Protein: SDE2
Splicing regulator SDE2 (Replication stress response regulator SDE2)

Gene: SDE2
Organism: Homo sapiens
Interactions: 34
UniProt ID: Q6IQ49

Gene Ontology (top 5):
GO:0000479 - endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003684 - damaged DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

605006

HXB6
Homeobox protein Hox-B6

1

1

High-throughput

0.536

High

634850

HXA5
Homeobox protein Hox-A5

1

2

High-throughput

0.536

High

1235102

RBM8A
RNA-binding protein 8A

1

3

High-throughput

0.536

High

1235094

HBAP1
HSPB1-associated protein 1

1

0

High-throughput

0.530

High

1235096

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.513

High

185774

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

551101

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.480

High

260084

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

372300

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

406284

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.479

High

588928

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

695715

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

714194

PML
Protein PML

1

2

High-throughput

0.479

High

768432

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

970659

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

1016948

H33
Histone H3.3

1

1

High-throughput

0.479

High

1096721

RFA4
Replication protein A 30 kDa subunit

1

3

High-throughput

0.479

High

1113398

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1137068

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

5

High-throughput

0.479

High

1235090

MEPCE
7SK snRNA methylphosphate capping enzyme

1

1

High-throughput

0.479

High

1235098

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1235099

DTL
Denticleless protein homolog

1

4

Small-scale

0.479

High

1235100

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1235101

XPO7
Exportin-7

1

1

High-throughput

0.479

High

293847

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

973054

RS29
Small ribosomal subunit protein uS14

1

0

High-throughput

0.458

High

980846

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

1095265

REST
RE1-silencing transcription factor

1

0

High-throughput

0.458

High

1235089

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1235091

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1235093

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.458

High

1235095

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1235097

HAUS2
HAUS augmin-like complex subunit 2

1

0

High-throughput

0.458

High

1235092

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.445

High


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Last updated: 11Aug2025