Protein: MBD2
Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2)

Gene: MBD2
Organism: Homo sapiens
Interactions: 112
UniProt ID: Q9UBB5

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000792 - heterochromatin
GO:0003229 - ventricular cardiac muscle tissue development
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1038773

HDAC1
Histone deacetylase 1

16

12

Small-scale

0.986

High

1205828

P66A
Transcriptional repressor p66-alpha

11

7

Small-scale

0.979

High

1270493

HDAC2
Histone deacetylase 2

11

12

Small-scale

0.975

High

1263987

P66B
Transcriptional repressor p66-beta

6

7

Small-scale

0.951

High

328669

MBD3
Methyl-CpG-binding domain protein 3

6

9

Small-scale

0.946

High

296160

MTA2
Metastasis-associated protein MTA2

5

15

Small-scale

0.906

High

1312035

MTA3
Metastasis-associated protein MTA3

2

15

High-throughput

0.789

High

1353856

MBD2
Methyl-CpG-binding domain protein 2

2

9

Small-scale

0.754

High

1083414

RBBP7
Histone-binding protein RBBP7

6

8

Small-scale

0.733

High

997938

RBBP4
Histone-binding protein RBBP4

6

8

Small-scale

0.732

High

146877

CDKA1
Cyclin-dependent kinase 2-associated protein 1

5

5

Small-scale

0.712

High

1350616

ZN219
Zinc finger protein 219

4

3

High-throughput

0.694

High

1018729

CHD3
Chromodomain-helicase-DNA-binding protein 3

4

20

Small-scale

0.689

High

1059915

CHD4
Chromodomain-helicase-DNA-binding protein 4

4

19

Small-scale

0.686

High

486974

MYBB
Myb-related protein B

1

1

High-throughput

0.618

High

1031965

MTA1
Metastasis-associated protein MTA1

1

15

High-throughput

0.618

High

1307031

ANM1
Protein arginine N-methyltransferase 1

2

1

Small-scale

0.614

High

68324

P20L1
PHD finger protein 20-like protein 1

2

1

High-throughput

0.611

High

987005

SUH
Recombining binding protein suppressor of hairless

2

2

High-throughput

0.611

High

1296258

Z512B
Zinc finger protein 512B

2

4

High-throughput

0.611

High

1319439

BC11B
B-cell lymphoma/leukemia 11B

2

8

High-throughput

0.611

High

1353863

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

2

5

High-throughput

0.611

High

1302460

SIN3A
Paired amphipathic helix protein Sin3a

2

4

Small-scale

0.606

High

153820

ANM5
Protein arginine N-methyltransferase 5

2

1

Small-scale

0.584

High

1033749

IKZF1
DNA-binding protein Ikaros

2

3

Small-scale

0.584

High

1255049

CHD5
Chromodomain-helicase-DNA-binding protein 5

2

19

Small-scale

0.584

High

1309305

MEP50
Methylosome protein WDR77

2

1

Small-scale

0.584

High

1353862

IKZF3
Zinc finger protein Aiolos

2

3

Small-scale

0.584

High

1300542

PURB
Transcriptional regulator protein Pur-beta

2

0

High-throughput

0.580

High

1263090

MB3L1
Methyl-CpG-binding domain protein 3-like 1

1

9

Small-scale

0.573

High

1309335

HINFP
Histone H4 transcription factor

1

2

Small-scale

0.573

High

370616

ESR1
Estrogen receptor

2

6

High-throughput

0.571

High

641294

DNMT1
DNA

2

2

Small-scale

0.571

High

1084925

SMN
Survival motor neuron protein

1

0

High-throughput

0.558

High

994372

DHX9
ATP-dependent RNA helicase A

1

0

Small-scale

0.549

High

1052844

FAK2
Protein-tyrosine kinase 2-beta

1

0

Small-scale

0.549

High

1336401

GPN1
GPN-loop GTPase 1

1

0

Small-scale

0.549

High

990374

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.541

High

782394

KDM5C
Lysine-specific demethylase 5C

1

2

High-throughput

0.536

High

818556

SOX2
Transcription factor SOX-2

1

8

High-throughput

0.536

High

853742

IMA5
Importin subunit alpha-5

1

3

High-throughput

0.536

High

1274116

STMN2
Stathmin-2

1

1

High-throughput

0.536

High

1342343

HM20A
High mobility group protein 20A

1

6

High-throughput

0.536

High

1345496

SALL1
Sal-like protein 1

1

5

High-throughput

0.536

High

1353860

TRPS1
Zinc finger transcription factor Trps1

1

9

High-throughput

0.536

High

1353861

SALL4
Sal-like protein 4

1

5

High-throughput

0.536

High

1353865

TACC3
Transforming acidic coiled-coil-containing protein 3

1

0

Small-scale

0.529

High

1246267

MB3L2
Methyl-CpG-binding domain protein 3-like 2

1

9

Small-scale

0.527

High

1197551

RALYL
RNA-binding Raly-like protein

1

0

High-throughput

0.518

High

1291126

CDCA5
Sororin

1

0

High-throughput

0.513

High

1237278

BEND7
BEN domain-containing protein 7

1

1

High-throughput

0.494

High

846602

INSL3
Insulin-like 3

1

1

High-throughput

0.489

High

589932

TBP
TATA-box-binding protein

1

0

Small-scale

0.480

High

158864

HAT1
Histone acetyltransferase type B catalytic subunit

1

1

High-throughput

0.479

High

182938

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

198067

PHF1
PHD finger protein 1

1

3

High-throughput

0.479

High

229512

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

20

High-throughput

0.479

High

232562

KDM1A
Lysine-specific histone demethylase 1A

1

1

Small-scale

0.479

High

245046

BRD4
Bromodomain-containing protein 4

1

5

High-throughput

0.479

High

257842

SIN3B
Paired amphipathic helix protein Sin3b

1

4

High-throughput

0.479

High

265274

SAP30
Histone deacetylase complex subunit SAP30

1

2

High-throughput

0.479

High

268313

EED
Polycomb protein EED

1

2

High-throughput

0.479

High

279819

CDKA2
Cyclin-dependent kinase 2-associated protein 2

1

5

Small-scale

0.479

High

348127

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

375025

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

470189

H2AZ
Histone H2A.Z

1

3

High-throughput

0.479

High

487810

ANDR
Androgen receptor

1

6

High-throughput

0.479

High

537112

TRI27
Zinc finger protein RFP

1

1

Small-scale

0.479

High

555673

H2AX
Histone H2AX

1

2

High-throughput

0.479

High

570140

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

658746

SMCA1
Probable global transcription activator SNF2L1

1

20

High-throughput

0.479

High

727818

SOX5
Transcription factor SOX-5

1

7

High-throughput

0.479

High

727936

SOX6
Transcription factor SOX-6

1

10

High-throughput

0.479

High

831755

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.479

High

918072

H4
Histone H4

1

2

High-throughput

0.479

High

935327

H31
Histone H3.1

1

5

High-throughput

0.479

High

1017361

BPTF
Nucleosome-remodeling factor subunit BPTF

1

16

High-throughput

0.479

High

1024528

CAF1A
Chromatin assembly factor 1 subunit A

1

2

High-throughput

0.479

High

1024603

CAF1B
Chromatin assembly factor 1 subunit B

1

1

High-throughput

0.479

High

1061791

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

20

High-throughput

0.479

High

1063660

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

1080429

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

High-throughput

0.479

High

1086010

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.479

High

1117711

ARI4B
AT-rich interactive domain-containing protein 4B

1

5

High-throughput

0.479

High

1119830

LIN52
Protein lin-52 homolog

1

1

High-throughput

0.479

High

1129661

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

3

High-throughput

0.479

High

1137055

LIN9
Protein lin-9 homolog

1

1

High-throughput

0.479

High

1221080

BAP18
Chromatin complexes subunit BAP18

1

1

High-throughput

0.479

High

1235681

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

2

High-throughput

0.479

High

1241373

HJURP
Holliday junction recognition protein

1

1

High-throughput

0.479

High

1260518

ZN296
Zinc finger protein 296

1

8

High-throughput

0.479

High

1260555

GATD1
GATA zinc finger domain-containing protein 1

1

1

High-throughput

0.479

High

1292973

LIN37
Protein lin-37 homolog

1

1

High-throughput

0.479

High

1298461

PWP2A
PWWP domain-containing protein 2A

1

2

High-throughput

0.479

High

1300618

PHF12
PHD finger protein 12

1

20

High-throughput

0.479

High

1318613

DPY30
Protein dpy-30 homolog

1

1

High-throughput

0.479

High

1327631

SP130
Histone deacetylase complex subunit SAP130

1

3

High-throughput

0.479

High

1328478

BC11A
B-cell lymphoma/leukemia 11A

1

8

High-throughput

0.479

High

1333161

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

3

High-throughput

0.479

High

1353857

KDM5B
Lysine-specific demethylase 5B

1

2

Small-scale

0.479

High

1353858

HMGX4
HMG domain-containing protein 4

1

8

High-throughput

0.479

High

1353864

MTF2
Metal-response element-binding transcription factor 2

1

3

High-throughput

0.479

High

625080

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

817543

RFX3
Transcription factor RFX3

1

0

High-throughput

0.458

High

966303

TFAP4
Transcription factor AP-4

1

0

Small-scale

0.458

High

1342366

MLXPL
Carbohydrate-responsive element-binding protein

1

0

Small-scale

0.458

High

1348874

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1331517

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

414388

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.426

High

1353859

LTOR3
Ragulator complex protein LAMTOR3

1

0

High-throughput

0.251

Low

1347507

RM22
Large ribosomal subunit protein uL22m

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024