Protein: XPC
DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125)

Gene: XPC
Organism: Homo sapiens
Interactions: 191
UniProt ID: Q01831

Gene Ontology (top 5):
GO:0000109 - nucleotide-excision repair complex
GO:0000111 - nucleotide-excision repair factor 2 complex
GO:0000404 - heteroduplex DNA loop binding
GO:0000405 - bubble DNA binding
GO:0000720 - pyrimidine dimer repair by nucleotide-excision repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

872258

RD23B
UV excision repair protein RAD23 homolog B

18

15

Small-scale

0.986

High

872143

RD23A
UV excision repair protein RAD23 homolog A

6

14

Small-scale

0.950

High

781540

CETN2
Centrin-2

11

4

Small-scale

0.757

High

455334

PARP1
Poly [ADP-ribose] polymerase 1

6

2

Small-scale

0.736

High

171130

CETN3
Centrin-3

5

4

Small-scale

0.716

High

967059

DDB2
DNA damage-binding protein 2

5

3

Small-scale

0.714

High

552525

RFA2
Replication protein A 32 kDa subunit

5

1

High-throughput

0.714

High

697736

TF2H1
General transcription factor IIH subunit 1

5

3

Small-scale

0.709

High

555418

H2AX
Histone H2AX

4

6

Small-scale

0.694

High

917133

H4
Histone H4

4

1

High-throughput

0.694

High

934673

H31
Histone H3.1

4

2

High-throughput

0.686

High

523681

XRCC6
X-ray repair cross-complementing protein 6

3

2

High-throughput

0.675

High

967019

SSRP1
FACT complex subunit SSRP1

3

1

High-throughput

0.675

High

967023

RFA4
Replication protein A 30 kDa subunit

3

1

High-throughput

0.667

High

967062

H2B1A
Histone H2B type 1-A

3

6

High-throughput

0.667

High

260847

H2AY
Core histone macro-H2A.1

3

8

High-throughput

0.662

High

584585

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

3

1

Small-scale

0.660

High

967081

WDR76
WD repeat-containing protein 76

3

3

High-throughput

0.656

High

967061

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

2

Small-scale

0.639

High

417817

DPOLB
DNA polymerase beta

3

0

High-throughput

0.638

High

967051

APLF
Aprataxin and PNK-like factor

3

0

High-throughput

0.638

High

967071

SPI2B
Spindlin-2B

3

0

High-throughput

0.638

High

967087

RN146
E3 ubiquitin-protein ligase RNF146

3

0

High-throughput

0.638

High

967085

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

3

0

High-throughput

0.634

High

967105

SP16H
FACT complex subunit SPT16

3

0

High-throughput

0.634

High

470354

H2A1
Histone H2A type 1

2

5

High-throughput

0.628

High

617947

H2B1O
Histone H2B type 1-O

2

6

High-throughput

0.628

High

886087

H2B1D
Histone H2B type 1-D

2

6

High-throughput

0.628

High

967020

CETN1
Centrin-1

2

4

High-throughput

0.628

High

967048

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

2

2

High-throughput

0.628

High

967072

MACD1
ADP-ribose glycohydrolase MACROD1

2

2

High-throughput

0.628

High

967092

H2AW
Core histone macro-H2A.2

2

8

High-throughput

0.628

High

967094

PARP2
Poly [ADP-ribose] polymerase 2

2

1

High-throughput

0.628

High

650990

RFA1
Replication protein A 70 kDa DNA-binding subunit

3

0

Small-scale

0.619

High

391659

H2A1B
Histone H2A type 1-B/E

2

5

High-throughput

0.611

High

952281

H33
Histone H3.3

2

2

High-throughput

0.611

High

713080

SDC2
Syndecan-2

2

0

High-throughput

0.602

High

967047

NAA40
N-alpha-acetyltransferase 40

2

0

High-throughput

0.602

High

470000

H2AZ
Histone H2A.Z

2

6

Small-scale

0.601

High

612473

XPA
DNA repair protein complementing XP-A cells

2

1

Small-scale

0.595

High

586690

CSK22
Casein kinase II subunit alpha'

2

0

High-throughput

0.585

High

720259

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.585

High

931592

CSK2B
Casein kinase II subunit beta

2

0

High-throughput

0.585

High

967055

SIR6
NAD-dependent protein deacylase sirtuin-6

2

0

High-throughput

0.585

High

122675

MEN1
Menin

2

1

High-throughput

0.584

High

918298

H2B1C
Histone H2B type 1-C/E/F/G/I

2

6

High-throughput

0.584

High

967016

PO5F1
POU domain, class 5, transcription factor 1

2

1

Small-scale

0.584

High

369430

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

449680

HMGB1
High mobility group protein B1

1

1

Small-scale

0.561

High

967035

DDB1
DNA damage-binding protein 1

2

0

Small-scale

0.559

High

322493

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

0

High-throughput

0.547

High

962736

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.537

High

215338

U3IP2
U3 small nucleolar RNA-interacting protein 2

1

1

High-throughput

0.536

High

304491

ALX3
Homeobox protein aristaless-like 3

1

1

High-throughput

0.536

High

524884

XRCC5
X-ray repair cross-complementing protein 5

1

2

High-throughput

0.536

High

967036

H2A2C
Histone H2A type 2-C

1

5

High-throughput

0.536

High

967037

H2B2E
Histone H2B type 2-E

1

6

High-throughput

0.536

High

967039

LARP7
La-related protein 7

1

1

High-throughput

0.536

High

967041

H2A2A
Histone H2A type 2-A

1

5

High-throughput

0.536

High

967045

H2BWT
Histone H2B type W-T

1

7

High-throughput

0.536

High

967049

H2A2B
Histone H2A type 2-B

1

5

High-throughput

0.536

High

967054

H2B3B
Histone H2B type 3-B

1

6

High-throughput

0.536

High

967079

BAFL
Barrier-to-autointegration factor-like protein

1

1

High-throughput

0.536

High

906994

PRS8
26S proteasome regulatory subunit 8

1

3

Small-scale

0.527

High

967028

BTG3
Protein BTG3

1

0

High-throughput

0.518

High

125874

CDC7
Cell division cycle 7-related protein kinase

1

0

High-throughput

0.513

High

130234

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

1

0

High-throughput

0.513

High

396920

HMGN1
Non-histone chromosomal protein HMG-14

1

0

High-throughput

0.513

High

418184

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

447929

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

518641

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

High-throughput

0.513

High

564866

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.513

High

801088

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

841170

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.513

High

857455

HMGA2
High mobility group protein HMGI-C

1

0

High-throughput

0.513

High

948779

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

967018

EMX2
Homeobox protein EMX2

1

0

High-throughput

0.513

High

967031

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.513

High

967033

RNPS1
RNA-binding protein with serine-rich domain 1

1

0

High-throughput

0.513

High

967052

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

0

High-throughput

0.513

High

967053

CA174
UPF0688 protein C1orf174

1

0

High-throughput

0.513

High

967056

SEN2
tRNA-splicing endonuclease subunit Sen2

1

0

High-throughput

0.513

High

967065

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

967096

PHF8
Histone lysine demethylase PHF8

1

0

High-throughput

0.513

High

967101

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.513

High

967027

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

Small-scale

0.504

High

967099

RT33
Small ribosomal subunit protein mS33

1

0

High-throughput

0.493

High

912146

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

0

High-throughput

0.486

High

967034

SMAD1
Mothers against decapentaplegic homolog 1

1

0

High-throughput

0.486

High

967067

Z512B
Zinc finger protein 512B

1

0

High-throughput

0.486

High

181953

OGG1
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase

1

0

Small-scale

0.480

High

874076

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.480

High

268447

BAF
Barrier-to-autointegration factor

1

1

Small-scale

0.479

High

305168

UBE4B
Ubiquitin conjugation factor E4 B

1

1

Small-scale

0.479

High

377259

GCR
Glucocorticoid receptor

1

2

High-throughput

0.479

High

472847

H2AB2
Histone H2A-Bbd type 2/3

1

6

High-throughput

0.479

High

475643

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

Small-scale

0.479

High

707594

H2B1B
Histone H2B type 1-B

1

6

High-throughput

0.479

High

828196

CENPA
Histone H3-like centromeric protein A

1

2

High-throughput

0.479

High

846936

SMCA4
Transcription activator BRG1

1

1

Small-scale

0.479

High

940795

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

967021

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

Small-scale

0.479

High

967025

ATM
Serine-protein kinase ATM

1

1

Small-scale

0.479

High

967026

ATR
Serine/threonine-protein kinase ATR

1

1

Small-scale

0.479

High

967043

RN111
E3 ubiquitin-protein ligase Arkadia

1

1

Small-scale

0.479

High

967044

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

967057

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.479

High

967060

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

967097

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

1

Small-scale

0.479

High

170340

TIF1A
Transcription intermediary factor 1-alpha

1

0

High-throughput

0.458

High

179606

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

346558

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

374075

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

386554

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

486515

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

569611

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

750227

COIL
Coilin

1

0

High-throughput

0.458

High

890614

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.458

High

959357

VIGLN
Vigilin

1

0

High-throughput

0.458

High

967022

CAF1A
Chromatin assembly factor 1 subunit A

1

0

Small-scale

0.458

High

967024

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

967032

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

967042

ANO7
Anoctamin-7

1

0

Small-scale

0.458

High

967046

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

967058

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

967064

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.458

High

967074

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.458

High

967077

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

967082

CLSPN
Claspin

1

0

Small-scale

0.458

High

967086

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

967093

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

967102

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

133444

NOP56
Nucleolar protein 56

1

3

High-throughput

0.445

High

229369

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

2

High-throughput

0.445

High

281237

RL1D1
Ribosomal L1 domain-containing protein 1

1

1

High-throughput

0.445

High

400855

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.445

High

722219

RFC1
Replication factor C subunit 1

1

1

High-throughput

0.445

High

843614

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.445

High

922527

RL10A
Large ribosomal subunit protein uL1

1

1

High-throughput

0.445

High

967076

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.445

High

967089

DDX18
ATP-dependent RNA helicase DDX18

1

1

High-throughput

0.445

High

967095

MRT4
mRNA turnover protein 4 homolog

1

1

High-throughput

0.445

High

967100

NOP58
Nucleolar protein 58

1

3

High-throughput

0.445

High

242431

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

0

High-throughput

0.426

High

283494

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.426

High

321056

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

442080

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.426

High

508462

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.426

High

508949

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.426

High

563072

YBOX3
Y-box-binding protein 3

1

0

High-throughput

0.426

High

574306

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.426

High

575018

RL7
Large ribosomal subunit protein uL30

1

0

High-throughput

0.426

High

642302

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.426

High

647875

MARK3
MAP/microtubule affinity-regulating kinase 3

1

0

High-throughput

0.426

High

760013

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.426

High

773329

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.426

High

802061

NOP2
Probable 28S rRNA

1

0

High-throughput

0.426

High

805963

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.426

High

806287

RL21
Large ribosomal subunit protein eL21

1

0

High-throughput

0.426

High

806485

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.426

High

825169

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.426

High

842460

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.426

High

851199

CCNH
Cyclin-H

1

0

Small-scale

0.426

High

898600

RL26
Large ribosomal subunit protein uL24

1

0

High-throughput

0.426

High

899717

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.426

High

913484

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.426

High

916527

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.426

High

923325

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.426

High

967017

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.426

High

967029

RRP5
Protein RRP5 homolog

1

0

High-throughput

0.426

High

967030

NUMA1
Nuclear mitotic apparatus protein 1

1

0

High-throughput

0.426

High

967038

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.426

High

967040

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.426

High

967066

DDX27
Probable ATP-dependent RNA helicase DDX27

1

0

High-throughput

0.426

High

967068

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.426

High

967069

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.426

High

967070

EBP2
Probable rRNA-processing protein EBP2

1

0

High-throughput

0.426

High

967075

HELZ2
3'-5' exoribonuclease HELZ2

1

0

High-throughput

0.426

High

967078

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.426

High

967080

CCD86
Coiled-coil domain-containing protein 86

1

0

High-throughput

0.426

High

967083

SSF1
Suppressor of SWI4 1 homolog

1

0

High-throughput

0.426

High

967084

DDX21
Nucleolar RNA helicase 2

1

0

High-throughput

0.426

High

967088

SPS2L
SPATS2-like protein

1

0

High-throughput

0.426

High

967090

RBM28
RNA-binding protein 28

1

0

High-throughput

0.426

High

967098

NIP7
60S ribosome subunit biogenesis protein NIP7 homolog

1

0

High-throughput

0.426

High

967103

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.426

High

967104

TBL2
Transducin beta-like protein 2

1

1

High-throughput

0.407

High

967063

ZN428
Zinc finger protein 428

1

0

High-throughput

0.279

Low

967091

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.269

Low

967050

CCD71
Coiled-coil domain-containing protein 71

1

0

Small-scale

0.249

Low

967073

CG050
Uncharacterized protein C7orf50

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024