Protein: ACVR1
Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I)

Gene: ACVR1
Organism: Homo sapiens
Interactions: 63
UniProt ID: Q04771

Gene Ontology (top 5):
GO:0001569 - branching involved in blood vessel morphogenesis
GO:0001701 - in utero embryonic development
GO:0001702 - gastrulation with mouth forming second
GO:0001707 - mesoderm formation
GO:0001755 - neural crest cell migration

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

738336

BMR1A
Bone morphogenetic protein receptor type-1A

4

20

Small-scale

0.899

High

981119

BMPR2
Bone morphogenetic protein receptor type-2

3

20

Small-scale

0.868

High

739526

ACVL1
Serine/threonine-protein kinase receptor R3

3

19

High-throughput

0.861

High

738444

ACV1B
Activin receptor type-1B

3

19

Small-scale

0.847

High

574199

BMP7
Bone morphogenetic protein 7

2

20

Small-scale

0.778

High

646030

AVR2A
Activin receptor type-2A

2

20

Small-scale

0.754

High

981134

LRIQ1
Leucine-rich repeat and IQ domain-containing protein 1

2

20

High-throughput

0.726

High

383757

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.691

High

412142

FYN
Tyrosine-protein kinase Fyn

1

4

High-throughput

0.691

High

537732

INSRR
Insulin receptor-related protein

1

20

High-throughput

0.691

High

674401

UFO
Tyrosine-protein kinase receptor UFO

1

7

High-throughput

0.691

High

981118

AVR2B
Activin receptor type-2B

1

20

High-throughput

0.691

High

981128

RN149
E3 ubiquitin-protein ligase RNF149

3

11

High-throughput

0.667

High

981129

TGFA1
Transforming growth factor-beta receptor-associated protein 1

3

5

High-throughput

0.667

High

602929

BMP6
Bone morphogenetic protein 6

1

20

Small-scale

0.647

High

981114

ACVR1
Activin receptor type-1

1

19

Small-scale

0.647

High

981142

GDF2
Growth/differentiation factor 2

1

20

Small-scale

0.647

High

981121

SMAD1
Mothers against decapentaplegic homolog 1

3

20

Small-scale

0.642

High

981131

ASTRA
Protein Aster-A

3

0

High-throughput

0.638

High

981133

MRAP2
Melanocortin-2 receptor accessory protein 2

2

5

High-throughput

0.628

High

981140

CD320
CD320 antigen

2

2

High-throughput

0.628

High

739957

TGFR2
TGF-beta receptor type-2

1

18

Small-scale

0.621

High

439885

INHBA
Inhibin beta A chain

1

20

Small-scale

0.618

High

792917

GDF5
Growth/differentiation factor 5

1

20

Small-scale

0.618

High

923822

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

1

7

Small-scale

0.618

High

981141

EPHA6
Ephrin type-A receptor 6

1

13

Small-scale

0.618

High

738532

TGFR1
TGF-beta receptor type-1

1

19

High-throughput

0.590

High

206953

SMAD6
Mothers against decapentaplegic homolog 6

2

20

Small-scale

0.584

High

981137

SMAD5
Mothers against decapentaplegic homolog 5

2

20

Small-scale

0.584

High

981139

SMUF1
E3 ubiquitin-protein ligase SMURF1

2

19

Small-scale

0.584

High

981130

OSTF1
Osteoclast-stimulating factor 1

1

10

High-throughput

0.553

High

121475

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

7

High-throughput

0.536

High

154348

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

10

High-throughput

0.536

High

981124

KCNKI
Potassium channel subfamily K member 18

1

5

High-throughput

0.536

High

981135

OPALI
Opalin

1

3

High-throughput

0.536

High

981136

MYADM
Myeloid-associated differentiation marker

1

1

High-throughput

0.536

High

981143

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

4

High-throughput

0.536

High

981148

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

5

High-throughput

0.536

High

526886

TDGF1
Protein Cripto

1

7

Small-scale

0.501

High

981115

BAMBI
BMP and activin membrane-bound inhibitor homolog

1

5

Small-scale

0.501

High

981146

FBX7
F-box only protein 7

1

1

High-throughput

0.501

High

981126

NRSN1
Neurensin-1

1

2

High-throughput

0.489

High

826402

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

1

1

Small-scale

0.481

High

130857

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

4

Small-scale

0.479

High

167350

SMAD7
Mothers against decapentaplegic homolog 7

1

20

Small-scale

0.479

High

571117

EGLN
Endoglin

1

12

Small-scale

0.479

High

981116

SQSTM
Sequestosome-1

1

4

Small-scale

0.479

High

981117

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

981120

T22D1
TSC22 domain family protein 1

1

6

Small-scale

0.479

High

981122

DCAF6
DDB1- and CUL4-associated factor 6

1

4

High-throughput

0.479

High

981123

RGMB
Repulsive guidance molecule B

1

6

Small-scale

0.479

High

981127

IGSF1
Immunoglobulin superfamily member 1

1

7

Small-scale

0.479

High

981144

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

Small-scale

0.479

High

981147

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

14

Small-scale

0.479

High

940811

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

981145

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

High-throughput

0.458

High

684650

STIP1
Stress-induced-phosphoprotein 1

1

2

Small-scale

0.457

High

981132

OTUB1
Ubiquitin thioesterase OTUB1

1

4

Small-scale

0.457

High

602248

CD9
CD9 antigen

1

4

High-throughput

0.445

High

654276

CALX
Calnexin

1

5

High-throughput

0.437

High

981125

PEG10
Retrotransposon-derived protein PEG10

1

8

Small-scale

0.437

High

981138

ARV1
Protein ARV1

3

0

High-throughput

0.347

High


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Last updated: 15 Jul 2024