Protein: PAK5
Serine/threonine-protein kinase PAK 5 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7) (PAK-7)

Gene: PAK5
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q9P286

Gene Ontology (top 5):
GO:0001558 - regulation of cell growth
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

894540

CDC42
Cell division control protein 42 homolog

6

20

Small-scale

0.953

High

160818

AURKA
Aurora kinase A

3

18

High-throughput

0.871

High

256119

OBSL1
Obscurin-like protein 1

3

3

High-throughput

0.871

High

331100

PAK4
Serine/threonine-protein kinase PAK 4

3

16

High-throughput

0.861

High

1289849

INKA1
PAK4-inhibitor INKA1

2

2

High-throughput

0.819

High

861957

PLK1
Serine/threonine-protein kinase PLK1

2

18

High-throughput

0.811

High

1139711

CARL1
F-actin-uncapping protein LRRC16A

2

5

High-throughput

0.811

High

1350164

TBD2B
TBC1 domain family member 2B

2

14

High-throughput

0.811

High

851793

CCNG1
Cyclin-G1

2

5

High-throughput

0.811

High

822392

KC1D
Casein kinase I isoform delta

2

6

High-throughput

0.783

High

1330966

RHOJ
Rho-related GTP-binding protein RhoJ

2

20

High-throughput

0.783

High

1302565

CRBN
Protein cereblon

2

0

High-throughput

0.769

High

1350160

PAK5
Serine/threonine-protein kinase PAK 5

2

19

Small-scale

0.768

High

1335963

TANC2
Protein TANC2

2

2

High-throughput

0.726

High

1329064

CARD9
Caspase recruitment domain-containing protein 9

4

17

High-throughput

0.698

High

1045551

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

13

High-throughput

0.691

High

984128

SRS11
Serine/arginine-rich splicing factor 11

1

0

Small-scale

0.687

High

1263041

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

3

1

High-throughput

0.675

High

1234830

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

3

0

High-throughput

0.654

High

124108

SPT5H
Transcription elongation factor SPT5

2

6

High-throughput

0.628

High

167116

ARHGB
Rho guanine nucleotide exchange factor 11

2

13

High-throughput

0.628

High

1164673

MAP12
Methionine aminopeptidase 1D, mitochondrial

2

2

High-throughput

0.628

High

1273290

ARHG2
Rho guanine nucleotide exchange factor 2

2

20

High-throughput

0.628

High

1294500

GMPPA
Mannose-1-phosphate guanyltransferase alpha

2

2

High-throughput

0.628

High

1350161

UXT
Protein UXT

2

1

High-throughput

0.628

High

925692

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.618

High

1260308

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

2

High-throughput

0.618

High

1327259

CLPB
Mitochondrial disaggregase

1

4

High-throughput

0.618

High

910114

1433E
14-3-3 protein epsilon

2

20

High-throughput

0.611

High

1344041

PDLI7
PDZ and LIM domain protein 7

2

8

High-throughput

0.608

High

905206

1433G
14-3-3 protein gamma

2

20

High-throughput

0.606

High

640650

DDX6
Probable ATP-dependent RNA helicase DDX6

2

8

High-throughput

0.606

High

1087940

PTN21
Tyrosine-protein phosphatase non-receptor type 21

2

13

High-throughput

0.606

High

1102814

CCD57
Coiled-coil domain-containing protein 57

2

20

High-throughput

0.606

High

1218351

ARHGJ
Rho guanine nucleotide exchange factor 19

2

9

High-throughput

0.606

High

1252529

LNX1
E3 ubiquitin-protein ligase LNX

2

20

High-throughput

0.606

High

1293311

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

1

High-throughput

0.606

High

1318462

TSG10
Testis-specific gene 10 protein

2

20

High-throughput

0.606

High

1348554

RM39
Large ribosomal subunit protein mL39

2

0

High-throughput

0.602

High

1266481

PSMF1
Proteasome inhibitor PI31 subunit

2

0

High-throughput

0.593

High

412388

FYN
Tyrosine-protein kinase Fyn

1

20

High-throughput

0.590

High

1243117

CTSR1
Cation channel sperm-associated protein 1

2

0

High-throughput

0.580

High

1350162

GCP4
Gamma-tubulin complex component 4

2

1

High-throughput

0.576

High

612908

FBLN1
Fibulin-1

2

5

High-throughput

0.574

High

235609

VINEX
Vinexin

1

20

High-throughput

0.573

High

1286976

GCC1
GRIP and coiled-coil domain-containing protein 1

1

20

High-throughput

0.573

High

1350167

EXOS1
Exosome complex component CSL4

1

1

High-throughput

0.573

High

1044725

FHL3
Four and a half LIM domains protein 3

2

8

High-throughput

0.555

High

1350163

DNPEP
Aspartyl aminopeptidase

1

0

Small-scale

0.554

High

839199

EMD
Emerin

1

0

High-throughput

0.549

High

1286118

LENG1
Leukocyte receptor cluster member 1

1

0

High-throughput

0.549

High

1310196

LZTS2
Leucine zipper putative tumor suppressor 2

1

20

High-throughput

0.541

High

387644

P53
Cellular tumor antigen p53

1

5

High-throughput

0.536

High

391478

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

10

High-throughput

0.536

High

444803

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

10

High-throughput

0.536

High

647344

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

683779

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.536

High

686087

ARRB2
Beta-arrestin-2

1

5

High-throughput

0.536

High

926721

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

10

High-throughput

0.536

High

927609

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

982573

1433F
14-3-3 protein eta

1

20

High-throughput

0.536

High

1048678

DSG2
Desmoglein-2

1

8

High-throughput

0.536

High

1068687

PLEC
Plectin

1

10

High-throughput

0.536

High

1081764

AINX
Alpha-internexin

1

11

High-throughput

0.536

High

1085086

DREB
Drebrin

1

9

High-throughput

0.536

High

1199703

ZN598
E3 ubiquitin-protein ligase ZNF598

1

4

High-throughput

0.536

High

1273938

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

12

High-throughput

0.536

High

1329215

GAN
Gigaxonin

1

8

High-throughput

0.536

High

416529

S10A9
Protein S100-A9

1

19

High-throughput

0.515

High

678519

S10A7
Protein S100-A7

1

19

High-throughput

0.515

High

721654

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.515

High

422309

NFL
Neurofilament light polypeptide

1

12

High-throughput

0.515

High

557503

PECA1
Platelet endothelial cell adhesion molecule

1

2

High-throughput

0.515

High

792040

HD
Huntingtin

1

6

High-throughput

0.515

High

1295653

MY15B
Unconventional myosin-XVB

1

20

High-throughput

0.515

High

930124

SPT4H
Transcription elongation factor SPT4

1

0

High-throughput

0.513

High

1068958

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.513

High

1132507

FA83B
Protein FAM83B

1

0

High-throughput

0.513

High

1219649

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

High-throughput

0.513

High

1239480

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

1

0

High-throughput

0.513

High

1317880

PUS3
tRNA pseudouridine(38/39) synthase

1

0

High-throughput

0.513

High

1349513

TAP26
Thyroid transcription factor 1-associated protein 26

1

0

High-throughput

0.493

High

941831

RBM6
RNA-binding protein 6

1

6

High-throughput

0.489

High

204079

HTRA2
Serine protease HTRA2, mitochondrial

1

2

High-throughput

0.479

High

265071

MPPB
Mitochondrial-processing peptidase subunit beta

1

5

High-throughput

0.479

High

279220

ATP5H
ATP synthase subunit d, mitochondrial

1

1

High-throughput

0.479

High

360497

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

10

Small-scale

0.479

High

509150

TOP2A
DNA topoisomerase 2-alpha

1

1

Small-scale

0.479

High

513906

DMD
Dystrophin

1

11

Small-scale

0.479

High

539857

IDE
Insulin-degrading enzyme

1

8

High-throughput

0.479

High

669031

PML
Protein PML

1

12

Small-scale

0.479

High

684370

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

809463

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

12

Small-scale

0.479

High

864111

AP2S1
AP-2 complex subunit sigma

1

5

High-throughput

0.479

High

926652

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

12

High-throughput

0.479

High

990372

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1014537

MPPA
Mitochondrial-processing peptidase subunit alpha

1

5

High-throughput

0.479

High

1115355

PKHN1
Pleckstrin homology domain-containing family N member 1

1

11

Small-scale

0.479

High

1127418

PREP
Presequence protease, mitochondrial

1

8

High-throughput

0.479

High

1150504

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

1

6

High-throughput

0.479

High

1285872

COA7
Cytochrome c oxidase assembly factor 7

1

6

High-throughput

0.479

High

1315482

PRAX
Periaxin

1

4

Small-scale

0.479

High

1326606

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

1343490

XPP3
Xaa-Pro aminopeptidase 3

1

2

High-throughput

0.479

High

1350165

HIG1A
HIG1 domain family member 1A, mitochondrial

1

2

High-throughput

0.479

High

281928

WFS1
Wolframin

1

1

High-throughput

0.470

High

816121

ATPO
ATP synthase subunit O, mitochondrial

1

0

High-throughput

0.458

High

835272

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

High-throughput

0.458

High

878796

SCOT1
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

1

0

High-throughput

0.458

High

961304

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1306469

MIPEP
Mitochondrial intermediate peptidase

1

0

High-throughput

0.458

High

1350166

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.458

High

1350168

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

1314157

Q9BVR6
Gamma-tubulin complex component

1

1

High-throughput

0.457

High

1315718

AP1M1
AP-1 complex subunit mu-1

1

6

High-throughput

0.457

High

1128604

GNAS1
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

1

12

High-throughput

0.445

High

1332159

F124B
Protein FAM124B

1

0

High-throughput

0.438

High

1202866

AMZ2
Archaemetzincin-2

2

0

High-throughput

0.328

High

1327840

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.316

High

1332372

ARMC7
Armadillo repeat-containing protein 7

1

0

High-throughput

0.299

High

1297648

CC138
Coiled-coil domain-containing protein 138

1

0

High-throughput

0.279

Low

1188481

GLUCM
D-glutamate cyclase, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024