Protein: TBCD4
TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160)

Gene: TBCD4, TBC1D4
Organism: Homo sapiens
Interactions: 126
UniProt ID: O60343

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005829 - cytosol
GO:0016192 - vesicle-mediated transport
GO:0031339 - negative regulation of vesicle fusion
GO:0031982 - vesicle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

232701

APBB2
Amyloid beta precursor protein binding family B member 2

3

1

High-throughput

0.770

High

232662

1433Z
14-3-3 protein zeta/delta

7

20

Small-scale

0.742

High

232646

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.716

High

232667

1433F
14-3-3 protein eta

5

20

High-throughput

0.716

High

232640

1433T
14-3-3 protein theta

5

20

Small-scale

0.712

High

232657

1433G
14-3-3 protein gamma

4

20

High-throughput

0.699

High

232659

1433E
14-3-3 protein epsilon

4

3

High-throughput

0.697

High

232688

TBCD1
TBC1 domain family member 1

1

8

High-throughput

0.691

High

232698

RAB2B
Ras-related protein Rab-2B

1

20

High-throughput

0.691

High

232637

CCNA2
Cyclin-A2

3

1

High-throughput

0.667

High

232643

TMOD1
Tropomodulin-1

3

1

High-throughput

0.667

High

225989

PRKN
E3 ubiquitin-protein ligase parkin

3

9

High-throughput

0.640

High

232694

IF4E3
Eukaryotic translation initiation factor 4E type 3

3

0

High-throughput

0.638

High

232638

MYF6
Myogenic factor 6

2

1

High-throughput

0.628

High

232731

FBW1B
F-box/WD repeat-containing protein 11

2

2

High-throughput

0.624

High

149955

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

3

2

High-throughput

0.609

High

232704

T53I1
Tumor protein p53-inducible nuclear protein 1

2

0

High-throughput

0.602

High

232652

GSK3A
Glycogen synthase kinase-3 alpha

2

4

High-throughput

0.601

High

232655

CDC42
Cell division control protein 42 homolog

1

20

Small-scale

0.590

High

232651

CCNF
Cyclin-F

2

3

High-throughput

0.584

High

232734

FBW1A
F-box/WD repeat-containing protein 1A

2

2

High-throughput

0.584

High

232684

LRC8E
Volume-regulated anion channel subunit LRRC8E

2

1

High-throughput

0.574

High

232726

TMOD3
Tropomodulin-3

2

1

High-throughput

0.574

High

232645

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.545

High

232621

DJC13
DnaJ homolog subfamily C member 13

1

3

High-throughput

0.536

High

232636

NCF2
Neutrophil cytosol factor 2

1

3

High-throughput

0.536

High

232660

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

2

High-throughput

0.536

High

232663

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

2

High-throughput

0.536

High

232671

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

1

High-throughput

0.536

High

232672

CUL2
Cullin-2

1

4

High-throughput

0.536

High

232712

MPP8
M-phase phosphoprotein 8

1

2

High-throughput

0.536

High

232715

UBXN6
UBX domain-containing protein 6

1

2

High-throughput

0.536

High

232724

ARL8B
ADP-ribosylation factor-like protein 8B

1

12

High-throughput

0.536

High

206300

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.518

High

232647

1433S
14-3-3 protein sigma

1

20

High-throughput

0.515

High

232653

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.515

High

232661

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

2

High-throughput

0.515

High

232676

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.515

High

232703

H2B1H
Histone H2B type 1-H

1

1

High-throughput

0.515

High

232644

TKT
Transketolase

1

0

High-throughput

0.513

High

232656

ARP2
Actin-related protein 2

1

0

High-throughput

0.513

High

232695

COMD1
COMM domain-containing protein 1

1

0

High-throughput

0.513

High

232710

ANR27
Ankyrin repeat domain-containing protein 27

1

0

High-throughput

0.513

High

232713

SOSB1
SOSS complex subunit B1

1

0

High-throughput

0.513

High

232716

MIS12
Protein MIS12 homolog

1

0

High-throughput

0.513

High

232737

NEUR2
Sialidase-2

1

0

High-throughput

0.513

High

232677

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.493

High

171180

CTDSL
CTD small phosphatase-like protein

1

2

High-throughput

0.489

High

232666

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

20

Small-scale

0.489

High

232668

DSC1
Desmocollin-1

1

4

High-throughput

0.489

High

232678

PPR29
Protein phosphatase 1 regulatory subunit 29

1

5

High-throughput

0.489

High

232680

CF141
Uncharacterized protein C6orf141

1

1

High-throughput

0.489

High

232693

FAM9B
Protein FAM9B

1

1

High-throughput

0.489

High

232714

SPXN
Spexin

1

1

High-throughput

0.489

High

232721

LRC40
Leucine-rich repeat-containing protein 40

1

1

High-throughput

0.489

High

232729

NRBP
Nuclear receptor-binding protein

1

1

High-throughput

0.489

High

232738

EMIL1
EMILIN-1

1

1

High-throughput

0.489

High

232669

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.480

High

232626

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

232629

K2C8
Keratin, type II cytoskeletal 8

1

3

High-throughput

0.479

High

232639

IKBA
NF-kappa-B inhibitor alpha

1

1

Small-scale

0.479

High

232648

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

232658

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

232670

HDAC1
Histone deacetylase 1

1

2

High-throughput

0.479

High

232681

RN123
E3 ubiquitin-protein ligase RNF123

1

3

High-throughput

0.479

High

232689

TAXB1
Tax1-binding protein 1

1

4

High-throughput

0.479

High

232690

DYR2
Dihydrofolate reductase 2, mitochondrial

1

2

High-throughput

0.479

High

232706

AURKB
Aurora kinase B

1

4

High-throughput

0.479

High

232717

TOLIP
Toll-interacting protein

1

1

High-throughput

0.479

High

232720

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

232725

DDX56
Probable ATP-dependent RNA helicase DDX56

1

2

High-throughput

0.479

High

232728

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

232635

H12
Histone H1.2

1

2

High-throughput

0.470

High

232675

H31T
Histone H3.1t

1

1

High-throughput

0.470

High

232709

EP400
E1A-binding protein p400

1

2

Small-scale

0.464

High

232641

MARK3
MAP/microtubule affinity-regulating kinase 3

1

0

Small-scale

0.458

High

232650

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.458

High

232674

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

232691

CEP57
Centrosomal protein of 57 kDa

1

0

High-throughput

0.458

High

232700

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

232727

CEP72
Centrosomal protein of 72 kDa

1

0

High-throughput

0.458

High

232732

DNPEP
Aspartyl aminopeptidase

1

0

High-throughput

0.458

High

232735

NINL
Ninein-like protein

1

0

High-throughput

0.458

High

232711

CK5P2
CDK5 regulatory subunit-associated protein 2

1

1

Small-scale

0.457

High

232628

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

232630

CALM1
Calmodulin-1

1

7

High-throughput

0.445

High

232631

CALM2
Calmodulin-2

1

7

High-throughput

0.445

High

232632

CALM3
Calmodulin-3

1

7

High-throughput

0.445

High

232682

PKHA7
Pleckstrin homology domain-containing family A member 7

1

9

High-throughput

0.445

High

232623

NFAT5
Nuclear factor of activated T-cells 5

1

0

Small-scale

0.438

High

232733

ZMIZ1
Zinc finger MIZ domain-containing protein 1

1

0

Small-scale

0.438

High

204790

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.437

High

231893

KDM1A
Lysine-specific histone demethylase 1A

1

2

High-throughput

0.437

High

232622

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.437

High

232624

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.437

High

232625

NTRK1
High affinity nerve growth factor receptor

1

19

High-throughput

0.437

High

232633

H14
Histone H1.4

1

2

High-throughput

0.437

High

232634

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

232642

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

232649

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

232664

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.437

High

232685

FBX42
F-box only protein 42

1

4

High-throughput

0.437

High

232687

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

232705

PF21A
PHD finger protein 21A

1

2

High-throughput

0.437

High

232719

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

232679

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

232692

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.426

High

232699

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

Small-scale

0.417

High

232665

FOXK1
Forkhead box protein K1

2

0

High-throughput

0.328

High

232673

DGCR6
Protein DGCR6

1

0

High-throughput

0.279

Low

232686

MBOA1
Lysophospholipid acyltransferase 1

1

0

High-throughput

0.279

Low

232696

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.279

Low

232702

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.279

Low

232707

ZN414
Zinc finger protein 414

1

0

High-throughput

0.279

Low

232708

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

0

High-throughput

0.279

Low

232718

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.279

Low

232627

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.269

Low

165349

SR140
U2 snRNP-associated SURP motif-containing protein

1

0

Small-scale

0.265

Low

232683

TET2
Methylcytosine dioxygenase TET2

1

0

Small-scale

0.265

Low

232723

RBM12
RNA-binding protein 12

1

0

Small-scale

0.265

Low

230559

KATIP
Katanin-interacting protein

1

0

Small-scale

0.238

Low

232654

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

1

0

High-throughput

0.238

Low

232697

NAV1
Neuron navigator 1

1

0

Small-scale

0.238

Low

232722

RESF1
Retroelement silencing factor 1

1

0

Small-scale

0.238

Low

232730

TASOR
Protein TASOR

1

0

Small-scale

0.238

Low

232736

S45A1
Proton-associated sugar transporter A

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024