Protein: HSP74
Heat shock protein SSA4

Gene: HSP74, SSA4
Organism: Saccharomyces cerevisiae S288C
Interactions: 148
UniProt ID: P22202

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

605300

SIS1
Protein SIS1

4

20

Small-scale

0.881

High

493216

HSP72
Heat shock protein SSA2

3

16

High-throughput

0.839

High

605303

MAS5
Mitochondrial protein import protein MAS5

3

20

Small-scale

0.827

High

490356

HSP71
Heat shock protein SSA1

2

16

High-throughput

0.789

High

605318

HSP7F
Heat shock protein homolog SSE1

2

17

High-throughput

0.789

High

449910

HSP73
Heat shock protein SSA3

2

15

High-throughput

0.783

High

605378

APJ1
J domain-containing protein APJ1

2

20

Small-scale

0.754

High

605319

HSP79
Heat shock protein homolog SSE2

2

17

High-throughput

0.737

High

510278

SSB1
Ribosome-associated molecular chaperone SSB1

1

15

High-throughput

0.691

High

365802

HSP82
ATP-dependent molecular chaperone HSP82

3

17

Small-scale

0.641

High

543209

HSC82
ATP-dependent molecular chaperone HSC82

3

17

High-throughput

0.640

High

605349

CSK2C
Casein kinase II subunit beta'

2

4

High-throughput

0.621

High

605383

MCE1
mRNA-capping enzyme subunit alpha

2

2

High-throughput

0.621

High

477907

HSP77
Import motor subunit, mitochondrial

1

15

High-throughput

0.618

High

604348

CLH
Clathrin heavy chain

2

7

High-throughput

0.611

High

605297

HSP74
Heat shock protein SSA4

1

15

High-throughput

0.590

High

549702

STI1
Heat shock protein STI1

2

20

Small-scale

0.586

High

605341

FES1
Hsp70 nucleotide exchange factor FES1

2

8

Small-scale

0.586

High

480989

RL23B
Large ribosomal subunit protein uL14B

2

1

High-throughput

0.584

High

605312

HS104
Heat shock protein 104

2

10

Small-scale

0.584

High

605338

GBLP
Small ribosomal subunit protein RACK1

2

18

Small-scale

0.584

High

605362

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

10

High-throughput

0.584

High

560564

BIP
Endoplasmic reticulum chaperone BiP

1

14

High-throughput

0.575

High

605329

MDJ1
DnaJ homolog 1, mitochondrial

1

20

High-throughput

0.575

High

605353

HSP7E
Heat shock protein SSC3, mitochondrial

1

17

High-throughput

0.575

High

605324

HSP78
Heat shock protein 78, mitochondrial

2

11

High-throughput

0.571

High

605371

MSN5
Protein MSN5

1

12

Small-scale

0.561

High

334613

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

10

High-throughput

0.536

High

605354

IMB4
Importin subunit beta-4

1

11

High-throughput

0.536

High

605391

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

1

20

High-throughput

0.536

High

526780

CG13
G1/S-specific cyclin CLN3

1

9

High-throughput

0.515

High

605307

PCL2
PHO85 cyclin-2

1

5

High-throughput

0.508

High

605328

CLG1
PHO85 cyclin CLG1

1

3

High-throughput

0.508

High

605392

PCL8
PHO85 cyclin-8

1

8

High-throughput

0.508

High

477130

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

12

High-throughput

0.501

High

605320

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

12

Small-scale

0.501

High

429632

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

4

High-throughput

0.500

High

589262

FKBP
FK506-binding protein 1

1

15

High-throughput

0.500

High

605323

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

2

High-throughput

0.500

High

605350

TCPB
T-complex protein 1 subunit beta

1

13

High-throughput

0.500

High

605363

ATG18
Autophagy-related protein 18

1

14

High-throughput

0.500

High

605380

2ABA
Protein phosphatase PP2A regulatory subunit B

1

5

High-throughput

0.500

High

605382

AP1M1
AP-1 complex subunit mu-1-I

1

16

High-throughput

0.500

High

605401

AP2M
AP-2 complex subunit mu

1

17

High-throughput

0.500

High

605358

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

6

High-throughput

0.489

High

605372

UTP8
U3 small nucleolar RNA-associated protein 8

1

2

High-throughput

0.489

High

599160

RIR1
Ribonucleoside-diphosphate reductase large chain 1

1

3

Small-scale

0.481

High

141158

RS9A
Small ribosomal subunit protein uS4A

1

4

High-throughput

0.479

High

340023

KPYK1
Pyruvate kinase 1

1

5

High-throughput

0.479

High

343355

TPIS
Triosephosphate isomerase

1

2

High-throughput

0.479

High

343534

PMG1
Phosphoglycerate mutase 1

1

9

High-throughput

0.479

High

357888

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.479

High

375579

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

7

Small-scale

0.479

High

382956

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.479

High

402882

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

6

Small-scale

0.479

High

405436

RL26A
Large ribosomal subunit protein uL24A

1

3

High-throughput

0.479

High

406793

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

407732

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.479

High

410307

SC160
Protein SCP160

1

7

High-throughput

0.479

High

413310

RS14A
Small ribosomal subunit protein uS11A

1

4

High-throughput

0.479

High

421572

FAS1
Fatty acid synthase subunit beta

1

6

High-throughput

0.479

High

423760

ATPA
ATP synthase subunit alpha, mitochondrial

1

7

High-throughput

0.479

High

472023

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.479

High

479927

RS6A
Small ribosomal subunit protein eS6A

1

3

High-throughput

0.479

High

480488

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.479

High

498439

METK1
S-adenosylmethionine synthase 1

1

6

High-throughput

0.479

High

501154

HSF
Heat shock transcription factor

1

18

High-throughput

0.479

High

580512

FAS2
Fatty acid synthase subunit alpha

1

3

High-throughput

0.479

High

604748

PSB4
Proteasome subunit beta type-4

1

13

Small-scale

0.479

High

605298

CG22
G2/mitotic-specific cyclin-2

1

8

Small-scale

0.479

High

605301

RNQ1
[PIN+] prion protein RNQ1

1

1

High-throughput

0.479

High

605302

RS2
Small ribosomal subunit protein uS5

1

6

Small-scale

0.479

High

605304

MET14
Karyogamy protein KAR4

1

4

Small-scale

0.479

High

605305

TAH1
TPR repeat-containing protein associated with Hsp90

1

20

Small-scale

0.479

High

605306

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

1

6

Small-scale

0.479

High

605308

CYPC
Peptidyl-prolyl cis-trans isomerase C, mitochondrial

1

10

High-throughput

0.479

High

605309

RL16A
Large ribosomal subunit protein uL13A

1

3

High-throughput

0.479

High

605311

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.479

High

605313

GLNA
Glutamine synthetase

1

2

High-throughput

0.479

High

605314

EF2
Elongation factor 2

1

12

High-throughput

0.479

High

605316

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

605317

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

5

High-throughput

0.479

High

605321

RSSA1
Small ribosomal subunit protein uS2A

1

5

High-throughput

0.479

High

605322

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

605325

IXR1
Intrastrand cross-link recognition protein

1

12

Small-scale

0.479

High

605326

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.479

High

605327

TSA1
Peroxiredoxin TSA1

1

8

High-throughput

0.479

High

605330

DEF1
RNA polymerase II degradation factor 1

1

5

High-throughput

0.479

High

605331

RS27A
Small ribosomal subunit protein eS27A

1

4

High-throughput

0.479

High

605332

EF1G2
Elongation factor 1-gamma 2

1

8

High-throughput

0.479

High

605336

GLYC
Serine hydroxymethyltransferase, cytosolic

1

4

High-throughput

0.479

High

605337

GLY1
Low specificity L-threonine aldolase

1

2

High-throughput

0.479

High

605339

AHP1
Peroxiredoxin AHP1

1

2

High-throughput

0.479

High

605340

APN2
DNA-(apurinic or apyrimidinic site) endonuclease 2

1

4

Small-scale

0.479

High

605342

GID4
Vacuolar import and degradation protein 24

1

2

High-throughput

0.479

High

605344

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

605345

NMD3
60S ribosomal export protein NMD3

1

2

Small-scale

0.479

High

605357

TM108
Protein TMA108

1

8

High-throughput

0.479

High

605359

MKT1
Post-transcriptional regulator MKT1

1

2

High-throughput

0.479

High

605361

PXA1
Peroxisomal long-chain fatty acid import protein 2

1

4

High-throughput

0.479

High

605364

NMD5
Nonsense-mediated mRNA decay protein 5

1

13

Small-scale

0.479

High

605367

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.479

High

605368

VATG
V-type proton ATPase subunit G

1

4

High-throughput

0.479

High

605370

SKP1
Suppressor of kinetochore protein 1

1

3

Small-scale

0.479

High

605376

IGO1
mRNA stability protein IGO1

1

2

Small-scale

0.479

High

605377

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

3

Small-scale

0.479

High

605379

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

9

High-throughput

0.479

High

605381

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

8

High-throughput

0.479

High

605384

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.479

High

605385

TOM1
E3 ubiquitin-protein ligase TOM1

1

10

High-throughput

0.479

High

605387

BUL2
Ubiquitin ligase-binding protein BUL2

1

5

High-throughput

0.479

High

605389

PDS5
Sister chromatid cohesion protein PDS5

1

4

High-throughput

0.479

High

605390

TFC6
Transcription factor tau 91 kDa subunit

1

2

High-throughput

0.479

High

605393

TMA46
Translation machinery-associated protein 46

1

2

High-throughput

0.479

High

605394

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

10

High-throughput

0.479

High

605397

HSP42
Heat shock protein 42

1

4

High-throughput

0.479

High

605399

CMR1
DNA damage-binding protein CMR1

1

12

High-throughput

0.479

High

605400

SMC6
Structural maintenance of chromosomes protein 6

1

11

High-throughput

0.479

High

527214

HAP3
Transcriptional activator HAP3

1

5

High-throughput

0.457

High

605347

AIM46
Altered inheritance of mitochondria protein 46, mitochondrial

1

3

High-throughput

0.457

High

605360

COPB2
Coatomer subunit beta'

1

10

High-throughput

0.457

High

605373

COPA
Coatomer subunit alpha

1

13

High-throughput

0.457

High

605388

WDR59
Maintenance of telomere capping protein 5

1

20

High-throughput

0.457

High

587934

HSP60
Heat shock protein 60, mitochondrial

1

7

High-throughput

0.445

High

605343

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

5

High-throughput

0.445

High

605346

RIX1
Pre-rRNA-processing protein RIX1

1

2

High-throughput

0.445

High

605351

TCPD
T-complex protein 1 subunit delta

1

12

High-throughput

0.445

High

605356

6P21
6-phosphofructo-2-kinase 1

1

11

High-throughput

0.445

High

605366

CYP7
Peptidyl-prolyl cis-trans isomerase CYP7

1

15

Small-scale

0.445

High

605374

LTO1
Protein LTO1

1

2

High-throughput

0.445

High

605386

GCN5
Histone acetyltransferase GCN5

1

10

High-throughput

0.445

High

605395

NSL1
Kinetochore-associated protein NSL1

1

2

High-throughput

0.445

High

357206

RMAR
Small ribosomal subunit protein uS3m

1

2

High-throughput

0.437

High

605299

ERG6
Sterol 24-C-methyltransferase ERG6

1

5

High-throughput

0.437

High

605310

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

3

Small-scale

0.437

High

605315

OAC1
Mitochondrial oxaloacetate transport protein

1

15

High-throughput

0.437

High

605333

MCR1
NADH-cytochrome b5 reductase 2

1

10

Small-scale

0.437

High

605334

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

2

High-throughput

0.437

High

605335

MIC60
MICOS complex subunit MIC60

1

2

High-throughput

0.437

High

605369

TOM22
Mitochondrial import receptor subunit TOM22

1

3

High-throughput

0.437

High

605396

PER33
Pore and endoplasmic reticulum protein of 33 kDa

1

4

High-throughput

0.437

High

605398

YOP1
Protein YOP1

1

3

High-throughput

0.437

High

605355

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.426

High

605348

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

16

High-throughput

0.407

High

605375

CWC25
Pre-mRNA-splicing factor CWC25

1

1

High-throughput

0.407

High

605352

MBO1
Gamma tubulin complex adapter SPC72

1

0

High-throughput

0.251

Low

605365

GWT1
GPI-anchored wall transfer protein 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024