Protein: EMSY
BRCA2-interacting transcriptional repressor EMSY

Gene: EMSY
Organism: Homo sapiens
Interactions: 132
UniProt ID: Q7Z589

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0006281 - DNA repair
GO:0006325 - chromatin organization
GO:0006355 - regulation of DNA-templated transcription
GO:0042802 - identical protein binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

949826

CBX1
Chromobox protein homolog 1

3

7

Small-scale

0.891

High

1038491

HDAC1
Histone deacetylase 1

6

6

High-throughput

0.735

High

1190884

MO4L1
Mortality factor 4-like protein 1

5

4

High-throughput

0.718

High

1190857

GATD1
GATA zinc finger domain-containing protein 1

6

0

High-throughput

0.697

High

257800

SIN3B
Paired amphipathic helix protein Sin3b

4

4

High-throughput

0.694

High

727158

DDIT3
DNA damage-inducible transcript 3 protein

3

1

High-throughput

0.675

High

1083294

RBBP7
Histone-binding protein RBBP7

3

13

High-throughput

0.656

High

1190859

HDAC2
Histone deacetylase 2

3

6

High-throughput

0.656

High

1190864

PHF12
PHD finger protein 12

3

14

High-throughput

0.656

High

1190845

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

12

High-throughput

0.618

High

666540

KDM5A
Lysine-specific demethylase 5A

2

8

High-throughput

0.611

High

1190883

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

2

12

Small-scale

0.611

High

210915

GET3
ATPase GET3

2

1

High-throughput

0.606

High

637466

PSA1
Proteasome subunit alpha type-1

2

5

High-throughput

0.606

High

1152339

CNDH2
Condensin-2 complex subunit H2

2

0

High-throughput

0.602

High

347180

MYC
Myc proto-oncogene protein

2

11

High-throughput

0.584

High

1063007

MO4L2
Mortality factor 4-like protein 2

2

4

High-throughput

0.584

High

1190855

NUP43
Nucleoporin Nup43

2

20

High-throughput

0.584

High

847836

BRCA2
Breast cancer type 2 susceptibility protein

1

1

Small-scale

0.573

High

1071473

ZMY11
Zinc finger MYND domain-containing protein 11

1

13

Small-scale

0.573

High

164311

ZN646
Zinc finger protein 646

1

1

High-throughput

0.573

High

369906

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

855923

ZN131
Zinc finger protein 131

1

4

High-throughput

0.561

High

1190878

DISC1
Disrupted in schizophrenia 1 protein

2

1

High-throughput

0.553

High

1190876

ZN335
Zinc finger protein 335

1

0

Small-scale

0.548

High

470067

H2AZ
Histone H2A.Z

1

13

High-throughput

0.536

High

586831

CSK22
Casein kinase II subunit alpha'

1

8

High-throughput

0.536

High

964208

FOXK2
Forkhead box protein K2

1

9

High-throughput

0.536

High

997782

RBBP4
Histone-binding protein RBBP4

1

11

High-throughput

0.536

High

1050688

FHL2
Four and a half LIM domains protein 2

1

19

High-throughput

0.536

High

1070734

RBBP5
Retinoblastoma-binding protein 5

1

20

Small-scale

0.536

High

1167253

BCOR
BCL-6 corepressor

1

15

Small-scale

0.536

High

1190874

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

2

High-throughput

0.536

High

1190882

FOXJ2
Forkhead box protein J2

1

10

High-throughput

0.536

High

1190887

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

2

High-throughput

0.536

High

928625

DYLT1
Dynein light chain Tctex-type 1

2

1

High-throughput

0.533

High

559154

H15
Histone H1.5

1

8

High-throughput

0.515

High

1190851

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

Small-scale

0.513

High

681920

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

Small-scale

0.501

High

851561

NEK4
Serine/threonine-protein kinase Nek4

1

7

High-throughput

0.489

High

871639

HSP72
Heat shock-related 70 kDa protein 2

1

5

High-throughput

0.489

High

1019324

TRI26
Tripartite motif-containing protein 26

1

3

High-throughput

0.489

High

1101503

KIF7
Kinesin-like protein KIF7

1

2

High-throughput

0.489

High

1190856

FBLI1
Filamin-binding LIM protein 1

1

7

High-throughput

0.489

High

266378

TAD2A
Transcriptional adapter 2-alpha

1

8

High-throughput

0.479

High

308836

KI20A
Kinesin-like protein KIF20A

1

10

High-throughput

0.479

High

316927

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

387004

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

453855

RU2A
U2 small nuclear ribonucleoprotein A'

1

6

High-throughput

0.479

High

486805

MYB
Transcriptional activator Myb

1

4

High-throughput

0.479

High

487553

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

505246

EGR2
E3 SUMO-protein ligase EGR2

1

6

High-throughput

0.479

High

507459

ERG
Transcriptional regulator ERG

1

20

High-throughput

0.479

High

523846

XRCC6
X-ray repair cross-complementing protein 6

1

5

High-throughput

0.479

High

542033

ETS1
Protein C-ets-1

1

20

High-throughput

0.479

High

553062

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

632793

TYY1
Transcriptional repressor protein YY1

1

5

High-throughput

0.479

High

668791

PML
Protein PML

1

11

High-throughput

0.479

High

692157

ELF1
ETS-related transcription factor Elf-1

1

20

High-throughput

0.479

High

720804

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

727280

NU214
Nuclear pore complex protein Nup214

1

13

High-throughput

0.479

High

749626

BRCA1
Breast cancer type 1 susceptibility protein

1

12

High-throughput

0.479

High

782584

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

785377

ELK3
ETS domain-containing protein Elk-3

1

20

High-throughput

0.479

High

824144

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

8

High-throughput

0.479

High

831461

CEBPA
CCAAT/enhancer-binding protein alpha

1

10

High-throughput

0.479

High

852970

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

3

High-throughput

0.479

High

858003

NUP98
Nuclear pore complex protein Nup98-Nup96

1

10

High-throughput

0.479

High

884192

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

917506

H4
Histone H4

1

9

High-throughput

0.479

High

952435

H33
Histone H3.3

1

17

High-throughput

0.479

High

963639

E2F1
Transcription factor E2F1

1

7

High-throughput

0.479

High

980797

TLE3
Transducin-like enhancer protein 3

1

17

High-throughput

0.479

High

1019006

TP53B
TP53-binding protein 1

1

13

High-throughput

0.479

High

1029579

TIF1B
Transcription intermediary factor 1-beta

1

12

High-throughput

0.479

High

1046638

KLF9
Krueppel-like factor 9

1

20

High-throughput

0.479

High

1047504

NFYC
Nuclear transcription factor Y subunit gamma

1

2

High-throughput

0.479

High

1056880

MDC1
Mediator of DNA damage checkpoint protein 1

1

17

High-throughput

0.479

High

1077566

ELF2
ETS-related transcription factor Elf-2

1

20

High-throughput

0.479

High

1109048

CHD9
Chromodomain-helicase-DNA-binding protein 9

1

8

High-throughput

0.479

High

1190846

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

1190849

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.479

High

1190850

SLX4
Structure-specific endonuclease subunit SLX4

1

16

High-throughput

0.479

High

1190854

PHC3
Polyhomeotic-like protein 3

1

14

High-throughput

0.479

High

1190862

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

17

High-throughput

0.479

High

1190863

MBD6
Methyl-CpG-binding domain protein 6

1

8

High-throughput

0.479

High

1190867

ELF4
ETS-related transcription factor Elf-4

1

20

High-throughput

0.479

High

1190868

KLF6
Krueppel-like factor 6

1

20

High-throughput

0.479

High

1190870

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

7

High-throughput

0.479

High

1190871

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.479

High

1190872

WWTR1
WW domain-containing transcription regulator protein 1

1

14

High-throughput

0.479

High

1190873

BRD8
Bromodomain-containing protein 8

1

17

High-throughput

0.479

High

1190875

FOXP1
Forkhead box protein P1

1

11

Small-scale

0.479

High

1190879

MRGBP
MRG/MORF4L-binding protein

1

2

High-throughput

0.479

High

1190880

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.479

High

1190881

RTEL1
Regulator of telomere elongation helicase 1

1

2

High-throughput

0.479

High

1190885

KLF15
Krueppel-like factor 15

1

20

High-throughput

0.479

High

1190886

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

10

Small-scale

0.479

High

1190888

ASF1A
Histone chaperone ASF1A

1

8

High-throughput

0.479

High

1190889

ZN281
Zinc finger protein 281

1

2

High-throughput

0.479

High

1190890

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.479

High

1190891

MOFA1
MORF4 family-associated protein 1

1

1

High-throughput

0.479

High

215649

AKAP8
A-kinase anchor protein 8

1

0

High-throughput

0.458

High

278476

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.458

High

1190847

PALB2
Partner and localizer of BRCA2

1

0

High-throughput

0.458

High

1190865

NUP88
Nuclear pore complex protein Nup88

1

0

High-throughput

0.458

High

90022

D6RA96
Regulator of telomere elongation helicase 1

1

2

High-throughput

0.445

High

508591

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.445

High

948813

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

3

High-throughput

0.445

High

1061154

NUMA1
Nuclear mitotic apparatus protein 1

1

6

High-throughput

0.445

High

1087222

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.445

High

178973

FOXP2
Forkhead box protein P2

1

12

Small-scale

0.437

High

577661

SON
Protein SON

1

13

High-throughput

0.437

High

737895

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

5

High-throughput

0.437

High

1060318

NFIX
Nuclear factor 1 X-type

1

17

High-throughput

0.437

High

1101049

QSER1
Glutamine and serine-rich protein 1

1

10

High-throughput

0.437

High

1188494

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

12

High-throughput

0.437

High

1190848

FOXP4
Forkhead box protein P4

1

11

Small-scale

0.437

High

1190866

FEV
Protein FEV

1

20

High-throughput

0.437

High

1190869

KLF16
Krueppel-like factor 16

1

20

High-throughput

0.437

High

1190861

DDT4L
DNA damage-inducible transcript 4-like protein

1

3

High-throughput

0.417

High

1086198

H31T
Histone H3.1t

1

17

High-throughput

0.408

High

714280

HSP74
Heat shock 70 kDa protein 4

1

7

High-throughput

0.407

High

1190853

GG6L2
Golgin subfamily A member 6-like protein 2

1

13

High-throughput

0.407

High

1190877

LN28A
Protein lin-28 homolog A

1

1

High-throughput

0.407

High

1190858

TM171
Transmembrane protein 171

3

0

High-throughput

0.347

High

1132202

CLVS2
Clavesin-2

2

0

High-throughput

0.316

High

1190852

LIX1
Protein limb expression 1 homolog

2

0

High-throughput

0.316

High

1190860

AIDA
Axin interactor, dorsalization-associated protein

2

0

High-throughput

0.316

High

515892

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.279

Low

408850

K1C18
Keratin, type I cytoskeletal 18

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024