

1

High-throughput

0.536

High

176437

PSME1
Proteasome activator complex subunit 1

1

1

High-throughput

0.536

High

176439

AHNK
Neuroblast differentiation-associated protein AHNAK

1

2

High-throughput

0.536

High

176463

MYH14
Myosin-14

1

2

High-throughput

0.536

High

176476

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

High-throughput

0.536

High

176500

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.536

High

176501

NECP2
Adaptin ear-binding coat-associated protein 2

1

2

High-throughput

0.536

High

176335

CD4
T-cell surface glycoprotein CD4

1

0

High-throughput

0.518

High

176327

UGDH
UDP-glucose 6-dehydrogenase

1

0

High-throughput

0.513

High

176329

BAF
Barrier-to-autointegration factor

1

0

High-throughput

0.513

High

176330

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.513

High

176331

AL1A1
Aldehyde dehydrogenase 1A1

1

0

High-throughput

0.513

High

176334

PGK1
Phosphoglycerate kinase 1

1

0

High-throughput

0.513

High

176346

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

High-throughput

0.513

High

176350

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

0

High-throughput

0.513

High

176355

GSTP1
Glutathione S-transferase P

1

0

High-throughput

0.513

High

176366

RLBP1
Retinaldehyde-binding protein 1

1

0

High-throughput

0.513

High

176373

NQO1
NAD(P)H dehydrogenase [quinone] 1

1

0

High-throughput

0.513

High

176384

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.513

High

176397

TALDO
Transaldolase

1

0

High-throughput

0.513

High

176400

MDHC
Malate dehydrogenase, cytoplasmic

1

0

High-throughput

0.513

High

176401

NAA10
N-alpha-acetyltransferase 10

1

0

High-throughput

0.513

High

176416

ACLY
ATP-citrate synthase

1

0

High-throughput

0.513

High

176417

SUMO3
Small ubiquitin-related modifier 3

1

0

High-throughput

0.513

High

176421

TYB4
Thymosin beta-4

1

0

High-throughput

0.513

High

176431

BASP1
Brain acid soluble protein 1

1

0

High-throughput

0.513

High

176458

DCNL2
DCN1-like protein 2

1

0

High-throughput

0.513

High

176459

SCIMP
SLP adapter and CSK-interacting membrane protein

1

0

High-throughput

0.513

High

176465

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

0

High-throughput

0.513

High

176467

TCAM1
TIR domain-containing adapter molecule 1

1

0

High-throughput

0.513

High

176471

CMIP
C-Maf-inducing protein

1

0

High-throughput

0.513

High

176482

THRSP
Thyroid hormone-inducible hepatic protein

1

0

High-throughput

0.513

High

176498

CA198
Uncharacterized protein C1orf198

1

0

High-throughput

0.513

High

176506

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.513

High

176502

PLEK2
Pleckstrin-2

1

4

Small-scale

0.512

High

176358

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

Small-scale

0.501

High

176418

NDK5
Nucleoside diphosphate kinase homolog 5

1

1

High-throughput

0.489

High

133771

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

High-throughput

0.479

High

162211

XPO1
Exportin-1

1

4

High-throughput

0.479

High

176328

PEX14
Peroxisomal membrane protein PEX14

1

1

High-throughput

0.479

High

176336

K1C14
Keratin, type I cytoskeletal 14

1

11

High-throughput

0.479

High

176338

K2C6B
Keratin, type II cytoskeletal 6B

1

8

High-throughput

0.479

High

176339

K2C1
Keratin, type II cytoskeletal 1

1

7

High-throughput

0.479

High

176342

ADT2
ADP/ATP translocase 2

1

1

High-throughput

0.479

High

176348

TBB5
Tubulin beta chain

1

4

High-throughput

0.479

High

176352

HS90B
Heat shock protein HSP 90-beta

1

4

High-throughput

0.479

High

176354

K1C16
Keratin, type I cytoskeletal 16

1

11

High-throughput

0.479

High

176361

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.479

High

176362

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

176364

K2C3
Keratin, type II cytoskeletal 3

1

8

High-throughput

0.479

High

176365

ADT3
ADP/ATP translocase 3

1

1

High-throughput

0.479

High

176368

CADH1
Cadherin-1

1

2

High-throughput

0.479

High

176370

K1C10
Keratin, type I cytoskeletal 10

1

12

High-throughput

0.479

High

176371

K2C5
Keratin, type II cytoskeletal 5

1

7

High-throughput

0.479

High

176375

HSP76
Heat shock 70 kDa protein 6

1

2

High-throughput

0.479

High

176376

DDX5
Probable ATP-dependent RNA helicase DDX5

1

1

High-throughput

0.479

High

176385

DDX6
Probable ATP-dependent RNA helicase DDX6

1

3

High-throughput

0.479

High

176387

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

176393

HS71L
Heat shock 70 kDa protein 1-like

1

2

High-throughput

0.479

High

176394

K1C9
Keratin, type I cytoskeletal 9

1

12

High-throughput

0.479

High

176396

K22E
Keratin, type II cytoskeletal 2 epidermal

1

8

High-throughput

0.479

High

176398

GRP75
Stress-70 protein, mitochondrial

1

5

High-throughput

0.479

High

176405

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

5

High-throughput

0.479

High

176407

K2C6C
Keratin, type II cytoskeletal 6C

1

7

High-throughput

0.479

High

176411

VASP
Vasodilator-stimulated phosphoprotein

1

3

High-throughput

0.479

High

176425

RAC1
Ras-related C3 botulinum toxin substrate 1

1

5

High-throughput

0.479

High

176429

TBB4B
Tubulin beta-4B chain

1

4

High-throughput

0.479

High

176435

K1C17
Keratin, type I cytoskeletal 17

1

11

High-throughput

0.479

High

176436

1433F
14-3-3 protein eta

1

17

High-throughput

0.479

High

176440

ACACA
Acetyl-CoA carboxylase 1

1

1

High-throughput

0.479

High

176443

TBB3
Tubulin beta-3 chain

1

4

High-throughput

0.479

High

176449

CCDC6
Coiled-coil domain-containing protein 6

1

9

High-throughput

0.479

High

176454

K2C79
Keratin, type II cytoskeletal 79

1

7

High-throughput

0.479

High

176456

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

176466

K2C73
Keratin, type II cytoskeletal 73

1

6

High-throughput

0.479

High

176481

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

176491

TBB6
Tubulin beta-6 chain

1

4

High-throughput

0.479

High

176493

TBB2B
Tubulin beta-2B chain

1

4

High-throughput

0.479

High

176510

MTCH2
Mitochondrial carrier homolog 2

1

2

High-throughput

0.479

High

176344

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.458

High

176374

H12
Histone H1.2

1

0

High-throughput

0.458

High

176399

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.458

High

176408

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.458

High

176427

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.458

High

176430

GTF2I
General transcription factor II-I

1

0

High-throughput

0.458

High

176433

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.458

High

176442

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

176445

CUL4A
Cullin-4A

1

0

Small-scale

0.458

High

176503

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

176505

ZN148
Zinc finger protein 148

1

0

High-throughput

0.458

High

100274

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

176428

TBA1B
Tubulin alpha-1B chain

1

2

High-throughput

0.437

High

176484

VP33A
Vacuolar protein sorting-associated protein 33A

1

2

High-throughput

0.437

High

176359

RPC22
Protein POLR1D, isoform 2

1

0

High-throughput

0.426

High

176356

MYZAP
Myocardial zonula adherens protein

1

2

High-throughput

0.407

High

176495

CD244
Natural killer cell receptor 2B4

1

6

Small-scale

0.407

High

176489

PCY2
Ethanolamine-phosphate cytidylyltransferase

3

0

High-throughput

0.345

High

176457

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

3

0

High-throughput

0.334

High

176323

TPD54
Tumor protein D54

2

0

High-throughput

0.328

High

176470

S22A9
Organic anion transporter 7

2

0

High-throughput

0.328

High

176499

CIAO3
Cytosolic iron-sulfur assembly component 3

2

0

High-throughput

0.328

High

176508

T184B
Transmembrane protein 184B

2

0

High-throughput

0.328

High

176420

VA0D1
V-type proton ATPase subunit d 1

2

0

High-throughput

0.318

High

176406

GLR
Glucagon receptor

1

0

High-throughput

0.279

Low

176451

INSY1
Inhibitory synaptic factor 1

1

0

High-throughput

0.279

Low

176461

BOP
Protein Bop

1

0

High-throughput

0.279

Low

176474

SYCE1
Synaptonemal complex central element protein 1

1

0

High-throughput

0.279

Low

176478

IL1FA
Interleukin-1 family member 10

1

0

High-throughput

0.279

Low

176487

DYDC2
DPY30 domain-containing protein 2

1

0

High-throughput

0.279

Low

176507

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

0

High-throughput

0.279

Low

176380

EFNA1
Ephrin-A1

1

0

Small-scale

0.261

Low

176369

ITA4
Integrin alpha-4

1

0

High-throughput

0.249

Low

176412

XK
Endoplasmic reticulum membrane adapter protein XK

1

0

High-throughput

0.249

Low

176486

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.249

Low

176357

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024