Protein: TF65
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)

Gene: TF65, Rela
Organism: Mus musculus
Interactions: 98
UniProt ID: Q04207

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

681976

NFKB1
Nuclear factor NF-kappa-B p105 subunit

19

17

Small-scale

0.987

High

1046000

IKBA
NF-kappa-B inhibitor alpha

21

20

Small-scale

0.986

High

1045998

NFKB2
Nuclear factor NF-kappa-B p100 subunit

7

20

Small-scale

0.957

High

1045971

IKBB
NF-kappa-B inhibitor beta

6

20

Small-scale

0.932

High

1045967

TF65
Transcription factor p65

3

18

Small-scale

0.840

High

449240

TNFA
Tumor necrosis factor

14

15

Small-scale

0.757

High

1045968

RELB
Transcription factor RelB

2

18

Small-scale

0.754

High

713200

NOS2
Nitric oxide synthase, inducible

12

3

Small-scale

0.754

High

470400

IL6
Interleukin-6

11

4

Small-scale

0.751

High

518943

CCL2
C-C motif chemokine 2

6

20

Small-scale

0.724

High

723156

CCL5
C-C motif chemokine 5

5

20

Small-scale

0.702

High

1045979

PANKY
Photoreceptor ankyrin repeat protein

1

11

High-throughput

0.698

High

1045987

ANKR7
Ankyrin repeat domain-containing protein 7

1

7

High-throughput

0.698

High

1045988

IL23A
Interleukin-23 subunit alpha

4

3

Small-scale

0.683

High

74273

EP300
Histone acetyltransferase p300

4

18

Small-scale

0.677

High

849292

IL12B
Interleukin-12 subunit beta

4

6

Small-scale

0.676

High

852340

CBP
Histone lysine acetyltransferase CREBBP

3

18

Small-scale

0.675

High

582536

REL
Proto-oncogene c-Rel

1

18

Small-scale

0.646

High

522164

BCL2
Apoptosis regulator Bcl-2

3

4

Small-scale

0.640

High

533541

CXCL2
C-X-C motif chemokine 2

3

15

Small-scale

0.640

High

1045985

ZDH13
Palmitoyltransferase ZDHHC13

1

5

High-throughput

0.625

High

432080

JUN
Transcription factor Jun

1

20

Small-scale

0.618

High

1036048

CTNB1
Catenin beta-1

2

13

Small-scale

0.611

High

547917

NGAL
Neutrophil gelatinase-associated lipocalin

2

3

Small-scale

0.601

High

583144

IRF1
Interferon regulatory factor 1

2

20

Small-scale

0.598

High

236656

IKBE
NF-kappa-B inhibitor epsilon

1

20

Small-scale

0.590

High

1045982

MED17
Mediator of RNA polymerase II transcription subunit 17

1

2

Small-scale

0.586

High

373680

MYC
Myc proto-oncogene protein

2

13

Small-scale

0.584

High

532188

IL1B
Interleukin-1 beta

2

7

Small-scale

0.584

High

671890

CCND1
G1/S-specific cyclin-D1

2

4

Small-scale

0.584

High

693160

TNR5
Tumor necrosis factor receptor superfamily member 5

2

5

Small-scale

0.584

High

1045970

TNAP3
Tumor necrosis factor alpha-induced protein 3

2

8

Small-scale

0.584

High

1045983

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

7

Small-scale

0.584

High

1045994

PIAS4
E3 SUMO-protein ligase PIAS4

2

7

Small-scale

0.584

High

1045980

MTA1
Metastasis-associated protein MTA1

1

4

Small-scale

0.561

High

1045975

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

8

Small-scale

0.554

High

1046001

FM1AA
Protein fem-1 homolog A-A

1

4

Small-scale

0.553

High

107065

F8VPR5
histone acetyltransferase

1

18

Small-scale

0.552

High

73939

BRPF1
Peregrin

1

1

High-throughput

0.541

High

568883

DNMT1
DNA

1

5

High-throughput

0.541

High

1045981

ZMY11
Zinc finger MYND domain-containing protein 11

1

8

High-throughput

0.541

High

1045986

CXXC1
CXXC-type zinc finger protein 1

1

8

High-throughput

0.541

High

1045999

SRBP1
Sterol regulatory element-binding protein 1

1

20

High-throughput

0.541

High

148681

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.536

High

1045978

NANOG
Homeobox protein NANOG

1

11

Small-scale

0.527

High

1045984

CERS2
Ceramide synthase 2

1

0

High-throughput

0.518

High

648048

MYD88
Myeloid differentiation primary response protein MyD88

1

1

Small-scale

0.515

High

555574

NR4A1
Nuclear receptor subfamily 4 group A member 1

1

20

Small-scale

0.500

High

236340

PIAS3
E3 SUMO-protein ligase PIAS3

1

7

High-throughput

0.481

High

205429

SOCS1
Suppressor of cytokine signaling 1

1

10

Small-scale

0.479

High

237232

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

3

Small-scale

0.479

High

312145

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

18

Small-scale

0.479

High

313407

SP1
Transcription factor Sp1

1

14

Small-scale

0.479

High

313426

CCL20
C-C motif chemokine 20

1

20

Small-scale

0.479

High

382471

P53
Cellular tumor antigen p53

1

8

Small-scale

0.479

High

408207

IL2
Interleukin-2

1

6

Small-scale

0.479

High

450392

CSF1
Macrophage colony-stimulating factor 1

1

3

Small-scale

0.479

High

556551

GROA
Growth-regulated alpha protein

1

13

Small-scale

0.479

High

576913

HMOX1
Heme oxygenase 1

1

1

Small-scale

0.479

High

587404

RAG1
V(D)J recombination-activating protein 1

1

8

Small-scale

0.479

High

605033

CXL10
C-X-C motif chemokine 10

1

16

Small-scale

0.479

High

640754

RAG2
V(D)J recombination-activating protein 2

1

1

Small-scale

0.479

High

771399

HES1
Transcription factor HES-1

1

5

Small-scale

0.479

High

789690

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.479

High

789724

THB
Thyroid hormone receptor beta

1

20

Small-scale

0.479

High

849286

IL12A
Interleukin-12 subunit alpha

1

4

Small-scale

0.479

High

871197

IL15
Interleukin-15

1

1

Small-scale

0.479

High

902767

RORA
Nuclear receptor ROR-alpha

1

20

Small-scale

0.479

High

927737

ATX1
Ataxin-1

1

4

High-throughput

0.479

High

999996

HDAC2
Histone deacetylase 2

1

20

Small-scale

0.479

High

1000210

GFI1
Zinc finger protein Gfi-1

1

2

Small-scale

0.479

High

1045969

NR4A2
Nuclear receptor subfamily 4 group A member 2

1

20

Small-scale

0.479

High

1045972

I17RA
Interleukin-17 receptor A

1

2

Small-scale

0.479

High

1045973

E2F1
Transcription factor E2F1

1

3

Small-scale

0.479

High

1045974

HS71A
Heat shock 70 kDa protein 1A

1

20

Small-scale

0.479

High

1045976

SQSTM
Sequestosome-1

1

2

Small-scale

0.479

High

1045991

KAT2A
Histone acetyltransferase KAT2A

1

6

Small-scale

0.479

High

1045992

TBX21
T-box transcription factor TBX21

1

4

Small-scale

0.479

High

1046002

HDAC6
Protein deacetylase HDAC6

1

20

Small-scale

0.479

High

488290

CSF3
Granulocyte colony-stimulating factor

1

0

Small-scale

0.458

High

705056

I23O1
Indoleamine 2,3-dioxygenase 1

1

0

Small-scale

0.458

High

1045977

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

Small-scale

0.458

High

1045989

HEPC
Hepcidin

1

0

Small-scale

0.458

High

1045995

GLRX1
Glutaredoxin-1

1

0

Small-scale

0.458

High

313119

HDAC3
Histone deacetylase 3

1

20

Small-scale

0.445

High

1040005

KPCZ
Protein kinase C zeta type

1

15

Small-scale

0.445

High

1045990

BRD4
Bromodomain-containing protein 4

1

7

Small-scale

0.445

High

1045996

TLR2
Toll-like receptor 2

1

1

Small-scale

0.445

High

378390

IFNB
Interferon beta

1

7

Small-scale

0.437

High

564897

ICAM1
Intercellular adhesion molecule 1

1

5

Small-scale

0.437

High

582051

IL9
Interleukin-9

1

2

Small-scale

0.437

High

1021250

PSME2
Proteasome activator complex subunit 2

1

2

Small-scale

0.437

High

1026924

LYAM2
E-selectin

1

3

Small-scale

0.437

High

770556

RAB21
Ras-related protein Rab-21

1

1

High-throughput

0.407

High

376952

NGF
Beta-nerve growth factor

1

0

Small-scale

0.249

Low

1045993

TREM1
Triggering receptor expressed on myeloid cells 1

1

0

Small-scale

0.249

Low

1045997

ENPP2
Autotaxin

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025