HitPredict

Interactor 1: CUL3 (Q17391)
Cullin-3 (CUL-3)
Gene: cul-3

Interactor 2: NEDD8 (Q93725)
Ubiquitin-like protein NEDD8 (Neddylin) (Protein NED-8)
Gene: ned-8

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	12781129, 17403899
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cullin~ubiquitin, Cullin_Nedd8~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 777 Ce			1 77
+	Hs
		1113199 CUL3_HUMAN (1-777): 0: 850: 47.95		NEDD8_HUMAN (1-76): 1.06e-37: 122: 88.16
+	Hs
		987016 CUL3_HUMAN (1-777): 0: 850: 47.95		RS27A_HUMAN (1-76): 5.08e-36: 120: 61.84
+	Dm
		1304389 Q8IP45_DROME (16-777): 0: 827: 47.65		NEDD8_DROME (1-76): 1.25e-34: 114: 89.47
+	At
		1456480 CUL3A_ARATH (7-777): 0: 819: 40.75		RUB1_ARATH (2-77): 5.19e-27: 97.5: 80.26
+	Hs
		1114845 CUL4A_HUMAN (10-777): 0: 785: 33.68		NEDD8_HUMAN (1-76): 1.06e-37: 122: 88.16
+	Hs
		987017 CUL4A_HUMAN (10-777): 0: 785: 33.68		RS27A_HUMAN (1-76): 5.08e-36: 120: 61.84
+	At
		1423046 CUL3B_ARATH (7-777): 0: 804: 40.88		RUB1_ARATH (2-77): 5.19e-27: 97.5: 80.26
+	Hs
		987352 CUL4A_HUMAN (10-777): 0: 785: 33.68		RL40_HUMAN (1-76): 9.9e-34: 113: 61.84
+	Hs
		1115212 CUL4B_HUMAN (5-777): 0: 771: 34.11		NEDD8_HUMAN (1-76): 1.06e-37: 122: 88.16
+	Hs
		987018 CUL4B_HUMAN (5-777): 0: 771: 34.11		RS27A_HUMAN (1-76): 5.08e-36: 120: 61.84
+	Hs
		507190 CUL4B_HUMAN (5-777): 0: 771: 34.11		UBB_HUMAN (1-76): 1.2e-30: 108: 61.84
+	Hs
		1112507 CUL1_HUMAN (19-777): 0: 697: 27.15		NEDD8_HUMAN (1-76): 1.06e-37: 122: 88.16
+	At
		1375606 CUL1_ARATH (20-777): 0: 700: 25.48		RUB1_ARATH (2-77): 5.19e-27: 97.5: 80.26
+	At
		1341732 CUL1_ARATH (20-777): 0: 700: 25.48		RUB2_ARATH (2-76): 2.67e-25: 92.9: 80.00
+	Hs
		1112853 CUL2_HUMAN (17-777): 0: 664: 25.66		NEDD8_HUMAN (1-76): 1.06e-37: 122: 88.16
+	Dm
		1173427 CUL1_DROME (1-777): 0: 665: 24.37		NEDD8_DROME (1-76): 1.25e-34: 114: 89.47
+	Sp
		151343 CUL1_SCHPO (30-777): 0: 638: 27.74		UBL1_SCHPO (1-76): 1.22e-32: 109: 82.90
+	Sp
		154027 CUL3_SCHPO (8-777): 0: 632: 32.23		UBL1_SCHPO (1-76): 1.22e-32: 109: 82.90
+	Hs
		1154894 CUL5_HUMAN (27-777): 0: 556: 21.92		NEDD8_HUMAN (1-76): 1.06e-37: 122: 88.16