Protein: APEX1
DNA repair nuclease/redox regulator APEX1 (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (Redox factor-1) (REF-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial]

Gene: APEX1
Organism: Mus musculus
Interactions: 12
UniProt ID: P28352

Gene Ontology (top 5):
GO:0003684 - damaged DNA binding
GO:0003677 - DNA binding
GO:0003691 - double-stranded telomeric DNA binding
GO:0003713 - transcription coactivator activity
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

148657

HDAC1
Histone deacetylase 1

1

4

Small-scale

0.479

High

609527

PCNA
Proliferating cell nuclear antigen

1

4

Small-scale

0.479

High

703225

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

1

Small-scale

0.479

High

703228

HDAC2
Histone deacetylase 2

1

4

Small-scale

0.479

High

703229

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

2

High-throughput

0.479

High

703230

SIN3A
Paired amphipathic helix protein Sin3a

1

1

Small-scale

0.479

High

703231

EED
Polycomb protein EED

1

1

High-throughput

0.479

High

703232

MUTYH
Adenine DNA glycosylase

1

3

Small-scale

0.479

High

147713

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

High-throughput

0.458

High

703233

AICDA
Single-stranded DNA cytosine deaminase

1

0

Small-scale

0.458

High

703226

HMGA2
High mobility group protein HMGI-C

1

1

High-throughput

0.445

High

703227

HMGB1
High mobility group protein B1

1

3

Small-scale

0.445

High


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Last updated: 11Aug2025