Protein: HTRA4
Serine protease HTRA4 (EC 3.4.21.-) (High-temperature requirement factor A4)

Gene: HTRA4
Organism: Homo sapiens
Interactions: 188
UniProt ID: P83105

Gene Ontology (top 5):
GO:0004175 - endopeptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0006508 - proteolysis
GO:0012501 - programmed cell death

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

949003

HTRA4
Serine protease HTRA4

3

15

Small-scale

0.840

High

949004

HTRA3
Serine protease HTRA3

1

15

Small-scale

0.724

High

949037

HTRA1
Serine protease HTRA1

1

15

Small-scale

0.724

High

341582

CFAB
Complement factor B

1

2

High-throughput

0.691

High

495655

TGFB3
Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide

1

6

High-throughput

0.691

High

949005

XIAP
E3 ubiquitin-protein ligase XIAP

3

15

Small-scale

0.637

High

949007

OTUD4
OTU domain-containing protein 4

2

0

High-throughput

0.602

High

876938

CASP7
Caspase-7

1

2

High-throughput

0.597

High

317823

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

2

1

High-throughput

0.574

High

949039

TTC28
Tetratricopeptide repeat protein 28

2

1

High-throughput

0.574

High

949060

WDR26
WD repeat-containing protein 26

2

1

High-throughput

0.574

High

416606

S10A6
Protein S100-A6

1

9

High-throughput

0.554

High

876971

CASP9
Caspase-9

1

2

High-throughput

0.554

High

573220

TCPA
T-complex protein 1 subunit alpha

1

2

High-throughput

0.545

High

416401

S10A9
Protein S100-A9

1

9

High-throughput

0.536

High

427876

CAN1
Calpain-1 catalytic subunit

1

2

High-throughput

0.536

High

428138

TBB5
Tubulin beta chain

1

4

High-throughput

0.536

High

568972

CAN2
Calpain-2 catalytic subunit

1

2

High-throughput

0.536

High

638947

S100P
Protein S100-P

1

9

High-throughput

0.536

High

642932

S10A4
Protein S100-A4

1

9

High-throughput

0.536

High

678434

S10A7
Protein S100-A7

1

9

High-throughput

0.536

High

737308

LONM
Lon protease homolog, mitochondrial

1

4

High-throughput

0.536

High

949009

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

2

High-throughput

0.536

High

949010

DNJC3
DnaJ homolog subfamily C member 3

1

2

High-throughput

0.536

High

949045

S10AD
Protein S100-A13

1

9

High-throughput

0.536

High

949063

DBLOH
Diablo IAP-binding mitochondrial protein

1

1

High-throughput

0.536

High

949065

DD19A
ATP-dependent RNA helicase DDX19A

1

2

High-throughput

0.536

High

949080

HYOU1
Hypoxia up-regulated protein 1

1

2

High-throughput

0.536

High

121990

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

High-throughput

0.513

High

153446

PDCD5
Programmed cell death protein 5

1

0

High-throughput

0.513

High

181316

ARPC5
Actin-related protein 2/3 complex subunit 5

1

0

High-throughput

0.513

High

211563

ACTN4
Alpha-actinin-4

1

0

High-throughput

0.513

High

386518

P53
Cellular tumor antigen p53

1

0

High-throughput

0.513

High

457105

LKHA4
Leukotriene A-4 hydrolase

1

0

High-throughput

0.513

High

575722

VINC
Vinculin

1

0

High-throughput

0.513

High

893649

PSA6
Proteasome subunit alpha type-6

1

0

High-throughput

0.513

High

949048

CPPED
Serine/threonine-protein phosphatase CPPED1

1

0

High-throughput

0.513

High

949075

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

High-throughput

0.513

High

729639

VGFR2
Vascular endothelial growth factor receptor 2

1

4

Small-scale

0.501

High

175770

HMGB3
High mobility group protein B3

1

2

High-throughput

0.489

High

202747

TPD54
Tumor protein D54

1

1

High-throughput

0.489

High

259724

PDCD6
Programmed cell death protein 6

1

2

High-throughput

0.489

High

278049

PIAS1
E3 SUMO-protein ligase PIAS1

1

1

High-throughput

0.489

High

278783

DNJC8
DnaJ homolog subfamily C member 8

1

1

High-throughput

0.489

High

312242

IPO7
Importin-7

1

1

High-throughput

0.489

High

320513

OXSR1
Serine/threonine-protein kinase OSR1

1

3

High-throughput

0.489

High

330975

PAK4
Serine/threonine-protein kinase PAK 4

1

2

High-throughput

0.489

High

335804

COX2
Cytochrome c oxidase subunit 2

1

1

High-throughput

0.489

High

340801

KAD1
Adenylate kinase isoenzyme 1

1

1

High-throughput

0.489

High

414858

CDK1
Cyclin-dependent kinase 1

1

3

High-throughput

0.489

High

418936

TPM3
Tropomyosin alpha-3 chain

1

1

High-throughput

0.489

High

451239

TPM1
Tropomyosin alpha-1 chain

1

1

High-throughput

0.489

High

574303

RL35A
Large ribosomal subunit protein eL33

1

2

High-throughput

0.489

High

589179

ANXA7
Annexin A7

1

3

High-throughput

0.489

High

643322

HMGB2
High mobility group protein B2

1

2

High-throughput

0.489

High

647542

MK03
Mitogen-activated protein kinase 3

1

2

High-throughput

0.489

High

656447

PSB4
Proteasome subunit beta type-4

1

1

High-throughput

0.489

High

668338

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

1

High-throughput

0.489

High

682578

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

4

High-throughput

0.489

High

708420

MCM4
DNA replication licensing factor MCM4

1

1

High-throughput

0.489

High

724775

MYH9
Myosin-9

1

2

High-throughput

0.489

High

737741

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

3

High-throughput

0.489

High

757562

IF4A3
Eukaryotic initiation factor 4A-III

1

2

High-throughput

0.489

High

834583

NU153
Nuclear pore complex protein Nup153

1

4

High-throughput

0.489

High

841651

CDK9
Cyclin-dependent kinase 9

1

7

High-throughput

0.489

High

843484

ANX11
Annexin A11

1

3

High-throughput

0.489

High

843611

FXR1
RNA-binding protein FXR1

1

3

High-throughput

0.489

High

844871

RAB7A
Ras-related protein Rab-7a

1

1

High-throughput

0.489

High

852018

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

3

High-throughput

0.489

High

877239

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

1

High-throughput

0.489

High

878027

TPD52
Tumor protein D52

1

1

High-throughput

0.489

High

878639

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

4

High-throughput

0.489

High

885775

MTPN
Myotrophin

1

1

High-throughput

0.489

High

896723

ARP3
Actin-related protein 3

1

4

High-throughput

0.489

High

905831

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

3

High-throughput

0.489

High

906413

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

3

High-throughput

0.489

High

906810

PRS4
26S proteasome regulatory subunit 4

1

1

High-throughput

0.489

High

906989

PRS8
26S proteasome regulatory subunit 8

1

1

High-throughput

0.489

High

922520

RL10A
Large ribosomal subunit protein uL1

1

1

High-throughput

0.489

High

930804

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

4

High-throughput

0.489

High

933167

TBA1B
Tubulin alpha-1B chain

1

4

High-throughput

0.489

High

941974

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

2

High-throughput

0.489

High

949012

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

6

High-throughput

0.489

High

949013

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.489

High

949014

DX39B
Spliceosome RNA helicase DDX39B

1

3

High-throughput

0.489

High

949017

MCM6
DNA replication licensing factor MCM6

1

1

High-throughput

0.489

High

949019

SF3B4
Splicing factor 3B subunit 4

1

2

High-throughput

0.489

High

949020

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

3

High-throughput

0.489

High

949021

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

2

High-throughput

0.489

High

949023

TAF2
Transcription initiation factor TFIID subunit 2

1

1

High-throughput

0.489

High

949024

HAKAI
E3 ubiquitin-protein ligase Hakai

1

1

High-throughput

0.489

High

949026

TAOK1
Serine/threonine-protein kinase TAO1

1

2

High-throughput

0.489

High

949027

MYH14
Myosin-14

1

2

High-throughput

0.489

High

949028

S1A7A
Protein S100-A7A

1

9

High-throughput

0.489

High

949032

ZN444
Zinc finger protein 444

1

6

High-throughput

0.489

High

949033

RN169
E3 ubiquitin-protein ligase RNF169

1

1

High-throughput

0.489

High

949041

S10AG
Protein S100-A16

1

9

High-throughput

0.489

High

949042

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

1

High-throughput

0.489

High

949046

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

3

High-throughput

0.489

High

949047

TCPH
T-complex protein 1 subunit eta

1

2

High-throughput

0.489

High

949052

KIFC1
Kinesin-like protein KIFC1

1

1

High-throughput

0.489

High

949057

PABP3
Polyadenylate-binding protein 3

1

1

High-throughput

0.489

High

949062

S10AE
Protein S100-A14

1

8

High-throughput

0.489

High

949066

RBM28
RNA-binding protein 28

1

1

High-throughput

0.489

High

949067

CDK12
Cyclin-dependent kinase 12

1

5

High-throughput

0.489

High

949069

SPAST
Spastin

1

4

High-throughput

0.489

High

949076

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

2

High-throughput

0.489

High

949077

CD11A
Cyclin-dependent kinase 11A

1

4

High-throughput

0.489

High

949081

RN114
E3 ubiquitin-protein ligase RNF114

1

3

High-throughput

0.489

High

882236

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.437

High

891688

ACTB
Actin, cytoplasmic 1

1

4

High-throughput

0.437

High

949038

RBPMS
RNA-binding protein with multiple splicing

2

0

High-throughput

0.328

High

949059

WDCP
WD repeat and coiled-coil-containing protein

2

0

High-throughput

0.328

High

122323

ATOX1
Copper transport protein ATOX1

1

0

High-throughput

0.279

Low

123235

CBX4
E3 SUMO-protein ligase CBX4

1

0

High-throughput

0.279

Low

127245

IPO5
Importin-5

1

0

High-throughput

0.279

Low

168915

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

High-throughput

0.279

Low

170635

AXIN1
Axin-1

1

0

High-throughput

0.279

Low

202631

TXNL1
Thioredoxin-like protein 1

1

0

High-throughput

0.279

Low

209423

PLRG1
Pleiotropic regulator 1

1

0

High-throughput

0.279

Low

237197

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.279

Low

949029

CIR1
Corepressor interacting with RBPJ 1

1

0

High-throughput

0.279

Low

949030

DJC10
DnaJ homolog subfamily C member 10

1

0

High-throughput

0.279

Low

949031

SELH
Selenoprotein H

1

0

High-throughput

0.279

Low

949034

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

0

High-throughput

0.279

Low

949035

SELM
Selenoprotein M

1

0

High-throughput

0.279

Low

949036

NDRG1
Protein NDRG1

1

0

High-throughput

0.279

Low

949040

RMD1
Regulator of microtubule dynamics protein 1

1

0

High-throughput

0.279

Low

949043

EFGM
Elongation factor G, mitochondrial

1

0

High-throughput

0.279

Low

949044

NIBA2
Protein Niban 2

1

0

High-throughput

0.279

Low

949049

PELO
Protein pelota homolog

1

0

High-throughput

0.279

Low

949050

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.279

Low

949051

PDC10
Programmed cell death protein 10

1

0

High-throughput

0.279

Low

949053

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.279

Low

949054

RM09
Large ribosomal subunit protein bL9m

1

0

High-throughput

0.279

Low

949055

API5
Apoptosis inhibitor 5

1

0

High-throughput

0.279

Low

949056

NSRP1
Nuclear speckle splicing regulatory protein 1

1

0

High-throughput

0.279

Low

949058

GOLP3
Golgi phosphoprotein 3

1

0

High-throughput

0.279

Low

949061

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.279

Low

949064

SOSSC
SOSS complex subunit C

1

0

High-throughput

0.279

Low

949068

RCC2
Protein RCC2

1

0

High-throughput

0.279

Low

949070

PARP2
Poly [ADP-ribose] polymerase 2

1

0

High-throughput

0.279

Low

237389

CCNT2
Cyclin-T2

1

0

High-throughput

0.279

Low

237656

SEP15
Selenoprotein F

1

0

High-throughput

0.279

Low

254800

COBL
Protein cordon-bleu

1

0

High-throughput

0.279

Low

254892

CPNE3
Copine-3

1

0

High-throughput

0.279

Low

271550

ERAL1
GTPase Era, mitochondrial

1

0

High-throughput

0.279

Low

272102

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

0

High-throughput

0.279

Low

333526

CYB5
Cytochrome b5

1

0

High-throughput

0.279

Low

445367

RSSA
Small ribosomal subunit protein uS2

1

0

High-throughput

0.279

Low

540732

CX6B1
Cytochrome c oxidase subunit 6B1

1

0

High-throughput

0.279

Low

603448

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.279

Low

610352

CBL
E3 ubiquitin-protein ligase CBL

1

0

High-throughput

0.279

Low

671204

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.279

Low

672082

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

0

High-throughput

0.279

Low

728538

GLRX1
Glutaredoxin-1

1

0

High-throughput

0.279

Low

805957

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.279

Low

806281

RL21
Large ribosomal subunit protein eL21

1

0

High-throughput

0.279

Low

814762

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.279

Low

831978

PSB3
Proteasome subunit beta type-3

1

0

High-throughput

0.279

Low

834717

RBP2
E3 SUMO-protein ligase RanBP2

1

0

High-throughput

0.279

Low

844479

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.279

Low

846054

DAP1
Death-associated protein 1

1

0

High-throughput

0.279

Low

855398

TF2AA
Transcription initiation factor IIA subunit 1

1

0

High-throughput

0.279

Low

877209

ADK
Adenosine kinase

1

0

High-throughput

0.279

Low

880896

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.279

Low

888345

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.279

Low

896413

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.279

Low

930526

TYB10
Thymosin beta-10

1

0

High-throughput

0.279

Low

944640

NTH
Endonuclease III-like protein 1

1

0

High-throughput

0.279

Low

946846

RT22
Small ribosomal subunit protein mS22

1

0

High-throughput

0.279

Low

948543

RT09
Small ribosomal subunit protein uS9m

1

0

High-throughput

0.279

Low

949006

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.279

Low

949008

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.279

Low

949011

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.279

Low

949015

CAYP1
Calcyphosin

1

0

High-throughput

0.279

Low

949016

SEPT6
Septin-6

1

0

High-throughput

0.279

Low

949018

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.279

Low

949022

CDC73
Parafibromin

1

0

High-throughput

0.279

Low

949025

MARK2
Serine/threonine-protein kinase MARK2

1

0

High-throughput

0.279

Low

949072

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.279

Low

949073

TF3C4
General transcription factor 3C polypeptide 4

1

0

High-throughput

0.279

Low

949074

MCTS1
Malignant T-cell-amplified sequence 1

1

0

High-throughput

0.279

Low

949079

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.279

Low

702754

CADH5
Cadherin-5

1

0

Small-scale

0.261

Low

949078

SYCY1
Syncytin-1

1

0

Small-scale

0.261

Low

949071

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

0

Small-scale

0.251

Low


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Last updated: 15 Jul 2024