Protein: TRM61
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 (EC 2.1.1.220) (General control non-derepressible protein 14) (Protein GCD14) (tRNA(m1A58)-methyltransferase subunit TRM61) (tRNA(m1A58)MTase subunit TRM61)

Gene: TRM61, GCD14
Organism: Saccharomyces cerevisiae S288C
Interactions: 49
UniProt ID: P46959

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0030488 - tRNA methylation
GO:0031515 - tRNA (m1A) methyltransferase complex
GO:0160107 - tRNA (adenine(58)-N1)-methyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

836151

TRM6
tRNA

12

2

Small-scale

0.979

High

762841

TOR1
Serine/threonine-protein kinase TOR1

1

1

High-throughput

0.515

High

863256

YRA1
RNA annealing protein YRA1

1

2

High-throughput

0.515

High

817192

CHZ1
Histone H2A.Z-specific chaperone CHZ1

1

0

High-throughput

0.493

High

435189

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

644948

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

0

High-throughput

0.458

High

707477

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

709847

BMH1
Protein BMH1

1

0

High-throughput

0.458

High

735047

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

745795

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

747923

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

792119

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.458

High

863254

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

863259

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.458

High

531793

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.445

High

805192

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

1

1

High-throughput

0.445

High

863251

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.445

High

441988

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

674700

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.437

High

747445

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

403556

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.426

High

527021

HSP72
Heat shock protein SSA2

1

0

High-throughput

0.426

High

545356

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

684767

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.426

High

592337

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.407

High

383772

RS17A
Small ribosomal subunit protein eS17A

2

0

High-throughput

0.298

High

149835

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

410206

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

433713

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

455134

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

503118

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

504285

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

512515

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

514702

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

677461

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

682325

SPB4
ATP-dependent rRNA helicase SPB4

1

0

High-throughput

0.249

Low

753447

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

778400

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

802249

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

812434

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

863250

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

863252

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

863255

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

863258

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.249

Low

863253

UBC7
Ubiquitin-conjugating enzyme E2 7

1

0

High-throughput

0.238

Low

427335

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

689533

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.232

Low

712603

RL8B
Large ribosomal subunit protein eL8B

1

0

High-throughput

0.232

Low

863257

RL7B
Large ribosomal subunit protein uL30B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025