Protein: FRL
Formin-like protein (Formin related in leukocytes)

Gene: FRL
Organism: Drosophila melanogaster
Interactions: 139
UniProt ID: Q9VUC6

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0008360 - regulation of cell shape
GO:0016318 - ommatidial rotation
GO:0016319 - mushroom body development
GO:0016477 - cell migration

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

828034

RAC1
Ras-related protein Rac1

1

20

Small-scale

0.618

High

828061

CDC42
Cdc42 homolog

1

20

Small-scale

0.618

High

1486654

FRL
Formin-like protein

1

14

Small-scale

0.618

High

233560

SPY
Protein sprouty

2

0

High-throughput

0.547

High

661879

FUSED
Serine/threonine-protein kinase fused

1

3

High-throughput

0.541

High

1264447

Q7K0X9
LD23667p

2

2

High-throughput

0.533

High

614961

SYB
Synaptobrevin

2

3

High-throughput

0.521

High

1304920

Q8IPV3
Uncharacterized protein, isoform A

2

1

High-throughput

0.521

High

355994

O96692
small monomeric GTPase

1

12

High-throughput

0.514

High

852984

ACTZ
Actin-related protein 1

1

17

High-throughput

0.514

High

1270260

Q7KY04
small monomeric GTPase

1

10

High-throughput

0.514

High

900674

DSH
Segment polarity protein dishevelled

1

5

Small-scale

0.479

High

1173384

DIAP2
Death-associated inhibitor of apoptosis 2

1

2

High-throughput

0.479

High

1464170

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

High-throughput

0.479

High

1473393

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

1

High-throughput

0.479

High

1486675

SCN60
Sodium channel protein 60E

1

1

High-throughput

0.464

High

1266742

IMD
Protein immune deficiency

1

0

High-throughput

0.458

High

1428071

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.458

High

1463212

FADD
Fas-associated death domain protein

1

0

High-throughput

0.458

High

1483375

MBM
Protein mushroom body miniature

1

0

High-throughput

0.458

High

1486667

PGPLE
Peptidoglycan-recognition protein LE

1

0

High-throughput

0.458

High

1471259

DDX18
Probable ATP-dependent RNA helicase pitchoune

1

1

High-throughput

0.457

High

55831

A1Z9K0
Uncharacterized protein, isoform B

1

2

High-throughput

0.445

High

58115

A1ZBE9
Methionine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.445

High

614378

SGG
Protein kinase shaggy

1

5

High-throughput

0.445

High

911791

POLO
Serine/threonine-protein kinase polo

1

1

High-throughput

0.445

High

1059186

ROP
Protein ROP

1

2

High-throughput

0.445

High

1234132

SARM1
NAD(+) hydrolase sarm1

1

2

High-throughput

0.445

High

1267745

Q7KMQ0
26S proteasome regulatory subunit 7

1

2

High-throughput

0.445

High

1344252

Q8SY53
GH11935p

1

1

High-throughput

0.445

High

1346031

ENA
Protein enabled

1

6

High-throughput

0.445

High

1457460

XPO1
Exportin-1

1

2

High-throughput

0.445

High

1464470

Q9V3V6
26S proteasome regulatory complex subunit p50

1

6

High-throughput

0.445

High

1464885

Q9V405
26S proteasome regulatory subunit 6B

1

1

High-throughput

0.445

High

1474999

IPO9
Importin-9

1

1

High-throughput

0.445

High

1482348

Q9VN44
FI07923p

1

1

High-throughput

0.445

High

1486674

Q9W0L7
ubiquitinyl hydrolase 1

1

2

High-throughput

0.445

High

1486679

SYQ
Probable glutamine--tRNA ligase

1

1

High-throughput

0.445

High

56222

A1ZA03
Pms2

1

1

High-throughput

0.439

High

50257

A1A714
IP17403p

1

1

High-throughput

0.437

High

117924

M9MRE1
PDGF- and VEGF-receptor related, isoform K

1

2

High-throughput

0.437

High

1269267

Q7KTD0
ABC-type glutathione-S-conjugate transporter

1

1

High-throughput

0.437

High

1378442

Q95U21
receptor protein serine/threonine kinase

1

3

High-throughput

0.437

High

1486657

NEDD4
E3 ubiquitin-protein ligase Nedd-4

1

3

High-throughput

0.437

High

1486663

Q9VWJ6
FI03615p

1

1

High-throughput

0.437

High

782812

2AAA
Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit

1

0

High-throughput

0.426

High

909884

PFKA
ATP-dependent 6-phosphofructokinase

1

0

High-throughput

0.426

High

1464814

Q9V3Z4
GH11341p

1

0

High-throughput

0.426

High

1466775

Q9V9Q4
LD43819p

1

0

High-throughput

0.426

High

1473047

Q9VEP0
Regulatory protein zeste

1

0

High-throughput

0.426

High

1474185

ELP6
Elongator complex protein 6

1

0

High-throughput

0.426

High

1476306

Q9VHL2
T-complex protein 1 subunit eta

1

0

High-throughput

0.426

High

1477851

RAGP1
Ran GTPase-activating protein

1

0

High-throughput

0.426

High

1479432

NFS1
Cysteine desulfurase, mitochondrial

1

0

High-throughput

0.426

High

1480094

Q9VKZ8
Ubiquitin carboxyl-terminal hydrolase

1

0

High-throughput

0.426

High

1484210

Q9VQI5
Interferon-related developmental regulator 1

1

0

High-throughput

0.426

High

1485445

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.426

High

1486655

AIMP2
Probable aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.426

High

1486658

Q9VW54
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.426

High

1486666

SYRC
Probable arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

303889

O76417
MutL homolog PMS2

1

1

High-throughput

0.417

High

55482

A1Z9E3
Elongation factor Tu

1

1

High-throughput

0.407

High

304278

ERD2
ER lumen protein-retaining receptor

1

1

High-throughput

0.407

High

652116

ATC1
Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type

1

2

High-throughput

0.407

High

704408

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

1

High-throughput

0.407

High

852240

COPB
Coatomer subunit beta

1

5

High-throughput

0.407

High

875302

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.407

High

1057361

ARL2
ADP-ribosylation factor-like protein 2

1

5

High-throughput

0.407

High

1069779

Q0E931
GTP-binding protein 1

1

3

High-throughput

0.407

High

1176367

VATA2
V-type proton ATPase catalytic subunit A isoform 2

1

1

High-throughput

0.407

High

1202337

Q59DP9
Calcium-transporting ATPase

1

3

High-throughput

0.407

High

1236908

Q6NP35
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.407

High

1264052

NUP50
Nuclear pore complex protein Nup50

1

2

High-throughput

0.407

High

1265866

Q7K3J0
T-complex protein 1 subunit theta

1

1

High-throughput

0.407

High

1304546

Q8IPG1
PDGF- and VEGF-receptor related, isoform B

1

2

High-throughput

0.407

High

1344159

Q8SY39
ATP-dependent RNA helicase DDX54

1

1

High-throughput

0.407

High

1344475

Q8SYG3
E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.407

High

1346073

Q8T4G5
AFG3 like matrix AAA peptidase subunit 2, isoform A

1

3

High-throughput

0.407

High

1346285

Q8T8W3
AT21416p

1

1

High-throughput

0.407

High

1378503

Q95U38
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

1

High-throughput

0.407

High

1378653

Q95WY3
Nucleolar protein 56

1

1

High-throughput

0.407

High

1378897

Q960F6
SD03655p

1

1

High-throughput

0.407

High

1465639

Q9V470
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

1

1

High-throughput

0.407

High

1467974

Q9VAH7
N-terminal kinase-like protein

1

3

High-throughput

0.407

High

1472785

Q9VEH0
Aluminum tubes, isoform A

1

10

High-throughput

0.407

High

1473327

ATD3A
ATPase family AAA domain-containing protein 3A homolog

1

7

High-throughput

0.407

High

1476812

ARL8
ADP-ribosylation factor-like protein 8

1

5

High-throughput

0.407

High

1477161

Q9VI53
LD44267p

1

2

High-throughput

0.407

High

1479166

Q9VK56
ABC-type glutathione-S-conjugate transporter

1

1

High-throughput

0.407

High

1481111

Q9VLS7
LD21067p

1

1

High-throughput

0.407

High

1483296

Q9VPJ7
FI05267p

1

1

High-throughput

0.407

High

1486661

Q9VWI2
N(Alpha)-acetyltransferase 15/16, isoform A

1

1

High-throughput

0.407

High

1486662

Q9VWJ1
Uncharacterized protein, isoform A

1

1

High-throughput

0.407

High

1486664

Q9VWL0
Mec2

1

2

High-throughput

0.407

High

1486668

Q9VXR5
ATP-binding cassette sub-family F member 2

1

2

High-throughput

0.407

High

1486669

RENT1
Regulator of nonsense transcripts 1 homolog

1

2

High-throughput

0.407

High

1486670

Q9VZ88
AT07585p

1

1

High-throughput

0.407

High

1486672

Q9W0E4
Aminopeptidase

1

2

High-throughput

0.407

High

1486676

Q9W3N1
RH59310p

1

1

High-throughput

0.407

High

1486677

Q9W414
Regulatory particle triple-A ATPase 4

1

2

High-throughput

0.407

High

1377162

Q95R82
SD02746p

2

0

High-throughput

0.298

High

1469147

Q9VBF0
Ras modification protein ERF4

2

0

High-throughput

0.298

High

1486659

Q9VW70
FI21813p1

2

0

High-throughput

0.298

High

1237498

Q6NQZ7
LD40663p

1

0

High-throughput

0.249

Low

53184

A1Z7K8
AaRS-interacting multifunctional protein 1

1

0

High-throughput

0.232

Low

53721

A1Z843
Nodal modulator 3

1

0

High-throughput

0.232

Low

120953

M9PEG6
Zinc transporter 63C, isoform F

1

0

High-throughput

0.232

Low

263417

PENG
Protein penguin

1

0

High-throughput

0.232

Low

360595

COX2
Cytochrome c oxidase subunit 2

1

0

High-throughput

0.232

Low

1070126

Q0E9E2
Pyruvate carboxylase

1

0

High-throughput

0.232

Low

1071058

Q0KIB3
Histone acetyltransferase type B catalytic subunit

1

0

High-throughput

0.232

Low

1173969

ISWI
Chromatin-remodeling complex ATPase chain Iswi

1

0

High-throughput

0.232

Low

1176027

MCM4
DNA replication licensing factor MCM4

1

0

High-throughput

0.232

Low

1263256

Q7JXU4
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.232

Low

1268367

DYM
Dymeclin

1

0

High-throughput

0.232

Low

1268739

CCD1D
Probable cytochrome P450 12d1 distal, mitochondrial

1

0

High-throughput

0.232

Low

1304848

Q8IPU8
BNIP3, isoform B

1

0

High-throughput

0.232

Low

1306301

Q8IRE7
PAN2-PAN3 deadenylation complex subunit PAN3

1

0

High-throughput

0.232

Low

1321465

Q8MSW0
Isoleucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.232

Low

1343176

Q8STG9
DSec61alpha

1

0

High-throughput

0.232

Low

1465147

API5
Apoptosis inhibitor 5 homolog

1

0

High-throughput

0.232

Low

1465205

Q9V434
Asparagine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.232

Low

1465479

Q9V455
Importin subunit alpha

1

0

High-throughput

0.232

Low

1468496

Q9VAW3
glutamine--fructose-6-phosphate transaminase

1

0

High-throughput

0.232

Low

1471690

Q9VDK7
Signal recognition particle subunit SRP72

1

0

High-throughput

0.232

Low

1477471

DDX47
ATP-dependent RNA helicase DDX47

1

0

High-throughput

0.232

Low

1478325

Q9VJD1
Glucosidase 2 subunit beta

1

0

High-throughput

0.232

Low

1480048

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.232

Low

1481498

Q9VM57
Septin interacting protein 2, isoform A

1

0

High-throughput

0.232

Low

1484355

Q9VQL7
Fatty acid synthase

1

0

High-throughput

0.232

Low

1485371

Q9VS47
Lysosomal dipeptide transporter MFSD1

1

0

High-throughput

0.232

Low

1485765

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.232

Low

1486656

Q9VV75
AT02348p

1

0

High-throughput

0.232

Low

1486660

IDH3A
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

1

0

High-throughput

0.232

Low

1486665

Q9VXK5
Putative rRNA methyltransferase

1

0

High-throughput

0.232

Low

1486671

Q9VZU8
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

High-throughput

0.232

Low

1486673

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.232

Low

1486678

Q9XZ53
dolichyl-diphosphooligosaccharide--protein glycotransferase

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025