Protein: TBX21
T-box transcription factor TBX21 (T-box protein 21) (T-cell-specific T-box transcription factor T-bet) (Transcription factor TBLYM)

Gene: TBX21
Organism: Mus musculus
Interactions: 20
UniProt ID: Q9JKD8

Gene Ontology (top 5):
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002296 - T-helper 1 cell lineage commitment
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

378461

IFNG
Interferon gamma

5

1

Small-scale

0.702

High

204352

ALX4
Homeobox protein aristaless-like 4

1

15

High-throughput

0.698

High

237273

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.698

High

1037932

GSC
Homeobox protein goosecoid

1

20

High-throughput

0.698

High

1225468

DLX1
Homeobox protein DLX-1

1

20

High-throughput

0.698

High

866410

PAX9
Paired box protein Pax-9

1

10

High-throughput

0.541

High

1223986

TEAD4
Transcriptional enhancer factor TEF-3

1

2

High-throughput

0.541

High

832859

BCL6
B-cell lymphoma 6 protein homolog

1

2

Small-scale

0.515

High

1225320

RUNX3
Runt-related transcription factor 3

1

1

Small-scale

0.515

High

408210

IL2
Interleukin-2

1

0

Small-scale

0.493

High

662689

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

5

High-throughput

0.481

High

838415

STA5A
Signal transducer and activator of transcription 5A

1

6

Small-scale

0.479

High

838421

STA5B
Signal transducer and activator of transcription 5B

1

6

Small-scale

0.479

High

902809

RORG
Nuclear receptor ROR-gamma

1

6

Small-scale

0.479

High

1042468

RUNX1
Runt-related transcription factor 1

1

1

Small-scale

0.479

High

1045992

TF65
Transcription factor p65

1

4

Small-scale

0.479

High

1189480

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

14

Small-scale

0.479

High

1221156

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

4

Small-scale

0.479

High

459949

IL4
Interleukin-4

1

0

Small-scale

0.458

High

1036039

PDCD1
Programmed cell death protein 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025