Protein: SPE
Spaetzle-processing enzyme (EC 3.4.21.-) (Spatzle-processing enzyme) [Cleaved into: Spaetzle-processing enzyme light chain; Spaetzle-processing enzyme heavy chain]

Gene: SPE
Organism: Drosophila melanogaster
Interactions: 28
UniProt ID: Q9VCJ8

Gene Ontology (top 5):
GO:0002225 - positive regulation of antimicrobial peptide production
GO:0002804 - positive regulation of antifungal peptide production
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1374348

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

2

1

High-throughput

0.571

High

1470482

Q9W0N8
Retinoid-inducible serine carboxypeptidase

2

1

High-throughput

0.571

High

661963

PP2A
Serine/threonine-protein phosphatase PP2A

2

0

High-throughput

0.547

High

1470476

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

2

0

High-throughput

0.547

High

384929

HSP26
Heat shock protein 26

2

2

High-throughput

0.521

High

1266616

Q7K4Q9
Hydroxymethylglutaryl-CoA synthase

2

1

High-throughput

0.521

High

1470485

NWK
Protein nervous wreck

1

0

High-throughput

0.481

High

85811

B8A405
Ferritin

1

2

High-throughput

0.479

High

119906

M9PBM3
Cysteine protease

1

1

High-throughput

0.437

High

1266028

Q7K3N4
GH26015p

1

8

High-throughput

0.437

High

1305985

Q8IR76
FAD synthase

1

2

High-throughput

0.437

High

1345212

Q8T0K1
F-box involved in polyQ pathogenesis, isoform B

1

1

High-throughput

0.437

High

1470477

Q9VD58
Isocitric dehydrogenase subunit beta

1

2

High-throughput

0.437

High

384837

HSP23
Heat shock protein 23

1

2

High-throughput

0.407

High

1302802

Q8IGU5
RE28319p

1

1

High-throughput

0.407

High

1470480

Q9VPW2
Cysteine protease

1

1

High-throughput

0.407

High

1470481

Q9VYI5
FAD synthase

1

2

High-throughput

0.407

High

705022

EXU
Maternal protein exuperantia

2

0

High-throughput

0.298

High

1261260

Q7JPS2
Igloo, isoform A

2

0

High-throughput

0.298

High

1266003

Q7K3M6
GH28654p

2

0

High-throughput

0.298

High

1266640

Q7K4R2
LD26477p

2

0

High-throughput

0.298

High

1465960

C6A13
Probable cytochrome P450 6a13

2

0

High-throughput

0.298

High

1469735

SIL1
Nucleotide exchange factor Sil1

2

0

High-throughput

0.298

High

1470478

Q9VJZ5
LD07294p

2

0

High-throughput

0.298

High

1470483

LST8
Protein LST8 homolog

2

0

High-throughput

0.298

High

1470484

EAF3
NuA4 complex subunit EAF3 homolog

2

0

High-throughput

0.298

High

1176847

CP4E2
Cytochrome P450 4e2

1

0

High-throughput

0.249

Low

1470479

Q9VP78
GH23156p

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025