Protein: FEM2
Protein phosphatase fem-2 (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase) (CaM-kinase phosphatase) (CaMKPase) (Feminization of XX and XO animals protein 2) (Sex-determining protein fem-2)

Gene: FEM2, fem-2
Organism: Caenorhabditis elegans
Interactions: 18
UniProt ID: P49594

Gene Ontology (top 5):
GO:0004721 - phosphoprotein phosphatase activity
GO:0004722 - protein serine/threonine phosphatase activity
GO:0006915 - apoptotic process
GO:0007165 - signal transduction
GO:0007530 - sex determination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

603139

FEM1
Sex-determining protein fem-1

3

2

Small-scale

0.657

High

760161

FEM3
Sex-determination protein fem-3

4

0

Small-scale

0.656

High

264250

KCC2D
Calcium/calmodulin-dependent protein kinase type II

1

7

Small-scale

0.647

High

760198

TRA1
Sex-determining transformer protein 1

1

1

Small-scale

0.515

High

884863

SEL10
F-box/WD repeat-containing protein sel-10

1

2

Small-scale

0.515

High

110957

G5ECL3
Pre-RNA processing 21

1

3

High-throughput

0.512

High

884864

Q9BKS1
Elongin-C

1

0

Small-scale

0.493

High

759881

GLH1
ATP-dependent RNA helicase glh-1

1

1

High-throughput

0.479

High

884865

PAR6
Partitioning defective protein 6

1

0

Small-scale

0.458

High

884866

Q9TXM1
Uncharacterized protein

1

1

High-throughput

0.437

High

145114

O01780
Chitin-binding type-2 domain-containing protein

1

0

High-throughput

0.292

High

884859

Q19279
Nematode Specific Peptide family, group B

1

0

High-throughput

0.292

High

884861

Q65ZJ7
protein-disulfide reductase

1

0

High-throughput

0.292

High

884867

Q9XUJ2
Uncharacterized protein

1

0

High-throughput

0.292

High

111422

CASY1
Calsyntenin-1 [Cleaved into: Secreted calsyntenin-1]

1

0

High-throughput

0.257

Low

144830

O01590
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.257

Low

884860

HRD1
E3 ubiquitin-protein ligase hrd-1

1

0

High-throughput

0.251

Low

884862

Q7YWW5
PDZ domain-containing protein

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025