Interactor 1: ATOX1 (O00244)
Copper transport protein ATOX1 (Metal transport protein ATX1)
Gene: ATOX1

Interactor 2: ATP7B (P35670)
Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa]
Gene: ATP7B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.930

The method score is based on:

Property Details
Experiments 10497213, 10557326, 16573520, 12968035, 17919502
Identification Methods two hybrid, pull down, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains E1-E2_ATPase~HMA, HMA~HMA, HMA~Hydrolase
Common GO terms GO:0005507 - copper ion binding
GO:0006825 - copper ion transport
GO:0006878 - intracellular copper ion homeostasis
Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 68
Hs

1 1465
+ At
+ At
+ At
+ At
+ Sc
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024