Protein: RO52
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)

Gene: RO52, Trim21
Organism: Mus musculus
Interactions: 22
UniProt ID: Q62191

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0000932 - P-body
GO:0003677 - DNA binding
GO:0003723 - RNA binding
GO:0004842 - ubiquitin-protein transferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1223886

DDX41
Probable ATP-dependent RNA helicase DDX41

1

5

Small-scale

0.691

High

987290

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

5

Small-scale

0.575

High

987308

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

4

Small-scale

0.575

High

1189942

Q3U7K7
E3 ubiquitin-protein ligase TRIM21

1

18

Small-scale

0.575

High

1201197

Q569Y6
Ubiquitin-conjugating enzyme E2 variant 1

1

20

Small-scale

0.575

High

508938

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

9

Small-scale

0.514

High

509100

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]

1

9

Small-scale

0.514

High

969108

PRS8
26S proteasome regulatory subunit 8

1

9

Small-scale

0.445

High

1034648

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

2

Small-scale

0.445

High

1135294

Q14AQ1
26S proteasome regulatory subunit 10B

1

9

Small-scale

0.445

High

1223884

Q8CFQ1
Signal transducer and activator of transcription 1

1

4

Small-scale

0.445

High

1223888

HOME1
Homer protein homolog 1

1

7

High-throughput

0.445

High

204970

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

5

Small-scale

0.407

High

574835

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

Small-scale

0.407

High

932165

PRS6B
26S proteasome regulatory subunit 6B

1

7

Small-scale

0.407

High

968850

PRS4
26S proteasome regulatory subunit 4

1

7

Small-scale

0.407

High

1189647

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

3

Small-scale

0.407

High

1190976

Q3UWW9
26S proteasome non-ATPase regulatory subunit 11

1

2

Small-scale

0.407

High

1223883

Q8BVQ9
26S proteasome regulatory subunit 7

1

7

Small-scale

0.407

High

1223885

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

3

Small-scale

0.407

High

1223887

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

1

Small-scale

0.407

High

1223882

SIG10
Sialic acid-binding Ig-like lectin 10

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025