Protein: NEDD8
Ubiquitin-like protein NEDD8 (Neddylin) (Protein NED-8)

Gene: NEDD8, ned-8
Organism: Caenorhabditis elegans
Interactions: 35
UniProt ID: Q93725

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0010629 - negative regulation of gene expression
GO:0019941 - modification-dependent protein catabolic process
GO:0030162 - regulation of proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1164808

CUL3
Cullin-3

2

19

Small-scale

0.768

High

1372640

DCN1
Defective in cullin neddylation protein 1

1

1

Small-scale

0.647

High

1372641

UBC12
NEDD8-conjugating enzyme ubc-12

1

16

Small-scale

0.647

High

1372633

NEDD8
Ubiquitin-like protein NEDD8

1

16

Small-scale

0.618

High

1285910

Q86FN3
Ubiquitin-like protease family profile domain-containing protein

1

6

Small-scale

0.553

High

1372635

MEL26
Protein maternal effect lethal 26

1

7

Small-scale

0.536

High

482121

HSP1
Heat shock protein hsp-1

1

5

Small-scale

0.479

High

714758

EF2
Elongation factor 2

1

3

Small-scale

0.479

High

909822

CYP3
Peptidyl-prolyl cis-trans isomerase 3

1

2

Small-scale

0.479

High

909836

CYP7
Peptidyl-prolyl cis-trans isomerase 7

1

2

Small-scale

0.479

High

910755

TBB2
Tubulin beta-2 chain

1

3

Small-scale

0.479

High

916466

EF1A
Elongation factor 1-alpha

1

3

Small-scale

0.479

High

1372639

Q9TXM1
Uncharacterized protein

1

1

High-throughput

0.479

High

1170036

Q21000
MYOsin heavy chain structural genes

1

0

Small-scale

0.458

High

1171344

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

0

Small-scale

0.458

High

1372638

Q9BL94
Histidine phosphatase family protein

1

0

Small-scale

0.458

High

1166933

RL26
Large ribosomal subunit protein uL24

1

3

Small-scale

0.437

High

1170612

RHO1
Ras-like GTP-binding protein rhoA

1

8

Small-scale

0.437

High

1171282

RS7
Small ribosomal subunit protein eS7

1

4

Small-scale

0.437

High

1176477

RL13A
Large ribosomal subunit protein uL13

1

4

Small-scale

0.437

High

1372636

Q95QD9
Copper transport protein

1

1

Small-scale

0.437

High

1372637

RL7A
Large ribosomal subunit protein eL8

1

4

Small-scale

0.437

High

112841

G5EET8
Up-regulated in Daf-2 domain-containing protein

1

0

Small-scale

0.249

Low

114770

H1ZUX3
RING-type domain-containing protein

1

0

High-throughput

0.249

Low

264060

INX14
Innexin-14

1

0

Small-scale

0.249

Low

759257

YLZ6
Putative esterase F42H10.6

1

0

Small-scale

0.249

Low

785686

NCS2
Neuronal calcium sensor 2

1

0

Small-scale

0.249

Low

1019458

P91871
Fatty acid synthase

1

0

Small-scale

0.249

Low

1068084

GUAA
Probable GMP synthase [glutamine-hydrolyzing]

1

0

Small-scale

0.249

Low

1169720

Q20314
Uncharacterized protein

1

0

Small-scale

0.249

Low

1170059

Q21032
Isocitrate dehydrogenase [NADP]

1

0

Small-scale

0.249

Low

1170895

VATH2
Probable V-type proton ATPase subunit H 2

1

0

Small-scale

0.249

Low

1372634

Q93838
Stress-associated endoplasmic reticulum protein 2

1

0

Small-scale

0.249

Low

1372642

Q9XWH3
Zinc transporter ZIP3

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025