Protein: DTL
Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein)

Gene: DTL
Organism: Homo sapiens
Interactions: 121
UniProt ID: Q9NZJ0

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005694 - chromosome
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1157970

DDB1
DNA damage-binding protein 1

14

19

Small-scale

0.983

High

1447189

KMT5A
N-lysine methyltransferase KMT5A

3

20

Small-scale

0.861

High

882197

TCPG
T-complex protein 1 subunit gamma

3

20

High-throughput

0.855

High

1415888

DDA1
DET1- and DDB1-associated protein 1

3

3

Small-scale

0.847

High

1407602

TCPH
T-complex protein 1 subunit eta

2

20

High-throughput

0.811

High

1007316

TCPB
T-complex protein 1 subunit beta

2

20

High-throughput

0.776

High

1115106

CUL4A
Cullin-4A

14

20

Small-scale

0.761

High

1115466

CUL4B
Cullin-4B

12

20

Small-scale

0.757

High

1135279

SHPRH
E3 ubiquitin-protein ligase SHPRH

2

20

Small-scale

0.754

High

551300

PCNA
Proliferating cell nuclear antigen

7

1

Small-scale

0.749

High

1370414

CSN5
COP9 signalosome complex subunit 5

6

7

Small-scale

0.724

High

1369170

KAT2A
Histone acetyltransferase KAT2A

1

20

Small-scale

0.724

High

808183

CDN1A
Cyclin-dependent kinase inhibitor 1

5

4

Small-scale

0.716

High

1272579

CSN6
COP9 signalosome complex subunit 6

4

3

Small-scale

0.694

High

876206

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.691

High

1363710

TCPW
T-complex protein 1 subunit zeta-2

1

20

High-throughput

0.691

High

1431928

PDCL3
Phosducin-like protein 3

1

4

High-throughput

0.691

High

1431414

CDT1
DNA replication factor Cdt1

4

1

Small-scale

0.686

High

822889

VHL
von Hippel-Lindau disease tumor suppressor

1

2

High-throughput

0.665

High

414743

P53
Cellular tumor antigen p53

3

4

Small-scale

0.664

High

1326558

CARME
Carnosine N-methyltransferase

4

0

High-throughput

0.661

High

1094428

CSN1
COP9 signalosome complex subunit 1

3

9

Small-scale

0.650

High

906801

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

9

Small-scale

0.647

High

957853

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

9

Small-scale

0.647

High

1109524

ATR
Serine/threonine-protein kinase ATR

1

8

Small-scale

0.647

High

983995

RBX1
E3 ubiquitin-protein ligase RBX1

3

3

Small-scale

0.646

High

1413208

CSN4
COP9 signalosome complex subunit 4

3

3

Small-scale

0.640

High

1143870

TCAL1
Transcription elongation factor A protein-like 1

3

0

High-throughput

0.638

High

163178

CHK1
Serine/threonine-protein kinase Chk1

2

1

Small-scale

0.629

High

1371207

GLMN
Glomulin

2

2

High-throughput

0.628

High

1406132

CSN8
COP9 signalosome complex subunit 8

2

1

High-throughput

0.628

High

1453338

PFD2
Prefoldin subunit 2

2

4

High-throughput

0.628

High

1293829

FBX11
F-box only protein 11

2

2

Small-scale

0.624

High

972072

1433E
14-3-3 protein epsilon

2

3

Small-scale

0.620

High

224378

BUB3
Mitotic checkpoint protein BUB3

1

18

Small-scale

0.618

High

355608

NSD2
Histone-lysine N-methyltransferase NSD2

1

20

Small-scale

0.618

High

610920

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.618

High

909400

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

9

Small-scale

0.618

High

957532

UBC12
NEDD8-conjugating enzyme Ubc12

1

8

High-throughput

0.618

High

993780

UBC9
SUMO-conjugating enzyme UBC9

1

11

High-throughput

0.618

High

1116786

AAMP
Angio-associated migratory cell protein

1

16

Small-scale

0.618

High

1127775

HLTF
Helicase-like transcription factor

1

13

Small-scale

0.618

High

1350218

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

1

8

High-throughput

0.618

High

1363098

DDB2
DNA damage-binding protein 2

1

16

Small-scale

0.618

High

1381211

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

9

Small-scale

0.618

High

1397299

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

9

Small-scale

0.618

High

1448645

STRN4
Striatin-4

1

16

Small-scale

0.618

High

259146

DNJA2
DnaJ homolog subfamily A member 2

2

13

High-throughput

0.601

High

243151

PRKN
E3 ubiquitin-protein ligase parkin

2

13

High-throughput

0.584

High

730925

1433S
14-3-3 protein sigma

2

20

Small-scale

0.584

High

1453340

CSN3
COP9 signalosome complex subunit 3

2

9

Small-scale

0.584

High

1453342

POLH
DNA polymerase eta

1

1

Small-scale

0.578

High

1410154

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

19

Small-scale

0.575

High

239234

ZNRD2
Protein ZNRD2

2

1

High-throughput

0.574

High

958724

CSN2
COP9 signalosome complex subunit 2

2

9

Small-scale

0.571

High

1213854

KPRP
Keratinocyte proline-rich protein

2

3

High-throughput

0.558

High

1434083

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.553

High

1110911

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

Small-scale

0.537

High

635646

FILA
Filaggrin

1

4

High-throughput

0.536

High

839635

HUTH
Histidine ammonia-lyase

1

1

High-throughput

0.536

High

1110578

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

2

High-throughput

0.536

High

1150496

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

2

High-throughput

0.536

High

1453341

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

2

High-throughput

0.536

High

965288

WDR5
WD repeat-containing protein 5

1

18

Small-scale

0.515

High

659145

LORI
Loricrin

1

0

High-throughput

0.513

High

443542

CDK1
Cyclin-dependent kinase 1

1

8

Small-scale

0.501

High

668049

CDK2
Cyclin-dependent kinase 2

1

8

Small-scale

0.501

High

897473

TOB1
Protein Tob1

1

1

Small-scale

0.501

High

261885

PFD1
Prefoldin subunit 1

1

3

High-throughput

0.489

High

892143

KLK7
Kallikrein-7

1

1

High-throughput

0.489

High

1248746

SBSN
Suprabasin

1

1

High-throughput

0.489

High

1252606

DEFI8
Differentially expressed in FDCP 8 homolog

1

4

High-throughput

0.489

High

1309626

SPA12
Serpin A12

1

3

High-throughput

0.489

High

1358594

POF1B
Protein POF1B

1

1

High-throughput

0.489

High

1439486

DPOD4
DNA polymerase delta subunit 4

1

0

Small-scale

0.480

High

66372

ARGFX
Arginine-fifty homeobox

1

7

High-throughput

0.479

High

463805

LYN
Tyrosine-protein kinase Lyn

1

2

Small-scale

0.479

High

485475

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

20

High-throughput

0.479

High

564463

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.479

High

637767

FLNA
Filamin-A

1

13

High-throughput

0.479

High

650995

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

19

High-throughput

0.479

High

684038

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

4

High-throughput

0.479

High

691486

1433T
14-3-3 protein theta

1

20

Small-scale

0.479

High

730296

1433B
14-3-3 protein beta/alpha

1

20

Small-scale

0.479

High

761907

HSP74
Heat shock 70 kDa protein 4

1

9

Small-scale

0.479

High

831549

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

846685

MSH2
DNA mismatch repair protein Msh2

1

2

Small-scale

0.479

High

909721

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

20

High-throughput

0.479

High

913417

MSH6
DNA mismatch repair protein Msh6

1

5

Small-scale

0.479

High

966953

1433G
14-3-3 protein gamma

1

20

Small-scale

0.479

High

990802

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.479

High

1028424

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

Small-scale

0.479

High

1045850

TF65
Transcription factor p65

1

6

High-throughput

0.479

High

1049843

1433F
14-3-3 protein eta

1

20

Small-scale

0.479

High

1061188

SRSF1
Serine/arginine-rich splicing factor 1

1

19

High-throughput

0.479

High

1114488

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1198214

PDCD4
Programmed cell death protein 4

1

2

Small-scale

0.479

High

1235099

SDE2
Splicing regulator SDE2

1

4

Small-scale

0.479

High

1391812

AURKB
Aurora kinase B

1

5

Small-scale

0.479

High

1396836

SNX27
Sorting nexin-27

1

4

High-throughput

0.479

High

1397499

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1449232

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

Small-scale

0.479

High

1450418

PANK4
4'-phosphopantetheine phosphatase

1

1

Small-scale

0.479

High

1453337

CSN7A
COP9 signalosome complex subunit 7a

1

4

High-throughput

0.479

High

596896

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

Small-scale

0.458

High

629167

CCNA2
Cyclin-A2

1

0

Small-scale

0.458

High

1226546

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.458

High

1244840

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1339596

FBH1
F-box DNA helicase 1

1

0

Small-scale

0.458

High

1391665

VMP1
Vacuole membrane protein 1

1

0

Small-scale

0.458

High

1448744

OSTC
Oligosaccharyltransferase complex subunit OSTC

1

0

Small-scale

0.458

High

1453339

PNMA2
Paraneoplastic antigen Ma2

1

2

High-throughput

0.445

High

1240975

S27A4
Long-chain fatty acid transport protein 4

1

2

Small-scale

0.437

High

1418482

ACE2
Angiotensin-converting enzyme 2

1

1

Small-scale

0.437

High

190504

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

261668

CATL2
Cathepsin L2

1

0

High-throughput

0.279

Low

1333052

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

1

0

High-throughput

0.279

Low

1431049

RNAS7
Ribonuclease 7

1

0

High-throughput

0.279

Low

1249272

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1453343

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.249

Low

1417621

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025