Protein: CHK2
Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2)

Gene: CHK2, CHEK2
Organism: Homo sapiens
Interactions: 211
UniProt ID: O96017

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

331182

CHK2
Serine/threonine-protein kinase Chk2

10

15

Small-scale

0.982

High

331223

MPIP3
M-phase inducer phosphatase 3

13

4

Small-scale

0.981

High

331222

MPIP1
M-phase inducer phosphatase 1

6

4

Small-scale

0.952

High

331237

PLK1
Serine/threonine-protein kinase PLK1

3

18

Small-scale

0.899

High

331339

PLK3
Serine/threonine-protein kinase PLK3

3

16

Small-scale

0.882

High

175362

PPM1D
Protein phosphatase 1D

2

9

Small-scale

0.825

High

282449

RNF8
E3 ubiquitin-protein ligase RNF8

2

9

Small-scale

0.819

High

176089

PPM1G
Protein phosphatase 1G

2

10

Small-scale

0.773

High

331209

CD11B
Cyclin-dependent kinase 11B

1

15

Small-scale

0.770

High

331221

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

5

Small-scale

0.759

High

331299

ELAV1
ELAV-like protein 1

1

7

Small-scale

0.756

High

226186

PRKN
E3 ubiquitin-protein ligase parkin

2

20

High-throughput

0.754

High

331184

P53
Cellular tumor antigen p53

8

6

Small-scale

0.751

High

331227

BRCA1
Breast cancer type 1 susceptibility protein

8

4

Small-scale

0.751

High

161277

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

8

Small-scale

0.747

High

331273

ATM
Serine-protein kinase ATM

6

20

Small-scale

0.737

High

331329

SRPK1
SRSF protein kinase 1

1

19

High-throughput

0.735

High

331286

MDC1
Mediator of DNA damage checkpoint protein 1

1

3

Small-scale

0.724

High

331353

CD11A
Cyclin-dependent kinase 11A

1

15

Small-scale

0.715

High

331207

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

12

Small-scale

0.713

High

179920

TLR3
Toll-like receptor 3

1

2

High-throughput

0.698

High

331333

RHBT2
Rho-related BTB domain-containing protein 2

1

12

High-throughput

0.698

High

331337

PRD14
PR domain zinc finger protein 14

1

1

High-throughput

0.698

High

331228

CDN1A
Cyclin-dependent kinase inhibitor 1

1

9

Small-scale

0.692

High

331231

KI67
Proliferation marker protein Ki-67

1

2

High-throughput

0.691

High

331250

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.691

High

331255

FOXK1
Forkhead box protein K1

1

8

High-throughput

0.691

High

331259

FOXK2
Forkhead box protein K2

1

11

High-throughput

0.691

High

331347

RAI14
Ankycorbin

1

6

High-throughput

0.691

High

331249

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

4

15

Small-scale

0.686

High

331258

MDM2
E3 ubiquitin-protein ligase Mdm2

3

4

Small-scale

0.685

High

331244

ARP2
Actin-related protein 2

1

8

High-throughput

0.665

High

331274

2A5G
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

2

6

Small-scale

0.660

High

331254

PRKDC
DNA-dependent protein kinase catalytic subunit

3

19

Small-scale

0.655

High

200079

DAPK3
Death-associated protein kinase 3

1

16

Small-scale

0.647

High

331253

SRPK2
SRSF protein kinase 2

1

14

High-throughput

0.647

High

331342

LATS2
Serine/threonine-protein kinase LATS2

1

15

Small-scale

0.647

High

331236

IMA1
Importin subunit alpha-1

2

2

Small-scale

0.646

High

331362

TX264
Testis-expressed protein 264

3

0

High-throughput

0.638

High

331338

P63
Tumor protein 63

2

6

High-throughput

0.628

High

235648

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

3

Small-scale

0.625

High

268566

SF3B1
Splicing factor 3B subunit 1

1

5

Small-scale

0.625

High

331206

CSK22
Casein kinase II subunit alpha'

1

16

Small-scale

0.625

High

331212

SFPQ
Splicing factor, proline- and glutamine-rich

1

8

Small-scale

0.625

High

331232

RBM25
RNA-binding protein 25

1

15

Small-scale

0.625

High

331251

CSK21
Casein kinase II subunit alpha

1

20

Small-scale

0.625

High

331261

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

14

Small-scale

0.625

High

331269

TADBP
TAR DNA-binding protein 43

1

10

Small-scale

0.625

High

331294

NONO
Non-POU domain-containing octamer-binding protein

1

13

Small-scale

0.625

High

331297

SF3B3
Splicing factor 3B subunit 3

1

4

Small-scale

0.625

High

331331

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

9

Small-scale

0.625

High

331349

PUF60
Poly(U)-binding-splicing factor PUF60

1

4

Small-scale

0.625

High

331292

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

2

6

Small-scale

0.625

High

318040

DIRA3
GTP-binding protein Di-Ras3

1

1

High-throughput

0.625

High

331230

MSH2
DNA mismatch repair protein Msh2

2

1

Small-scale

0.624

High

331188

RB
Retinoblastoma-associated protein

1

2

Small-scale

0.620

High

171917

GP182
G-protein coupled receptor 182

1

3

High-throughput

0.618

High

331308

MPRIP
Myosin phosphatase Rho-interacting protein

1

12

High-throughput

0.618

High

331311

P2RY8
P2Y purinoceptor 8

1

2

High-throughput

0.618

High

331345

RBM28
RNA-binding protein 28

1

4

High-throughput

0.618

High

331277

SQSTM
Sequestosome-1

1

4

High-throughput

0.618

High

331340

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

331238

TERA
Transitional endoplasmic reticulum ATPase

2

3

Small-scale

0.612

High

331235

BRCA2
Breast cancer type 2 susceptibility protein

3

0

Small-scale

0.608

High

331278

ATR
Serine/threonine-protein kinase ATR

2

19

Small-scale

0.602

High

331321

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

6

Small-scale

0.602

High

331205

XRCC1
DNA repair protein XRCC1

1

0

Small-scale

0.593

High

331346

AATF
Protein AATF

1

0

Small-scale

0.589

High

331198

XRCC5
X-ray repair cross-complementing protein 5

2

3

Small-scale

0.588

High

331305

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

11

High-throughput

0.582

High

199078

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

5

Small-scale

0.578

High

331301

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

6

Small-scale

0.578

High

331282

FHL1
Four and a half LIM domains protein 1

1

5

Small-scale

0.573

High

331245

PSME3
Proteasome activator complex subunit 3

2

0

Small-scale

0.569

High

331359

STRAP
Serine-threonine kinase receptor-associated protein

1

4

Small-scale

0.569

High

331219

PML
Protein PML

1

4

Small-scale

0.561

High

331229

VHL
von Hippel-Lindau disease tumor suppressor

1

3

Small-scale

0.561

High

331326

MUS81
Crossover junction endonuclease MUS81

1

4

Small-scale

0.561

High

331327

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

3

Small-scale

0.561

High

331325

LRAT2
Protein LRATD2

1

0

High-throughput

0.558

High

331242

PER3
Period circadian protein homolog 3

1

8

Small-scale

0.554

High

331355

PSF2
DNA replication complex GINS protein PSF2

1

2

Small-scale

0.554

High

331288

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

6

Small-scale

0.552

High

331293

2A5B
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

1

6

Small-scale

0.552

High

331300

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

6

Small-scale

0.552

High

331187

HMGN1
Non-histone chromosomal protein HMG-14

1

2

High-throughput

0.541

High

331189

ENOA
Alpha-enolase

1

5

High-throughput

0.541

High

331191

HXC6
Homeobox protein Hox-C6

1

2

High-throughput

0.541

High

331195

ADT3
ADP/ATP translocase 3

1

2

High-throughput

0.541

High

331199

CCL5
C-C motif chemokine 5

1

1

High-throughput

0.541

High

331204

STMN1
Stathmin

1

2

High-throughput

0.541

High

331240

CAD13
Cadherin-13

1

8

High-throughput

0.541

High

331241

ANM2
Protein arginine N-methyltransferase 2

1

3

High-throughput

0.541

High

331248

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

3

High-throughput

0.541

High

331262

RHG01
Rho GTPase-activating protein 1

1

3

High-throughput

0.541

High

331334

NSD3
Histone-lysine N-methyltransferase NSD3

1

2

High-throughput

0.541

High

331341

BEX1
Protein BEX1

1

1

High-throughput

0.541

High

331360

ST14
Suppressor of tumorigenicity 14 protein

1

2

High-throughput

0.541

High

331298

MED1
Mediator of RNA polymerase II transcription subunit 1

1

1

Small-scale

0.536

High

179512

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.536

High

214454

MYO1B
Unconventional myosin-Ib

1

15

High-throughput

0.536

High

230192

SI1L3
Signal-induced proliferation-associated 1-like protein 3

1

2

High-throughput

0.536

High

313714

SVIL
Supervillin

1

4

High-throughput

0.536

High

331183

FOS
Protein c-Fos

1

4

High-throughput

0.536

High

331190

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.536

High

331194

EPB41
Protein 4.1

1

5

High-throughput

0.536

High

331226

MYH10
Myosin-10

1

9

High-throughput

0.536

High

331266

TP53B
TP53-binding protein 1

1

2

Small-scale

0.536

High

331279

PWP1
Periodic tryptophan protein 1 homolog

1

12

High-throughput

0.536

High

331302

CYTSB
Cytospin-B

1

13

High-throughput

0.536

High

331306

CYTSA
Cytospin-A

1

12

High-throughput

0.536

High

331309

SV2A
Synaptic vesicle glycoprotein 2A

1

2

High-throughput

0.536

High

331320

RAD50
DNA repair protein RAD50

1

17

Small-scale

0.536

High

331322

EFMT3
EEF1A lysine methyltransferase 3

1

6

High-throughput

0.536

High

331330

DCR1C
Protein artemis

1

2

High-throughput

0.536

High

331335

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

331351

MYO5B
Unconventional myosin-Vb

1

10

High-throughput

0.536

High

331352

MYO6
Unconventional myosin-VI

1

11

High-throughput

0.536

High

331268

IL24
Interleukin-24

1

1

High-throughput

0.532

High

331283

FHL3
Four and a half LIM domains protein 3

1

8

Small-scale

0.527

High

331247

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.518

High

331317

BAALC
Brain and acute leukemia cytoplasmic protein

1

0

High-throughput

0.518

High

331348

HOP2
Homologous-pairing protein 2 homolog

1

0

High-throughput

0.518

High

331260

CNTN2
Contactin-2

1

0

Small-scale

0.517

High

331201

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.515

High

331344

DCA13
DDB1- and CUL4-associated factor 13

1

3

High-throughput

0.515

High

331192

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

0

High-throughput

0.513

High

331291

RRS1
Ribosome biogenesis regulatory protein homolog

1

0

High-throughput

0.513

High

169223

MDM4
Protein Mdm4

1

4

Small-scale

0.501

High

238290

REV3L
DNA polymerase zeta catalytic subunit

1

3

Small-scale

0.501

High

331185

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

331193

TAU
Microtubule-associated protein tau

1

18

Small-scale

0.501

High

331263

FOXM1
Forkhead box protein M1

1

4

Small-scale

0.501

High

246147

NBN
Nibrin

1

0

Small-scale

0.500

High

331186

CP17A
Steroid 17-alpha-hydroxylase/17,20 lyase

1

3

High-throughput

0.494

High

331233

KLK7
Kallikrein-7

1

1

High-throughput

0.494

High

331350

KLK9
Kallikrein-9

1

1

High-throughput

0.494

High

164546

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

3

High-throughput

0.489

High

331217

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

3

High-throughput

0.489

High

331239

CAD12
Cadherin-12

1

7

High-throughput

0.489

High

331267

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

4

High-throughput

0.489

High

331271

KLRD1
Natural killer cells antigen CD94

1

4

High-throughput

0.489

High

331314

SYT2
Synaptotagmin-2

1

1

High-throughput

0.489

High

211097

BUB3
Mitotic checkpoint protein BUB3

1

4

Small-scale

0.484

High

263465

PR40A
Pre-mRNA-processing factor 40 homolog A

1

10

Small-scale

0.484

High

311452

SMC2
Structural maintenance of chromosomes protein 2

1

8

Small-scale

0.484

High

331196

TPR
Nucleoprotein TPR

1

18

Small-scale

0.484

High

331200

KPYM
Pyruvate kinase PKM

1

1

Small-scale

0.484

High

331208

LMNB1
Lamin-B1

1

14

Small-scale

0.484

High

331213

MCM3
DNA replication licensing factor MCM3

1

13

Small-scale

0.484

High

331216

EF1G
Elongation factor 1-gamma

1

7

Small-scale

0.484

High

331220

EF1D
Elongation factor 1-delta

1

1

Small-scale

0.484

High

331224

MCM5
DNA replication licensing factor MCM5

1

8

Small-scale

0.484

High

331225

MCM7
DNA replication licensing factor MCM7

1

9

Small-scale

0.484

High

331246

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

5

Small-scale

0.484

High

331257

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

6

Small-scale

0.484

High

331264

DHX9
ATP-dependent RNA helicase A

1

4

Small-scale

0.484

High

331265

AP1B1
AP-1 complex subunit beta-1

1

4

Small-scale

0.484

High

331284

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

15

Small-scale

0.484

High

331287

SMC1A
Structural maintenance of chromosomes protein 1A

1

12

Small-scale

0.484

High

331289

IMB1
Importin subunit beta-1

1

4

Small-scale

0.484

High

331290

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

Small-scale

0.484

High

331295

PCBP1
Poly(rC)-binding protein 1

1

5

Small-scale

0.484

High

331296

PCBP2
Poly(rC)-binding protein 2

1

4

Small-scale

0.484

High

331304

UBR4
E3 ubiquitin-protein ligase UBR4

1

7

Small-scale

0.484

High

331312

LRC8A
Volume-regulated anion channel subunit LRRC8A

1

3

Small-scale

0.484

High

331332

MBB1A
Myb-binding protein 1A

1

1

Small-scale

0.484

High

331336

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

7

Small-scale

0.484

High

331343

SMC4
Structural maintenance of chromosomes protein 4

1

9

Small-scale

0.484

High

331354

SMC3
Structural maintenance of chromosomes protein 3

1

8

Small-scale

0.484

High

331356

RUVB1
RuvB-like 1

1

1

Small-scale

0.484

High

331211

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

14

High-throughput

0.481

High

92144

E9PAV9
G patch domain-containing protein 4

1

1

High-throughput

0.479

High

150806

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

10

High-throughput

0.479

High

206782

FOXO3
Forkhead box protein O3

1

13

Small-scale

0.479

High

303989

UBR5
E3 ubiquitin-protein ligase UBR5

1

19

Small-scale

0.479

High

331197

XRCC6
X-ray repair cross-complementing protein 6

1

3

Small-scale

0.479

High

331202

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

331203

H2AX
Histone H2AX

1

16

Small-scale

0.479

High

331214

RBTN2
Rhombotin-2

1

9

Small-scale

0.479

High

331215

RBTN1
Rhombotin-1

1

8

Small-scale

0.479

High

331218

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

331234

MXI1
Max-interacting protein 1

1

5

Small-scale

0.479

High

331243

UBC12
NEDD8-conjugating enzyme Ubc12

1

3

High-throughput

0.479

High

331270

RFA4
Replication protein A 30 kDa subunit

1

6

High-throughput

0.479

High

331272

TIF1B
Transcription intermediary factor 1-beta

1

6

Small-scale

0.479

High

331275

CTBP1
C-terminal-binding protein 1

1

3

High-throughput

0.479

High

331280

CUL1
Cullin-1

1

9

Small-scale

0.479

High

331281

CUL4A
Cullin-4A

1

9

Small-scale

0.479

High

331285

FHL2
Four and a half LIM domains protein 2

1

8

Small-scale

0.479

High

331313

CCAR2
Cell cycle and apoptosis regulator protein 2

1

3

Small-scale

0.479

High

331316

LMO3
LIM domain only protein 3

1

8

Small-scale

0.479

High

331318

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

7

Small-scale

0.479

High

331319

KAT2B
Histone acetyltransferase KAT2B

1

3

Small-scale

0.479

High

331323

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

5

Small-scale

0.479

High

331324

CK5P3
CDK5 regulatory subunit-associated protein 3

1

1

Small-scale

0.479

High

331328

CIC
Protein capicua homolog

1

9

High-throughput

0.479

High

331210

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

Small-scale

0.464

High

331252

GTF2I
General transcription factor II-I

1

0

Small-scale

0.464

High

331276

SF3B2
Splicing factor 3B subunit 2

1

0

Small-scale

0.464

High

331315

FBX22
F-box only protein 22

1

0

Small-scale

0.464

High

331357

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

Small-scale

0.464

High

331256

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

1

Small-scale

0.439

High

331358

FIS1
Mitochondrial fission 1 protein

1

1

High-throughput

0.437

High

331303

GPTC4
G patch domain-containing protein 4

1

1

High-throughput

0.407

High

310258

LYPD3
Ly6/PLAUR domain-containing protein 3

1

0

High-throughput

0.282

High

331310

ITIH5
Inter-alpha-trypsin inhibitor heavy chain H5

1

0

High-throughput

0.282

High

319481

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

331307

HEAT6
HEAT repeat-containing protein 6

1

0

High-throughput

0.279

Low

331361

CCG2
Voltage-dependent calcium channel gamma-2 subunit

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024