Protein: DUS6
Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)

Gene: DUS6, DUSP6
Organism: Homo sapiens
Interactions: 122
UniProt ID: Q16828

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001933 - negative regulation of protein phosphorylation
GO:0004725 - protein tyrosine phosphatase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

658961

MK01
Mitogen-activated protein kinase 1

12

20

Small-scale

0.975

High

647597

MK03
Mitogen-activated protein kinase 3

8

20

Small-scale

0.968

High

1088004

DUS6
Dual specificity protein phosphatase 6

2

15

High-throughput

0.754

High

1088038

DUS9
Dual specificity protein phosphatase 9

2

16

High-throughput

0.754

High

1088033

SRPK1
SRSF protein kinase 1

1

0

High-throughput

0.697

High

1088048

F217B
Protein FAM217B

3

0

High-throughput

0.638

High

678628

METK2
S-adenosylmethionine synthase isoform type-2

3

1

High-throughput

0.633

High

789814

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

3

10

High-throughput

0.633

High

848385

IRAK1
Interleukin-1 receptor-associated kinase 1

1

2

High-throughput

0.618

High

1027857

DUS8
Dual specificity protein phosphatase 8

1

16

High-throughput

0.618

High

1082560

MK14
Mitogen-activated protein kinase 14

1

20

Small-scale

0.618

High

1088005

DUS7
Dual specificity protein phosphatase 7

1

16

High-throughput

0.618

High

1088025

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

16

High-throughput

0.618

High

1088031

AURKB
Aurora kinase B

1

3

High-throughput

0.618

High

1088041

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

8

Small-scale

0.618

High

789024

TXK
Tyrosine-protein kinase TXK

2

7

High-throughput

0.606

High

388476

HSPB1
Heat shock protein beta-1

2

6

High-throughput

0.571

High

502157

BIP
Endoplasmic reticulum chaperone BiP

2

6

High-throughput

0.571

High

504154

HSP7C
Heat shock cognate 71 kDa protein

2

4

High-throughput

0.571

High

564086

HSP76
Heat shock 70 kDa protein 6

2

4

High-throughput

0.571

High

643870

SYVC
Valine--tRNA ligase

2

3

High-throughput

0.571

High

751652

GRP75
Stress-70 protein, mitochondrial

2

7

High-throughput

0.571

High

770857

TCPZ
T-complex protein 1 subunit zeta

2

6

High-throughput

0.571

High

842887

TCPQ
T-complex protein 1 subunit theta

2

9

High-throughput

0.571

High

843217

TCPD
T-complex protein 1 subunit delta

2

6

High-throughput

0.571

High

906844

PRS4
26S proteasome regulatory subunit 4

2

4

High-throughput

0.571

High

922064

RL39
Large ribosomal subunit protein eL39

2

1

High-throughput

0.571

High

943250

TCPB
T-complex protein 1 subunit beta

2

4

High-throughput

0.571

High

1030271

G3BP1
Ras GTPase-activating protein-binding protein 1

2

2

High-throughput

0.571

High

1053867

CAPR1
Caprin-1

2

3

High-throughput

0.571

High

1088056

G3BP2
Ras GTPase-activating protein-binding protein 2

2

2

High-throughput

0.571

High

547082

EZRI
Ezrin

2

0

High-throughput

0.547

High

788848

RS27
Small ribosomal subunit protein eS27

2

0

High-throughput

0.547

High

843700

FXR1
RNA-binding protein FXR1

2

0

High-throughput

0.547

High

1088022

SERB1
SERPINE1 mRNA-binding protein 1

2

0

High-throughput

0.547

High

1070972

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.541

High

1088016

MAEA
E3 ubiquitin-protein transferase MAEA

1

4

High-throughput

0.536

High

1088019

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

3

High-throughput

0.536

High

833232

TMEDA
Transmembrane emp24 domain-containing protein 10

2

1

High-throughput

0.521

High

1088037

MDFI
MyoD family inhibitor

1

0

High-throughput

0.518

High

394812

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.515

High

1088052

ZN212
Zinc finger protein 212

1

1

Small-scale

0.508

High

666607

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.494

High

968391

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.494

High

1088015

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.494

High

1088020

LMTK2
Serine/threonine-protein kinase LMTK2

1

20

High-throughput

0.494

High

1088021

TEX11
Testis-expressed protein 11

1

1

High-throughput

0.494

High

1088030

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.493

High

1088035

PHB2
Prohibitin-2

1

0

High-throughput

0.493

High

169089

ARPC3
Actin-related protein 2/3 complex subunit 3

1

2

High-throughput

0.479

High

301841

TRI37
E3 ubiquitin-protein ligase TRIM37

1

6

Small-scale

0.479

High

391406

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

16

High-throughput

0.479

High

437375

4F2
Amino acid transporter heavy chain SLC3A2

1

3

High-throughput

0.479

High

437758

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

1

2

High-throughput

0.479

High

444739

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

16

High-throughput

0.479

High

525519

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

3

High-throughput

0.479

High

585964

SPEE
Spermidine synthase

1

6

High-throughput

0.479

High

588611

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

3

High-throughput

0.479

High

803927

NSF
Vesicle-fusing ATPase

1

5

High-throughput

0.479

High

845857

RAB13
Ras-related protein Rab-13

1

2

High-throughput

0.479

High

868517

ATX1
Ataxin-1

1

4

Small-scale

0.479

High

891406

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

1

High-throughput

0.479

High

896628

RAB14
Ras-related protein Rab-14

1

2

High-throughput

0.479

High

926593

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

14

High-throughput

0.479

High

926689

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

16

High-throughput

0.479

High

966708

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

2

High-throughput

0.479

High

968582

TAGL
Transgelin

1

4

Small-scale

0.479

High

979307

UBXN1
UBX domain-containing protein 1

1

3

High-throughput

0.479

High

1028310

NDK3
Nucleoside diphosphate kinase 3

1

6

High-throughput

0.479

High

1088011

S27A4
Long-chain fatty acid transport protein 4

1

1

High-throughput

0.479

High

1088013

TRI65
E3 ubiquitin-protein ligase TRIM65

1

4

Small-scale

0.479

High

1088017

HDDC2
5'-deoxynucleotidase HDDC2

1

2

High-throughput

0.479

High

1088029

TRI11
E3 ubiquitin-protein ligase TRIM11

1

2

Small-scale

0.479

High

1088034

PARK7
Parkinson disease protein 7

1

6

High-throughput

0.479

High

1088036

CHP1
Calcineurin B homologous protein 1

1

3

High-throughput

0.479

High

1088046

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

2

High-throughput

0.479

High

1088047

AAAS
Aladin

1

2

High-throughput

0.479

High

1088050

KBRS2
NF-kappa-B inhibitor-interacting Ras-like protein 2

1

10

High-throughput

0.479

High

1088051

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

1

High-throughput

0.479

High

1088055

VPS4A
Vacuolar protein sorting-associated protein 4A

1

6

High-throughput

0.479

High

1088057

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

3

High-throughput

0.479

High

1088059

SRPRB
Signal recognition particle receptor subunit beta

1

12

High-throughput

0.479

High

230143

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

0

High-throughput

0.458

High

238798

UGDH
UDP-glucose 6-dehydrogenase

1

0

High-throughput

0.458

High

378537

OAT
Ornithine aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

959942

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

1037954

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.458

High

1088006

DCAF6
DDB1- and CUL4-associated factor 6

1

0

High-throughput

0.458

High

1088043

CNO10
CCR4-NOT transcription complex subunit 10

1

0

High-throughput

0.458

High

1088044

RDH14
Retinol dehydrogenase 14

1

0

High-throughput

0.458

High

242173

TI17B
Mitochondrial import inner membrane translocase subunit Tim17-B

1

5

High-throughput

0.437

High

438770

SRPRA
Signal recognition particle receptor subunit alpha

1

2

High-throughput

0.437

High

565364

TMM11
Transmembrane protein 11, mitochondrial

1

2

High-throughput

0.437

High

654375

CALX
Calnexin

1

2

High-throughput

0.437

High

844544

RAB5C
Ras-related protein Rab-5C

1

8

High-throughput

0.437

High

895356

RAB5B
Ras-related protein Rab-5B

1

8

High-throughput

0.437

High

950628

ARF5
ADP-ribosylation factor 5

1

9

High-throughput

0.437

High

1088008

SGMR2
Sigma intracellular receptor 2

1

2

High-throughput

0.437

High

1088010

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

1

2

High-throughput

0.437

High

1088026

FACR1
Fatty acyl-CoA reductase 1

1

2

High-throughput

0.437

High

1088027

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

1

High-throughput

0.437

High

1088028

AP3S1
AP-3 complex subunit sigma-1

1

8

High-throughput

0.437

High

1088032

TMX3
Protein disulfide-isomerase TMX3

1

4

High-throughput

0.437

High

1088042

T126A
Transmembrane protein 126A

1

1

High-throughput

0.437

High

1088045

TPC
Mitochondrial thiamine pyrophosphate carrier

1

1

High-throughput

0.437

High

1088053

SEC63
Translocation protein SEC63 homolog

1

6

High-throughput

0.437

High

1088054

TMCO1
Calcium load-activated calcium channel

1

1

High-throughput

0.437

High

1088058

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

6

High-throughput

0.437

High

1088007

R39L5
Putative ribosomal protein eL39-like 5

1

1

High-throughput

0.407

High

1088012

RL22L
Ribosomal protein eL22-like

2

0

High-throughput

0.298

High

1088023

RP9
Retinitis pigmentosa 9 protein

2

0

High-throughput

0.298

High

1088049

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

2

0

High-throughput

0.298

High

1088018

PAQR2
Adiponectin receptor protein 2

1

0

High-throughput

0.279

Low

123379

GET1
Guided entry of tail-anchored proteins factor 1

1

0

High-throughput

0.249

Low

740919

FDFT
Squalene synthase

1

0

High-throughput

0.249

Low

1088009

GL8D1
Glycosyltransferase 8 domain-containing protein 1

1

0

High-throughput

0.249

Low

1088014

MIC27
MICOS complex subunit MIC27

1

0

High-throughput

0.249

Low

1088024

HUMMR
Protein MGARP

1

0

High-throughput

0.249

Low

1088039

CYBC1
Cytochrome b-245 chaperone 1

1

0

High-throughput

0.249

Low

1088040

TIM21
Mitochondrial import inner membrane translocase subunit Tim21

1

0

High-throughput

0.249

Low

1088060

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024