Protein: EXOSX
Exosome complex component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2)

Gene: EXOSX, EXOSC10
Organism: Homo sapiens
Interactions: 217
UniProt ID: Q01780

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

966400

C1D
Nuclear nucleic acid-binding protein C1D

5

0

Small-scale

0.887

High

786929

MTREX
Exosome RNA helicase MTR4

2

5

High-throughput

0.754

High

966487

EXOS4
Exosome complex component RRP41

8

9

Small-scale

0.752

High

966490

EXOS3
Exosome complex component RRP40

8

1

Small-scale

0.750

High

966407

EXOS7
Exosome complex component RRP42

8

11

Small-scale

0.748

High

966489

EXOS5
Exosome complex component RRP46

7

11

Small-scale

0.747

High

966509

EXOS1
Exosome complex component CSL4

7

8

Small-scale

0.745

High

966453

EXOS8
Exosome complex component RRP43

7

11

Small-scale

0.745

High

966399

EXOS2
Exosome complex component RRP4

6

5

Small-scale

0.727

High

966385

EXOSX
Exosome complex component 10

2

5

Small-scale

0.726

High

966390

EXOS9
Exosome complex component RRP45

5

12

Small-scale

0.706

High

966462

MPH6
M-phase phosphoprotein 6

6

0

Small-scale

0.698

High

966514

RBM7
RNA-binding protein 7

4

2

High-throughput

0.694

High

966507

RRP44
Exosome complex exonuclease RRP44

4

5

Small-scale

0.687

High

966418

EXOS6
Exosome complex component MTR3

4

11

Small-scale

0.674

High

966431

ZCH18
Zinc finger CCCH domain-containing protein 18

3

2

High-throughput

0.667

High

966442

DI3L1
DIS3-like exonuclease 1

3

5

Small-scale

0.667

High

966412

SKI2
Superkiller complex protein 2

1

4

High-throughput

0.656

High

966413

IF16
Gamma-interferon-inducible protein 16

3

2

High-throughput

0.656

High

294725

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.618

High

966473

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.618

High

346555

MYC
Myc proto-oncogene protein

3

0

High-throughput

0.613

High

902530

SUMO2
Small ubiquitin-related modifier 2

2

4

High-throughput

0.602

High

418183

NPM
Nucleophosmin

2

0

High-throughput

0.602

High

571408

DDX5
Probable ATP-dependent RNA helicase DDX5

1

0

Small-scale

0.586

High

966405

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.586

High

227201

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

255694

OBSL1
Obscurin-like protein 1

2

2

High-throughput

0.584

High

552522

RFA2
Replication protein A 32 kDa subunit

2

1

High-throughput

0.584

High

650987

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

3

High-throughput

0.584

High

720256

RFA3
Replication protein A 14 kDa subunit

2

1

High-throughput

0.584

High

916526

RS6
Small ribosomal subunit protein eS6

2

1

High-throughput

0.584

High

966484

RENT2
Regulator of nonsense transcripts 2

2

0

Small-scale

0.575

High

726755

FUS
RNA-binding protein FUS

2

2

High-throughput

0.571

High

244303

BRD4
Bromodomain-containing protein 4

2

0

High-throughput

0.559

High

966423

ZCHC8
Zinc finger CCHC domain-containing protein 8

2

0

High-throughput

0.559

High

966471

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

2

0

High-throughput

0.559

High

966475

AICDA
Single-stranded DNA cytosine deaminase

2

0

Small-scale

0.559

High

966497

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.554

High

966445

TITIN
Titin

1

2

High-throughput

0.541

High

180290

MAGB2
Melanoma-associated antigen B2

1

1

High-throughput

0.536

High

369427

ESR1
Estrogen receptor

1

6

High-throughput

0.536

High

613421

SFPQ
Splicing factor, proline- and glutamine-rich

1

2

High-throughput

0.536

High

781728

MNDA
Myeloid cell nuclear differentiation antigen

1

2

High-throughput

0.536

High

796547

KSYK
Tyrosine-protein kinase SYK

1

1

High-throughput

0.536

High

907851

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

929404

RACK1
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.536

High

962015

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

2

High-throughput

0.536

High

966389

FAK1
Focal adhesion kinase 1

1

2

High-throughput

0.536

High

966398

CUL3
Cullin-3

1

2

High-throughput

0.536

High

966432

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

966443

PSPC1
Paraspeckle component 1

1

2

High-throughput

0.536

High

966460

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

966506

DRG1
Developmentally-regulated GTP-binding protein 1

1

2

High-throughput

0.536

High

779262

CCNF
Cyclin-F

1

1

High-throughput

0.515

High

585446

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

0

High-throughput

0.513

High

736408

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

805962

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

850906

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.513

High

899159

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.513

High

966388

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.513

High

966397

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

966503

SRPK3
SRSF protein kinase 3

1

0

High-throughput

0.513

High

966517

OAS3
2'-5'-oligoadenylate synthase 3

1

0

High-throughput

0.513

High

966392

SSRP1
FACT complex subunit SSRP1

1

4

High-throughput

0.508

High

966396

TADBP
TAR DNA-binding protein 43

1

2

High-throughput

0.508

High

966411

NOMO1
BOS complex subunit NOMO1

1

1

High-throughput

0.508

High

966452

RPE
Ribulose-phosphate 3-epimerase

1

1

High-throughput

0.508

High

966455

FXRD1
FAD-dependent oxidoreductase domain-containing protein 1

1

1

High-throughput

0.508

High

966476

XRN2
5'-3' exoribonuclease 2

1

2

High-throughput

0.508

High

966449

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

High-throughput

0.501

High

285159

DXO
Decapping and exoribonuclease protein

1

0

High-throughput

0.486

High

321395

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

0

High-throughput

0.486

High

966401

SCRIB
Protein scribble homolog

1

0

High-throughput

0.486

High

966427

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

0

High-throughput

0.486

High

966429

URP2
Fermitin family homolog 3

1

0

High-throughput

0.486

High

966436

CHSS2
Chondroitin sulfate synthase 2

1

0

High-throughput

0.486

High

966464

CIB1
Calcium and integrin-binding protein 1

1

0

High-throughput

0.486

High

966481

PGES2
Prostaglandin E synthase 2

1

0

High-throughput

0.486

High

966499

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

0

High-throughput

0.486

High

966504

B9D1
B9 domain-containing protein 1

1

0

High-throughput

0.486

High

966505

RUVB2
RuvB-like 2

1

0

High-throughput

0.486

High

966508

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

0

High-throughput

0.486

High

297487

TOX4
TOX high mobility group box family member 4

1

4

High-throughput

0.481

High

676661

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

2

High-throughput

0.481

High

966414

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.481

High

966437

XRN1
5'-3' exoribonuclease 1

1

2

High-throughput

0.481

High

966516

UBP16
Ubiquitin carboxyl-terminal hydrolase 16

1

3

High-throughput

0.481

High

125386

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.479

High

133156

MPP10
U3 small nucleolar ribonucleoprotein protein MPP10

1

3

High-throughput

0.479

High

177491

NVL
Nuclear valosin-containing protein-like

1

3

High-throughput

0.479

High

179604

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

2

High-throughput

0.479

High

202633

TXNL1
Thioredoxin-like protein 1

1

2

High-throughput

0.479

High

230342

ZC3H1
Zinc finger C3H1 domain-containing protein

1

1

High-throughput

0.479

High

273578

UTP20
Small subunit processome component 20 homolog

1

1

High-throughput

0.479

High

374072

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

386552

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

442079

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.479

High

487343

ANDR
Androgen receptor

1

6

High-throughput

0.479

High

523680

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.479

High

569610

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

582233

NUCL
Nucleolin

1

2

High-throughput

0.479

High

665862

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

2

High-throughput

0.479

High

684642

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

749388

BRCA1
Breast cancer type 1 susceptibility protein

1

4

High-throughput

0.479

High

793908

MATR3
Matrin-3

1

1

High-throughput

0.479

High

808525

YAP1
Transcriptional coactivator YAP1

1

3

High-throughput

0.479

High

817934

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

850002

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

4

High-throughput

0.479

High

853572

IMA5
Importin subunit alpha-5

1

1

High-throughput

0.479

High

856994

THOP1
Thimet oligopeptidase

1

1

High-throughput

0.479

High

870759

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

903139

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.479

High

908395

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

917132

H4
Histone H4

1

1

High-throughput

0.479

High

918297

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

922127

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.479

High

934670

H31
Histone H3.1

1

2

High-throughput

0.479

High

940682

NOP14
Nucleolar protein 14

1

1

High-throughput

0.479

High

944744

RED1
Double-stranded RNA-specific editase 1

1

4

High-throughput

0.479

High

966393

ARL16
ADP-ribosylation factor-like protein 16

1

5

High-throughput

0.479

High

966394

TBL3
Transducin beta-like protein 3

1

6

High-throughput

0.479

High

966395

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

966404

BMS1
Ribosome biogenesis protein BMS1 homolog

1

3

High-throughput

0.479

High

966408

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

966409

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

966410

WDR43
WD repeat-containing protein 43

1

7

High-throughput

0.479

High

966417

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

1

High-throughput

0.479

High

966421

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

966422

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.479

High

966425

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

966428

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

966433

WDR75
WD repeat-containing protein 75

1

7

High-throughput

0.479

High

966435

SLX4
Structure-specific endonuclease subunit SLX4

1

3

High-throughput

0.479

High

966438

SIR6
NAD-dependent protein deacylase sirtuin-6

1

4

High-throughput

0.479

High

966439

PAPD5
Terminal nucleotidyltransferase 4B

1

5

High-throughput

0.479

High

966440

WDR36
WD repeat-containing protein 36

1

7

High-throughput

0.479

High

966444

DNJC9
DnaJ homolog subfamily C member 9

1

1

High-throughput

0.479

High

966448

RENT1
Regulator of nonsense transcripts 1

1

6

Small-scale

0.479

High

966450

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.479

High

966451

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

5

High-throughput

0.479

High

966456

RN185
E3 ubiquitin-protein ligase RNF185

1

4

High-throughput

0.479

High

966457

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

966459

RANB9
Ran-binding protein 9

1

1

High-throughput

0.479

High

966461

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

1

High-throughput

0.479

High

966463

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

1

High-throughput

0.479

High

966466

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

2

High-throughput

0.479

High

966467

RIOK1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.479

High

966468

NOC4L
Nucleolar complex protein 4 homolog

1

3

High-throughput

0.479

High

966469

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

1

High-throughput

0.479

High

966474

WWTR1
WW domain-containing transcription regulator protein 1

1

3

High-throughput

0.479

High

966478

ZN106
Zinc finger protein 106

1

3

High-throughput

0.479

High

966479

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

966480

HEAT1
HEAT repeat-containing protein 1

1

1

High-throughput

0.479

High

966485

RC3H2
Roquin-2

1

3

High-throughput

0.479

High

966486

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

1

High-throughput

0.479

High

966488

BRD7
Bromodomain-containing protein 7

1

1

High-throughput

0.479

High

966492

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

4

High-throughput

0.479

High

966493

ARL8B
ADP-ribosylation factor-like protein 8B

1

1

High-throughput

0.479

High

966498

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

966500

HECD1
E3 ubiquitin-protein ligase HECTD1

1

3

High-throughput

0.479

High

966502

WDR3
WD repeat-containing protein 3

1

7

High-throughput

0.479

High

966513

HBS1L
HBS1-like protein

1

2

High-throughput

0.479

High

966496

PALS2
Protein PALS2

1

0

High-throughput

0.460

High

122674

MEN1
Menin

1

0

High-throughput

0.458

High

148696

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

172418

NKRF
NF-kappa-B-repressing factor

1

0

High-throughput

0.458

High

237200

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

298436

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

435050

SP1
Transcription factor Sp1

1

0

High-throughput

0.458

High

603456

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

849184

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

0

High-throughput

0.458

High

877699

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

920150

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

966386

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

966406

MTF1
Metal regulatory transcription factor 1

1

0

High-throughput

0.458

High

966416

PCID2
PCI domain-containing protein 2

1

0

High-throughput

0.458

High

966424

GGYF2
GRB10-interacting GYF protein 2

1

0

High-throughput

0.458

High

966430

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

966434

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

966441

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

966446

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

966454

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

966458

LENG8
Leukocyte receptor cluster member 8

1

0

High-throughput

0.458

High

966465

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

966470

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

966477

REN3A
Regulator of nonsense transcripts 3A

1

0

Small-scale

0.458

High

966482

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.458

High

966491

ANLN
Anillin

1

0

High-throughput

0.458

High

966494

SDA1
Protein SDA1 homolog

1

0

High-throughput

0.458

High

966495

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

966501

CC14A
Dual specificity protein phosphatase CDC14A

1

0

High-throughput

0.458

High

966510

RRP15
RRP15-like protein

1

0

High-throughput

0.458

High

966511

RNF11
RING finger protein 11

1

0

Small-scale

0.458

High

966512

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

966515

RBM8A
RNA-binding protein 8A

1

0

High-throughput

0.458

High

401862

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

496874

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

966403

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.445

High

966447

ESR2
Estrogen receptor beta

1

6

High-throughput

0.445

High

966472

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

966415

NOMO2
BOS complex subunit NOMO2

1

1

High-throughput

0.439

High

966420

MF14B
Hippocampus abundant transcript-like protein 1

1

0

High-throughput

0.438

High

384668

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

674398

UFO
Tyrosine-protein kinase receptor UFO

1

1

High-throughput

0.437

High

966426

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

2

Small-scale

0.437

High

306117

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

0

High-throughput

0.426

High

966387

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.426

High

966391

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.426

High

966419

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

966483

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

831236

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

615395

KALM
Anosmin-1

1

0

High-throughput

0.279

Low

378465

LCAT
Phosphatidylcholine-sterol acyltransferase

1

0

High-throughput

0.251

Low

738196

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

0

High-throughput

0.249

Low

966402

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024