Protein: PP2A
Serine/threonine-protein phosphatase PP2A (EC 3.1.3.16) (Protein microtubule star)

Gene: PP2A, mts
Organism: Drosophila melanogaster
Interactions: 110
UniProt ID: P23696

Gene Ontology (top 5):
GO:0000159 - protein phosphatase type 2A complex
GO:0000226 - microtubule cytoskeleton organization
GO:0000278 - mitotic cell cycle
GO:0000785 - chromatin
GO:0004722 - protein serine/threonine phosphatase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

661973

Q9VJZ5
LD07294p

6

20

Small-scale

0.931

High

661961

Q9VB23
Serine/threonine protein phosphatase 2A regulatory subunit

2

20

Small-scale

0.754

High

661918

2AAA
Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit

2

20

High-throughput

0.737

High

662002

Q9W5W6
TIP41-like protein

1

5

High-throughput

0.656

High

661952

HIPPO
Serine/threonine-protein kinase hippo

3

20

Small-scale

0.640

High

661919

2ABA
Protein phosphatase PP2A 55 kDa regulatory subunit

3

20

Small-scale

0.633

High

661956

Q95TZ7
GH19182p

1

3

High-throughput

0.621

High

355885

O96689
FI11703p

2

3

Small-scale

0.620

High

356502

O97111
LD29223p

1

7

Small-scale

0.618

High

661927

Q0KHR3
Bazooka, isoform B

1

11

Small-scale

0.618

High

661969

Q9VEC6
LD29902p

1

20

Small-scale

0.618

High

661971

Q9VEV3
Tetratricopeptide repeat protein 1

1

4

High-throughput

0.618

High

661930

SGO1
Shugoshin

3

0

Small-scale

0.613

High

56114

APKC
Atypical protein kinase C

2

16

Small-scale

0.584

High

662004

EAF3
NuA4 complex subunit EAF3 homolog

2

0

High-throughput

0.575

High

661921

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

High-throughput

0.560

High

661955

CYCG
Cyclin G

1

9

Small-scale

0.552

High

661940

Q7K4R2
LD26477p

2

0

High-throughput

0.547

High

661963

SPE
Spaetzle-processing enzyme

2

0

High-throughput

0.547

High

661967

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

2

0

High-throughput

0.547

High

661939

Q7K4Q9
Hydroxymethylglutaryl-CoA synthase

2

1

High-throughput

0.521

High

55192

A1Z992
1,4-alpha-glucan branching enzyme

1

1

High-throughput

0.508

High

661925

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.508

High

661934

Q59E05
Transcription factor Ouib

1

4

High-throughput

0.508

High

661954

Q95RB1
Pre-mRNA-splicing factor RBM22

1

5

High-throughput

0.508

High

661996

SAHH2
Adenosylhomocysteinase-like 1

1

1

High-throughput

0.508

High

661999

Q9W1U7
FI01017p

1

2

High-throughput

0.508

High

662001

Q9W414
Regulatory particle triple-A ATPase 4

1

2

High-throughput

0.508

High

661916

CAND
Calpain-D

1

0

High-throughput

0.486

High

661929

DTX
Protein deltex

1

0

High-throughput

0.486

High

661933

GCM
Transcription factor glial cells missing

1

0

High-throughput

0.486

High

661938

NO66
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66

1

0

High-throughput

0.486

High

661949

Q8STA5
Histidine triad nucleotide binding protein 1, isoform A

1

0

High-throughput

0.486

High

661958

Q9V9M6
LD10456p

1

0

High-throughput

0.486

High

661966

Q9VCU8
LD15939p

1

0

High-throughput

0.486

High

661975

Q9VKR2
Replication termination factor 2

1

0

High-throughput

0.486

High

661989

SGF11
SAGA-associated factor 11 homolog

1

0

High-throughput

0.486

High

661993

BAP60
Brahma-associated protein of 60 kDa

1

0

High-throughput

0.486

High

118029

M9MS50
non-specific serine/threonine protein kinase

1

14

High-throughput

0.481

High

119514

M9NHC5
Uncharacterized protein, isoform C

1

2

High-throughput

0.481

High

661924

BRC1
Broad-complex core protein isoforms 1/2/3/4/5

1

7

High-throughput

0.481

High

661928

Q0KHU0
Myosin 10A, isoform D

1

12

High-throughput

0.481

High

661932

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

Small-scale

0.481

High

661941

Q7KS72
C15

1

5

High-throughput

0.481

High

661942

Q7KTJ2
cytidine deaminase

1

1

High-throughput

0.481

High

661959

NUBPL
Iron-sulfur cluster transfer protein Nubpl

1

2

Small-scale

0.481

High

92274

D3DML3
Connector of kinase to AP-1, isoform E

1

12

Small-scale

0.479

High

119894

M9PBM3
Cysteine protease

1

1

High-throughput

0.479

High

263512

MK38B
Mitogen-activated protein kinase p38b

1

10

Small-scale

0.479

High

465788

L2GL

1

3

Small-scale

0.479

High

624280

CI
Transcriptional activator cubitus interruptus

1

9

Small-scale

0.479

High

654196

DDX6
ATP-dependent RNA helicase me31b

1

5

High-throughput

0.479

High

661923

KCC2A
Calcium/calmodulin-dependent protein kinase type II alpha chain

1

8

Small-scale

0.479

High

661926

ARL2
ADP-ribosylation factor-like protein 2

1

3

Small-scale

0.479

High

661937

MOB4
MOB kinase activator-like 4

1

4

Small-scale

0.479

High

661944

AKT1
RAC serine/threonine-protein kinase

1

12

Small-scale

0.479

High

661947

Q8IR76
FAD synthase

1

3

High-throughput

0.479

High

661957

FMR1
Fragile X messenger ribonucleoprotein 1 homolog

1

3

Small-scale

0.479

High

661962

Q9VCD8
Structural maintenance of chromosomes protein

1

2

Small-scale

0.479

High

661964

Q9VCQ7
LD40758p

1

2

Small-scale

0.479

High

661970

Q9VEN3
non-specific serine/threonine protein kinase

1

20

Small-scale

0.479

High

661984

ORB2
Translational regulator orb2

1

8

Small-scale

0.479

High

661998

Q9W1G7
LD21576p

1

3

Small-scale

0.479

High

662000

LST8
Protein LST8 homolog

1

3

High-throughput

0.479

High

145776

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

5

High-throughput

0.464

High

661945

Q8INT9
Uncharacterized protein, isoform A

1

4

High-throughput

0.464

High

661960

Q9VA71
FI19924p1

1

2

High-throughput

0.464

High

661981

Q9VR90
Syntaxin 16

1

4

High-throughput

0.464

High

68889

MBD56
Methyl-CpG-binding domain protein 5/6 homolog sba

1

0

High-throughput

0.458

High

195204

SYFM
Probable phenylalanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

661951

TANT
Protein tantalus

1

0

High-throughput

0.458

High

661972

DALMA
Protein dalmatian

1

0

Small-scale

0.458

High

661974

ZUC
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.458

High

661977

Q9VM62
LD34181p

1

0

Small-scale

0.458

High

119823

HAKAI
E3 ubiquitin-protein ligase Hakai

1

1

High-throughput

0.457

High

661920

PRS4
26S proteasome regulatory subunit 4

1

2

High-throughput

0.457

High

661931

BRC4
Broad-complex core protein isoform 6

1

7

High-throughput

0.457

High

661946

Q8IQB4
Z band alternatively spliced PDZ-motif protein 66, isoform E

1

1

High-throughput

0.457

High

661948

Q8MYW5
RE61749p

1

5

High-throughput

0.457

High

661953

Q8T8Y3
cytidine deaminase

1

1

High-throughput

0.457

High

661968

Q9VD99
Homeodomain-containing protein

1

5

High-throughput

0.457

High

661976

Q9VM49
Caper, isoform A

1

8

High-throughput

0.457

High

661979

Q9VNV0
non-specific serine/threonine protein kinase

1

16

High-throughput

0.457

High

661990

ELL
RNA polymerase II elongation factor Ell

1

9

High-throughput

0.457

High

661991

Q9VWG1
LD37169p

1

2

High-throughput

0.457

High

661995

Q9VZ45
Myosin 10A, isoform C

1

12

High-throughput

0.457

High

661980

Q9VPW2
Cysteine protease

1

1

High-throughput

0.445

High

661985

Q9VSY1
LD09868p

1

1

High-throughput

0.445

High

661992

Q9VXF9
AT13091p

1

2

High-throughput

0.445

High

661994

Q9VYI5
FAD synthase

1

3

High-throughput

0.445

High

662003

FL2D
Pre-mRNA-splicing regulator female-lethal(2)D

1

7

Small-scale

0.445

High

120868

M9PEB0
Uncharacterized protein, isoform D

1

1

High-throughput

0.439

High

120100

M9PCD4
Liprin-alpha, isoform E

1

14

Small-scale

0.437

High

661922

SMO
Protein smoothened

1

8

Small-scale

0.437

High

661917

FAT
Cadherin-related tumor suppressor

1

1

Small-scale

0.417

High

661950

Q8SXX8
RE67729p

1

1

High-throughput

0.417

High

661935

Q7JPS2
Igloo, isoform A

2

0

High-throughput

0.298

High

543364

TERM
Protein terminus

1

0

High-throughput

0.265

Low

583732

AMAL
Protein amalgam

1

0

High-throughput

0.265

Low

661936

Q7JWN2
RE25177p

1

0

High-throughput

0.265

Low

661943

PEN2
Gamma-secretase subunit pen-2

1

0

High-throughput

0.265

Low

661965

Q9VCT6
Uncharacterized protein

1

0

High-throughput

0.265

Low

661978

MBOA7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase frj

1

0

High-throughput

0.265

Low

661983

Q9VRS6
Jonah 65Aiv

1

0

High-throughput

0.265

Low

661987

Q9VVC2
Uncharacterized protein

1

0

High-throughput

0.265

Low

661988

Q9VVQ1
Allatostatin C receptor 1

1

0

High-throughput

0.265

Low

661986

Q9VUK7
RE36140p

1

0

Small-scale

0.249

Low

661982

Q9VRE6
GH12419p1

1

0

High-throughput

0.238

Low

234824

O46070
EG:25E8.4 protein

1

0

High-throughput

0.232

Low

661997

Q9W0N8
Retinoid-inducible serine carboxypeptidase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025