Protein: UBP21
Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21)

Gene: UBP21, USP21
Organism: Homo sapiens
Interactions: 160
UniProt ID: Q9UK80

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

476545

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

11

20

Small-scale

0.976

High

1356320

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

2

17

High-throughput

0.789

High

398134

ISG15
Ubiquitin-like protein ISG15

2

20

Small-scale

0.778

High

1200179

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

2

17

Small-scale

0.776

High

1334438

NANOG
Homeobox protein NANOG

4

2

Small-scale

0.715

High

160840

AURKA
Aurora kinase A

3

11

Small-scale

0.667

High

456658

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

3

10

High-throughput

0.662

High

271216

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

15

High-throughput

0.647

High

777085

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

14

High-throughput

0.647

High

870926

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

14

High-throughput

0.647

High

1024442

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

18

High-throughput

0.647

High

1174033

UBP51
Ubiquitin carboxyl-terminal hydrolase 51

1

15

High-throughput

0.647

High

1257044

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

19

High-throughput

0.647

High

1273952

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

16

High-throughput

0.647

High

1301529

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

18

High-throughput

0.647

High

1356314

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

16

High-throughput

0.647

High

1356322

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

15

High-throughput

0.647

High

301499

WDR47
WD repeat-containing protein 47

1

3

Small-scale

0.621

High

1084658

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

2

6

High-throughput

0.606

High

1167004

ATL4
ADAMTS-like protein 4

2

1

High-throughput

0.606

High

1348446

HXC10
Homeobox protein Hox-C10

2

1

High-throughput

0.606

High

647975

MARK3
MAP/microtubule affinity-regulating kinase 3

2

7

Small-scale

0.601

High

905236

1433G
14-3-3 protein gamma

2

20

High-throughput

0.601

High

982605

1433F
14-3-3 protein eta

2

20

High-throughput

0.601

High

1183143

MARK2
Serine/threonine-protein kinase MARK2

2

8

Small-scale

0.601

High

1349675

MARK1
Serine/threonine-protein kinase MARK1

2

9

Small-scale

0.601

High

1038334

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

2

8

Small-scale

0.595

High

620591

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

2

1

Small-scale

0.584

High

993354

FOXM1
Forkhead box protein M1

1

1

Small-scale

0.578

High

1133775

BEND3
BEN domain-containing protein 3

2

0

Small-scale

0.576

High

1149396

K1C40
Keratin, type I cytoskeletal 40

1

17

High-throughput

0.573

High

632944

TYY1
Transcriptional repressor protein YY1

1

1

Small-scale

0.561

High

328069

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

7

High-throughput

0.553

High

1183911

KCTD9
BTB/POZ domain-containing protein KCTD9

2

3

High-throughput

0.553

High

1241208

KCTD6
BTB/POZ domain-containing protein KCTD6

1

4

Small-scale

0.552

High

847925

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.537

High

910137

1433E
14-3-3 protein epsilon

1

4

High-throughput

0.536

High

927636

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

167034

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

5

High-throughput

0.515

High

614458

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

4

High-throughput

0.515

High

784110

KPCI
Protein kinase C iota type

1

4

High-throughput

0.515

High

809196

UTRN
Utrophin

1

2

High-throughput

0.515

High

1126060

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

3

High-throughput

0.515

High

1216460

RBM45
RNA-binding protein 45

1

6

High-throughput

0.515

High

1356325

RBM8A
RNA-binding protein 8A

1

6

High-throughput

0.515

High

387699

P53
Cellular tumor antigen p53

1

5

Small-scale

0.501

High

548134

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

10

High-throughput

0.501

High

647707

MK03
Mitogen-activated protein kinase 3

1

1

Small-scale

0.501

High

707785

H2B1B
Histone H2B type 1-B

1

14

Small-scale

0.501

High

828050

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

3

Small-scale

0.501

High

849482

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

2

Small-scale

0.501

High

868360

ATX3
Ataxin-3

1

2

High-throughput

0.501

High

1065242

JOS1
Josephin-1

1

2

High-throughput

0.501

High

1086943

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

5

Small-scale

0.501

High

1138868

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.501

High

1267235

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

10

High-throughput

0.501

High

1282068

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.501

High

1288106

OTUB2
Ubiquitin thioesterase OTUB2

1

3

High-throughput

0.501

High

1291602

OTUB1
Ubiquitin thioesterase OTUB1

1

3

High-throughput

0.501

High

1297119

SENP8
Sentrin-specific protease 8

1

3

High-throughput

0.501

High

1317484

TRI54
Tripartite motif-containing protein 54

1

20

High-throughput

0.501

High

1331200

SENP3
Sentrin-specific protease 3

1

3

High-throughput

0.501

High

1356323

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.501

High

375824

FUCO
Tissue alpha-L-fucosidase

1

0

High-throughput

0.493

High

1318140

REN3B
Regulator of nonsense transcripts 3B

1

0

High-throughput

0.493

High

966499

EXOSX
Exosome complex component 10

1

0

High-throughput

0.486

High

610528

CBL
E3 ubiquitin-protein ligase CBL

1

5

High-throughput

0.481

High

734808

TRI23
E3 ubiquitin-protein ligase TRIM23

1

3

High-throughput

0.481

High

842149

R144A
E3 ubiquitin-protein ligase RNF144A

1

7

High-throughput

0.481

High

1165224

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

2

High-throughput

0.481

High

1238407

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

4

High-throughput

0.481

High

1244143

SYNE1
Nesprin-1

1

4

Small-scale

0.481

High

1292362

RN185
E3 ubiquitin-protein ligase RNF185

1

7

High-throughput

0.481

High

1309729

SLF1
SMC5-SMC6 complex localization factor protein 1

1

8

Small-scale

0.481

High

1316715

PCGF6
Polycomb group RING finger protein 6

1

15

High-throughput

0.481

High

1317098

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

14

High-throughput

0.481

High

1318357

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

20

High-throughput

0.481

High

1318685

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

20

High-throughput

0.481

High

1318717

TRIM5
Tripartite motif-containing protein 5

1

14

High-throughput

0.481

High

1356317

CBLC
E3 ubiquitin-protein ligase CBL-C

1

5

High-throughput

0.481

High

317776

STABP
STAM-binding protein

1

0

High-throughput

0.480

High

1056822

ESPL1
Separin

1

0

High-throughput

0.480

High

146553

BHE40
Class E basic helix-loop-helix protein 40

1

1

Small-scale

0.479

High

157092

AIM2
Interferon-inducible protein AIM2

1

2

Small-scale

0.479

High

166627

DCLK1
Serine/threonine-protein kinase DCLK1

1

4

High-throughput

0.479

High

206861

FOXO3
Forkhead box protein O3

1

1

Small-scale

0.479

High

230927

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

6

High-throughput

0.479

High

237339

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

2

High-throughput

0.479

High

253429

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

2

High-throughput

0.479

High

258841

O75271
non-specific serine/threonine protein kinase

1

5

High-throughput

0.479

High

264435

GGYF1
GRB10-interacting GYF protein 1

1

2

High-throughput

0.479

High

316287

NADK
NAD kinase

1

1

High-throughput

0.479

High

321322

IL33
Interleukin-33

1

1

Small-scale

0.479

High

321949

RIGI
Antiviral innate immune response receptor RIG-I

1

14

Small-scale

0.479

High

326814

SNAI1
Zinc finger protein SNAI1

1

8

Small-scale

0.479

High

436758

GLI1
Zinc finger protein GLI1

1

1

Small-scale

0.479

High

455983

PARP1
Poly [ADP-ribose] polymerase 1

1

6

Small-scale

0.479

High

485093

GLI2
Zinc finger protein GLI2

1

1

Small-scale

0.479

High

598541

NF1
Neurofibromin

1

3

High-throughput

0.479

High

654070

MAP4
Microtubule-associated protein 4

1

9

Small-scale

0.479

High

673532

MPIP2
M-phase inducer phosphatase 2

1

2

High-throughput

0.479

High

717412

CTNB1
Catenin beta-1

1

8

Small-scale

0.479

High

734442

TCF7
Transcription factor 7

1

3

Small-scale

0.479

High

816518

MAOX
NADP-dependent malic enzyme

1

2

Small-scale

0.479

High

876533

AFAD
Afadin

1

5

High-throughput

0.479

High

880847

HDAC4
Histone deacetylase 4

1

7

High-throughput

0.479

High

960423

CDK16
Cyclin-dependent kinase 16

1

5

High-throughput

0.479

High

988159

RAD51
DNA repair protein RAD51 homolog 1

1

1

Small-scale

0.479

High

1022469

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

1

High-throughput

0.479

High

1031300

SKP2
S-phase kinase-associated protein 2

1

2

Small-scale

0.479

High

1042807

CUL3
Cullin-3

1

9

Small-scale

0.479

High

1047837

CKAP5
Cytoskeleton-associated protein 5

1

7

Small-scale

0.479

High

1057209

MELK
Maternal embryonic leucine zipper kinase

1

9

High-throughput

0.479

High

1136490

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

1

High-throughput

0.479

High

1136559

SPD2A
SH3 and PX domain-containing protein 2A

1

4

High-throughput

0.479

High

1139648

DEN4C
DENN domain-containing protein 4C

1

1

High-throughput

0.479

High

1153439

PKHA7
Pleckstrin homology domain-containing family A member 7

1

13

High-throughput

0.479

High

1197850

PHLB2
Pleckstrin homology-like domain family B member 2

1

10

High-throughput

0.479

High

1217998

KSR1
Kinase suppressor of Ras 1

1

3

High-throughput

0.479

High

1253344

F110B
Protein FAM110B

1

2

High-throughput

0.479

High

1256266

DEN1A
DENN domain-containing protein 1A

1

1

High-throughput

0.479

High

1263474

SRS12
Serine/arginine-rich splicing factor 12

1

4

High-throughput

0.479

High

1273293

ARHG2
Rho guanine nucleotide exchange factor 2

1

2

Small-scale

0.479

High

1286221

DHX58
ATP-dependent RNA helicase DHX58

1

11

Small-scale

0.479

High

1296789

MARK4
MAP/microtubule affinity-regulating kinase 4

1

6

High-throughput

0.479

High

1300447

RAB3I
Rab-3A-interacting protein

1

1

High-throughput

0.479

High

1300691

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

6

High-throughput

0.479

High

1301722

TESK2
Dual specificity testis-specific protein kinase 2

1

1

High-throughput

0.479

High

1309182

F110A
Protein FAM110A

1

2

High-throughput

0.479

High

1317608

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

13

Small-scale

0.479

High

1343631

KI13B
Kinesin-like protein KIF13B

1

3

High-throughput

0.479

High

1350021

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

2

High-throughput

0.479

High

1350500

HECW2
E3 ubiquitin-protein ligase HECW2

1

11

High-throughput

0.479

High

1355273

LIMA1
LIM domain and actin-binding protein 1

1

4

High-throughput

0.479

High

1355773

BAZ2A
Bromodomain adjacent to zinc finger domain protein 2A

1

11

Small-scale

0.479

High

1355992

NGAP
Ras GTPase-activating protein nGAP

1

2

High-throughput

0.479

High

1356316

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.479

High

1356318

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

1

High-throughput

0.479

High

1356319

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.479

High

1356321

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

1356324

KCTD3
BTB/POZ domain-containing protein KCTD3

1

2

High-throughput

0.479

High

958861

EM55
55 kDa erythrocyte membrane protein

1

0

Small-scale

0.460

High

1326844

ZN350
Zinc finger protein 350

1

0

Small-scale

0.460

High

196525

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

0

High-throughput

0.458

High

1060644

ZN638
Zinc finger protein 638

1

0

High-throughput

0.458

High

1308732

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

1311608

RTKN
Rhotekin

1

0

High-throughput

0.458

High

1349855

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.458

High

1356315

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.458

High

1151394

H2A2A
Histone H2A type 2-A

1

14

Small-scale

0.457

High

216986

KIF1C
Kinesin-like protein KIF1C

1

3

High-throughput

0.437

High

882168

GSC
Homeobox protein goosecoid

1

2

Small-scale

0.437

High

1148533

KCD11
BTB/POZ domain-containing protein KCTD11

1

2

Small-scale

0.437

High

1149010

AN34A
Ankyrin repeat domain-containing protein 34A

1

11

High-throughput

0.437

High

1173161

SYDE1
Rho GTPase-activating protein SYDE1

1

3

High-throughput

0.437

High

1260797

DEP1B
DEP domain-containing protein 1B

1

4

High-throughput

0.437

High

1086140

FOXD1
Forkhead box protein D1

1

0

Small-scale

0.292

High

1109699

TBC25
TBC1 domain family member 25

1

0

High-throughput

0.249

Low

1348455

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024