Protein: HUTH
Histidine ammonia-lyase (Histidase) (EC 4.3.1.3)

Gene: HUTH, HAL
Organism: Homo sapiens
Interactions: 137
UniProt ID: P42357

Gene Ontology (top 5):
GO:0004397 - histidine ammonia-lyase activity
GO:0005829 - cytosol
GO:0006548 - L-histidine catabolic process
GO:0019556 - L-histidine catabolic process to glutamate and formamide
GO:0019557 - L-histidine catabolic process to glutamate and formate

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

787787

RAB9B
Ras-related protein Rab-9B

3

1

High-throughput

0.667

High

787714

CF298
Cilia- and flagella-associated protein 298

3

0

High-throughput

0.638

High

787728

GPR18
N-arachidonyl glycine receptor

3

1

High-throughput

0.609

High

365164

FRIH
Ferritin heavy chain

2

0

High-throughput

0.602

High

787726

CUL1
Cullin-1

2

0

High-throughput

0.602

High

787771

DOC10
Dedicator of cytokinesis protein 10

2

0

High-throughput

0.602

High

787774

HEXI2
Protein HEXIM2

2

0

High-throughput

0.602

High

787775

CDK15
Cyclin-dependent kinase 15

2

0

High-throughput

0.602

High

787784

PKHA3
Pleckstrin homology domain-containing family A member 3

2

0

High-throughput

0.602

High

787752

PLCZ1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

2

0

High-throughput

0.585

High

787729

TNIP1
TNFAIP3-interacting protein 1

2

0

High-throughput

0.559

High

787715

RB11A
Ras-related protein Rab-11A

2

0

High-throughput

0.547

High

500395

THA
Thyroid hormone receptor alpha

1

1

High-throughput

0.536

High

174370

FANCG
Fanconi anemia group G protein

1

0

High-throughput

0.513

High

236893

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

0

High-throughput

0.513

High

565892

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

594468

PSB1
Proteasome subunit beta type-1

1

0

High-throughput

0.513

High

599629

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

0

High-throughput

0.513

High

608912

SPR2D
Small proline-rich protein 2D

1

0

High-throughput

0.513

High

676730

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

0

High-throughput

0.513

High

787710

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

0

High-throughput

0.513

High

787711

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

High-throughput

0.513

High

787713

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

787716

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.513

High

787717

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

787719

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

0

High-throughput

0.513

High

787720

ENL
Protein ENL

1

0

High-throughput

0.513

High

787721

UBE3A
Ubiquitin-protein ligase E3A

1

0

High-throughput

0.513

High

787730

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.513

High

787732

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.513

High

787738

VWA3B
von Willebrand factor A domain-containing protein 3B

1

0

High-throughput

0.513

High

787744

RN111
E3 ubiquitin-protein ligase Arkadia

1

0

High-throughput

0.513

High

787750

AROS
Active regulator of SIRT1

1

0

High-throughput

0.513

High

787757

UB2J2
Ubiquitin-conjugating enzyme E2 J2

1

0

High-throughput

0.513

High

787766

THAP4
Peroxynitrite isomerase THAP4

1

0

High-throughput

0.513

High

787777

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.513

High

787790

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

787793

DTL
Denticleless protein homolog

1

0

High-throughput

0.513

High

787802

RN115
E3 ubiquitin-protein ligase RNF115

1

0

High-throughput

0.513

High

303665

OR2A4
Olfactory receptor 2A4

1

1

High-throughput

0.489

High

312784

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

1

High-throughput

0.489

High

787756

S39AB
Zinc transporter ZIP11

1

1

High-throughput

0.489

High

787779

S39A3
Zinc transporter ZIP3

1

1

High-throughput

0.489

High

348556

RASN
GTPase NRas

1

1

High-throughput

0.479

High

787718

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

325648

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.458

High

373835

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

386253

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

453200

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

503605

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

787706

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

787727

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

0

High-throughput

0.458

High

787736

GLYR1
Cytokine-like nuclear factor N-PAC

1

0

High-throughput

0.458

High

787788

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

211805

TLX3
T-cell leukemia homeobox protein 3

1

2

High-throughput

0.457

High

213303

TLX2
T-cell leukemia homeobox protein 2

1

1

High-throughput

0.457

High

537723

INSRR
Insulin receptor-related protein

1

1

High-throughput

0.457

High

665446

EPHA8
Ephrin type-A receptor 8

1

1

High-throughput

0.457

High

781156

ETV3
ETS translocation variant 3

1

1

High-throughput

0.457

High

785340

ELK3
ETS domain-containing protein Elk-3

1

1

High-throughput

0.457

High

787709

LHX2
LIM/homeobox protein Lhx2

1

2

High-throughput

0.457

High

787754

LMTK2
Serine/threonine-protein kinase LMTK2

1

2

High-throughput

0.457

High

787768

LHX4
LIM/homeobox protein Lhx4

1

2

High-throughput

0.457

High

787796

LHX3
LIM/homeobox protein Lhx3

1

2

High-throughput

0.457

High

787628

PI4KA
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.445

High

782497

HNF4A
Hepatocyte nuclear factor 4-alpha

1

1

Small-scale

0.437

High

787712

UCP2
Dicarboxylate carrier SLC25A8

1

1

High-throughput

0.437

High

787737

Q4LE69
1-phosphatidylinositol 4-kinase

1

2

High-throughput

0.437

High

787724

STK4
Serine/threonine-protein kinase 4

1

0

High-throughput

0.426

High

787740

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

787759

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

2

High-throughput

0.407

High

787708

VEGFB
Vascular endothelial growth factor B

3

0

High-throughput

0.347

High

787731

U2AFM
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

3

0

High-throughput

0.347

High

787745

DPPA4
Developmental pluripotency-associated protein 4

3

0

High-throughput

0.347

High

787773

GMCL1
Germ cell-less protein-like 1

3

0

High-throughput

0.347

High

787733

ZIC1
Zinc finger protein ZIC 1

2

0

High-throughput

0.328

High

787734

CCD27
Coiled-coil domain-containing protein 27

2

0

High-throughput

0.328

High

787743

KCD16
BTB/POZ domain-containing protein KCTD16

2

0

High-throughput

0.328

High

787747

SO6A1
Solute carrier organic anion transporter family member 6A1

2

0

High-throughput

0.328

High

787791

TB22B
TBC1 domain family member 22B

2

0

High-throughput

0.328

High

787800

FCF1
rRNA-processing protein FCF1 homolog

2

0

High-throughput

0.328

High

563813

ZSC20
Zinc finger and SCAN domain-containing protein 20

2

0

High-throughput

0.318

High

787760

UBAC2
Ubiquitin-associated domain-containing protein 2

2

0

High-throughput

0.318

High

787798

DD19B
ATP-dependent RNA helicase DDX19B

2

0

High-throughput

0.318

High

200812

ZSC12
Zinc finger and SCAN domain-containing protein 12

2

0

High-throughput

0.288

High

183022

P2RX6
P2X purinoceptor 6

1

0

High-throughput

0.279

Low

217547

NDUS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

1

0

High-throughput

0.279

Low

239837

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.279

Low

265615

E2F6
Transcription factor E2F6

1

0

High-throughput

0.279

Low

328112

SG1D1
Secretoglobin family 1D member 1

1

0

High-throughput

0.279

Low

392924

IFNA4
Interferon alpha-4

1

0

High-throughput

0.279

Low

518277

ADT3
ADP/ATP translocase 3

1

0

High-throughput

0.279

Low

580343

TSN8
Tetraspanin-8

1

0

High-throughput

0.279

Low

686608

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.279

Low

787723

FGL1
Fibrinogen-like protein 1

1

0

High-throughput

0.279

Low

787725

ZN154
Zinc finger protein 154

1

0

High-throughput

0.279

Low

787735

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

787739

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.279

Low

787741

CJ120
Uncharacterized protein C10orf120

1

0

High-throughput

0.279

Low

787742

AHDC1
Transcription factor Gibbin

1

0

High-throughput

0.279

Low

787746

APTX
Aprataxin

1

0

High-throughput

0.279

Low

787748

MOGT3
2-acylglycerol O-acyltransferase 3

1

0

High-throughput

0.279

Low

787749

BPHL
Valacyclovir hydrolase

1

0

High-throughput

0.279

Low

787751

SFR1
Swi5-dependent recombination DNA repair protein 1 homolog

1

0

High-throughput

0.279

Low

787753

CDKL3
Cyclin-dependent kinase-like 3

1

0

High-throughput

0.279

Low

787755

UBAD2
UBA-like domain-containing protein 2

1

0

High-throughput

0.279

Low

787758

FGRL1
Fibroblast growth factor receptor-like 1

1

0

High-throughput

0.279

Low

787761

O13C3
Olfactory receptor 13C3

1

0

High-throughput

0.279

Low

787762

MYBPP
MYCBP-associated protein

1

0

High-throughput

0.279

Low

787765

ITLN2
Intelectin-2

1

0

High-throughput

0.279

Low

787767

WNT8B
Protein Wnt-8b

1

0

High-throughput

0.279

Low

787769

PIGT
GPI transamidase component PIG-T

1

0

High-throughput

0.279

Low

787770

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

0

High-throughput

0.279

Low

787772

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

787776

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.279

Low

787778

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.279

Low

787780

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.279

Low

787782

COE2
Transcription factor COE2

1

0

High-throughput

0.279

Low

787783

CLK4
Dual specificity protein kinase CLK4

1

0

High-throughput

0.279

Low

787785

HES4
Transcription factor HES-4

1

0

High-throughput

0.279

Low

787786

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

0

High-throughput

0.279

Low

787789

TSSP
Thymus-specific serine protease

1

0

High-throughput

0.279

Low

787792

TLR7
Toll-like receptor 7

1

0

High-throughput

0.279

Low

787795

TXD16
Thioredoxin domain-containing protein 16

1

0

High-throughput

0.279

Low

787797

PHF11
PHD finger protein 11

1

0

High-throughput

0.279

Low

787799

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.279

Low

787781

CF062
Uncharacterized protein C6orf62

1

0

High-throughput

0.269

Low

787722

PAX8
Paired box protein Pax-8

1

0

High-throughput

0.261

Low

787763

SP7
Transcription factor Sp7

1

0

High-throughput

0.261

Low

601160

VDAC1
Voltage-dependent anion-selective channel protein 1

1

0

High-throughput

0.249

Low

621637

FCAR
Immunoglobulin alpha Fc receptor

1

0

High-throughput

0.249

Low

654139

CALX
Calnexin

1

0

High-throughput

0.249

Low

787707

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.249

Low

787764

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

High-throughput

0.249

Low

787794

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

787801

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.249

Low

230589

KATIP
Katanin-interacting protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024